meclofenoxate has been researched along with Parkinson Disease in 3 studies
Meclofenoxate: An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In our previous study, we have shown that chronic administration of rotenone to rats is able to produce motor dysfunction, which increases progressively with rotenone treatment and centrophenoxine (CPH) co-treatment is able to attenuate these motor defects." | 1.35 | Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease. ( Nehru, B; Verma, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Parui, A | 1 |
| Biswas, S | 1 |
| Roy, I | 1 |
| Wang, S | 1 |
| Zhang, S | 1 |
| Xu, C | 1 |
| Barron, A | 1 |
| Galiano, F | 1 |
| Patel, D | 1 |
| Lee, YJ | 1 |
| Caldwell, GA | 1 |
| Caldwell, KA | 1 |
| Witt, SN | 1 |
| Verma, R | 1 |
| Nehru, B | 1 |
3 other studies available for meclofenoxate and Parkinson Disease
| Article | Year |
|---|---|
Meclofenoxate Inhibits Aggregation of Alpha-synuclein
Topics: alpha-Synuclein; Animals; Dopamine; Humans; Meclofenoxate; Parkinson Disease; Protein Aggregates | 2023 |
Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carboxy-Lyases; C | 2016 |
Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Cerebellum; Cerebral Cortex; Cytoprotection; Disease Models, Animal; | 2009 |