meclofenamic acid has been researched along with Disease Models, Animal in 22 studies
Meclofenamic Acid: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
meclofenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coronary effects of endothelin-1 and vasopressin during acute hypotension, and the role of NO and prostanoids in these effects were examined in anesthetized goats." | 7.73 | Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats. ( Diéguez, G; Fernández, N; García-Villalón, AL; Martínez, MA; Monge, L, 2005) |
| " A selective and potent 5-LO inhibitor, zileuton (N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) was evaluated in models of airway anaphylaxis, where leukotrienes are a major component." | 7.69 | The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. ( Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB, 1994) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 7.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| " In series 1 during acute cardiac failure, indomethacin administration produced striking reductions in RHF but failed to alter the high level of plasma renin activity (PRA)." | 7.66 | Effects of indomethacin in conscious dogs with experimental high-output heart failure. ( Davis, JO; Dietz, JR; Echtenkamp, SF; Freeman, RH; Villarreal, D, 1983) |
| " The dextran sulfate sodium (DSS)-induced colitis model was used to identify the therapeutic effect of meclofenamic acid." | 3.96 | Comprehensive analysis of key biomarkers, immune infiltration and potential therapeutic agents for ulcerative colitis. ( Chen, Y; Han, P; Lei, Y; Lin, Z; Tian, D, 2020) |
| "Modafinil is a non-amphetaminic wake-promoting compound used as therapy against sleepiness and narcolepsy." | 3.83 | Impact of Astroglial Connexins on Modafinil Pharmacological Properties. ( Charvériat, M; Chauveau, F; Dauvilliers, Y; Duchêne, A; Giaume, C; Jeanson, T; Lagarde, D; Lin, JS; Liu, X; Mouthon, F; Perier, M; Picoli, C; Piérard, C; Thomasson, J; Zhao, Y, 2016) |
| "Coronary effects of endothelin-1 and vasopressin during acute hypotension, and the role of NO and prostanoids in these effects were examined in anesthetized goats." | 3.73 | Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats. ( Diéguez, G; Fernández, N; García-Villalón, AL; Martínez, MA; Monge, L, 2005) |
| " A selective and potent 5-LO inhibitor, zileuton (N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) was evaluated in models of airway anaphylaxis, where leukotrienes are a major component." | 3.69 | The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. ( Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB, 1994) |
| "The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats." | 3.67 | The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. ( Fagbemi, SO, 1984) |
| " In series 1 during acute cardiac failure, indomethacin administration produced striking reductions in RHF but failed to alter the high level of plasma renin activity (PRA)." | 3.66 | Effects of indomethacin in conscious dogs with experimental high-output heart failure. ( Davis, JO; Dietz, JR; Echtenkamp, SF; Freeman, RH; Villarreal, D, 1983) |
| "Gap junctions have been implicated in seizure generation and propagation, and as such, may represent a novel therapeutic target but have been little investigated in vivo." | 1.33 | Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy. ( Cock, HR; Kelso, AR; Nilsen, KE, 2006) |
| "The incidence of ventricular tachycardia was reduced from 75% to 25% (P<0." | 1.30 | Delayed protection against ventricular arrhythmias by monophosphoryl lipid-A in a canine model of ischaemia and reperfusion. ( György, K; Papp, JG; Parratt, JR; Rastegar, MA; Végh, A, 1999) |
| "In this study we treated groups of MAIDS-infected mice with combinations of pentoxifylline, an agent which increases cAMP and inhibits phosphodiesterases, and sodium meclofenamic acid, a PgE2 inhibitor." | 1.29 | Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS. ( Ambrus, JL; Butsch, J; Chadha, KC; Mathur, N; Munschauer, F; Nakeeb, S; Satchidanand, SK; Stadler, I; Toumbis, C; Vladutiu, A, 1994) |
| "During oligemia, untreated hemorrhagic shock dogs exhibited dramatic reductions in MABP, SMAF, and RAF which were transiently restored following reinfusion, but markedly decreased 100 minutes after reinfusion." | 1.26 | Beneficial effect of arachidonic acid during hemorrhagic shock in the dog. ( Flynn, JT; Lefer, AM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, Y | 1 |
| Chen, Y | 1 |
| Lin, Z | 1 |
| Tian, D | 1 |
| Han, P | 1 |
| Kumar, S | 1 |
| Ramakrishnan, H | 1 |
| Viswanathan, S | 1 |
| Akopian, A | 1 |
| Bloomfield, SA | 1 |
| Saigo, C | 1 |
| Nomura, Y | 1 |
| Yamamoto, Y | 1 |
| Sagata, M | 1 |
| Matsunaga, R | 1 |
| Jono, H | 1 |
| Nishi, K | 1 |
| Saito, H | 1 |
| Duchêne, A | 1 |
| Perier, M | 1 |
| Zhao, Y | 1 |
| Liu, X | 1 |
| Thomasson, J | 1 |
| Chauveau, F | 1 |
| Piérard, C | 1 |
| Lagarde, D | 1 |
| Picoli, C | 1 |
| Jeanson, T | 1 |
| Mouthon, F | 1 |
| Dauvilliers, Y | 1 |
| Giaume, C | 1 |
| Lin, JS | 1 |
| Charvériat, M | 1 |
| Menzler, J | 1 |
| Zeck, G | 1 |
| Fernández, N | 1 |
| Martínez, MA | 1 |
| García-Villalón, AL | 1 |
| Monge, L | 1 |
| Diéguez, G | 1 |
| Nilsen, KE | 1 |
| Kelso, AR | 1 |
| Cock, HR | 1 |
| White, RP | 1 |
| Robertson, JT | 1 |
| Villarreal, D | 1 |
| Davis, JO | 1 |
| Freeman, RH | 1 |
| Dietz, JR | 1 |
| Echtenkamp, SF | 1 |
| Fagbemi, SO | 1 |
| Schricker, K | 1 |
| Holmer, S | 1 |
| Krämer, BK | 1 |
| Riegger, G | 1 |
| Kurtz, A | 1 |
| Schuster, DP | 1 |
| Howard, DK | 1 |
| Wiseman, JS | 1 |
| Senagore, AJ | 1 |
| Chaudry, IH | 1 |
| Malo, PE | 1 |
| Bell, RL | 1 |
| Shaughnessy, TK | 1 |
| Summers, JB | 1 |
| Brooks, DW | 1 |
| Carter, GW | 1 |
| Martínez, FJ | 1 |
| Villa, E | 1 |
| García-Robles, R | 1 |
| Romero, JC | 1 |
| Chen, BN | 1 |
| Rayner, TE | 1 |
| Menadue, MF | 1 |
| McLennan, PL | 1 |
| Oliver, JR | 1 |
| Stadler, I | 1 |
| Chadha, KC | 1 |
| Nakeeb, S | 1 |
| Toumbis, C | 1 |
| Butsch, J | 1 |
| Mathur, N | 1 |
| Munschauer, F | 1 |
| Vladutiu, A | 1 |
| Satchidanand, SK | 1 |
| Ambrus, JL | 1 |
| Kaye, AD | 1 |
| Ibrahim, IN | 1 |
| Kadowitz, PJ | 1 |
| Nossaman, BD | 1 |
| Yaghi, A | 1 |
| McCormack, DG | 1 |
| Végh, A | 1 |
| György, K | 1 |
| Rastegar, MA | 1 |
| Papp, JG | 1 |
| Parratt, JR | 1 |
| Flynn, JT | 1 |
| Lefer, AM | 1 |
| Konstam, MA | 1 |
| Hill, NS | 1 |
| Bonin, JD | 1 |
| Isner, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation in Healthy Subjects[NCT03182413] | Phase 1 | 20 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for meclofenamic acid and Disease Models, Animal
| Article | Year |
|---|---|
Comprehensive analysis of key biomarkers, immune infiltration and potential therapeutic agents for ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Colitis; Colitis, Ulcerative | 2020 |
Neuroprotection of the Inner Retina Also Prevents Secondary Outer Retinal Pathology in a Mouse Model of Glaucoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Electroretinography; Glauc | 2021 |
Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Urea Nitrogen; Creatini | 2014 |
Impact of Astroglial Connexins on Modafinil Pharmacological Properties.
Topics: Animals; Astrocytes; Benzhydryl Compounds; Connexin 30; Connexin 43; Connexins; Disease Models, Anim | 2016 |
Network oscillations in rod-degenerated mouse retinas.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Age Factors; Animals; Carbenoxolone; Cyclooxygenase | 2011 |
Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats.
Topics: Acute Disease; Anesthesia; Animals; Blood Pressure; Coronary Circulation; Cyclooxygenase Inhibitors; | 2005 |
Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy.
Topics: Administration, Topical; Animals; Anticonvulsants; Behavior, Animal; Carbenoxolone; Cerebral Cortex; | 2006 |
Comparison of piroxicam, meclofenamate, ibuprofen, aspirin, and prostacyclin efficacy in a chronic model of cerebral vasospasm.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Behavior, Animal; Cerebral Angiography; Disease Models, | 1983 |
Effects of indomethacin in conscious dogs with experimental high-output heart failure.
Topics: Animals; Blood Pressure; Dinoprostone; Disease Models, Animal; Dogs; Female; Heart; Heart Failure; H | 1983 |
The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.
Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Coronary Vessels; Disease Models, | 1984 |
Control of renin gene expression in 2 kidney-1 clip rats.
Topics: Animals; Arginine; Denervation; Disease Models, Animal; Furosemide; Gene Expression Regulation; Hype | 1994 |
The effect of positive end-expiratory pressure on regional pulmonary perfusion during acute lung injury.
Topics: Acute Disease; Animals; Disease Models, Animal; Dogs; Extravascular Lung Water; Meclofenamic Acid; O | 1994 |
Methods to prevent colonic injury in pelvic radiation.
Topics: Acute Disease; Animals; Chronic Disease; Colon; Disease Models, Animal; Drug Evaluation, Preclinical | 1994 |
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, | 1994 |
Effect of nitric oxide and prostaglandins on renal function in insulin-resistant hypertensive dogs.
Topics: Acetylcholine; Animals; Arginine; Disease Models, Animal; Diuresis; Dogs; Fructose; Glomerular Filtr | 1993 |
Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart.
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Diterpenes; Eicosanoids; Ginkgolides; He | 1993 |
Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cells, Cultured; Disease Models, Animal; Male; Meclofen | 1994 |
Analysis of responses to pentoxifylline in the pulmonary vascular bed of the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arginine | 1996 |
Pulmonary artery contractility in pneumonia: role of cyclooxygenase products and nitric oxide.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Rela | 1999 |
Delayed protection against ventricular arrhythmias by monophosphoryl lipid-A in a canine model of ischaemia and reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels | 1999 |
Beneficial effect of arachidonic acid during hemorrhagic shock in the dog.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cathepsins; Disease Models, Animal; Dogs; Kidney; Male; | 1977 |
Prostaglandin mediation of hemodynamic responses to pulmonary microembolism in rabbits: effects of ibuprofen and meclofenamate.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Hemodynamics; Ibuprofen; Meclofenam | 1987 |