mechlorethamine has been researched along with Thrombopenia in 24 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighteen patients with advanced Hodgkin's disease, refractory to combination chemotherapy with nitrogen mustard, vincristine, prednisone, and procarbazine (MOPP), were treated with vinblastine, doxorubicin (Adriamycin), bleomycin, CCNU, and dacarbazine (DTIC) (VABCD)." | 2.65 | Treatment of MOPP-refractory Hodgkin's disease with vinblastine, doxorubicin, bleomycin, CCNU, and dacarbazine. ( Bond, WH; Chenoweth, L; Einhorn, LH; Stevens, EE; Williams, SD, 1983) |
| " This side effect could be explained by a cycling of the hematopoietic stem-cells and call to some caution when androgens are used during cancer chemotherapy." | 2.64 | [Increased hematological toxicity of antineoplastic drugs with simultaneous androgenotherapy (author's transl)]. ( Barthélémy, M; Bilski-Pasquier, G; Blanc, CM; Bouchard, M; Bousser, J; Zittoun, R, 1977) |
| "Sixteen patients with Hodgkin's disease were treated with MOPP/ABVD and filgrastim support between January 1992 and March 1994." | 1.30 | G-CSF (filgrastim) as an adjunct to MOPP/ABVD therapy in Hodgkin's disease. ( Gustavsson, A, 1997) |
| "We report a 54-year-old patient with Hodgkin's disease who achieved a complete remission after combined modality treatment." | 1.29 | Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease. ( Bendandi, M; Cantagalli, F; Macchi, S; Mancino, A; Simoncelli, F; Stefanati, V; Tura, S; Visani, G; Zaccaria, A; Zinzani, PL, 1995) |
| " From a dose-response showing that the administration of increasing doses of tissue thromboplastin resulted in a subsequent progressive increase of thrombus weight, two concentrations of tissue thromboplastin were chosen: a high dose (550 microL/kg, IV) where thrombus formation was optimal and a concentration (7 microL/kg, IV) where tissue thromboplastin-hypercoagulability was intermediate." | 1.28 | Importance of platelets in experimental venous thrombosis in the rat. ( Bernat, A; Herbert, JM; Maffrand, JP, 1992) |
| "One patient with Hodgkin's disease involving the liver is alive at 36 months with further therapy." | 1.26 | Adriamycin, bleomycin, DIC, CCNU, and prednisone (ABDIC) chemotherapy in MOPP-resistant Hodgkin's disease. ( Gamble, JF; Loh, KK; Rodgers, RW; Shullenberger, CC, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (75.00) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MEYER, LM | 1 |
| FLIEDNER, TD | 1 |
| CRONKITE, EP | 1 |
| BURNINGHAM, RA | 1 |
| RESTREPO, A | 1 |
| PUGH, RP | 1 |
| BROWN, EB | 1 |
| SCHLOSSMAN, SF | 1 |
| KHURI, PD | 1 |
| LESSNER, HE | 1 |
| HARRINGTON, WJ | 1 |
| NORIN, T | 1 |
| BEAHRS, OH | 1 |
| CALDAROLA, VT | 1 |
| HARRISON, EG | 1 |
| KEIDAN, SE | 1 |
| MAINWARING, D | 1 |
| Rodgers, RW | 1 |
| Gamble, JF | 1 |
| Loh, KK | 1 |
| Shullenberger, CC | 1 |
| Einhorn, LH | 1 |
| Williams, SD | 1 |
| Stevens, EE | 1 |
| Bond, WH | 1 |
| Chenoweth, L | 1 |
| Somers, R | 1 |
| Carde, P | 1 |
| Thomas, J | 1 |
| Tirelli, U | 1 |
| Keuning, JJ | 1 |
| Bron, D | 1 |
| Delmer, A | 1 |
| de Bock, R | 1 |
| De Wolf-Peeters, C | 1 |
| Keunig, JJ | 1 |
| Bendandi, M | 1 |
| Zaccaria, A | 1 |
| Zinzani, PL | 1 |
| Visani, G | 1 |
| Stefanati, V | 1 |
| Cantagalli, F | 1 |
| Mancino, A | 1 |
| Macchi, S | 1 |
| Simoncelli, F | 1 |
| Tura, S | 1 |
| Canellos, GP | 1 |
| Petroni, GR | 1 |
| Barcos, M | 1 |
| Duggan, DB | 1 |
| Peterson, BA | 1 |
| Watkins, SM | 1 |
| Gustavsson, A | 1 |
| Hansen, HH | 1 |
| Selawry, OS | 1 |
| Simon, R | 1 |
| Carr, DT | 1 |
| van Wyk, CE | 1 |
| Tucker, RD | 1 |
| Sealy, R | 1 |
| Trump, DL | 1 |
| Cowall, DE | 1 |
| Zittoun, R | 1 |
| Barthélémy, M | 1 |
| Bouchard, M | 1 |
| Blanc, CM | 1 |
| Bousser, J | 1 |
| Bilski-Pasquier, G | 1 |
| de Kreek, EJ | 1 |
| Sybesma, HB | 1 |
| Lipinski, B | 1 |
| Gurewich, V | 1 |
| Herbert, JM | 1 |
| Bernat, A | 1 |
| Maffrand, JP | 1 |
| Skjorten, F | 1 |
| Evensen, SA | 1 |
| Fairley, GH | 1 |
| Smirnova, IN | 1 |
| Lucaya, J | 1 |
| Brown, JC | 1 |
| Lavelle, SM | 1 |
| Sawyer, PN | 1 |
| Evatt, BL | 1 |
| Levin, J | 1 |
5 trials available for mechlorethamine and Thrombopenia
| Article | Year |
|---|---|
Treatment of MOPP-refractory Hodgkin's disease with vinblastine, doxorubicin, bleomycin, CCNU, and dacarbazine.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 1983 |
EORTC study of non-Hodgkin's lymphoma: phase III study comparing CHVmP-VB and ProMACE-MOPP in patients with stage II, III, and IV intermediate- and high-grade lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; C | 1994 |
Etoposide, vinblastine, and doxorubicin: an active regimen for the treatment of Hodgkin's disease in relapse following MOPP. Cancer and Leukemia Group B.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubici | 1995 |
Combination chemotherapy of advanced lung cancer: a randomized trial.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; | 1976 |
[Increased hematological toxicity of antineoplastic drugs with simultaneous androgenotherapy (author's transl)].
Topics: Androgens; Anemia; Antineoplastic Agents; Drug Therapy, Combination; Humans; Lymphoma; Mechlorethami | 1977 |
19 other studies available for mechlorethamine and Thrombopenia
| Article | Year |
|---|---|
AUTOLOGOUS BONE-MARROW TRANSFUSION FOLLOWING CHEMOTHERAPY.
Topics: Autoradiography; Biomedical Research; Blood Cell Count; Blood Platelets; Bone Marrow; Bone Marrow Tr | 1964 |
WEEKLY HIGH-DOSAGE GLUCOCORTICOSTEROID TREATMENT OF LYMPHOCYTIC LEUKEMIAS AND LYMPHOMAS.
Topics: Anemia; Anemia, Hemolytic; Betamethasone; Chlorambucil; Dexamethasone; Geriatrics; Humans; Leukemia; | 1964 |
MELPHALAN (PHENYLALANIN NITROGEN MUSTARD) -TREATMENT IN MYELOMATOSIS.
Topics: Albuminuria; Blood Protein Electrophoresis; Humans; Leukocyte Disorders; Leukopenia; Mechlorethamine | 1964 |
TREATMENT OF CANCER OF THE HEAD AND NECK BY CHEMOTHERAPY.
Topics: Alopecia; Diarrhea; Erythema; Head; Head and Neck Neoplasms; Injections, Intra-Arterial; Leukopenia; | 1964 |
ASSOCIATION OF HERPES ZOSTER WITH LEUKEMIA AND LYMPHOMA IN CHILDREN.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Child; Cyclophosphamide; Drug Therapy; Herpes Zoster; Ho | 1965 |
Adriamycin, bleomycin, DIC, CCNU, and prednisone (ABDIC) chemotherapy in MOPP-resistant Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bleomycin; Dacarbazine; Doxorubicin; Drug Administra | 1980 |
Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Blood Transfusion; Combined Modality | 1995 |
Predicting neutropenia after chemotherapy for lymphoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cy | 1993 |
G-CSF (filgrastim) as an adjunct to MOPP/ABVD therapy in Hodgkin's disease.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antine | 1997 |
Acute myelogenous leukemia as a late complication of the multimodality therapy for Hodgkin's disease.
Topics: Adult; Biopsy; Bone Marrow; Cytarabine; Daunorubicin; Hodgkin Disease; Humans; Leukemia, Myeloid, Ac | 1977 |
[From tumors to scales].
Topics: Agranulocytosis; Humans; Immunologic Deficiency Syndromes; Leg Ulcer; Leukopenia; Male; Mechloretham | 1975 |
The effect of leukopenia versus thrombocytopenia on endotoxin induced intravascular coagulation.
Topics: Animals; Blood Cell Count; Blood Platelets; Disseminated Intravascular Coagulation; Drug Interaction | 1976 |
Importance of platelets in experimental venous thrombosis in the rat.
Topics: Animals; Blood Platelets; Clopidogrel; Disease Models, Animal; Heparin; Hirudins; Leukopenia; Male; | 1992 |
Disseminated intravascular coagulation induced by liquoid in normal, thrombocytopenic and granulocytopenic rabbits. Light and electron microscope studies.
Topics: Agranulocytosis; Animals; Blood Cell Count; Blood Platelets; Blood Proteins; Busulfan; Capillaries; | 1972 |
The use of different drugs and combinations in the treatment of Hodgkin's disease.
Topics: Administration, Oral; Anemia; Drug Evaluation; Drug Therapy, Combination; Hodgkin Disease; Humans; I | 1973 |
[Results of treatment of tonsillar tumors by olivomycin].
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chlorpromazine; Cyclophosp | 1969 |
Histiocytosis X.
Topics: Age Factors; Aminopterin; Biopsy; Bone Diseases; Bone Marrow Cells; Bone Marrow Examination; Child; | 1971 |
Relationship between electrical and spontaneous thrombosis. Coagulation inhibition of intrinsic system.
Topics: Animals; Blood Coagulation; Blood Platelets; Dogs; Electrodes; Factor VIII; Factor XII; Hemophilia A | 1969 |
Measurement of thrombopoiesis in rabbits using 75selenomethionine.
Topics: Animals; Blood Platelets; Blood Transfusion; Culture Techniques; Guinea Pigs; Hematopoiesis; Hemorrh | 1969 |