meclofenamic acid has been researched along with Pregnancy in 50 studies
Meclofenamic Acid: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
meclofenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite activation of the renin-angiotensin system during pregnancy, renal and peripheral vascular blood flows increase, and the systemic blood pressure and the pressor response to exogenous angiotensin II (Ang II) fall." | 7.67 | Angiotensin II receptor alterations during pregnancy in rabbits. ( Brown, GP; Venuto, RC, 1986) |
| "Treatment with meclofenamic acid supported the establishment of pregnancy in recipient mares that ovulated before the donors." | 3.73 | Meclofenamic acid extends donor-recipient asynchrony in equine embryo transfer. ( Allen, WR; Kölling, M; Wilsher, S, 2006) |
| " Because angiogenic growth factors such as basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) are increased in pregnancy, we hypothesized that treatment of uterine and fetoplacental arteries with bFGF, VEGF, and EGF would further enhance the pregnancy-induced increase in PGI2 production." | 3.70 | Effects of angiogenic growth factors on endothelium-derived prostacyclin production by ovine uterine and placental arteries. ( Bird, IM; Krishnamurthy, P; Magness, RR; Sheppard, C, 1999) |
| "Although the potential for endothelium-dependent relaxation is augmented in mesenteric arteries of the pregnant rat, the decreased sensitivity to phenylephrine during pregnancy is not modulated acutely by endothelium-derived relaxing factor or by prostaglandin products of the cyclooxygenase pathway." | 3.68 | Endogenous modulation of the blunted adrenergic response in resistance-sized mesenteric arteries from the pregnant rat. ( Davidge, ST; McLaughlin, MK, 1992) |
| " We found that pregnancy decreased systemic vascular resistance and the systemic vascular resistance response to angiotensin II infusion but not to phenylephrine hydrochloride infusion in awake, unstressed guinea pigs." | 3.67 | Blunted vasoreactivity in pregnant guinea pigs is not restored by meclofenamate. ( Harrison, GL; Moore, LG, 1989) |
| "Despite activation of the renin-angiotensin system during pregnancy, renal and peripheral vascular blood flows increase, and the systemic blood pressure and the pressor response to exogenous angiotensin II (Ang II) fall." | 3.67 | Angiotensin II receptor alterations during pregnancy in rabbits. ( Brown, GP; Venuto, RC, 1986) |
| "Meclofenamic acid was superior to placebo from 6 h after treatment and it almost suppressed subjective pain at the end of the observation period (28th h)." | 2.67 | Use of meclofenamic acid in gynecology and obstetrics: effects on postsurgical stress. ( De Pietri, R; Facchinetti, F; Genazzani, AR; Giunchi, M, 1991) |
| ") did not alter the dose-response curves." | 1.29 | Role of angiotensin II and prostaglandins in the regulation of uteroplacental blood flow. ( Woods, LL, 1993) |
| "There is an increased incidence of preeclampsia at high compared with low altitude." | 1.28 | Systemic vascular reactivity during high-altitude pregnancy. ( Harrison, GL; Moore, LG, 1990) |
| "Meclofenamic acid treatment in late pregnancy modified the normal initiation of lactation, as indicated by the high concentration of lactose and low concentrations of protein and Na+ in colostrum in treated sows compared to controls." | 1.26 | Influence of meclofenamic acid on the initiation of parturition and lactation in the sow. ( Barker, I; Gooneratne, AD; Hartmann, PE, 1982) |
| "Fetal hypoxemia, induced by delivering a hypoxic gas mixture to the ewe, was characterized by a reduction in fetal PaO2 from 20." | 1.26 | Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero. ( Baig, H; Millard, RW; Vatner, SF, 1979) |
| "Indomethacin treatment did not terminate pregnancy: the proportion of animals pregnant on Days 5, 7, 10 and 16 was not affected, although fetal mortality was slightly greater in these animals." | 1.26 | The importance of prostaglandin synthesis for the initiation of blastocyst implantation in the hamster. ( Evans, CA; Kennedy, TG, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (58.00) | 18.7374 |
| 1990's | 10 (20.00) | 18.2507 |
| 2000's | 9 (18.00) | 29.6817 |
| 2010's | 1 (2.00) | 24.3611 |
| 2020's | 1 (2.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diel de Amorim, M | 1 |
| Bramer, SA | 1 |
| Rajamanickam, GD | 1 |
| Klein, C | 1 |
| Card, C | 1 |
| Liu, X | 1 |
| Hashimoto-Torii, K | 1 |
| Torii, M | 1 |
| Ding, C | 1 |
| Rakic, P | 1 |
| Mateev, S | 1 |
| Sillau, AH | 1 |
| Mouser, R | 1 |
| McCullough, RE | 1 |
| White, MM | 1 |
| Young, DA | 1 |
| Moore, LG | 4 |
| Cooke, CL | 1 |
| Davidge, ST | 4 |
| Veerareddy, S | 1 |
| Campbell, ME | 1 |
| Williams, SJ | 2 |
| Baker, PN | 1 |
| Hemmings, DG | 1 |
| Skidmore, JA | 2 |
| Billah, M | 1 |
| Wilsher, S | 1 |
| Kölling, M | 1 |
| Allen, WR | 2 |
| Weems, YS | 2 |
| Kim, L | 1 |
| Tsuda, V | 1 |
| Yin, C | 1 |
| Weems, CW | 2 |
| Paller, MS | 1 |
| Pascoe, RR | 2 |
| Gooneratne, AD | 2 |
| Bryant-Greenwood, G | 1 |
| Walker, FM | 1 |
| Nottage, HM | 1 |
| Hartmann, PE | 2 |
| Murai, DT | 2 |
| Clyman, RI | 2 |
| Mauray, FE | 2 |
| Lee, CC | 2 |
| Kitterman, JA | 4 |
| Venuto, R | 1 |
| Min, I | 1 |
| Barone, P | 1 |
| Donker, A | 1 |
| Cunningham, E | 1 |
| Cooke, RG | 1 |
| Knifton, A | 1 |
| Cassin, S | 1 |
| Barker, I | 1 |
| Reeves, JT | 1 |
| Critser, ES | 1 |
| Rutledge, JJ | 1 |
| French, LR | 1 |
| Liggins, GC | 1 |
| Savich, RD | 1 |
| Guerra, FA | 1 |
| Woods, LL | 2 |
| Starbuck, GR | 1 |
| Lamming, GE | 1 |
| Krishnamurthy, P | 1 |
| Bird, IM | 1 |
| Sheppard, C | 1 |
| Magness, RR | 1 |
| Lammoglia, MA | 1 |
| Lewis, AW | 1 |
| Randel, RD | 1 |
| Sasser, RG | 1 |
| Morita, I | 1 |
| Thompson, LP | 1 |
| Weiner, CP | 1 |
| Zenge, JP | 1 |
| Rairigh, RL | 1 |
| Grover, TR | 1 |
| Storme, L | 1 |
| Parker, TA | 1 |
| Kinsella, JP | 1 |
| Abman, SH | 3 |
| Millard, RW | 1 |
| Baig, H | 1 |
| Vatner, SF | 1 |
| Mitchell, MD | 1 |
| Flint, AP | 1 |
| Evans, CA | 1 |
| Kennedy, TG | 1 |
| Venuto, RC | 2 |
| Cox, JW | 1 |
| Stein, JH | 1 |
| Ferris, TF | 1 |
| Terragno, NA | 1 |
| Terragno, DA | 1 |
| McGiff, JC | 1 |
| McLaughlin, MK | 1 |
| Facchinetti, F | 1 |
| De Pietri, R | 1 |
| Giunchi, M | 1 |
| Genazzani, AR | 1 |
| Velvis, H | 1 |
| Moore, P | 1 |
| Heymann, MA | 1 |
| Accurso, FJ | 2 |
| Wilkening, RB | 1 |
| Worthen, GS | 1 |
| Henson, P | 1 |
| Harrison, GL | 2 |
| Wallen, LD | 1 |
| Lee, CH | 1 |
| Ballard, PL | 1 |
| Guthrie, HD | 1 |
| Brown, GP | 1 |
| Riemer, RK | 1 |
| Goldfien, AC | 1 |
| Goldfien, A | 1 |
| Roberts, JM | 1 |
| Davidson, D | 1 |
| Conrad, KP | 1 |
| Colpoys, MC | 1 |
| MacKenzie, LW | 1 |
| Garfield, RE | 1 |
| Petrere, JA | 1 |
| Humphrey, RR | 1 |
| Anderson, JA | 1 |
| Fitzgerald, JE | 1 |
| de la Iglesia, FA | 1 |
| Kollenberg, LO | 1 |
| Hudyma, EO | 1 |
| Robbins, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation[NCT02391519] | 84 participants (Anticipated) | Observational | 2016-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for meclofenamic acid and Pregnancy
| Article | Year |
|---|---|
Role of prostaglandins and thromboxanes in the control of the pulmonary circulation in the fetus and newborn.
Topics: Aging; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Epoprostenol; Female; Fetus; Hum | 1980 |
Control of time of parturition in pigs.
Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animal Husbandry; Animals; Dinoprost; Fema | 1985 |
1 trial available for meclofenamic acid and Pregnancy
| Article | Year |
|---|---|
Use of meclofenamic acid in gynecology and obstetrics: effects on postsurgical stress.
Topics: Adult; Delivery, Obstetric; Female; Genital Diseases, Female; Humans; Hydrocortisone; Hysterectomy; | 1991 |
47 other studies available for meclofenamic acid and Pregnancy
| Article | Year |
|---|---|
Serum progesterone and oxytocinase, and endometrial and luteal gene expression in pregnant, nonpregnant, oxytocin, carbetocin and meclofenamic acid treated mares.
Topics: Animals; Corpus Luteum; Cystinyl Aminopeptidase; Endometrium; Female; Gene Expression; Horses; Meclo | 2023 |
Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Boron Compounds; | 2010 |
Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow.
Topics: Altitude; Animals; Arteries; Atmosphere Exposure Chambers; Blood Flow Velocity; Chronic Disease; Enz | 2003 |
Pregnancy-induced alterations of vascular function in mouse mesenteric and uterine arteries.
Topics: Animals; Cyclooxygenase 1; Enzyme Inhibitors; Female; In Vitro Techniques; Isoenzymes; Male; Meclofe | 2003 |
Myogenic reactivity is enhanced in rat radial uterine arteries in a model of maternal undernutrition.
Topics: Animals; Arteries; Cyclooxygenase Inhibitors; Female; Hemorheology; Malnutrition; Meclofenamic Acid; | 2004 |
Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy.
Topics: Animals; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Hypoxia; In Vitro Techniques; Male; M | 2005 |
Embryo transfer in the dromedary camel (Camelus dromedarius) using asynchronous, meclofenamic acid-treated recipients.
Topics: Animals; Buserelin; Camelus; Embryo Transfer; Female; Fetal Death; Luteal Phase; Meclofenamic Acid; | 2005 |
Meclofenamic acid extends donor-recipient asynchrony in equine embryo transfer.
Topics: Animals; Cyclooxygenase Inhibitors; Embryo Transfer; Female; Horses; Luteolysis; Meclofenamic Acid; | 2006 |
What regulates placental steroidogenesis in 90-day pregnant ewes?
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprost; Estradiol; Female; Gene Expression Regulation, Develo | 2007 |
Mechanism of decreased pressor responsiveness to ANG II, NE, and vasopressin in pregnant rats.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Captopril; Female; Meclofenamic Acid; | 1984 |
Methods for the treatment of twin pregnancy in the mare.
Topics: Abortion, Induced; Abortion, Veterinary; Animals; Dinoprost; Female; Horse Diseases; Horses; Meclofe | 1983 |
Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 alpha and 13,14-dihydro-15-keto prostaglandin F-2 alpha in meclofenamic acid-treated sows.
Topics: Animals; Dinoprost; Female; Labor, Obstetric; Meclofenamic Acid; Milk; ortho-Aminobenzoates; Pregnan | 1983 |
Meclofenamate and prostaglandin E2 affect breathing movements independently of glucose concentrations in fetal sheep.
Topics: Animals; Blood Glucose; Dinoprostone; Electroencephalography; Female; Fetal Movement; Fetus; Glucose | 1984 |
Blood pressure control in pregnant rabbits: norepinephrine and prostaglandin interactions.
Topics: Animals; Blood Pressure; Dinoprostone; Female; Homeostasis; Meclofenamic Acid; Norepinephrine; Phent | 1984 |
Lack of effect of multiple oral doses of meclofenamic acid on parturition in goats.
Topics: Animals; Dinoprost; Female; Gestational Age; Goats; Labor, Obstetric; Meclofenamic Acid; ortho-Amino | 1981 |
Influence of meclofenamic acid on the initiation of parturition and lactation in the sow.
Topics: Animals; Female; Labor, Obstetric; Lactation; Meclofenamic Acid; ortho-Aminobenzoates; Pregnancy; Pr | 1982 |
Pregnancy blunts pulmonary vascular reactivity in dogs.
Topics: Animals; Blood Pressure; Dogs; Estrogens; Female; Hypoxia; Lung; Meclofenamic Acid; Pregnancy; Pregn | 1980 |
Effect of indomethacin on the interestrous interval of intact and hysterectomized pseudopregnant mice.
Topics: Anestrus; Animals; Estrus; Female; Hysterectomy; Indomethacin; Meclofenamic Acid; Mice; Pharmaceutic | 1981 |
Fetal breathing movements and inhibitors of prostaglandin synthesis.
Topics: Animals; Cerebral Cortex; Electroencephalography; Female; Fetus; Humans; Indomethacin; Meclofenamic | 1980 |
Effect of inhibition of prostaglandin synthesis on breathing movements and pulmonary blood flow in fetal sheep.
Topics: Animals; Blood Gas Analysis; Electrodes, Implanted; Electroencephalography; Female; Fetus; Meclofena | 1995 |
Role of angiotensin II and prostaglandins in the regulation of uteroplacental blood flow.
Topics: Angiotensin II; Animals; Blood Flow Velocity; Blood Pressure; Captopril; Dogs; Female; Homeostasis; | 1993 |
Control of luteolysis in the one-humped camel (Camelus dromedarius).
Topics: Animals; Camelus; Cyclooxygenase Inhibitors; Dinoprost; Endometrium; Female; Luteolysis; Meclofenami | 1998 |
Effects of angiogenic growth factors on endothelium-derived prostacyclin production by ovine uterine and placental arteries.
Topics: Animals; Arteries; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascul | 1999 |
PGE2 induces its own secretion in vitro by bovine 270-day placenta but not by 200-day placenta.
Topics: Abortifacient Agents, Nonsteroidal; Animals; Aspartic Acid Endopeptidases; Biological Transport; Cat | 1999 |
Pregnancy enhances G protein activation and nitric oxide release from uterine arteries.
Topics: Acetylcholine; Animals; Arteries; Bradykinin; Cholera Toxin; Cyclooxygenase Inhibitors; Endothelium, | 2001 |
NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Pressure; Cyclic GMP; Cyclooxygenase Inhibito | 2001 |
A possible new treatment for twin pregnancy in the mare.
Topics: Abortion, Induced; Animals; Female; Horses; Meclofenamic Acid; Pregnancy; Pregnancy, Animal; Pregnan | 1979 |
Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Bradycardia; Female; Fetal Hypoxia; Fetus; Heart Rate; | 1979 |
Use of meclofenamic acid to investigate the role of prostaglandin biosynthesis during induced parturition in sheep.
Topics: Animals; Dexamethasone; Estrogens; Female; Labor, Induced; Meclofenamic Acid; ortho-Aminobenzoates; | 1978 |
The importance of prostaglandin synthesis for the initiation of blastocyst implantation in the hamster.
Topics: Animals; Blastocyst; Castration; Cricetinae; Embryo Implantation; Endometrium; Evans Blue; Female; I | 1978 |
The effect of changes in perfusion pressure on uteroplacental blood flow in the pregnant rabbit.
Topics: Animals; Blood Pressure; Cardiac Output; Carotid Arteries; Depression, Chemical; Female; Homeostasis | 1976 |
The role of prostagandins in the control of uterine blood flow.
Topics: Angiotensin II; Animals; Blood Pressure; Bradykinin; Dogs; Female; Humans; In Vitro Techniques; Indo | 1976 |
Endogenous modulation of the blunted adrenergic response in resistance-sized mesenteric arteries from the pregnant rat.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Meclofenamic Aci | 1992 |
Prostaglandin inhibition prevents the fall in pulmonary vascular resistance as a result of rhythmic distension of the lungs in fetal lambs.
Topics: Animals; Animals, Newborn; Female; Fetus; Lung; Meclofenamic Acid; Pregnancy; Prostaglandin Antagoni | 1991 |
Fetal pulmonary vasodilation after exogenous platelet-activating factor.
Topics: Animals; Female; Fetus; Hemodynamics; Meclofenamic Acid; Phospholipid Ethers; Platelet Activating Fa | 1991 |
Systemic vascular reactivity during high-altitude pregnancy.
Topics: Altitude; Angiotensin II; Animals; Blood Pressure; Female; Guinea Pigs; In Vitro Techniques; Meclofe | 1990 |
Importance of prostaglandins in hypertension during reduced uteroplacental perfusion pressure.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Fatty Acids, Unsaturated; Fe | 1989 |
Meclofenamate does not affect lung development in fetal sheep.
Topics: Animals; Dinoprostone; Female; Heart; Hydrocortisone; Lung; Maternal-Fetal Exchange; Meclofenamic Ac | 1989 |
Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation.
Topics: Animals; Blood Pressure; Ductus Arteriosus; Female; Fetus; Lung; Meclofenamic Acid; Oxygen; Pregnanc | 1989 |
Blunted vasoreactivity in pregnant guinea pigs is not restored by meclofenamate.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Cardiac Output; Female; Guinea Pigs; Meclo | 1989 |
Angiotensin II receptor alterations during pregnancy in rabbits.
Topics: Adrenal Glands; Angiotensin II; Animals; Binding Sites; Female; Kidney Glomerulus; Meclofenamic Acid | 1986 |
Rabbit uterine oxytocin receptors and in vitro contractile response: abrupt changes at term and the role of eicosanoids.
Topics: Animals; Arginine Vasopressin; Binding, Competitive; Carbachol; Decidua; Female; In Vitro Techniques | 1986 |
Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Blood Pressure; Body Temperature; Cardiac O | 1988 |
Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats.
Topics: Angiotensin II; Animals; Blood Pressure; Female; Glomerular Filtration Rate; Hemodynamics; Indometha | 1986 |
Hormonal control of gap junctions in the myometrium.
Topics: Animals; Castration; Diethylstilbestrol; Estradiol; Female; Freeze Fracturing; Indomethacin; Interce | 1985 |
Studies on reproduction in rats with meclofenamate sodium, a nonsteroidal anti-inflammatory agent.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Fe | 1985 |
Nonsteroidal anti-inflammatory agents. A review of the literature.
Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diflunisal; Drug Interactions; Female; Fenoprofen; Ha | 1985 |