medigoxin and Anuria

medigoxin has been researched along with Anuria* in 1 studies

Other Studies

1 other study(ies) available for medigoxin and Anuria

ArticleYear
Extrarenal clearance, distribution volume, and elimination rate of digoxin and metildigoxin in anuric patients.
    International journal of clinical pharmacology, therapy, and toxicology, 1981, Volume: 19, Issue:9

    The pharmacokinetics of 3H-labeled digoxin and metildigoxin were compared in six anuric patients. The following means +/- s.e.m. were obtained: extrarenal clearance of digoxin, 43.3 +/- 5.4 ml/min, of metildigoxin, 30.3 +/- 2.9 ml/min; distribution volume of digoxin, 315 +/- 29 1, of metildigoxin, 258 +/- 22 1; rate constant for elimination of digoxin, 0.0086 +/- 0.0013 h-1, of metildogixon, 0.0071 +/- 0.0007 h-1. The elimination rates correspond to half-lives of 80 h for digoxin and of 97 h for metildigoxin. From our investigations and published data a weighed mean of 47 ml/min was calculated for the extrarenal clearance of metildigoxin. This is not significantly different from the mean extrarenal clearance of 40 ml/min reported for digoxin. A total body clearance of 40 ml/min and a daily intravenous dose of 0.1 mg correspond to an average steady-state glycoside concentration of 1.74 ng/ml.

    Topics: Anuria; Digoxin; Humans; Medigoxin; Metabolic Clearance Rate; Renal Dialysis

1981