meclofenoxate has been researched along with Aging in 56 studies
Meclofenoxate: An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicergoline (NE)--a cerebral vasodilator with nicotinic acid esterified in its molecule--and Antagonic-Stress (AS) composition--a neurometabolic nootropic, also containing nicotinic acid but with fast and prolonged release--were evaluated in senile dementia of Alzheimer's type (SDAT), mild to moderate intensity (DSM-IV Options Book, 1991 and ICD-10, 1990 criteria)." | 5.07 | Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry. ( Mateescu, R; Măties, R; Mihalas, G; Mihalas, IG; Popa, R; Schneider, F; Stefanigă, P, 1994) |
| " Treatment of aging mice with meclofenoxate, a drug that is reported to cause dissolution of lipofuscin, failed to prevent accumulation of dolichol and dolichyl phosphate with age." | 3.68 | Changes in murine tissue concentrations of dolichol and dolichol derivatives associated with age. ( Daniels, I; Hemming, FW, 1990) |
| "4." | 1.29 | Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs. ( Alova, LG; Stancheva, SL, 1994) |
| "Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy." | 1.29 | Effects of cytidine diphosphate choline on rats with memory deficits. ( Getova, D; Kehayov, RA; Lazarova, MB; Mosharrof, AH; Petkov, VD; Petkov, VV; Vaglenova, J, 1993) |
| " A dosage of 80 mg/Kg produced greater changes than a 120 mg/Kg dosage." | 1.27 | Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain. ( Pathak, DN; Roy, D; Singh, R, 1983) |
| "Senile white rats were treated with centrophenoxine at a dosage of 100 mg/Kg body weight/day for 60 days intraperitoneally." | 1.27 | Cytochemical interaction of nucleolus and cytoplasm in the Purkinje cells of senile white rats under the influence of centrophenoxine. ( Patro, IK; Sharma, SP, 1984) |
| " With the dosage employed neurons of the central nervous system showed in all animals a significant reduction of lipofuscin pigment." | 1.25 | [Centrophenoxin-induced dissolution and removal of lipofuscin. An electron microscopic study (author's transl)]. ( Glees, P; Spoerri, PE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (69.64) | 18.7374 |
| 1990's | 14 (25.00) | 18.2507 |
| 2000's | 2 (3.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bakhtogarimov, IR | 1 |
| Kudryavtseva, AV | 1 |
| Krasnov, GS | 1 |
| Gladysh, NS | 1 |
| Volodin, VV | 1 |
| Kudryavtsev, AA | 1 |
| Bulavkina, EV | 1 |
| Goncharova, MA | 1 |
| Ledyaeva, VS | 1 |
| Pastukhov, IS | 1 |
| Vershinina, YS | 1 |
| Starkova, AM | 1 |
| Snezhkina, AV | 1 |
| Shuvalova, AI | 1 |
| Pavlov, VS | 1 |
| Nikiforov-Nikishin, DL | 1 |
| Moskalev, AA | 1 |
| Guvatova, ZG | 1 |
| Bhalla, P | 1 |
| Nehru, B | 1 |
| Wittenborn, JR | 1 |
| Zs-Nagy, I | 5 |
| Semsei, I | 1 |
| Viticchi, C | 1 |
| Gentile, S | 1 |
| Piantanelli, L | 1 |
| Nagy, K | 3 |
| Nagy, V | 2 |
| Bertoni-Freddari, C | 2 |
| Nagy, I | 3 |
| van Bezooijen, CF | 1 |
| Sakkee, AN | 1 |
| Knook, DL | 1 |
| Dylewski, DP | 1 |
| Nandy, S | 1 |
| Nandy, K | 4 |
| Katz, ML | 1 |
| Robison, WG | 1 |
| Roy, D | 2 |
| Pathak, DN | 1 |
| Singh, R | 3 |
| Patro, IK | 2 |
| Sharma, SP | 2 |
| Jänicke, B | 1 |
| Wrobel, D | 1 |
| Aloj Totàro, E | 1 |
| Pisanti, FA | 1 |
| Kalmár, A | 1 |
| Nagy, E | 1 |
| Jamieson, DD | 1 |
| Taylor, KM | 1 |
| Brahma, KC | 1 |
| Patnaik, BK | 1 |
| Giuli, C | 2 |
| Pieri, C | 2 |
| Sharma, D | 1 |
| Stancheva, SL | 3 |
| Alova, LG | 2 |
| Predescu, V | 1 |
| Riga, D | 2 |
| Riga, S | 2 |
| Turlea, J | 1 |
| Bărbat, IM | 1 |
| Botezat-Antonescu, L | 1 |
| Schneider, F | 1 |
| Popa, R | 1 |
| Mihalas, G | 1 |
| Stefanigă, P | 1 |
| Mihalas, IG | 1 |
| Măties, R | 1 |
| Mateescu, R | 1 |
| Petkov, VD | 4 |
| Kehayov, RA | 1 |
| Mosharrof, AH | 2 |
| Petkov, VV | 4 |
| Getova, D | 1 |
| Lazarova, MB | 1 |
| Vaglenova, J | 1 |
| Iarygin, VN | 2 |
| Bibaeva, LV | 1 |
| al-Zuhair, H | 1 |
| Abd el-Fattah, A | 1 |
| el-Sayed, MI | 1 |
| Tomonaga, M | 1 |
| Izumiyama, N | 1 |
| Kameyama, M | 1 |
| Baste, C | 1 |
| Schneider, FH | 1 |
| Del Moro, M | 1 |
| Kent, S | 1 |
| Spoerri, PE | 2 |
| Glees, P | 3 |
| Patro, N | 1 |
| Zolotov, NN | 1 |
| Kutenova, OA | 1 |
| Voronina, TA | 1 |
| Pozdnev, VF | 1 |
| Smirnov, LD | 1 |
| Diumaev, KM | 1 |
| Daniels, I | 1 |
| Hemming, FW | 1 |
| Belcheva, S | 1 |
| Stoyanova, V | 1 |
| Wustmann, C | 1 |
| Blaschke, M | 1 |
| Rudolph, E | 1 |
| Fischer, HD | 1 |
| Schmidt, J | 1 |
| Ohta, M | 1 |
| Kitani, K | 1 |
| Wood, WG | 1 |
| Gorka, C | 1 |
| Armbrecht, HJ | 1 |
| Williamson, LS | 1 |
| Strong, R | 1 |
| Potapov, SI | 1 |
| Grigor'eva, AV | 1 |
| Schneider, EL | 1 |
| Reed, JD | 1 |
| Dowson, JH | 1 |
| Oliver, JE | 1 |
| Restell, M | 1 |
| Meier, C | 1 |
| Schmidt, H | 1 |
| Broicher, H | 1 |
| Hochschild, R | 1 |
| Pogády, J | 1 |
| Ruscák, M | 1 |
| Orlický, J | 1 |
| Chemnitius, KH | 1 |
| Machnik, G | 1 |
| Löw, O | 1 |
| Arnrich, M | 1 |
| Urban, J | 1 |
5 reviews available for meclofenoxate and Aging
| Article | Year |
|---|---|
Pharmacotherapy for age-related behavioral deficiencies.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Brain; Central | 1981 |
A survey of the available data on a new nootropic drug, BCE-001.
Topics: Aging; Animals; Cell Membrane; Drug Design; Free Radical Scavengers; Humans; Meclofenoxate; Psychotr | 1994 |
Pharmacological interventions against aging through the cell plasma membrane: a review of the experimental results obtained in animals and humans.
Topics: 2,4-Dichlorophenoxyacetic Acid; Aging; Animals; Brain; Cell Membrane; Deanol; Esters; Free Radical S | 2002 |
Solving the riddle of lipofuscin's origin may uncover clues to the aging process.
Topics: Aging; Animals; Brain; Cell Survival; Ceroid; Humans; Lipofuscin; Lysosomes; Meclofenoxate; Nerve De | 1976 |
Life extension.
Topics: Aged; Aging; Animals; Antioxidants; Dehydroepiandrosterone; Diet; Energy Intake; Ethics, Medical; Fe | 1985 |
2 trials available for meclofenoxate and Aging
| Article | Year |
|---|---|
Antagonic-stress. A new treatment in gerontopsychiatry and for a healthy productive life.
Topics: Aged; Aging; Cognition Disorders; Double-Blind Method; Drug Combinations; Female; Humans; Male; Mecl | 1994 |
Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry.
Topics: Aged; Aging; Dementia; Double-Blind Method; Drug Combinations; Female; Geriatric Assessment; Humans; | 1994 |
49 other studies available for meclofenoxate and Aging
| Article | Year |
|---|---|
The Effect of Meclofenoxate on the Transcriptome of Aging Brain of
Topics: Aging; Animals; Brain; Cyprinodontiformes; Female; Fundulidae; Meclofenoxate; Transcriptome | 2022 |
Modulatory effects of centrophenoxine on different regions of ageing rat brain.
Topics: Aging; Animals; Brain; Catalase; Cerebellum; Female; Glutathione; Glutathione Reductase; Hypothalamu | 2005 |
Centrophenoxine increases the rates of total and mRNA synthesis in the brain cortex of old rats: an explanation of its action in terms of the membrane hypothesis of aging.
Topics: Aging; Animals; Brain; Cell Membrane; Cerebral Cortex; Deanol; Female; Free Radicals; Glycolates; Me | 1984 |
Centrophenoxine-induced increase of beta-adrenoceptor density in brain cortex of old mice.
Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Glycolates; Meclofenoxate; Mice; Mice, Inbred BALB C | 1984 |
Alterations of the synaptosomal membrane 'microviscosity' in the brain cortex of rats during aging and centrophenoxine treatment.
Topics: Aging; Animals; Cerebral Cortex; Fluorescence Polarization; Glycolates; In Vitro Techniques; Male; M | 1983 |
Meclofenoxate decreases protein and albumin synthesis in hepatocytes isolated from old rats.
Topics: Aging; Albumins; Animals; Female; Glycolates; In Vitro Techniques; Liver; Meclofenoxate; Protein Bio | 1983 |
Effects of centrophenoxine on lipofuscin in the retinal pigment epithelium of old mice.
Topics: Aging; Animals; Female; Glycolates; Lipofuscin; Meclofenoxate; Mice; Mice, Inbred C57BL; Microscopy, | 1983 |
Lipofuscin response to the "aging-reversal" drug centrophenoxine in rat retinal pigment epithelium and frontal cortex.
Topics: Aging; Animals; Cerebral Cortex; Female; Glycolates; Lipofuscin; Meclofenoxate; Pigment Epithelium o | 1983 |
Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain.
Topics: Aging; Animals; Brain; Catalase; Female; Glutathione Peroxidase; Glutathione Reductase; Glycolates; | 1983 |
Cytochemical interaction of nucleolus and cytoplasm in the Purkinje cells of senile white rats under the influence of centrophenoxine.
Topics: Acid Phosphatase; Aging; Animals; Cell Nucleolus; Cytoplasm; Esterases; Female; Glycolates; Histocyt | 1984 |
Changes in motor activity with age and the effects of pharmacologic treatment.
Topics: Aging; Animals; Body Weight; Dextroamphetamine; Dihydroergotoxine; Female; Meclofenoxate; Motor Acti | 1984 |
Alterations in the molecular weight distribution of proteins in rat brain synaptosomes during aging and centrophenoxine treatment of old rats.
Topics: Aging; Animals; Brain; Cell Membrane Permeability; Female; Glycolates; Meclofenoxate; Membrane Prote | 1984 |
Biological bases and prospects of the lipofuscinolitic activity of meclofenoxate: a study of Torpedo m. neurons.
Topics: Aging; Animals; Fishes; Glycolates; Lipofuscin; Meclofenoxate; Models, Biological; Neurons; Pigments | 1980 |
Alterations in total content and solubility characteristics of proteins in rat brain and liver during ageing and centrophenoxine treatment.
Topics: Aging; Animals; Brain; Female; Glycolates; Liver; Male; Meclofenoxate; Microscopy, Electron; Nerve T | 1981 |
Effects of centrophenoxine, piracetam and hydergine on rat brain lipid peroxidation.
Topics: Aging; Animals; Brain; Dihydroergotoxine; Glycolates; In Vitro Techniques; Lipid Peroxides; Male; Me | 1981 |
Changes in the characteristics of collagen of young male garden lizards following centrophenoxine and lysine treatment.
Topics: Aging; Animals; Bone and Bones; Collagen; Glycolates; Lizards; Lysine; Male; Meclofenoxate; Skin; Te | 1982 |
The effect of acute and chronic centrophenoxine treatment on the synaptic plasticity of old rats.
Topics: Aging; Animals; Cerebellum; Female; Glycolates; Meclofenoxate; Neuronal Plasticity; Rats; Rats, Inbr | 1982 |
Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats.
Topics: Acetylcholinesterase; Aging; Animals; Enzyme Activation; Hippocampus; Male; Meclofenoxate; Rats; Rat | 1995 |
Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs.
Topics: Aging; Animals; Biogenic Monoamines; Brain; Corpus Striatum; Frontal Lobe; In Vitro Techniques; Mecl | 1994 |
Effects of cytidine diphosphate choline on rats with memory deficits.
Topics: Aging; Animals; Avoidance Learning; Clonidine; Cytidine Diphosphate Choline; Electroshock; Fetal Alc | 1993 |
[Biomedical aspects of health preservation strategy: role of catecholaminergic neuronal populations].
Topics: Adaptation, Physiological; Adolescent; Adult; Aging; Animals; Catecholamines; Female; Health Status; | 1997 |
The effect of meclofenoxate with ginkgo biloba extract or zinc on lipid peroxide, some free radical scavengers and the cardiovascular system of aged rats.
Topics: Aging; Animals; Brain; Cardiovascular System; Drug Evaluation, Preclinical; Drug Therapy, Combinatio | 1998 |
Lipofuscinogenesis in mice early treated with centrophenoxine.
Topics: Aging; Animals; Cerebral Cortex; Female; Glycolates; Hippocampus; Lipofuscin; Meclofenoxate; Mice; N | 1978 |
[On the effect of centrophenoxine for the lipofuscin in the nerve cells of the aged guinea pigs (author's transl)].
Topics: Aging; Animals; Glycolates; Guinea Pigs; Lipofuscin; Meclofenoxate; Neurons; Pigments, Biological | 1978 |
Further studies on the effects of centrophenoxine on lipofuscin pigment in neuroblastoma cells in culture: an electron microscopic study.
Topics: Aging; Animals; Cells, Cultured; Glycolates; Lipofuscin; Meclofenoxate; Mice; Neoplasms, Experimenta | 1978 |
Effects of centrophenoxine on the monovalent electrolyte contents of the large brain cortical cells of old rats.
Topics: Aging; Animals; Cell Nucleus; Cerebral Cortex; Chlorides; Cytoplasm; Electrolytes; Female; Glycolate | 1979 |
The mode of lipofuscin removal from hypothalamic neurons.
Topics: Aging; Animals; Guinea Pigs; Hypothalamus; Lipofuscin; Meclofenoxate; Neurons; Pigments, Biological | 1975 |
[Centrophenoxin-induced dissolution and removal of lipofuscin. An electron microscopic study (author's transl)].
Topics: Aging; Animals; Capillaries; Central Nervous System; Dose-Response Relationship, Drug; Endoplasmic R | 1975 |
Lipofuscin accumulation in ageing myocardium & its removal by meclophenoxate.
Topics: Aging; Animals; Heart; Lipofuscin; Meclofenoxate; Myocardium; Rats; Rats, Inbred Strains | 1992 |
Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor--nootropic agent adafenoxate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Brain; Cyclic AMP; Kinetics; Meclofenoxate; Ner | 1991 |
[The possible participation of brain peptidases in regulating the memory function during aging].
Topics: Aging; Animals; Antioxidants; Brain; Deanol; Drug Combinations; Endopeptidases; Glutamates; Lipid Pe | 1991 |
Changes in murine tissue concentrations of dolichol and dolichol derivatives associated with age.
Topics: Aging; Animals; Body Weight; Dolichol Phosphates; Dolichols; Female; Heart; Kidney; Lipofuscin; Live | 1990 |
Effects of nootropic agents on the performing of active two-way avoidance tasks in young and old rats.
Topics: Aging; Animals; Avoidance Learning; Male; Meclofenoxate; Memory; Piracetam; Psychotropic Drugs; Rats | 1990 |
Influence of nootropic drugs on the age-dependent potassium-coupling of transmitter release.
Topics: Aging; Animals; Calcium-Transporting ATPases; Dopamine; Dose-Response Relationship, Drug; Meclofenox | 1990 |
Effect of centrophenoxine and BCE-001 treatment on lateral diffusion of proteins in the hepatocyte plasma membrane as revealed by fluorescence recovery after photobleaching in rat liver smears.
Topics: Aging; Animals; Cell Membrane Permeability; Fluorescence; Free Radicals; Glycolates; Humans; Liver; | 1989 |
Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice.
Topics: Aging; Animals; Brain; Electron Spin Resonance Spectroscopy; Glycolates; In Vitro Techniques; Meclof | 1986 |
[Indices of sympathetic neurocyte transcription and the survival indices of fractionally and partially chemically sympathectomized rats against a background of atsefen use].
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cell Nucleus; Dose-Response Relationship, Drug; G | 1988 |
Effects of meclofenoxate and citicholine on learning and memory in aged rats.
Topics: Aging; Animals; Choline; Cytidine Diphosphate Choline; Glycolates; Learning; Male; Meclofenoxate; Me | 1987 |
Effects of the nootropic agents adafenoxate and meclofenoxate on brain biogenic monoamines in aged rats.
Topics: Aging; Animals; Biogenic Amines; Brain; Dopamine; Glycolates; Male; Meclofenoxate; Norepinephrine; R | 1988 |
Age-related change in the multiple unit activity of the rat brain parietal cortex and the effect of centrophenoxine.
Topics: Aging; Animals; Electric Conductivity; Electroencephalography; Female; Glycolates; Meclofenoxate; Pa | 1988 |
Quantitative studies of the effects of aging, meclofenoxate, and dihydroergotoxine on intraneuronal lipopigment accumulation in the rat.
Topics: Aging; Animals; Dihydroergotamine; Female; Fluorescence; Glycolates; Hippocampus; Injections, Intrap | 1985 |
Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats.
Topics: Acetates; Age Factors; Aging; Animals; Central Nervous System; Central Nervous System Stimulants; Ce | 1974 |
Serial testing in assessing the effect of meclofenoxate on patients with memory defects.
Topics: Aged; Aging; Central Nervous System Stimulants; Female; Humans; Male; Meclofenoxate; Memory; Mental | 1967 |
Further studies on the effects of centrophenoxine on the lipofuscin pigment in the neurons of senile guinea pigs.
Topics: Acetates; Aging; Animals; Central Nervous System Stimulants; Electron Transport Complex IV; Glucose; | 1968 |
[Effect of centrophenoxin on the old age pigment in satellite cells and neurons of senile rat spinal ganglia. Electronmicroscopical study].
Topics: Acetates; Aging; Animals; Central Nervous System Stimulants; Ganglia, Spinal; Histological Technique | 1971 |
[Clinical results after the treatment of cases of cerebral insufficiency with centrophenoxine (Helfergin)].
Topics: Acetates; Aged; Aging; Central Nervous System Stimulants; Cerebrovascular Disorders; Female; Humans; | 1970 |
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant | 1971 |
Hypoxia and some therapeutic problems in gerontopsychiatry.
Topics: Aged; Aging; Brain; Brain Chemistry; Chlormethiazole; Chlorpromazine; Glycolysis; Humans; Hypoxia; L | 1972 |
[Drug action on the age-dependent changes. I. Reduction of lipofuscin contents in ganglion cells of the nucleus reticularis gigantocellularis of albino rats following the use of centrophenoxine, p-chlorphenoxyacetic acid diethyl-amino-ester hydrochloride
Topics: Acetates; Aging; Animals; Brain Chemistry; Brain Stem; Ganglia; Histocytochemistry; Histological Tec | 1970 |