mechlorethamine has been researched along with Primary Myelofibrosis in 5 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Primary Myelofibrosis: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients with Hodgkin's disease and bone marrow fibrosis are presented in whom the clinical presentation was dominated by cytopenias; this was associated with a delayed diagnosis for an average of 20 months." | 1.28 | Hodgkin's disease presenting as myelofibrosis. ( Crawford, J; Kaufman, RE; Laszlo, J; Meadows, LM; Moore, JO; Rosse, WR, 1989) |
| "Malignant myelosclerosis or acute myelofibrosis is a rare acute myeloproliferative disorder characterized by pancytopenia, myeloblastosis and marrow fibrosis." | 1.26 | Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy. ( Ali, NO; Janes, WO, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MORROW, LB | 1 |
| ANDERSON, RE | 1 |
| Ali, NO | 1 |
| Janes, WO | 1 |
| Meadows, LM | 1 |
| Rosse, WR | 1 |
| Moore, JO | 1 |
| Crawford, J | 1 |
| Laszlo, J | 1 |
| Kaufman, RE | 1 |
| Carroll, WL | 1 |
| Berberich, FR | 1 |
| Glader, BE | 1 |
| Young, RC | 1 |
| Canellos, GP | 1 |
| Chabner, BA | 1 |
| Schein, PS | 1 |
| DeVita, VT | 1 |
1 trial available for mechlorethamine and Primary Myelofibrosis
| Article | Year |
|---|---|
Maintenance chemotherapy for advanced Hodgkin's disease in remission.
Topics: Blood Cell Count; Blood Platelets; Hodgkin Disease; Humans; Lymphocytes; Mechlorethamine; Nitrosoure | 1973 |
4 other studies available for mechlorethamine and Primary Myelofibrosis
| Article | Year |
|---|---|
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leu | 1965 |
Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy.
Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Glom | 1979 |
Hodgkin's disease presenting as myelofibrosis.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Diagnosis, Differential; Female; | 1989 |
Pancytopenia with myelofibrosis. An unusual presentation of childhood Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Female; Hodgkin Disease; Humans; | 1986 |