Compounds > meclizine
Page last updated: 2024-10-30

meclizine and Abnormalities, Drug-Induced

meclizine has been researched along with Abnormalities, Drug-Induced in 42 studies

Meclizine: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
" The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine combination."1.40Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats. ( Alvin, JM; Sandeep, M, 2014)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199038 (90.48)18.7374
1990's1 (2.38)18.2507
2000's1 (2.38)29.6817
2010's2 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sandeep, M1
Alvin, JM1
Tauqeer, S1
Khan, RA1
Siddiqui, AA1
Källén, B1
Mottet, I1
SMITHELLS, RW1
CHINN, ER1
HARLEY, JD2
FARRAR, JF2
GRAY, JB1
DUNLOP, IC1
PETTERSSON, F3
DIGGORY, PL1
O'LEARY, JL1
O'LEARY, JA1
MEYBERG, J1
MAUSS, HJ1
KENDRICK, FJ1
WEAVER, SA3
VIVELL, O1
WEICKER, H1
WINBERG, J2
FRASER, FC1
DOERING, GK1
HOSSFELD, C1
NARROD, SA2
WILK, AL1
KING, CT3
Giurgea, M1
Puigdevall, J1
Lastra-Lastra, A1
Sánchez-Hernandez, J1
Jiménez-Balderas, EA1
Jaffe, P1
Liberman, MM1
McFadyen, I1
Valman, HB1
Shapiro, S1
Kaufman, DW1
Rosenberg, L1
Slone, D1
Monson, RR1
Siskind, V1
Heinonen, OP1
Milkovich, L2
van den Berg, BJ1
Courtney, KD1
Valerio, DA1
Derr, JE1
Sadusk, JF1
Palmisano, PA1
Stalsberg, H1
Wilson, JG2
Gavan, JA1
Smith, DW1
Kozaczenko, J1
Suzuki, M1
Murai, N1
Frohberg, H1
Calli, LJ1
Sack, K1
Lenz, W1
Yerushalmy, J1
De Rom, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825]Phase 261 participants (Actual)Interventional2006-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in the Area Under the Concentration vs. Time Curve in the Second and Third Trimesters of Pregnancy.

"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy

Interventionng/ML/day (Mean)
AUC -1AUC - 2
Part 1115136

Reviews

5 reviews available for meclizine and Abnormalities, Drug-Induced

ArticleYear
Present status of drugs as teratogens in man.
    Teratology, 1973, Volume: 7, Issue:1

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics;

1973
[Effect of drugs, ingested by the mother during pregnancy, on the fetus].
    Ginekologia polska, 1969, Volume: 40, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Caffeine; Female; Humans; Meclizine; Pregnancy;

1969
[Fetal diseases caused by environmental polltuion].
    Sanfujinka no jissai. Practice of gynecology and obstetrics, 1971, Volume: 20, Issue:10

    Topics: Abnormalities, Drug-Induced; Air Pollution; Congenital Abnormalities; Environment; Environmental Pol

1971
[Present position of the toxicology of drugs].
    Munchener medizinische Wochenschrift (1950), 1970, Aug-28, Volume: 112, Issue:35

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo

1970
Malformations caused by drugs in pregnancy.
    American journal of diseases of children (1960), 1966, Volume: 112, Issue:2

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Cyclophosphamide; Female; Humans; Infant, Newborn

1966

Trials

1 trial available for meclizine and Abnormalities, Drug-Induced

ArticleYear
An evaluation of the teratogenicity of certain antinauseant drugs.
    American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2

    Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami

1976

Other Studies

36 other studies available for meclizine and Abnormalities, Drug-Induced

ArticleYear
Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.
    Indian journal of experimental biology, 2014, Volume: 52, Issue:12

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Caffeine; Dose-Response Rel

2014
Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs.
    Pakistan journal of pharmaceutical sciences, 2012, Volume: 25, Issue:1

    Topics: Abnormalities, Drug-Induced; alpha-Tocopherol; Animals; Antiemetics; Antihypertensive Agents; Drug E

2012
Delivery outcome after the use of meclozine in early pregnancy.
    European journal of epidemiology, 2003, Volume: 18, Issue:7

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Antiemetics; Body Mass Index; Disease Model

2003
MECLOZINE AND FOETAL MALFORMATIONS: A PROSPECTIVE STUDY.
    British medical journal, 1964, Jan-25, Volume: 1, Issue:5377

    Topics: Abnormalities, Drug-Induced; Female; Meclizine; Pregnancy; Pregnancy Complications; Prospective Stud

1964
AROMATIC DRUGS AND CONGENITAL CATARACTS.
    Lancet (London, England), 1964, Feb-29, Volume: 1, Issue:7331

    Topics: Abnormalities, Drug-Induced; Acetaminophen; Acetazolamide; Anti-Bacterial Agents; Cardiovascular Age

1964
MECLOZINE AND CONGENITAL MALFORMATIONS.
    Lancet (London, England), 1964, Mar-21, Volume: 1, Issue:7334

    Topics: Abnormalities, Drug-Induced; Cleft Palate; Female; Heart Defects, Congenital; Humans; Hypospadias; M

1964
MECLOZINE AND CONGENITAL MALFORMATIONS.
    Lancet (London, England), 1964, Apr-04, Volume: 1, Issue:7336

    Topics: Abnormalities, Drug-Induced; Meclizine; Pregnancy; Toxicology

1964
NONTHALIDOMIDE ECTROMELIA: REPORT OF A CASE.
    Obstetrics and gynecology, 1964, Volume: 23

    Topics: Abnormalities, Drug-Induced; Chlorpromazine; Ectromelia; Meclizine; Pregnancy; Toxicology

1964
[MECLIZINE AND FETAL MALFORMATIONS].
    Die Medizinische Welt, 1963, Nov-23, Volume: 47

    Topics: Abnormalities, Drug-Induced; Female; Fetal Diseases; Humans; Hyperemesis Gravidarum; Infant, Newborn

1963
[DRUG USE DURING PREGNANCY AFTER DISCOVERY OF THALIDOMIDE EMBRYOPATHY].
    Deutsche medizinische Wochenschrift (1946), 1964, Feb-21, Volume: 89

    Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Ectromelia; Female;

1964
ALTERATION IN AMNIOTIC FLUID VOLUME AND OTHER FINDINGS IN MECLIZINE HYDROCHLORIDE INDUCED ANOMALIES.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 114

    Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Cleft Palate; Extraembryonic Membranes; Female; Fetus;

1963
MATERNAL DRUG THERAPY AND CONGENITAL CATARACTS.
    The Medical journal of Australia, 1964, Feb-08, Volume: 1

    Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyreti

1964
[TERATOGENIC SUBSTANCES?].
    Medizinische Klinik, 1964, Jan-31, Volume: 59

    Topics: Abnormalities, Drug-Induced; Ectromelia; Fetal Diseases; Infant, Newborn; Meclizine; Phenmetrazine;

1964
MECLOZINE AND CONGENITAL MALFORMATIONS.
    Lancet (London, England), 1964, May-30, Volume: 1, Issue:7344

    Topics: Abnormalities, Drug-Induced; Cleft Palate; Female; Humans; Hyperemesis Gravidarum; Hypospadias; Infa

1964
[TERSTOGENIC SUBSTANCES?].
    Medizinische Klinik, 1963, Dec-13, Volume: 58

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meclizine; Ph

1963
[ANALYSIS OF THE POSSIBLE RELATION OF FETAL DAMAGE AND DRUGS. V. PRELIMINARY STUDY ON THE INFLUENCE OF 4 ANTIEMETICS ON FETAL DEVELOPMENT].
    Svenska lakartidningen, 1964, Mar-25, Volume: 61

    Topics: Abnormalities, Drug-Induced; Abortion, Induced; Abortion, Spontaneous; Antiemetics; Birth Weight; Ca

1964
[INVESTIGATION ON THE POSSIBLE RELATION OF FETAL INJURIES AND DRUGS. IV. RETROSPECTIVE STUDY ON DRUG CONSUMPTION AMONG MOTHERS WITH MALFORMED CHILDREN].
    Svenska lakartidningen, 1964, Mar-18, Volume: 61

    Topics: Abnormalities, Drug-Induced; Diphenhydramine; Down Syndrome; Fetal Diseases; Hip Dislocation; Hip Di

1964
EXPERIMENTAL TERATOGENESIS IN RELATION TO CONGENITAL MALFORMATIONS IN MAN.
    World-wide abstracts of general medicine, 1964, Volume: 7

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Caffeine; Cortisone; Insulin; Lagomorph

1964
[MECLIZINE AND ABNORMALITIES].
    Svenska lakartidningen, 1964, Apr-29, Volume: 61

    Topics: Abnormalities, Drug-Induced; Meclizine; Pregnancy; Statistics as Topic; Sweden; Toxicology

1964
[ON THE HAZARDS OF AN EXAGGERATED FEAR OF DRUGS IN PREGNANCY. STUDIES ON THE INFLUENCE OF HYPEREMESIS GRAVIDARUM AS WELL AS VARIOUS ANTIEMETICS (MECLIZINE, PHENOTHIAZINE DERIVATIVES) ON THE INCIDENCE OF MALFORMATIONS].
    Deutsche medizinische Wochenschrift (1946), 1964, May-29, Volume: 89

    Topics: Abnormalities, Drug-Induced; Antiemetics; Antipsychotic Agents; Cerium; Chlorpromazine; Congenital A

1964
METABOLISM OF MECLIZINE IN THE RAT.
    The Journal of pharmacology and experimental therapeutics, 1965, Volume: 147

    Topics: Abnormalities, Drug-Induced; Amines; Blood; Chromatography; Feces; Female; Gastrointestinal Tract; H

1965
ANTIHISTAMINES AND TERATOGENICITY IN THE RAT.
    The Journal of pharmacology and experimental therapeutics, 1965, Volume: 147

    Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Cleft Palate; Embryo Implantation; Histamine Anta

1965
Experimental teratology with Meclozine.
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1966, Volume: 15, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Humans; Meclizine; Mice; Pregnancy; Pregn

1966
[Cleft lip and palate associated with meclozine].
    Ginecologia y obstetricia de Mexico, 1996, Volume: 64

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Female; Humans; Infant, Newborn;

1996
Letter: Incidence of congenital limb-reduction deformities.
    Lancet (London, England), 1975, Mar-01, Volume: 1, Issue:7905

    Topics: Abnormalities, Drug-Induced; Arm; Benzyl Compounds; Birth Weight; Congenital Abnormalities; England;

1975
Meclizine in pregnancy in relation to congenital malformations.
    British medical journal, 1978, Feb-25, Volume: 1, Issue:6111

    Topics: Abnormalities, Drug-Induced; Child; Female; Humans; Meclizine; Pregnancy

1978
Teratology in the Macaca mulatta.
    Teratology, 1968, Volume: 1, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Clomiphene; Encephalocele; Female; Fetal Death; Haplo

1968
Benzhydrylpiperazine antihistamines, hydramnios, and congenital malformations in the rat.
    American journal of obstetrics and gynecology, 1965, Oct-15, Volume: 93, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Histamine H1 Antagonists; Meclizine; Poly

1965
Teratogenic effect of meclizine, cyclizine, and chlorcyclizine.
    JAMA, 1965, Nov-29, Volume: 194, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Cyclizine; Female; Histamine H1 Antagonists; Humans; Legislati

1965
[Antiemetics and congenital malformations--meclizine, cyclizine and cholrcyclizine].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1965, Dec-15, Volume: 85, Issue:24

    Topics: Abnormalities, Drug-Induced; Cyclizine; Histamine H1 Antagonists; Humans; Meclizine; Piperazines

1965
Congenital malformations in nonhuman primates: spontaneous and experimentally induced.
    The Anatomical record, 1967, Volume: 158, Issue:1

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Congenital Abnormalities; Female; Haplor

1967
Discussion: familial spina bifida.
    Birth defects original article series, 1974, Volume: 10, Issue:7

    Topics: Abnormalities, Drug-Induced; Female; Humans; Hyperemesis Gravidarum; Infant, Newborn; Meclizine; Pre

1974
Ocular hypertelorism and nasal agenesis (midface syndrome) with limb anomalies.
    Birth defects original article series, 1971, Volume: 7, Issue:7

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cleft Palate; Craniofacial Dysostosis; Humans;

1971
[Transverse tongue cleft in mandibular arch syndrome].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1969, Volume: 112, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Humans; Infant, Newborn; Mandib

1969
Evaluation of the teratogenic effect of meclizine in man.
    American journal of obstetrics and gynecology, 1965, Oct-15, Volume: 93, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; California; Cyclizine; Female; Fetal Death; Humans; Hyperemesis

1965
[Meclizine and congenital malformations].
    Geburtshilfe und Frauenheilkunde, 1966, Volume: 26, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Anencephaly; Ectromelia; Female; Humans; Intestinal Atresia; Mat

1966