mechlorethamine has been researched along with Psoriasis in 38 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two groups of 20 patients with psoriasis were treated with mechlorethamine applied topically (group A) or with PUVA combined with mechlorethamine (group B)." | 9.05 | PUVA therapy prevents sensitization to mechlorethamine in patients with psoriasis. ( Mauduit, G; Silvestre, O; Thivolet, J, 1985) |
| "The topical application of mechlorethamine is associated with a high incidence of irritant contact dermatitis." | 7.66 | Topical mechlorethamine for psoriasis. An attempt to avoid the development of sensitization by the use of a topical tolerogenic schedule. ( Price, NM, 1979) |
| "Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization." | 7.65 | Intravenous desensitization to mechlorethamine in patients with psoriasis. ( Childers, RC; Halprin, KM; Kechijian, P; Pariser, DM; Taylor, JR, 1976) |
| "Using OKT6 monoclonal antibody, we investigated the number of epidermal Langerhans' cells (LCs) in involved skin from patients with psoriasis, before and after mechlorethamine (HN2) or PUVA treatment." | 5.06 | Effects of PUVA and mechlorethamine treatment of psoriatic patients on epidermal Langerhans' cells. ( Haftek, M; Mauduit, G; Thivolet, J; Torinuki, W, 1987) |
| "Two groups of 20 patients with psoriasis were treated with mechlorethamine applied topically (group A) or with PUVA combined with mechlorethamine (group B)." | 5.05 | PUVA therapy prevents sensitization to mechlorethamine in patients with psoriasis. ( Mauduit, G; Silvestre, O; Thivolet, J, 1985) |
| "Solutions of mechlorethamine hydrochloride used to treat patients with mycosis fungoides and psoriasis are stable for many months, especially when they are refrigerated." | 3.66 | Mechlorethamine hydrochloride solutions and ointment. Prolonged stability and biological activity. ( Aoyagi, T; Halprin, KM; Levine, V; Taylor, JR, 1980) |
| "Presented herein is a review of the beneficial use of the folic acid antagonist, aminopterin, in the treatment of psoriasis and other dermatologic disorders." | 3.66 | Introduction of antifolics in psoriasis. A twenty-five year retrospect of antineoplastic agents in nonmalignant disease. ( Gubner, RS, 1979) |
| "The topical application of mechlorethamine is associated with a high incidence of irritant contact dermatitis." | 3.66 | Topical mechlorethamine for psoriasis. An attempt to avoid the development of sensitization by the use of a topical tolerogenic schedule. ( Price, NM, 1979) |
| "Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization." | 3.65 | Intravenous desensitization to mechlorethamine in patients with psoriasis. ( Childers, RC; Halprin, KM; Kechijian, P; Pariser, DM; Taylor, JR, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (94.74) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parier, J | 1 |
| Dubertret, L | 2 |
| VILANOVA, X | 2 |
| PINOL, J | 2 |
| FROMER, JL | 1 |
| SIBER, FJ | 1 |
| PEZZINI, G | 1 |
| JIMENEZ DIAZ, C | 1 |
| MERCHANTE, A | 1 |
| PERIANES, J | 1 |
| LOPEZ GARCIA, E | 1 |
| GOMEZ ORBANEJA, J | 1 |
| Nusbaum, BP | 1 |
| Edwards, EK | 1 |
| Horwitz, SN | 1 |
| Frost, P | 1 |
| Halprin, KM | 3 |
| Comerford, M | 1 |
| Presser, SE | 1 |
| Taylor, JR | 5 |
| Owen, OE | 1 |
| Dellatorre, DL | 1 |
| Van Scott, EJ | 3 |
| Cohen, MR | 1 |
| Levine, V | 1 |
| Aoyagi, T | 1 |
| Revuz, J | 2 |
| Mathoret, C | 1 |
| Veret, G | 1 |
| Touraine, R | 3 |
| Gubner, RS | 1 |
| Price, NM | 1 |
| Handler, RM | 1 |
| Medansky, RS | 1 |
| Rees, RB | 1 |
| Leshaw, S | 1 |
| Simon, RS | 1 |
| Bear, RL | 1 |
| Pariser, DM | 1 |
| Childers, RC | 1 |
| Kechijian, P | 2 |
| Michel, FJ | 1 |
| Baker, H | 1 |
| du Vivier, A | 1 |
| Stoughton, RB | 1 |
| Breza, TS | 1 |
| Purdy, MJ | 2 |
| Rotstein, H | 1 |
| Baker, C | 1 |
| Torinuki, W | 1 |
| Mauduit, G | 3 |
| Haftek, M | 1 |
| Thivolet, J | 3 |
| Silvestre, O | 1 |
| Avril, MF | 1 |
| Salle, G | 1 |
| Schott, AM | 1 |
| Yu, KY | 1 |
| Flaxman, BA | 1 |
| Sosis, AC | 1 |
| Boulvin, F | 1 |
| Yu, RJ | 1 |
| Baer, RL | 1 |
| Michaelides, P | 1 |
| Prestia, AE | 1 |
| Zackheim, HS | 1 |
| Arnold, JE | 1 |
| Farber, EM | 1 |
| Cox, AJ | 1 |
| Epstein, E | 1 |
| Ugel, AR | 1 |
| Mandy, S | 1 |
| Halprin, K | 1 |
4 reviews available for mechlorethamine and Psoriasis
| Article | Year |
|---|---|
[Psoriasis of the scalp].
Topics: Administration, Topical; Alkylating Agents; Cholecalciferol; Humans; Mechlorethamine; Psoriasis; Sca | 2002 |
Psoriasis: a review. II.
Topics: Adrenal Cortex Hormones; Anthralin; Azathioprine; Azauridine; Fluorouracil; Humans; Hydroxyurea; Lom | 1975 |
The treatment of psoriasis.
Topics: Administration, Oral; Administration, Topical; Anthralin; Anti-Inflammatory Agents; Bed Rest; Chroni | 1990 |
[Some developments in psoriasis research abroad].
Topics: Aza Compounds; Female; Humans; Hydroxyurea; Male; Mechlorethamine; Methotrexate; Psoriasis; Uridine | 1974 |
5 trials available for mechlorethamine and Psoriasis
| Article | Year |
|---|---|
Psoriasis therapy. The effect of UV radiation on sensitization to mechlorethamine.
Topics: Administration, Topical; Aged; Clinical Trials as Topic; Dermatitis, Contact; Drug Hypersensitivity; | 1983 |
Effects of PUVA and mechlorethamine treatment of psoriatic patients on epidermal Langerhans' cells.
Topics: Antibodies, Monoclonal; Humans; Langerhans Cells; Mechlorethamine; Psoriasis; PUVA Therapy; Skin | 1987 |
PUVA therapy prevents sensitization to mechlorethamine in patients with psoriasis.
Topics: Adult; Aged; Dermatitis, Atopic; Dermatitis, Contact; Drug Eruptions; Drug Therapy, Combination; Fem | 1985 |
Treatment of patients with psoriasis by PUVA therapy and mechlorethamine.
Topics: Dermatitis, Contact; Drug Therapy, Combination; Humans; Mechlorethamine; Psoriasis; PUVA Therapy | 1986 |
Effects of topical mechlorethamine on skin lesions of psoriasis.
Topics: Adult; Drug Hypersensitivity; Edema; Erythema; Female; Humans; Lactose; Male; Mechlorethamine; Middl | 1970 |
29 other studies available for mechlorethamine and Psoriasis
| Article | Year |
|---|---|
[Treatment of psoriasis, poikilodermatomyositis and erythroderma with nitrogen mustards].
Topics: Dermatitis, Exfoliative; Dermatomyositis; Humans; Mechlorethamine; Nitrogen Mustard Compounds; Pigme | 1952 |
WHAT IS YOUR DIAGNOSIS?
Topics: Diagnosis, Differential; Humans; Mechlorethamine; Mycosis Fungoides; Neoplasms; Phosphorus Isotopes; | 1964 |
[REMARKS ON THE USE OF SMALL INTERMITTENT DOSES OF AN ANTIFOLIC AGENT AMETHOPTERIN IN PSORIATIC RHEUMATISM AND OF NITROGEN MUSTARD IN CHRONIC PROTOTYPIC RHEUMATISM (C.E.P.)].
Topics: Arthritis; Arthritis, Rheumatoid; Drug Therapy; Folic Acid Antagonists; Humans; Mechlorethamine; Met | 1965 |
[Treatment of psoriasis with nitrogen mustard].
Topics: Humans; Mechlorethamine; Nitrogen Mustard Compounds; Psoriasis | 1950 |
[Treatment of psoriasis with nitrogen mustards].
Topics: Mechlorethamine; Nitrogen Mustard Compounds; Psoriasis | 1951 |
[Treatment of psoriasis, poikilodermatomyositis and erythrodermia with nitrogen mustards].
Topics: Mechlorethamine; Nitrogen Mustard Compounds; Pigmentation Disorders; Psoriasis; Skin Diseases | 1952 |
Ultraviolet light treatment delays contact sensitization to nitrogen mustard.
Topics: Adult; Aged; Dermatitis, Contact; Female; Humans; Male; Mechlorethamine; Middle Aged; Psoriasis; PUV | 1981 |
Accidental intramuscular injection of mechlorethamine.
Topics: Antidotes; Humans; Injections, Intramuscular; Male; Mechlorethamine; Medication Errors; Middle Aged; | 1980 |
Mechlorethamine hydrochloride solutions and ointment. Prolonged stability and biological activity.
Topics: Animals; Cell Division; Drug Stability; Drug Storage; Humans; In Vitro Techniques; Mechlorethamine; | 1980 |
[Treatment of psoriasis by topical application of mechlorethamine. 118 reports].
Topics: Administration, Topical; Drug Eruptions; Follow-Up Studies; Humans; Mechlorethamine; Psoriasis | 1976 |
Introduction of antifolics in psoriasis. A twenty-five year retrospect of antineoplastic agents in nonmalignant disease.
Topics: Adult; Aminopterin; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Male; Mechlorethamine; | 1979 |
Topical mechlorethamine for psoriasis. An attempt to avoid the development of sensitization by the use of a topical tolerogenic schedule.
Topics: Administration, Topical; Dermatitis, Contact; Drug Tolerance; Humans; Mechlorethamine; Psoriasis | 1979 |
Treatment of psoriasis with topical nitrogen mustard.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Humans; Hydrocortisone; | 1979 |
[Cutaneous psoriasis. Symptoms and therapy].
Topics: Adrenal Cortex Hormones; Female; Humans; Male; Mechlorethamine; Photochemotherapy; Psoriasis; Tars; | 1979 |
Psoriasis: clinical aspects and management.
Topics: Administration, Topical; Age Factors; Azauridine; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine | 1976 |
Failure to induce tolerance to mechlorethamine hydrochloride.
Topics: Dermatitis, Contact; Dinitrochlorobenzene; Humans; Immune Tolerance; Mechlorethamine; Mycosis Fungoi | 1977 |
Intravenous desensitization to mechlorethamine in patients with psoriasis.
Topics: Administration, Topical; Dermatitis, Contact; Desensitization, Immunologic; Drug Hypersensitivity; H | 1976 |
[Value of local applications of caryolysine in psoriasis].
Topics: Administration, Topical; Humans; Mechlorethamine; Psoriasis | 1976 |
An animal model for screening topical and systemic drugs for potential use in the treatment of psoriasis.
Topics: Administration, Topical; Animals; Cyclophosphamide; Disease Models, Animal; DNA; Drug Evaluation, Pr | 1975 |
Mechlorethamine in psoriasis. Further attempts to induce immunological tolerance.
Topics: Adult; Dermatitis, Contact; Humans; Hypersensitivity; Immune Tolerance; Male; Mechlorethamine; Psori | 1975 |
Topical mustine hydrochloride and psoriasis: a follow-up study.
Topics: Adolescent; Adult; Aged; Child; Desensitization, Immunologic; Drug Hypersensitivity; Female; Follow- | 1975 |
[Local Caryolysine].
Topics: Administration, Topical; Humans; Mechlorethamine; Mycosis Fungoides; Psoriasis; Time Factors | 1987 |
Changes in melanosome distribution in Caucasoid skin following topical application of nitrogen mustard.
Topics: Biopsy; Black People; Cell Aggregation; Cell Count; Epithelial Cells; Epithelium; Humans; Mechloreth | 1973 |
Topical mustine hydrochloride and psoriasis.
Topics: Drug Hypersensitivity; Female; Humans; Male; Mechlorethamine; Middle Aged; Psoriasis; Solutions | 1973 |
[Local chemotherapy of psoriasis with nitrogen mustard].
Topics: Administration, Topical; Biopsy; Cortisone; Drug Therapy, Combination; Female; Humans; Male; Mechlor | 1973 |
Antimitotic, antigenic, and structural relationships of nitrogen mustard and its homologues.
Topics: Animals; Antigens; Cross Reactions; Drug Hypersensitivity; Epithelial Cells; Epithelium; Ethanolamin | 1974 |
Failure to induce immune tolerance to nitrogen mustard. Intravenous administration preceding topical use in patients with proriasis.
Topics: Adult; Aged; Humans; Hypersensitivity, Delayed; Immune Tolerance; Immunosuppression Therapy; Male; M | 1972 |
Topical therapy of psoriasis with mechlorethamine.
Topics: Drug Hypersensitivity; Humans; Mechlorethamine; Microscopy, Electron; Psoriasis; Remission, Spontane | 1972 |
Topically applied mechlorethamine in the treatment of psoriasis.
Topics: Dermatitis, Contact; Humans; Hydrochloric Acid; Male; Mechlorethamine; Psoriasis; Solutions | 1971 |