medigoxin and Chronic-Disease

Topics: Adult; Aged; Biological Availability; Chronic Disease; Circadian Rhythm; Clinical Trials as Topic; Digoxin; Heart Failure; Humans; Medigoxin; Middle Aged; Monitoring, Physiologic

A 2 months old girl was given a tenfold increased dosage of Beta-Methyldigoxin for 2 weeks and subsequently developed severe symptoms of glycoside intoxication. In hospital she was treated by digoxin-specific Fab antibody fragments. 18 hours later the symptoms had totally disappeared. However, 48 hours from the beginning of the treatment free digoxin levels rose again to toxic ranges. In chronic intoxications the rediffusion of glycosides from tissues and interstitial space seems to be much more pronounced than in acute intoxications, and there is a higher risk of reintoxication.

Topics: Chronic Disease; Digoxin; Dose-Response Relationship, Drug; Female; Heart Septal Defects, Ventricular; Humans; Immunoglobulin Fab Fragments; Infant; Medigoxin

Topics: Chronic Disease; Digoxin; Heart Failure; Humans; Medigoxin

Topics: Adult; Aged; Atrial Fibrillation; Chronic Disease; Circadian Rhythm; Digitoxin; Digoxin; Drug Therapy, Combination; Heart Rate; Humans; Medigoxin; Middle Aged; Pindolol; Propranolol

Topics: Adult; Atrial Fibrillation; Chronic Disease; Digoxin; Female; Heart Rate; Humans; Male; Medigoxin; Middle Aged; Physical Exertion; Rest