meclofenamic acid has been researched along with Anoxemia in 53 studies
Meclofenamic Acid: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
meclofenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We wanted to assess the respective roles of arachidonic acid products and nitric oxide in the modulation of pulmonary hypertension in chronically hypoxic rats." | 3.68 | Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide. ( Barer, G; Howard, P; Kapeller, K; Russell, P; Wright, C, 1993) |
| "The influence of methylene blue, an inhibitor of soluble guanylate cyclase, on responses to ventilatory and precapillary hypoxia was investigated in the intact-chest cat under conditions of controlled blood flow and constant left atrial pressure." | 3.68 | Methylene blue prevents hypoxic pulmonary vasoconstriction in cats. ( Hyman, AL; Kadowitz, PJ; Lippton, HL, 1991) |
| "We examined, in isolated blood perfused rat lungs, the effect of the cell permeable 8-bromo derivative of cGMP on pulmonary vasoconstriction induced by either alveolar hypoxia or angiotensin II." | 3.68 | Effect of cyclic guanosine monophosphate on hypoxic and angiotensin-II-induced pulmonary vasoconstriction. ( Fujimoto, K; Kobayashi, T; Kubo, K; Matsuzawa, Y; Sakai, A; Sekiguchi, M; Shinozaki, S; Ueda, G; Voelkel, NF; Yoshikawa, S, 1990) |
| "In order to determine the role of prostaglandins in the regulation of pulmonary vascular resistance, we investigated effects of prostaglandin cyclo-oxygenase inhibition by indomethacin (2 mg/kg), meclofenamate (2 mg/kg), and aspirin (40 mg/kg) upon canine and feline pulmonary vasoconstriction caused by two stimuli: acute hypoxia (6% O2) and exogenous PGF2 alpha." | 3.66 | Contribution of prostaglandins to the regulation of pulmonary vascular resistance in adult cats and dogs. ( Leffler, CW; Passmore, JC, 1979) |
| " Meclofenamate and N omega-nitro-L-arginine methyl ester shifted the dose-response curve for ANG IV to the left in a manner similar to that observed with ANG II and ANG III." | 1.29 | Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat. ( Feng, CJ; Kadowitz, PJ; Kaye, AD; Nossaman, BD, 1995) |
| "Substance P is a vasoactive peptide." | 1.27 | The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog. ( Archer, SL; Chesler, E; Kulik, TJ; Weir, EK, 1986) |
| "In dogs with acute lobar atelectasis, meclofenamate administration decreases shunt fraction uniformly and moderately without abolishing the wide variation of strength of hypoxic vasoconstriction and resultant variability of shunt fraction (J." | 1.27 | Relation of prostanoids to strength of hypoxic vasoconstriction in dogs with lobar atelectasis. ( Garrett, RC; Thomas, HM, 1985) |
| "Fetal hypoxemia, induced by delivering a hypoxic gas mixture to the ewe, was characterized by a reduction in fetal PaO2 from 20." | 1.26 | Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero. ( Baig, H; Millard, RW; Vatner, SF, 1979) |
| "The effects of the inhibitors on reactive hyperemia resulting from 5-, 10-, 15-, and 20-second occlusions and the dilation resulting from 90-second exposure to 8% O2 were also examined." | 1.26 | Prostaglandins and the control of blood flow in the canine myocardium. ( Hintze, TH; Kaley, G, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (64.15) | 18.7374 |
| 1990's | 15 (28.30) | 18.2507 |
| 2000's | 4 (7.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mateev, S | 1 |
| Sillau, AH | 1 |
| Mouser, R | 1 |
| McCullough, RE | 1 |
| White, MM | 1 |
| Young, DA | 1 |
| Moore, LG | 3 |
| Hemmings, DG | 1 |
| Williams, SJ | 1 |
| Davidge, ST | 1 |
| Pearson, JT | 1 |
| Shirai, M | 1 |
| Yokoyama, C | 1 |
| Tsuchimochi, H | 1 |
| Schwenke, DO | 1 |
| Shimouchi, A | 1 |
| Kangawa, K | 1 |
| Tanabe, T | 1 |
| Gee, MH | 2 |
| Perkowski, SZ | 2 |
| Havill, AM | 2 |
| Flynn, JT | 2 |
| Snapper, JR | 1 |
| Bernard, GR | 1 |
| Hinson, JM | 1 |
| Hutchison, AA | 1 |
| Loyd, JE | 2 |
| Ogletree, ML | 3 |
| Brigham, KL | 4 |
| Begley, CJ | 1 |
| Meyrick, BO | 2 |
| Hill, NS | 2 |
| Rounds, S | 1 |
| Newman, JH | 3 |
| Redding, GJ | 1 |
| McMurtry, I | 1 |
| Reeves, JT | 9 |
| Voelkel, NF | 2 |
| Walker, BR | 3 |
| Sprague, RS | 1 |
| Stephenson, AH | 1 |
| Heitmann, LJ | 1 |
| Lonigro, AJ | 1 |
| Weir, EK | 8 |
| Tierney, JF | 1 |
| Chesler, E | 2 |
| Lundquist, LJ | 1 |
| Craddock, PR | 1 |
| Garrett, RC | 2 |
| Thomas, HM | 2 |
| Gerber, JG | 1 |
| Voelkel, N | 1 |
| Nies, AS | 1 |
| McMurtry, IF | 7 |
| Weismann, DN | 1 |
| Russell, P | 1 |
| Wright, C | 1 |
| Kapeller, K | 1 |
| Barer, G | 1 |
| Howard, P | 1 |
| Nossaman, BD | 1 |
| Feng, CJ | 1 |
| Kaye, AD | 1 |
| Kadowitz, PJ | 3 |
| Wong, J | 1 |
| Vanderford, PA | 1 |
| Fineman, JR | 1 |
| Chang, R | 1 |
| Soifer, SJ | 1 |
| Eddahibi, S | 2 |
| Springall, D | 1 |
| Mannan, M | 1 |
| Carville, C | 1 |
| Chabrier, PE | 1 |
| Levame, M | 1 |
| Raffestin, B | 2 |
| Polak, J | 1 |
| Adnot, S | 2 |
| Russ, RD | 1 |
| Fox, GA | 1 |
| Paterson, NA | 1 |
| McCormack, DG | 1 |
| Pham, I | 1 |
| Launay, JM | 1 |
| Aegerter, P | 1 |
| Sitbon, M | 1 |
| Villamor, E | 1 |
| Ruiz, T | 1 |
| Pérez-Vizcaíno, F | 1 |
| Tamargo, J | 1 |
| Moro, M | 1 |
| Archer, SL | 2 |
| Reeve, HL | 1 |
| Michelakis, E | 1 |
| Puttagunta, L | 1 |
| Waite, R | 1 |
| Nelson, DP | 1 |
| Dinauer, MC | 1 |
| Salameh, G | 1 |
| Karamsetty, MR | 1 |
| Warburton, RR | 1 |
| Klinger, JR | 1 |
| Ou, LC | 1 |
| Champion, HC | 1 |
| Villnave, DJ | 1 |
| Tower, A | 1 |
| Hyman, AL | 2 |
| Leffler, CW | 1 |
| Passmore, JC | 1 |
| Roos, SD | 1 |
| Mlczoch, J | 3 |
| Grover, RF | 5 |
| Millard, RW | 1 |
| Baig, H | 1 |
| Vatner, SF | 1 |
| Tucker, A | 1 |
| Hookway, BW | 1 |
| Roos, S | 1 |
| Hintze, TH | 1 |
| Kaley, G | 1 |
| Seavy, J | 1 |
| Cohen, JJ | 1 |
| Vaage, J | 1 |
| Bjertnaes, L | 1 |
| Hauge, A | 1 |
| Davidson, AB | 1 |
| Banerjee, M | 1 |
| Kang, KH | 1 |
| Morrow, JD | 1 |
| Roberts, LJ | 1 |
| Lippton, HL | 1 |
| Larsen, GL | 1 |
| Presley, DM | 1 |
| Graves, JP | 1 |
| Giclas, PC | 1 |
| Arnold-Aldea, SA | 1 |
| Auslender, RA | 1 |
| Parer, JT | 1 |
| Fujimoto, K | 1 |
| Sakai, A | 1 |
| Yoshikawa, S | 1 |
| Shinozaki, S | 1 |
| Matsuzawa, Y | 1 |
| Kubo, K | 1 |
| Kobayashi, T | 1 |
| Ueda, G | 1 |
| Sekiguchi, M | 1 |
| Kulik, TJ | 1 |
| Harrison, GL | 1 |
| Broadley, KJ | 1 |
| Rothaul, AL | 1 |
| Morris, KG | 1 |
| Chapleau, MW | 1 |
| Wilson, LB | 1 |
| Gregory, TJ | 1 |
| Levitzky, MG | 1 |
| Butka, BJ | 1 |
| Herget, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation[NCT02391519] | 84 participants (Anticipated) | Observational | 2016-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
53 other studies available for meclofenamic acid and Anoxemia
| Article | Year |
|---|---|
Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow.
Topics: Altitude; Animals; Arteries; Atmosphere Exposure Chambers; Blood Flow Velocity; Chronic Disease; Enz | 2003 |
Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy.
Topics: Animals; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Hypoxia; In Vitro Techniques; Male; M | 2005 |
Alpha2-adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cyclooxygenase Inhibitors; Cyt | 2007 |
Role of prostaglandins and leukotrienes in complement-initiated lung vascular injury.
Topics: Animals; Catechols; Complement Activation; Epoprostenol; Hypertension, Pulmonary; Hypoxia; Leukocyte | 1983 |
Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.
Topics: Animals; Capillary Permeability; Chemotaxis, Leukocyte; Complement Activation; Endothelium; Hyperten | 1983 |
Endotoxemia-induced leukopenia in sheep. Correlation with lung vascular permeability and hypoxemia but not with pulmonary hypertension.
Topics: Animals; Capillary Permeability; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Hypoxia; Leu | 1983 |
Modification of pulmonary responses to endotoxemia in awake sheep by steroidal and nonsteroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Consciousness; Endotoxins; Escherichia coli; Hypertension, Pulmon | 1984 |
Vascular reactivity is increased in rat lungs injured with alpha-naphthylthiourea.
Topics: Angiotensin II; Animals; Blood Vessels; Hypoxia; Lung; Male; Meclofenamic Acid; Oxygen; Polysorbates | 1983 |
Cyclooxygenase inhibition during phorbol-induced granulocyte stimulation in awake sheep.
Topics: Animals; Consciousness; Cyclooxygenase Inhibitors; Granulocytes; Hypertension, Pulmonary; Hypoxia; I | 1984 |
Effects of meclofenamate on pulmonary vascular resistance correlate with postnatal age in young piglets.
Topics: Animals; Blood Pressure; Cardiac Output; Hypoxia; Meclofenamic Acid; ortho-Aminobenzoates; Pulmonary | 1984 |
Chronic propranolol treatment decreases pulmonary artery pressure in conscious dogs.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Hemodynamics; Hypoxia; Isoproterenol; Mec | 1984 |
Differential response of the pulmonary circulation to prostaglandins E2 and F2 alpha in the presence of unilateral alveolar hypoxia.
Topics: Animals; Cardiac Output; Dinoprost; Dinoprostone; Dogs; Hypoxia; Indomethacin; Male; Meclofenamic Ac | 1984 |
Zymosan activation of plasma reduces hypoxic pulmonary vasoconstriction.
Topics: Animals; Complement Activation; Dogs; Endotoxins; Female; Hypoxia; Male; Meclofenamic Acid; Plasma; | 1983 |
Meclofenamate uniformly decreases shunt fraction in dogs with lobar atelectasis.
Topics: Animals; Arteries; Blood Circulation; Blood Pressure; Dogs; Hypoxia; Meclofenamic Acid; ortho-Aminob | 1983 |
Inhibition of hypoxia-induced ADH release by meclofenamate in the conscious dog.
Topics: Animals; Blood Pressure; Cardiac Output; Consciousness; Dogs; Female; Hypoxia; Meclofenamic Acid; or | 1983 |
Moderation of hypoxic vasoconstriction by infused arachidonic acid: role of PGI2.
Topics: Animals; Arachidonic Acids; Dogs; Epoprostenol; Female; Hemodynamics; Hypoxia; Male; Meclofenamic Ac | 1980 |
Pregnancy blunts pulmonary vascular reactivity in dogs.
Topics: Animals; Blood Pressure; Dogs; Estrogens; Female; Hypoxia; Lung; Meclofenamic Acid; Pregnancy; Pregn | 1980 |
Altered renal hemodynamic and urinary prostaglandin response to acute hypoxemia after inhibition of prostaglandin synthesis in the anesthetized dog.
Topics: Acute Disease; Animals; Blood Pressure; Dogs; Female; Glomerular Filtration Rate; Hemodynamics; Hydr | 1981 |
Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arachidonic Acid; Arginine; Blood Pressure; Dilatation; Dinopro | 1993 |
Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1995 |
Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Argin | 1993 |
Dilator effect of endothelins in pulmonary circulation: changes associated with chronic hypoxia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Autoradiograp | 1993 |
Maintained endothelium-dependent pulmonary vasodilation following chronic hypoxia in the rat.
Topics: Air Pressure; Animals; Arginine; Arginine Vasopressin; Calcimycin; Chronic Disease; Endothelium, Vas | 1993 |
Cyclooxygenase inhibition and vascular reactivity in a rat model of hyperdynamic sepsis.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Hemodynamics; Hypoxia; Male; Meclofenamic Acid; Ph | 1996 |
Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cyclooxygenase Inhibito | 1997 |
Endothelium-derived nitric oxide-dependent response to hypoxia in piglet intrapulmonary arteries.
Topics: Animals; Animals, Newborn; Arginine; Benzoquinones; Coronary Vessels; Eicosanoids; Endothelium, Vasc | 1997 |
O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.
Topics: Animals; Blood Pressure; Granulomatous Disease, Chronic; Hemodynamics; Hypoxia; In Vitro Techniques; | 1999 |
Differences in acute hypoxic pulmonary vasoresponsiveness between rat strains: role of endothelium.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Endothelium, Va | 1999 |
A novel right-heart catheterization technique for in vivo measurement of vascular responses in lungs of intact mice.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cardiac Catheterization; Cardiac Output; Cyclooxygenas | 2000 |
Contribution of prostaglandins to the regulation of pulmonary vascular resistance in adult cats and dogs.
Topics: Animals; Arachidonic Acids; Aspirin; Cats; Cyclooxygenase Inhibitors; Dogs; Hypoxia; Indomethacin; M | 1979 |
Meclofenamate does not reduce chronic hypoxic pulmonary vasoconstriction.
Topics: Altitude; Animals; Cardiomegaly; Female; Hypoxia; Meclofenamic Acid; ortho-Aminobenzoates; Pulmonary | 1976 |
Pulmonary vascular effects of endotoxin in leukopenic dogs.
Topics: Animals; Blood Pressure; Dogs; Endotoxins; Escherichia coli; Female; Hypoxia; Leukocytes; Male; Mecl | 1978 |
Prostaglandin control of the renal circulation in response to hypoxemia in the fetal lamb in utero.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Bradycardia; Female; Fetal Hypoxia; Fetus; Heart Rate; | 1979 |
Prostaglandin synthetase inhibitors do not decrease hypoxic pulmonary vasoconstriction.
Topics: Animals; Cattle; Cyclooxygenase Inhibitors; Dogs; Female; Hypoxia; Indomethacin; Lung Diseases, Obst | 1976 |
Red blood cells play a crucial role in maintaining vascular reactivity to hypoxia in isolated rat lungs.
Topics: Adenosine; Angiotensin II; Animals; Blood Platelets; Erythrocytes; Glucose; Hypoxia; Lung; Meclofena | 1977 |
Prostaglandins and the control of blood flow in the canine myocardium.
Topics: Adenosine; Angiotensin II; Animals; Arachidonic Acids; Blood Pressure; Coronary Circulation; Coronar | 1977 |
Platelet antiserum inhibits hypoxic pulmonary vasoconstriction in the dog.
Topics: Animals; Antibodies; Blood Platelets; Blood Pressure; Dogs; Female; Hypoxia; Lung; Male; Meclofenami | 1976 |
Endotoxin and prevention of hypoxic pulmonary vasoconstriction.
Topics: Animals; Blood Platelets; Blood Pressure; Dogs; Endotoxins; Humans; Hypoxia; Indomethacin; Leukocyte | 1976 |
The pulmonary vasoconstrictor response to hypoxia: effects of inhibitors of prostaglandin biosynthesis.
Topics: Animals; Aspirin; Blood Pressure; Depression, Chemical; Hypoxia; Indomethacin; Meclofenamic Acid; or | 1975 |
Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs.
Topics: Angiotensin II; Animals; Calcium; Hypoxia; Male; Meclofenamic Acid; Proadifen; Prostaglandins; Prost | 1976 |
Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ.
Topics: Animals; Blood Pressure; Dinoprost; Female; Hypoxia; In Vitro Techniques; Lung; Meclofenamic Acid; M | 1992 |
Methylene blue prevents hypoxic pulmonary vasoconstriction in cats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adrenergic beta-A | 1991 |
The effect of intravascular complement activation and brief episodes of hypoxia on protein in bronchoalveolar lavage fluid in C5 sufficient and deficient mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Complement Activation; Complement C5; Dinoprostone; Elapid Ve | 1991 |
The effect of the inhibition of prostaglandin synthesis on renal blood flow in fetal sheep.
Topics: Animals; Cardiac Output; Fetus; Hypoxia; Meclofenamic Acid; Prostaglandin Antagonists; Reference Val | 1991 |
Effect of cyclic guanosine monophosphate on hypoxic and angiotensin-II-induced pulmonary vasoconstriction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Cyclic GMP; Dose-Response Relationship | 1990 |
The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog.
Topics: Acetylcysteine; Animals; Aorta; Atropine; Blood Pressure; Dinoprost; Dogs; Hypoxia; Lung; Meclofenam | 1986 |
Meclofenamate potentiates vasoreactivity to alpha-adrenergic stimulation in chronically hypoxic guinea pigs.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Aorta; Chronic Disease; Drug Synergism; Guinea P | 1986 |
The coronary vasodilator mediator released by hypoxia and isoprenaline is not affected by cyclo-oxygenase inhibition.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Coronary Vessels; Female; Guinea Pigs; Heart; Heart Tr | 1986 |
Platelet-activating factor causes pulmonary vasodilation in the rat.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Heart Rate; Hypoxia; Male; Meclofenamic Aci | 1986 |
Chemoreceptor stimulation interferes with regional hypoxic pulmonary vasoconstriction.
Topics: Animals; Blood Pressure; Chemoreceptor Cells; Dogs; Female; Hypoxia; Lung; Male; Meclofenamic Acid; | 1988 |
Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cardiac Output; Epoprostenol; Hemodynamics; H | 1986 |
Relation of prostanoids to strength of hypoxic vasoconstriction in dogs with lobar atelectasis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dogs; Hemodynamics; Hypoxia; Meclofenamic Acid; Prostaglandin | 1985 |
Effects of ouabain, low K+, and aldosterone on hypoxic pressor reactivity of rat lungs.
Topics: Aldosterone; Angiotensin II; Animals; Dose-Response Relationship, Drug; Hypoxia; In Vitro Techniques | 1985 |