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meclofenoxate and Aging

meclofenoxate has been researched along with Aging in 56 studies

Meclofenoxate: An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Nicergoline (NE)--a cerebral vasodilator with nicotinic acid esterified in its molecule--and Antagonic-Stress (AS) composition--a neurometabolic nootropic, also containing nicotinic acid but with fast and prolonged release--were evaluated in senile dementia of Alzheimer's type (SDAT), mild to moderate intensity (DSM-IV Options Book, 1991 and ICD-10, 1990 criteria)."5.07Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry. ( Mateescu, R; Măties, R; Mihalas, G; Mihalas, IG; Popa, R; Schneider, F; Stefanigă, P, 1994)
" Treatment of aging mice with meclofenoxate, a drug that is reported to cause dissolution of lipofuscin, failed to prevent accumulation of dolichol and dolichyl phosphate with age."3.68Changes in murine tissue concentrations of dolichol and dolichol derivatives associated with age. ( Daniels, I; Hemming, FW, 1990)
"4."1.29Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs. ( Alova, LG; Stancheva, SL, 1994)
"Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy."1.29Effects of cytidine diphosphate choline on rats with memory deficits. ( Getova, D; Kehayov, RA; Lazarova, MB; Mosharrof, AH; Petkov, VD; Petkov, VV; Vaglenova, J, 1993)
" A dosage of 80 mg/Kg produced greater changes than a 120 mg/Kg dosage."1.27Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain. ( Pathak, DN; Roy, D; Singh, R, 1983)
"Senile white rats were treated with centrophenoxine at a dosage of 100 mg/Kg body weight/day for 60 days intraperitoneally."1.27Cytochemical interaction of nucleolus and cytoplasm in the Purkinje cells of senile white rats under the influence of centrophenoxine. ( Patro, IK; Sharma, SP, 1984)
" With the dosage employed neurons of the central nervous system showed in all animals a significant reduction of lipofuscin pigment."1.25[Centrophenoxin-induced dissolution and removal of lipofuscin. An electron microscopic study (author's transl)]. ( Glees, P; Spoerri, PE, 1975)

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-199039 (69.64)18.7374
1990's14 (25.00)18.2507
2000's2 (3.57)29.6817
2010's0 (0.00)24.3611
2020's1 (1.79)2.80

Authors

AuthorsStudies
Bakhtogarimov, IR1
Kudryavtseva, AV1
Krasnov, GS1
Gladysh, NS1
Volodin, VV1
Kudryavtsev, AA1
Bulavkina, EV1
Goncharova, MA1
Ledyaeva, VS1
Pastukhov, IS1
Vershinina, YS1
Starkova, AM1
Snezhkina, AV1
Shuvalova, AI1
Pavlov, VS1
Nikiforov-Nikishin, DL1
Moskalev, AA1
Guvatova, ZG1
Bhalla, P1
Nehru, B1
Wittenborn, JR1
Zs-Nagy, I5
Semsei, I1
Viticchi, C1
Gentile, S1
Piantanelli, L1
Nagy, K3
Nagy, V2
Bertoni-Freddari, C2
Nagy, I3
van Bezooijen, CF1
Sakkee, AN1
Knook, DL1
Dylewski, DP1
Nandy, S1
Nandy, K4
Katz, ML1
Robison, WG1
Roy, D2
Pathak, DN1
Singh, R3
Patro, IK2
Sharma, SP2
Jänicke, B1
Wrobel, D1
Aloj Totàro, E1
Pisanti, FA1
Kalmár, A1
Nagy, E1
Jamieson, DD1
Taylor, KM1
Brahma, KC1
Patnaik, BK1
Giuli, C2
Pieri, C2
Sharma, D1
Stancheva, SL3
Alova, LG2
Predescu, V1
Riga, D2
Riga, S2
Turlea, J1
Bărbat, IM1
Botezat-Antonescu, L1
Schneider, F1
Popa, R1
Mihalas, G1
Stefanigă, P1
Mihalas, IG1
Măties, R1
Mateescu, R1
Petkov, VD4
Kehayov, RA1
Mosharrof, AH2
Petkov, VV4
Getova, D1
Lazarova, MB1
Vaglenova, J1
Iarygin, VN2
Bibaeva, LV1
al-Zuhair, H1
Abd el-Fattah, A1
el-Sayed, MI1
Tomonaga, M1
Izumiyama, N1
Kameyama, M1
Baste, C1
Schneider, FH1
Del Moro, M1
Kent, S1
Spoerri, PE2
Glees, P3
Patro, N1
Zolotov, NN1
Kutenova, OA1
Voronina, TA1
Pozdnev, VF1
Smirnov, LD1
Diumaev, KM1
Daniels, I1
Hemming, FW1
Belcheva, S1
Stoyanova, V1
Wustmann, C1
Blaschke, M1
Rudolph, E1
Fischer, HD1
Schmidt, J1
Ohta, M1
Kitani, K1
Wood, WG1
Gorka, C1
Armbrecht, HJ1
Williamson, LS1
Strong, R1
Potapov, SI1
Grigor'eva, AV1
Schneider, EL1
Reed, JD1
Dowson, JH1
Oliver, JE1
Restell, M1
Meier, C1
Schmidt, H1
Broicher, H1
Hochschild, R1
Pogády, J1
Ruscák, M1
Orlický, J1
Chemnitius, KH1
Machnik, G1
Löw, O1
Arnrich, M1
Urban, J1

Reviews

5 reviews available for meclofenoxate and Aging

ArticleYear
Pharmacotherapy for age-related behavioral deficiencies.
    The Journal of nervous and mental disease, 1981, Volume: 169, Issue:3

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Brain; Central

1981
A survey of the available data on a new nootropic drug, BCE-001.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Aging; Animals; Cell Membrane; Drug Design; Free Radical Scavengers; Humans; Meclofenoxate; Psychotr

1994
Pharmacological interventions against aging through the cell plasma membrane: a review of the experimental results obtained in animals and humans.
    Annals of the New York Academy of Sciences, 2002, Volume: 959

    Topics: 2,4-Dichlorophenoxyacetic Acid; Aging; Animals; Brain; Cell Membrane; Deanol; Esters; Free Radical S

2002
Solving the riddle of lipofuscin's origin may uncover clues to the aging process.
    Geriatrics, 1976, Volume: 31, Issue:5

    Topics: Aging; Animals; Brain; Cell Survival; Ceroid; Humans; Lipofuscin; Lysosomes; Meclofenoxate; Nerve De

1976
Life extension.
    The New England journal of medicine, 1985, May-02, Volume: 312, Issue:18

    Topics: Aged; Aging; Animals; Antioxidants; Dehydroepiandrosterone; Diet; Energy Intake; Ethics, Medical; Fe

1985

Trials

2 trials available for meclofenoxate and Aging

ArticleYear
Antagonic-stress. A new treatment in gerontopsychiatry and for a healthy productive life.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Aged; Aging; Cognition Disorders; Double-Blind Method; Drug Combinations; Female; Humans; Male; Mecl

1994
Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Aged; Aging; Dementia; Double-Blind Method; Drug Combinations; Female; Geriatric Assessment; Humans;

1994

Other Studies

49 other studies available for meclofenoxate and Aging

ArticleYear
The Effect of Meclofenoxate on the Transcriptome of Aging Brain of
    International journal of molecular sciences, 2022, Feb-24, Volume: 23, Issue:5

    Topics: Aging; Animals; Brain; Cyprinodontiformes; Female; Fundulidae; Meclofenoxate; Transcriptome

2022
Modulatory effects of centrophenoxine on different regions of ageing rat brain.
    Experimental gerontology, 2005, Volume: 40, Issue:10

    Topics: Aging; Animals; Brain; Catalase; Cerebellum; Female; Glutathione; Glutathione Reductase; Hypothalamu

2005
Centrophenoxine increases the rates of total and mRNA synthesis in the brain cortex of old rats: an explanation of its action in terms of the membrane hypothesis of aging.
    Experimental gerontology, 1984, Volume: 19, Issue:3

    Topics: Aging; Animals; Brain; Cell Membrane; Cerebral Cortex; Deanol; Female; Free Radicals; Glycolates; Me

1984
Centrophenoxine-induced increase of beta-adrenoceptor density in brain cortex of old mice.
    Archives of gerontology and geriatrics, 1984, Volume: 3, Issue:1

    Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Glycolates; Meclofenoxate; Mice; Mice, Inbred BALB C

1984
Alterations of the synaptosomal membrane 'microviscosity' in the brain cortex of rats during aging and centrophenoxine treatment.
    Archives of gerontology and geriatrics, 1983, Volume: 2, Issue:1-2

    Topics: Aging; Animals; Cerebral Cortex; Fluorescence Polarization; Glycolates; In Vitro Techniques; Male; M

1983
Meclofenoxate decreases protein and albumin synthesis in hepatocytes isolated from old rats.
    Biochemical pharmacology, 1983, Jul-15, Volume: 32, Issue:14

    Topics: Aging; Albumins; Animals; Female; Glycolates; In Vitro Techniques; Liver; Meclofenoxate; Protein Bio

1983
Effects of centrophenoxine on lipofuscin in the retinal pigment epithelium of old mice.
    Neurobiology of aging, 1983,Spring, Volume: 4, Issue:1

    Topics: Aging; Animals; Female; Glycolates; Lipofuscin; Meclofenoxate; Mice; Mice, Inbred C57BL; Microscopy,

1983
Lipofuscin response to the "aging-reversal" drug centrophenoxine in rat retinal pigment epithelium and frontal cortex.
    Journal of gerontology, 1983, Volume: 38, Issue:5

    Topics: Aging; Animals; Cerebral Cortex; Female; Glycolates; Lipofuscin; Meclofenoxate; Pigment Epithelium o

1983
Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain.
    Experimental gerontology, 1983, Volume: 18, Issue:3

    Topics: Aging; Animals; Brain; Catalase; Female; Glutathione Peroxidase; Glutathione Reductase; Glycolates;

1983
Cytochemical interaction of nucleolus and cytoplasm in the Purkinje cells of senile white rats under the influence of centrophenoxine.
    Experimental gerontology, 1984, Volume: 19, Issue:4

    Topics: Acid Phosphatase; Aging; Animals; Cell Nucleolus; Cytoplasm; Esterases; Female; Glycolates; Histocyt

1984
Changes in motor activity with age and the effects of pharmacologic treatment.
    Experimental gerontology, 1984, Volume: 19, Issue:5

    Topics: Aging; Animals; Body Weight; Dextroamphetamine; Dihydroergotoxine; Female; Meclofenoxate; Motor Acti

1984
Alterations in the molecular weight distribution of proteins in rat brain synaptosomes during aging and centrophenoxine treatment of old rats.
    Mechanisms of ageing and development, 1984, Volume: 28, Issue:2-3

    Topics: Aging; Animals; Brain; Cell Membrane Permeability; Female; Glycolates; Meclofenoxate; Membrane Prote

1984
Biological bases and prospects of the lipofuscinolitic activity of meclofenoxate: a study of Torpedo m. neurons.
    Acta neurologica, 1980, Volume: 2, Issue:2

    Topics: Aging; Animals; Fishes; Glycolates; Lipofuscin; Meclofenoxate; Models, Biological; Neurons; Pigments

1980
Alterations in total content and solubility characteristics of proteins in rat brain and liver during ageing and centrophenoxine treatment.
    Experimental gerontology, 1981, Volume: 16, Issue:3

    Topics: Aging; Animals; Brain; Female; Glycolates; Liver; Male; Meclofenoxate; Microscopy, Electron; Nerve T

1981
Effects of centrophenoxine, piracetam and hydergine on rat brain lipid peroxidation.
    Experientia, 1981, Volume: 37, Issue:8

    Topics: Aging; Animals; Brain; Dihydroergotoxine; Glycolates; In Vitro Techniques; Lipid Peroxides; Male; Me

1981
Changes in the characteristics of collagen of young male garden lizards following centrophenoxine and lysine treatment.
    Experimental gerontology, 1982, Volume: 17, Issue:5

    Topics: Aging; Animals; Bone and Bones; Collagen; Glycolates; Lizards; Lysine; Male; Meclofenoxate; Skin; Te

1982
The effect of acute and chronic centrophenoxine treatment on the synaptic plasticity of old rats.
    Archives of gerontology and geriatrics, 1982, Volume: 1, Issue:4

    Topics: Aging; Animals; Cerebellum; Female; Glycolates; Meclofenoxate; Neuronal Plasticity; Rats; Rats, Inbr

1982
Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats.
    Indian journal of experimental biology, 1995, Volume: 33, Issue:5

    Topics: Acetylcholinesterase; Aging; Animals; Enzyme Activation; Hippocampus; Male; Meclofenoxate; Rats; Rat

1995
Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs.
    General pharmacology, 1994, Volume: 25, Issue:5

    Topics: Aging; Animals; Biogenic Monoamines; Brain; Corpus Striatum; Frontal Lobe; In Vitro Techniques; Mecl

1994
Effects of cytidine diphosphate choline on rats with memory deficits.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:8

    Topics: Aging; Animals; Avoidance Learning; Clonidine; Cytidine Diphosphate Choline; Electroshock; Fetal Alc

1993
[Biomedical aspects of health preservation strategy: role of catecholaminergic neuronal populations].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1997, Issue:4

    Topics: Adaptation, Physiological; Adolescent; Adult; Aging; Animals; Catecholamines; Female; Health Status;

1997
The effect of meclofenoxate with ginkgo biloba extract or zinc on lipid peroxide, some free radical scavengers and the cardiovascular system of aged rats.
    Pharmacological research, 1998, Volume: 38, Issue:1

    Topics: Aging; Animals; Brain; Cardiovascular System; Drug Evaluation, Preclinical; Drug Therapy, Combinatio

1998
Lipofuscinogenesis in mice early treated with centrophenoxine.
    Mechanisms of ageing and development, 1978, Volume: 8, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Female; Glycolates; Hippocampus; Lipofuscin; Meclofenoxate; Mice; N

1978
[On the effect of centrophenoxine for the lipofuscin in the nerve cells of the aged guinea pigs (author's transl)].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1978, Volume: 15, Issue:4

    Topics: Aging; Animals; Glycolates; Guinea Pigs; Lipofuscin; Meclofenoxate; Neurons; Pigments, Biological

1978
Further studies on the effects of centrophenoxine on lipofuscin pigment in neuroblastoma cells in culture: an electron microscopic study.
    Experimental gerontology, 1978, Volume: 13, Issue:5

    Topics: Aging; Animals; Cells, Cultured; Glycolates; Lipofuscin; Meclofenoxate; Mice; Neoplasms, Experimenta

1978
Effects of centrophenoxine on the monovalent electrolyte contents of the large brain cortical cells of old rats.
    Gerontology, 1979, Volume: 25, Issue:2

    Topics: Aging; Animals; Cell Nucleus; Cerebral Cortex; Chlorides; Cytoplasm; Electrolytes; Female; Glycolate

1979
The mode of lipofuscin removal from hypothalamic neurons.
    Experimental gerontology, 1975, Volume: 10, Issue:3-4

    Topics: Aging; Animals; Guinea Pigs; Hypothalamus; Lipofuscin; Meclofenoxate; Neurons; Pigments, Biological

1975
[Centrophenoxin-induced dissolution and removal of lipofuscin. An electron microscopic study (author's transl)].
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Aging; Animals; Capillaries; Central Nervous System; Dose-Response Relationship, Drug; Endoplasmic R

1975
Lipofuscin accumulation in ageing myocardium & its removal by meclophenoxate.
    The Indian journal of medical research, 1992, Volume: 96

    Topics: Aging; Animals; Heart; Lipofuscin; Meclofenoxate; Myocardium; Rats; Rats, Inbred Strains

1992
Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor--nootropic agent adafenoxate.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Brain; Cyclic AMP; Kinetics; Meclofenoxate; Ner

1991
[The possible participation of brain peptidases in regulating the memory function during aging].
    Doklady Akademii nauk SSSR, 1991, Volume: 317, Issue:1

    Topics: Aging; Animals; Antioxidants; Brain; Deanol; Drug Combinations; Endopeptidases; Glutamates; Lipid Pe

1991
Changes in murine tissue concentrations of dolichol and dolichol derivatives associated with age.
    Lipids, 1990, Volume: 25, Issue:10

    Topics: Aging; Animals; Body Weight; Dolichol Phosphates; Dolichols; Female; Heart; Kidney; Lipofuscin; Live

1990
Effects of nootropic agents on the performing of active two-way avoidance tasks in young and old rats.
    Acta physiologica et pharmacologica Bulgarica, 1990, Volume: 16, Issue:3

    Topics: Aging; Animals; Avoidance Learning; Male; Meclofenoxate; Memory; Piracetam; Psychotropic Drugs; Rats

1990
Influence of nootropic drugs on the age-dependent potassium-coupling of transmitter release.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:7

    Topics: Aging; Animals; Calcium-Transporting ATPases; Dopamine; Dose-Response Relationship, Drug; Meclofenox

1990
Effect of centrophenoxine and BCE-001 treatment on lateral diffusion of proteins in the hepatocyte plasma membrane as revealed by fluorescence recovery after photobleaching in rat liver smears.
    Experimental gerontology, 1989, Volume: 24, Issue:4

    Topics: Aging; Animals; Cell Membrane Permeability; Fluorescence; Free Radicals; Glycolates; Humans; Liver;

1989
Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice.
    Life sciences, 1986, Dec-01, Volume: 39, Issue:22

    Topics: Aging; Animals; Brain; Electron Spin Resonance Spectroscopy; Glycolates; In Vitro Techniques; Meclof

1986
[Indices of sympathetic neurocyte transcription and the survival indices of fractionally and partially chemically sympathectomized rats against a background of atsefen use].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cell Nucleus; Dose-Response Relationship, Drug; G

1988
Effects of meclofenoxate and citicholine on learning and memory in aged rats.
    Acta physiologica et pharmacologica Bulgarica, 1987, Volume: 13, Issue:4

    Topics: Aging; Animals; Choline; Cytidine Diphosphate Choline; Glycolates; Learning; Male; Meclofenoxate; Me

1987
Effects of the nootropic agents adafenoxate and meclofenoxate on brain biogenic monoamines in aged rats.
    Acta physiologica et pharmacologica Bulgarica, 1988, Volume: 14, Issue:1

    Topics: Aging; Animals; Biogenic Amines; Brain; Dopamine; Glycolates; Male; Meclofenoxate; Norepinephrine; R

1988
Age-related change in the multiple unit activity of the rat brain parietal cortex and the effect of centrophenoxine.
    Experimental gerontology, 1988, Volume: 23, Issue:3

    Topics: Aging; Animals; Electric Conductivity; Electroencephalography; Female; Glycolates; Meclofenoxate; Pa

1988
Quantitative studies of the effects of aging, meclofenoxate, and dihydroergotoxine on intraneuronal lipopigment accumulation in the rat.
    Experimental gerontology, 1985, Volume: 20, Issue:6

    Topics: Aging; Animals; Dihydroergotamine; Female; Fluorescence; Glycolates; Hippocampus; Injections, Intrap

1985
Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats.
    Brain research, 1974, Jun-07, Volume: 72, Issue:2

    Topics: Acetates; Age Factors; Aging; Animals; Central Nervous System; Central Nervous System Stimulants; Ce

1974
Serial testing in assessing the effect of meclofenoxate on patients with memory defects.
    The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:495

    Topics: Aged; Aging; Central Nervous System Stimulants; Female; Humans; Male; Meclofenoxate; Memory; Mental

1967
Further studies on the effects of centrophenoxine on the lipofuscin pigment in the neurons of senile guinea pigs.
    Journal of gerontology, 1968, Volume: 23, Issue:1

    Topics: Acetates; Aging; Animals; Central Nervous System Stimulants; Electron Transport Complex IV; Glucose;

1968
[Effect of centrophenoxin on the old age pigment in satellite cells and neurons of senile rat spinal ganglia. Electronmicroscopical study].
    Acta neuropathologica, 1971, Volume: 17, Issue:4

    Topics: Acetates; Aging; Animals; Central Nervous System Stimulants; Ganglia, Spinal; Histological Technique

1971
[Clinical results after the treatment of cases of cerebral insufficiency with centrophenoxine (Helfergin)].
    Die Medizinische Welt, 1970, Aug-15, Volume: 33

    Topics: Acetates; Aged; Aging; Central Nervous System Stimulants; Cerebrovascular Disorders; Female; Humans;

1970
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
    Experimental gerontology, 1971, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant

1971
Hypoxia and some therapeutic problems in gerontopsychiatry.
    Activitas nervosa superior, 1972, Volume: 14, Issue:2

    Topics: Aged; Aging; Brain; Brain Chemistry; Chlormethiazole; Chlorpromazine; Glycolysis; Humans; Hypoxia; L

1972
[Drug action on the age-dependent changes. I. Reduction of lipofuscin contents in ganglion cells of the nucleus reticularis gigantocellularis of albino rats following the use of centrophenoxine, p-chlorphenoxyacetic acid diethyl-amino-ester hydrochloride
    Experimentelle Pathologie, 1970, Volume: 4, Issue:2

    Topics: Acetates; Aging; Animals; Brain Chemistry; Brain Stem; Ganglia; Histocytochemistry; Histological Tec

1970