Page last updated: 2024-10-30

meclizine and Pregnancy

meclizine has been researched along with Pregnancy in 58 studies

Meclizine: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
" Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined."	2.37	Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986)

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (96.55)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (1.72)	29.6817
2010's	1 (1.72)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Havnen, GC	1
Truong, MB	1
Do, MH	1
Heitmann, K	1
Holst, L	1
Nordeng, H	1
Källén, B	1
Mottet, I	1
BASS, RF	1
LEBHERZ, TB	1
HARRIS, JH	1
SEIDNER, HM	1
MULHERIN, CM	1
BRYANS, CI	1
BETHEA, RC	1
DIGGORY, PL	2
TOMKINSON, JS	1
HOPKINS, P	1
ROBERTSON, D	1
BARWELL, TE	1
SMITHELLS, RE	1
CHINN, ER	2
WATSON, GI	1
KING, CT	5
SMITHELLS, RW	1
HARLEY, JD	2
FARRAR, JF	2
GRAY, JB	1
DUNLOP, IC	1
PETTERSSON, F	3
O'LEARY, JL	1
O'LEARY, JA	1
MEYBERG, J	1
MAUSS, HJ	1
KENDRICK, FJ	2
WEAVER, SA	3
RHODES, P	1
VIVELL, O	1
WEICKER, H	1
WINBERG, J	2
VULKOV, T	1
SLAVOV, I	1
DOERING, GK	1
HOSSFELD, C	1
CHRISTIE, RW	1
BERGWALL, WL	1
NARROD, SA	2
WILK, AL	1
McKENNA, CJ	1
Giurgea, M	1
Puigdevall, J	1
Mato, M	1
Uchiyama, Y	1
Shapiro, S	1
Kaufman, DW	1
Rosenberg, L	1
Slone, D	1
Monson, RR	1
Siskind, V	1
Heinonen, OP	1
Milkovich, L	2
van den Berg, BJ	1
Morgan, PR	2
Leathem, AM	1
Courtney, KD	1
Valerio, DA	1
Derr, JE	1
Sadusk, JF	1
Palmisano, PA	1
Wilson, JG	2
Gavan, JA	1
Pestel, M	1
Smith, DW	1
Kozaczenko, J	1
Semmens, JP	1
Suzuki, M	1
Murai, N	1
Frohberg, H	1
Sack, K	1
Lenz, W	1
Harris, JW	1
Yerushalmy, J	1
De Rom, R	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825]			Phase 2	61 participants (Actual)	Interventional	2006-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in the Area Under the Concentration vs. Time Curve in the Second and Third Trimesters of Pregnancy.

"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy

Intervention	ng/ML/day (Mean)
	AUC -1	AUC - 2
Part 1	115	136

Reviews

6 reviews available for meclizine and Pregnancy

Article	Year
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. Clinical pharmacy, 1986, Volume: 5, Issue:8 Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema	1986
Present status of drugs as teratogens in man. Teratology, 1973, Volume: 7, Issue:1 Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics;	1973
[Effect of drugs, ingested by the mother during pregnancy, on the fetus]. Ginekologia polska, 1969, Volume: 40, Issue:3 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Meclizine; Pregnancy;	1969
[Fetal diseases caused by environmental polltuion]. Sanfujinka no jissai. Practice of gynecology and obstetrics, 1971, Volume: 20, Issue:10 Topics: Abnormalities, Drug-Induced; Air Pollution; Congenital Abnormalities; Environment; Environmental Pol	1971
[Present position of the toxicology of drugs]. Munchener medizinische Wochenschrift (1950), 1970, Aug-28, Volume: 112, Issue:35 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo	1970
Malformations caused by drugs in pregnancy. American journal of diseases of children (1960), 1966, Volume: 112, Issue:2 Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Cyclophosphamide; Female; Humans; Infant, Newborn	1966

Trials

2 trials available for meclizine and Pregnancy

Article	Year
An evaluation of the teratogenicity of certain antinauseant drugs. American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2 Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami	1976
Female sexuality and life situations. An etiologic psycho-socio-sexual profile of weight gain and nausea and vomiting in pregnancy. Obstetrics and gynecology, 1971, Volume: 38, Issue:4 Topics: Attitude; Body Weight; Clinical Trials as Topic; Family Characteristics; Female; Humans; Interperson	1971

Other Studies

50 other studies available for meclizine and Pregnancy

Article	Year
Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study. Scandinavian journal of primary health care, 2019, Volume: 37, Issue:1 Topics: Abortion, Induced; Activities of Daily Living; Adult; Antiemetics; Attitude; Cross-Sectional Studies	2019
Delivery outcome after the use of meclozine in early pregnancy. European journal of epidemiology, 2003, Volume: 18, Issue:7 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Antiemetics; Body Mass Index; Disease Model	2003
Bonamine--a notable advance in the therapy of nausea and vomiting of pregnancy. The Mississippi doctor, 1954, Volume: 32, Issue:6 Topics: Female; Histamine H1 Antagonists; Meclizine; Nausea; Pregnancy; Pregnancy Complications; Vomiting	1954
Bonamine: an effective new therapy in nausea and vomiting of pregnancy. Obstetrics and gynecology, 1955, Volume: 6, Issue:6 Topics: Female; Histamine H1 Antagonists; Meclizine; Nausea; Pregnancy; Pregnancy Complications; Vomiting	1955
Nausea and vomiting of pregnancy; preliminary trial of bonamine in sixteen patients. The Illinois medical journal, 1956, Volume: 109, Issue:1 Topics: Female; Histamine H1 Antagonists; Meclizine; Nausea; Pregnancy; Pregnancy Complications; Vomiting	1956
Evaluation of bonamine in nausea and vomiting of pregnancy. Journal of the Medical Association of Georgia, 1956, Volume: 45, Issue:2 Topics: Female; Histamine H1 Antagonists; Meclizine; Nausea; Pregnancy; Pregnancy Complications; Vomiting	1956
Evaluation of a combination of meclizine and pyridoxine in the control of nausea and vomiting in pregnancy. International record of medicine, 1960, Volume: 173 Topics: Anti-Allergic Agents; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Meclizine; N	1960
Nausea and vomiting in pregnancy. A trial of meclozine dihydrochloride with and without pyridoxine. Lancet (London, England), 1962, Aug-25, Volume: 2, Issue:7252 Topics: Antiemetics; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pregnancy; Pyridoxine; Vomit	1962
The effect of "Ancolan" and other drugs in early pregnancy. The Medical journal of Australia, 1963, Mar-02, Volume: 50(1) Topics: Congenital Abnormalities; Female; Humans; Meclizine; Pregnancy; Pregnancy Complications	1963
"Ancoloxin" and foetal abnormalities. British medical journal, 1962, Dec-22, Volume: 2, Issue:5320 Topics: Congenital Abnormalities; Female; Meclizine; Pregnancy; Pregnancy Complications; Pyridoxine	1962
Meclozine and foetal abnormalities. British medical journal, 1963, Jun-22, Volume: 1, Issue:5346 Topics: Congenital Abnormalities; Female; Humans; Meclizine; Pregnancy; Pregnancy Complications	1963
Meclozine ("ancoloxin") and foetal abnormalities. Preliminary report by the Epidemic Observation Unit of the College of General Practitioners. British medical journal, 1962, Dec-01, Volume: 2, Issue:5317 Topics: Congenital Abnormalities; Epidemics; Female; General Practitioners; Meclizine; Pregnancy; Universiti	1962
Teratogenic effects of meclizine hydrochloride on the rat. Science (New York, N.Y.), 1963, Jul-26, Volume: 141, Issue:3578 Topics: Animals; Congenital Abnormalities; Female; Meclizine; Pregnancy; Rats; Rats, Sprague-Dawley; Tongue	1963
MECLOZINE AND FOETAL MALFORMATIONS: A PROSPECTIVE STUDY. British medical journal, 1964, Jan-25, Volume: 1, Issue:5377 Topics: Abnormalities, Drug-Induced; Female; Meclizine; Pregnancy; Pregnancy Complications; Prospective Stud	1964
AROMATIC DRUGS AND CONGENITAL CATARACTS. Lancet (London, England), 1964, Feb-29, Volume: 1, Issue:7331 Topics: Abnormalities, Drug-Induced; Acetaminophen; Acetazolamide; Anti-Bacterial Agents; Cardiovascular Age	1964
MECLOZINE AND CONGENITAL MALFORMATIONS. Lancet (London, England), 1964, Mar-21, Volume: 1, Issue:7334 Topics: Abnormalities, Drug-Induced; Cleft Palate; Female; Heart Defects, Congenital; Humans; Hypospadias; M	1964
MECLOZINE AND CONGENITAL MALFORMATIONS. Lancet (London, England), 1964, Apr-04, Volume: 1, Issue:7336 Topics: Abnormalities, Drug-Induced; Meclizine; Pregnancy; Toxicology	1964
NONTHALIDOMIDE ECTROMELIA: REPORT OF A CASE. Obstetrics and gynecology, 1964, Volume: 23 Topics: Abnormalities, Drug-Induced; Chlorpromazine; Ectromelia; Meclizine; Pregnancy; Toxicology	1964
[MECLIZINE AND FETAL MALFORMATIONS]. Die Medizinische Welt, 1963, Nov-23, Volume: 47 Topics: Abnormalities, Drug-Induced; Female; Fetal Diseases; Humans; Hyperemesis Gravidarum; Infant, Newborn	1963
[DRUG USE DURING PREGNANCY AFTER DISCOVERY OF THALIDOMIDE EMBRYOPATHY]. Deutsche medizinische Wochenschrift (1946), 1964, Feb-21, Volume: 89 Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Ectromelia; Female;	1964
ALTERATION IN AMNIOTIC FLUID VOLUME AND OTHER FINDINGS IN MECLIZINE HYDROCHLORIDE INDUCED ANOMALIES. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 114 Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Cleft Palate; Extraembryonic Membranes; Female; Fetus;	1963
HYPEREMESIS GRAVIDARUM. The Practitioner, 1964, Volume: 192 Topics: Blood Chemical Analysis; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pathology; Pregn	1964
MATERNAL DRUG THERAPY AND CONGENITAL CATARACTS. The Medical journal of Australia, 1964, Feb-08, Volume: 1 Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyreti	1964
[TERATOGENIC SUBSTANCES?]. Medizinische Klinik, 1964, Jan-31, Volume: 59 Topics: Abnormalities, Drug-Induced; Ectromelia; Fetal Diseases; Infant, Newborn; Meclizine; Phenmetrazine;	1964
MECLOZINE AND CONGENITAL MALFORMATIONS. Lancet (London, England), 1964, May-30, Volume: 1, Issue:7344 Topics: Abnormalities, Drug-Induced; Cleft Palate; Female; Humans; Hyperemesis Gravidarum; Hypospadias; Infa	1964
[TERSTOGENIC SUBSTANCES?]. Medizinische Klinik, 1963, Dec-13, Volume: 58 Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meclizine; Ph	1963
[ANALYSIS OF THE POSSIBLE RELATION OF FETAL DAMAGE AND DRUGS. V. PRELIMINARY STUDY ON THE INFLUENCE OF 4 ANTIEMETICS ON FETAL DEVELOPMENT]. Svenska lakartidningen, 1964, Mar-25, Volume: 61 Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Antiemetics; Birth Weight; Ca	1964
[APROPOS OF THE TREATMENT OF HYPEREMESIS GRAVIDARUM]. Akusherstvo i ginekologiia, 1964, Volume: 3 Topics: Female; Humans; Hyperemesis Gravidarum; Meclizine; Pregnancy; Pyridoxine	1964
[INVESTIGATION ON THE POSSIBLE RELATION OF FETAL INJURIES AND DRUGS. IV. RETROSPECTIVE STUDY ON DRUG CONSUMPTION AMONG MOTHERS WITH MALFORMED CHILDREN]. Svenska lakartidningen, 1964, Mar-18, Volume: 61 Topics: Abnormalities, Drug-Induced; Diphenhydramine; Down Syndrome; Fetal Diseases; Hip Dislocation; Hip Di	1964
[MECLIZINE AND ABNORMALITIES]. Svenska lakartidningen, 1964, Apr-29, Volume: 61 Topics: Abnormalities, Drug-Induced; Meclizine; Pregnancy; Statistics as Topic; Sweden; Toxicology	1964
[ON THE HAZARDS OF AN EXAGGERATED FEAR OF DRUGS IN PREGNANCY. STUDIES ON THE INFLUENCE OF HYPEREMESIS GRAVIDARUM AS WELL AS VARIOUS ANTIEMETICS (MECLIZINE, PHENOTHIAZINE DERIVATIVES) ON THE INCIDENCE OF MALFORMATIONS]. Deutsche medizinische Wochenschrift (1946), 1964, May-29, Volume: 89 Topics: Abnormalities, Drug-Induced; Antiemetics; Antipsychotic Agents; Cerium; Chlorpromazine; Congenital A	1964
CONGENITAL LEUKEMIA. The Journal of the Indiana State Medical Association, 1964, Volume: 57 Topics: Antifungal Agents; Communicable Diseases; Dextropropoxyphene; Female; Humans; Infant, Newborn; Infan	1964
ORAL ANOMALIES INDUCED IN THE RAT BY MECLIZINE HYDROCHLORIDE. Oral surgery, oral medicine, and oral pathology, 1964, Volume: 18 Topics: Animals; Cleft Palate; Female; Humans; Maternal-Fetal Exchange; Meclizine; Mouth Abnormalities; Path	1964
METABOLISM OF MECLIZINE IN THE RAT. The Journal of pharmacology and experimental therapeutics, 1965, Volume: 147 Topics: Abnormalities, Drug-Induced; Amines; Blood; Chromatography; Feces; Female; Gastrointestinal Tract; H	1965
ANTIHISTAMINES AND TERATOGENICITY IN THE RAT. The Journal of pharmacology and experimental therapeutics, 1965, Volume: 147 Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Cleft Palate; Embryo Implantation; Histamine Anta	1965
A new treatment for nausea and vomiting of pregnancy (bonamine). American practitioner and digest of treatment, 1955, Volume: 6, Issue:3 Topics: Female; Histamine H1 Antagonists; Meclizine; Nausea; Pregnancy; Pregnancy Complications; Vomiting	1955
Experimental teratology with Meclozine. Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1966, Volume: 15, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Humans; Meclizine; Mice; Pregnancy; Pregn	1966
Ultrastructures of glosso-palatal fusion after treatment of meclozine-hydrochloride. Virchows Archiv. A, Pathological anatomy and histology, 1975, Dec-29, Volume: 369, Issue:1 Topics: Animals; Basement Membrane; Cell Adhesion; Cell Fusion; Cell Survival; Epithelial Cells; Epithelium;	1975
Meclizine in pregnancy in relation to congenital malformations. British medical journal, 1978, Feb-25, Volume: 1, Issue:6111 Topics: Abnormalities, Drug-Induced; Child; Female; Humans; Meclizine; Pregnancy	1978
The fate of the expected fusion zone in rat fetuses with experimentally-induced cleft palate - an ultrastructural study. Developmental biology, 1976, Jul-15, Volume: 51, Issue:2 Topics: Animals; Cleft Palate; Disease Models, Animal; Epithelium; Female; Gestational Age; Meclizine; Palat	1976
Teratology in the Macaca mulatta. Teratology, 1968, Volume: 1, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Clomiphene; Encephalocele; Female; Fetal Death; Haplo	1968
Benzhydrylpiperazine antihistamines, hydramnios, and congenital malformations in the rat. American journal of obstetrics and gynecology, 1965, Oct-15, Volume: 93, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Histamine H1 Antagonists; Meclizine; Poly	1965
Teratogenic effect of meclizine, cyclizine, and chlorcyclizine. JAMA, 1965, Nov-29, Volume: 194, Issue:9 Topics: Abnormalities, Drug-Induced; Animals; Cyclizine; Female; Histamine H1 Antagonists; Humans; Legislati	1965
Congenital malformations in nonhuman primates: spontaneous and experimentally induced. The Anatomical record, 1967, Volume: 158, Issue:1 Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Congenital Abnormalities; Female; Haplor	1967
[New drugs for nausea and vomiting. A clinical and physiological study]. La Presse medicale, 1969, May-24, Volume: 77, Issue:25 Topics: Adult; Anesthesia; Antiemetics; Atropa belladonna; Barbiturates; Child; Chlorpromazine; Cyclizine; F	1969
Discussion: familial spina bifida. Birth defects original article series, 1974, Volume: 10, Issue:7 Topics: Abnormalities, Drug-Induced; Female; Humans; Hyperemesis Gravidarum; Infant, Newborn; Meclizine; Pre	1974
[Transverse tongue cleft in mandibular arch syndrome]. Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1969, Volume: 112, Issue:1 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Humans; Infant, Newborn; Mandib	1969
The ultrastructure of palatal epithelium of rat embryos with meclozine-induced cleft palate. Journal of anatomy, 1969, Volume: 105, Issue:Pt 1 Topics: Animals; Cleft Palate; Epithelium; Female; Meclizine; Microscopy, Electron; Palate; Pregnancy; Rats	1969
Evaluation of the teratogenic effect of meclizine in man. American journal of obstetrics and gynecology, 1965, Oct-15, Volume: 93, Issue:4 Topics: Abnormalities, Drug-Induced; Adult; California; Cyclizine; Female; Fetal Death; Humans; Hyperemesis	1965
[Meclizine and congenital malformations]. Geburtshilfe und Frauenheilkunde, 1966, Volume: 26, Issue:5 Topics: Abnormalities, Drug-Induced; Adult; Anencephaly; Ectromelia; Female; Humans; Intestinal Atresia; Mat	1966