meclofenamic acid has been researched along with Muscle Contraction in 33 studies
Meclofenamic Acid: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
meclofenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A selective and potent 5-LO inhibitor, zileuton (N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) was evaluated in models of airway anaphylaxis, where leukotrienes are a major component." | 7.69 | The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. ( Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB, 1994) |
| "The effects of indomethacin and meclofenamate on active hyperemia following sustained, maximal isometric contractions were studied in free-flowing dog gracilis muscles." | 7.67 | Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia. ( Klabunde, RE; Rankin, RS, 1985) |
| " A selective and potent 5-LO inhibitor, zileuton (N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) was evaluated in models of airway anaphylaxis, where leukotrienes are a major component." | 3.69 | The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. ( Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB, 1994) |
| "The effects of indomethacin and meclofenamate on active hyperemia following sustained, maximal isometric contractions were studied in free-flowing dog gracilis muscles." | 3.67 | Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia. ( Klabunde, RE; Rankin, RS, 1985) |
| "1 X EC50) of NA were calculated from dose-response curves." | 1.27 | Effects of cyclooxygenase inhibitors and PGI2 on the adrenergic contractions of isolated rabbit arteries. ( Hadházy, P; Magyar, K; Malomvölgyi, B, 1984) |
| "Histamine tachyphylaxis was also studied both in the presence and in the absence of indomethacin in tracheal smooth muscle strips obtained from seven additional dogs." | 1.27 | Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition. ( Antol, PJ; Gunst, SJ; Hyatt, RE, 1988) |
| "Treatment with indomethacin attenuated the contraction-induced increase in mean arterial pressure and left ventricular dP/dt by 76% and 86%, respectively." | 1.27 | Prostaglandins contribute to cardiovascular reflexes evoked by static muscular contraction. ( Longhurst, JC; Maruoka, Y; Stebbins, CL, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (69.70) | 18.7374 |
| 1990's | 10 (30.30) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bennett, A | 2 |
| Jarosik, C | 1 |
| Sanger, GJ | 2 |
| Wilson, DE | 1 |
| Rimele, TJ | 1 |
| Vanhoutte, PM | 4 |
| Smith, RH | 2 |
| Palmer, RM | 2 |
| Reeds, PJ | 2 |
| Hadházy, P | 2 |
| Malomvölgyi, B | 2 |
| Magyar, K | 2 |
| Okpako, DT | 1 |
| Taiwo, YO | 1 |
| Atkinson, T | 1 |
| Pratt, D | 1 |
| Hay, DW | 1 |
| Hubbard, WC | 1 |
| Undem, BJ | 1 |
| Yu, MF | 1 |
| Wang, ZW | 1 |
| Robinson, NE | 2 |
| Derksen, FJ | 2 |
| Malo, PE | 1 |
| Bell, RL | 1 |
| Shaughnessy, TK | 1 |
| Summers, JB | 1 |
| Brooks, DW | 1 |
| Carter, GW | 1 |
| Yu, M | 1 |
| Wang, Z | 1 |
| Katusić, ZS | 1 |
| Schugel, J | 1 |
| Cosentino, F | 1 |
| Szarek, JL | 2 |
| Spurlock, B | 2 |
| Lash, JM | 1 |
| Nase, GP | 1 |
| Bohlen, HG | 1 |
| McGrath, MA | 1 |
| Shepherd, JT | 2 |
| Enero, MA | 1 |
| Morganroth, ML | 1 |
| Young, EW | 1 |
| Sparks, HV | 1 |
| Burka, JF | 1 |
| Eyre, P | 1 |
| Kulkarni, PS | 1 |
| Roberts, R | 1 |
| Needleman, P | 1 |
| Parekh, AB | 2 |
| Syed, MM | 2 |
| Tomita, T | 2 |
| Valle, J | 1 |
| García-Villalón, AL | 1 |
| Nava-Hernández, E | 1 |
| García, JL | 1 |
| Santamaría, L | 1 |
| Gómez, B | 1 |
| Diéguez, G | 1 |
| Loredo, JS | 1 |
| Gonzalez, RR | 1 |
| Hessinger, DA | 1 |
| Rubanyi, G | 1 |
| Paul, RJ | 1 |
| Blaise, G | 1 |
| Iqbal, A | 1 |
| Houston, DS | 1 |
| Antol, PJ | 1 |
| Gunst, SJ | 1 |
| Hyatt, RE | 1 |
| Saye, J | 1 |
| Binder, SB | 1 |
| Trachte, GJ | 1 |
| Peach, MJ | 1 |
| Stebbins, CL | 1 |
| Maruoka, Y | 1 |
| Longhurst, JC | 1 |
| Rankin, RS | 1 |
| Klabunde, RE | 1 |
| Perchonock, CD | 1 |
| Uzinskas, I | 1 |
| Ku, TW | 1 |
| McCarthy, ME | 1 |
| Bondinell, WE | 1 |
| Volpe, BW | 1 |
| Gleason, JG | 1 |
| Weichman, BM | 1 |
| Muccitelli, RM | 1 |
| DeVan, JF | 1 |
33 other studies available for meclofenamic acid and Muscle Contraction
| Article | Year |
|---|---|
Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol.
Topics: Acetylcholine; Animals; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydraz | 1980 |
Effects of inhibitors of arachidonic acid metabolism and calcium entry on responses to acetylcholine, potassium and norepinephrine in the isolated canine saphenous vein.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium Channel Blockers; Dogs | 1983 |
Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretching.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; In Vitro Techniques; Indomethacin; Meclofenam | 1983 |
Differential contractile responsiveness of isolated rabbit arteries from different vascular beds to cyclooxygenase inhibitors and PGI2.
Topics: Animals; Arteries; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation | 1984 |
Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Female; Guine | 1984 |
Effects of cyclooxygenase inhibitors and PGI2 on the adrenergic contractions of isolated rabbit arteries.
Topics: Animals; Arteries; Cyclooxygenase Inhibitors; Electric Stimulation; Epoprostenol; In Vitro Technique | 1984 |
The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles.
Topics: Animals; Calcium; Dinoprost; In Vitro Techniques; Indomethacin; Meclofenamic Acid; Muscle Contractio | 1983 |
Antagonism by fenamates of prostaglandin action in guinea-pig and human alimentary muscle.
Topics: Animals; Digestive System; Flufenamic Acid; Guinea Pigs; Humans; In Vitro Techniques; Male; Meclofen | 1980 |
Endothelin-induced contraction and mediator release in human bronchus.
Topics: Acetylcholine; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Dicarboxylic Acids; Endot | 1993 |
Modulation of bronchial smooth muscle function in horses with heaves.
Topics: Acetylcholine; Animals; Bronchi; Electric Stimulation; Epithelium; Female; Horse Diseases; Horses; I | 1994 |
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, | 1994 |
Independent modulation of horse airway smooth muscle by epithelium and prostanoids.
Topics: Acetylcholine; Animals; Bronchi; Electric Stimulation; Epithelium; Horses; In Vitro Techniques; Mecl | 1993 |
Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery.
Topics: Animals; Arginine; Basilar Artery; Cattle; Dogs; Endothelium, Vascular; Free Radicals; Hydrogen Pero | 1993 |
Antagonism of cholinergic nerve-mediated contractions by the sensory nerve inhibitory system in rat bronchi.
Topics: Acetylcholine; Analgesics; Animals; Bronchi; Capsaicin; Cyclooxygenase Inhibitors; Electric Stimulat | 1996 |
Sensory nerve-mediated inhibitory responses in airways of F344 rats.
Topics: Analgesics; Animals; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Male; Meclofena | 1997 |
Acute hyperglycemia depresses arteriolar NO formation in skeletal muscle.
Topics: Acetylcholine; Acute Disease; Animals; Arterioles; Cyclooxygenase Inhibitors; Endothelium, Vascular; | 1999 |
Inhibition of adrenergic neurotransmission in canine vascular smooth muscle by histamine: mediation by H2-receptors.
Topics: Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Hindlimb; Histamine; Meclofenamic Acid; M | 1976 |
Effect of drugs on the force of spontaneous mechanical activity in rat portal vein.
Topics: Adenosine; Animals; Calcium; Dipyridamole; Dose-Response Relationship, Drug; Female; Imidazoles; Mal | 1979 |
Prostaglandin and histaminergic mediation of prolonged vasodilation after exercise.
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Electric Stimulation; Fatigue; Hindlimb; Histamine; Indome | 1977 |
A pharmacological study of SRS-A on the bovine cutaneous vasculature.
Topics: Animals; Capillary Permeability; Cattle; Guinea Pigs; Histamine; Histamine Antagonists; Ileum; In Vi | 1977 |
Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate.
Topics: Animals; Arachidonic Acids; Arteries; Aspirin; Cattle; Coronary Vessels; Dogs; Dose-Response Relatio | 1976 |
Mechanical responses to catecholamines in the longitudinal muscle of guinea-pig gastric fundus.
Topics: Animals; Catecholamines; Dinoprostone; Epinephrine; Female; Gastric Fundus; Guinea Pigs; In Vitro Te | 1991 |
Receptors involved in mechanical responses to catecholamines in the circular muscle of guinea-pig stomach treated with meclofenamate.
Topics: Adrenergic alpha-Antagonists; Animals; Catecholamines; Female; Guinea Pigs; In Vitro Techniques; Mal | 1990 |
In vitro reactivity of dog cavernous carotid artery to stretch and adrenergic stimulation.
Topics: Acetylcholine; Animals; Aspirin; Carotid Artery, Internal; Dogs; Electric Stimulation; Endothelium, | 1989 |
Vascular effects of Physalia physalis venom in the skeletal muscle of the dog.
Topics: Alprostadil; Animals; Cnidarian Venoms; Dogs; Histamine; Male; Meclofenamic Acid; Muscle Contraction | 1985 |
Two distinct effects of oxygen on vascular tone in isolated porcine coronary arteries.
Topics: Animals; Aspirin; Coronary Vessels; Histamine Antagonists; Indomethacin; Isoproterenol; Meclofenamic | 1985 |
Inhibitors of cyclooxygenase augment serotonergic responsiveness in canine coronary arteries.
Topics: Animals; Coronary Vessels; Cyclooxygenase Inhibitors; Dinoprost; Dogs; Endothelium, Vascular; Female | 1988 |
Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets.
Topics: Adenine Nucleotides; Animals; Apyrase; Blood Platelets; Coronary Vessels; Dogs; Endothelium; Female; | 1985 |
Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition.
Topics: Airway Resistance; Animals; Dogs; Histamine; In Vitro Techniques; Indomethacin; Meclofenamic Acid; M | 1988 |
Angiotensin peptides and prostaglandin E2 synthesis: modulation of neurogenic responses in the rabbit vas deferens.
Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin III; Animals; Dinoprostone; Electric Stimulation | 1986 |
Prostaglandins contribute to cardiovascular reflexes evoked by static muscular contraction.
Topics: Animals; Captopril; Cardiovascular Physiological Phenomena; Cats; Dinoprostone; Female; Hemodynamics | 1986 |
Indomethacin and meclofenamate potentiation of skeletal muscle active hyperemia.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dogs; Hyperemia; Indomethacin; Male; Meclofenamic Acid | 1985 |
Synthesis and LTD4-antagonist activity of desamino-2-nor-leukotriene analogs.
Topics: Animals; Carbachol; Guinea Pigs; Indicators and Reagents; Meclofenamic Acid; Muscle Contraction; SRS | 1985 |