mechlorethamine has been researched along with Progeria in 1 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Progeria: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intervertebral disc degeneration (IDD) is a common and debilitating disorder that results in reduced flexibility of the spine, pain, and reduced mobility." | 1.36 | Accelerated aging of intervertebral discs in a mouse model of progeria. ( Alber, S; Bentley, D; Coehlo, P; Huard, J; Kang, J; Lee, J; Loppini, M; Niedernhofer, LJ; Robbins, PD; Robinson, A; Seo, HY; Sowa, G; Studer, R; Taylor, L; Usas, A; Vo, N; Wang, D; Watkins, SC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vo, N | 1 |
| Seo, HY | 1 |
| Robinson, A | 1 |
| Sowa, G | 1 |
| Bentley, D | 1 |
| Taylor, L | 1 |
| Studer, R | 1 |
| Usas, A | 1 |
| Huard, J | 1 |
| Alber, S | 1 |
| Watkins, SC | 1 |
| Lee, J | 1 |
| Coehlo, P | 1 |
| Wang, D | 1 |
| Loppini, M | 1 |
| Robbins, PD | 1 |
| Niedernhofer, LJ | 1 |
| Kang, J | 1 |
1 other study available for mechlorethamine and Progeria
| Article | Year |
|---|---|
Accelerated aging of intervertebral discs in a mouse model of progeria.
Topics: Aging; Animals; Apoptosis; Cellular Senescence; Disease Models, Animal; DNA-Binding Proteins; Endonu | 2010 |