mefenamic acid has been researched along with Alzheimer Disease in 5 studies
Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Flufenamic acid and mefenamic acid are efficacious in NLRP3-dependent rodent models of inflammation in air pouch and peritoneum." | 3.83 | Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models. ( Allan, SM; Bagnall, J; Baldwin, AG; Booth, SJ; Brough, D; Daniels, MJ; Eder, C; Fasolino, V; Fischer, N; Freeman, S; Galea, J; Harte, MK; Jackson, J; Koziel, V; Latta, C; Lawrence, CB; Paszek, P; Pillot, T; Rivers-Auty, J; Schilling, T; Spencer, NG; Watremez, W; White, CS; Wong, R; Yu, S, 2016) |
| "The protective effect of NSAIDs on Alzheimer's disease seems to occur through inactivation of ChE induced by NSAIDs radicals." | 1.35 | Inactivation of cholinesterase induced by non-steroidal anti-inflammatory drugs with horseradish peroxidase: implication for Alzheimer's disease. ( Miura, T; Muraoka, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stock, N | 1 |
| Munoz, B | 1 |
| Wrigley, JD | 1 |
| Shearman, MS | 1 |
| Beher, D | 1 |
| Peachey, J | 1 |
| Williamson, TL | 1 |
| Bain, G | 1 |
| Chen, W | 1 |
| Jiang, X | 1 |
| St-Jacques, R | 1 |
| Prasit, P | 1 |
| Daniels, MJ | 1 |
| Rivers-Auty, J | 1 |
| Schilling, T | 1 |
| Spencer, NG | 1 |
| Watremez, W | 1 |
| Fasolino, V | 1 |
| Booth, SJ | 1 |
| White, CS | 1 |
| Baldwin, AG | 1 |
| Freeman, S | 1 |
| Wong, R | 1 |
| Latta, C | 1 |
| Yu, S | 1 |
| Jackson, J | 1 |
| Fischer, N | 1 |
| Koziel, V | 1 |
| Pillot, T | 1 |
| Bagnall, J | 1 |
| Allan, SM | 1 |
| Paszek, P | 1 |
| Galea, J | 1 |
| Harte, MK | 1 |
| Eder, C | 1 |
| Lawrence, CB | 1 |
| Brough, D | 1 |
| Muraoka, S | 1 |
| Miura, T | 1 |
| Joo, Y | 1 |
| Kim, HS | 1 |
| Woo, RS | 1 |
| Park, CH | 1 |
| Shin, KY | 1 |
| Lee, JP | 1 |
| Chang, KA | 1 |
| Kim, S | 1 |
| Suh, YH | 1 |
| Asanuma, M | 1 |
| Nishibayashi-Asanuma, S | 1 |
| Miyazaki, I | 1 |
| Kohno, M | 1 |
| Ogawa, N | 1 |
5 other studies available for mefenamic acid and Alzheimer Disease
| Article | Year |
|---|---|
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, N | 2006 |
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cell Death; | 2016 |
Inactivation of cholinesterase induced by non-steroidal anti-inflammatory drugs with horseradish peroxidase: implication for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterases; Free Radicals; | 2009 |
Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase | 2006 |
Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoates; Cell Death; | 2001 |