medigoxin has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for medigoxin and Neoplasms
Article | Year |
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Evaluation of doxorubicin cardiotoxicity in patients treated intermittently with beta-methyldigoxin.
Twenty-one patients with various advanced neoplasms were treated with 60 to 75 mg/m2 of doxorubicin every 3 to 4 weeks and monitored by ECG and systolic time intervals (PEP/LVET) with the aim to establish whether a pretreatment with beta-methyldigoxin, administered intermittently, could prevent doxorubicin-induced cardiotoxicity. It was found that until patients received digitalis pretreatment the PEP/LVET ratio did not change significantly from mean basal values even after the highest cumulative dosages of doxorubicin. However, after interruption of the therapy with both drugs, PEP/LVET increased reaching a value not significantly different from that observed in a comparable group of patients treated only with doxorubicin. Moreover, of 9 patients who reached the cumulative limiting dose, 2 developed congestive heart failure. These results question the possibility that digitalis administered according to an intermittent treatment scheme may prevent doxorubicin cardiomyopathy. Topics: Adolescent; Adult; Aged; Child; Digoxin; Dose-Response Relationship, Drug; Doxorubicin; Electrocardiography; Female; Heart; Heart Function Tests; Humans; Male; Medigoxin; Middle Aged; Neoplasms; Systole | 1982 |