medigoxin and Poisoning

A 38-year-old man with endogenous depression was found comatose and with gasping respiration. Empty packets of tablets pointed to poisoning with methyldigoxin, nifedipine and indapamide. Pupils reacted slowly to light and no peripheral blood pressure could be measured.. Routine resuscitation measures (intubation, mechanical ventilation, external cardiac massage and drugs) were undertaken during transport to hospital where, in addition to further symptomatic treatment, digoxin antibodies were administered, but without noticeable effect. Percutaneous cardiopulmonary bypass was therefore undertaken. It achieved a cardiac output of 3.2l and a systolic pressure of 80 mm Hg: a stable rhythm and circulation were obtained within 15 hours indicating that electromechanical uncoupling had for the time being been overcome. The EEG suggested a midbrain syndrome. After another 18 hours of mechanical ventilation and symptomatic treatment asystole suddenly occurred. Renewed resuscitation procedures were not undertaken because of the very poor neurological state and prognosis.. Although haemodynamic stabilization was only temporarily achieved and the patient's death could not be prevented because of adverse pretreatment conditions, the application of percutaneously implantable, transportable heart-lung machine appears to be justified in cases of intoxication with cardio- and vasodepressive substances.

Topics: Adult; Cardiopulmonary Bypass; Echocardiography; Electrocardiography; Humans; Indapamide; Male; Medigoxin; Nifedipine; Poisoning; Respiration, Artificial; Shock, Cardiogenic; Time Factors

Topics: Antitussive Agents; Diazepam; Humans; Hydrochlorothiazide; Insulin; Male; Medazepam; Medigoxin; Middle Aged; Phenylbutyrates; Poisoning; Suicide, Attempted; Triamterene; Verapamil