Page last updated: 2024-10-30

mechlorethamine and Multiple Primary Neoplasms

mechlorethamine has been researched along with Multiple Primary Neoplasms in 38 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

ExcerptRelevanceReference
" After a median follow-up of more than 6 years following MOPP (mechlorethamine/vincristine/procarbazine/prednisone) chemotherapy with or without radiotherapy, 5% of patients with Hodgkin's disease developed second primaries, 60% of which were leukemias."4.78Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects. ( Petru, E; Schmähl, D, 1991)
"Relapses were most frequent in previously involved unirradiated areas."2.67Management of relapse and survival in advanced stage Hodgkin's disease: the EORTC experience. ( Breed, WP; Burgers, JM; Carde, P; de Pauw, BE; Hagenbeek, A; Henry-Amar, M; Monconduit, M; Somers, R; Tarayre, M; Thomas, J, 1991)
"Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm."2.65Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease. ( Bartolucci, AA; Durant, JR; Gams, RA; Liu, C, 1983)
"The outlook for patients with Hodgkin's disease has improved dramatically over the past 20 years."2.37Hodgkin's disease. ( Portlock, CS, 1984)
"The occurrence of HIV associated non-Hodgkin's lymphoma (NHL) is a well recognized event."1.29Hodgkin's disease and non-Hodgkin's lymphoma in an HIV positive patient. ( Brody, J; Goh, JC; Kaplan, MH; Koduru, P; Lichtman, SM; Susin, M, 1993)
"Three patients with Stage III or IVB Hodgkin's disease were cured with MOPP (regimen of nitrogen mustard, Oncovin, prednisone, and procarbazine) and/or B-DOPA (regimen of bleomycin, dacarbazine, Oncovin, prednisone, and Adriamycin)."1.28Secondary uncommon solid neoplasms in cured Hodgkin's disease and follow-up of the original B-DOPA chemotherapy patient group. ( Lokich, JJ, 1990)
" There were three fatal toxic events, two due to viral infection and one to a second malignant tumor (NHL)."1.28Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity. ( Berry, M; Blanchette, V; Chan, H; Doherty, M; Doyle, J; Freedman, M; Greenberg, M; Jenkin, D; Panzarella, T; Saunders, F, 1990)
"Hodgkin's disease is one of the most curable cancers thanks to progress in radiotherapy and multi-drug chemotherapy regimens such as mechloretamine-vincristine-procarbazine-prednisone, best known as MOPP."1.28Ten-year nodular sclerosis Hodgkin's disease and second malignancies. ( Mirimanoff, RO; Zulian, GB, 1989)
"Patients who had a relapse of Hodgkin's disease did not have an increased incidence of second malignancy."1.27Second malignancy complicating Hodgkin's disease. ( Mercier, JP; Tawil, E, 1983)
"A patient is described who developed Hodgkin's disease 16 years after treatment of Wilms' tumor with radiation and actinomycin D."1.27Hodgkin's disease following Wilms' tumor: a case report. ( Bell, BA; Esseltine, DW; Freeman, CR, 1987)
"A patient seen at presentation for Hodgkin's disease (HD) at stage IV B was successfully treated with MOPP."1.27Gastric non-Hodgkin's lymphoma after successful treatment of Hodgkin's disease. ( Eridani, S; Singh, AK, 1986)
"Four lesions were squamous cell carcinomas and two were basal cell carcinomas."1.26Second cutaneous malignancies in patients with mycosis fungoides treated with topical nitrogen mustard. ( Fritz, KA; Fritz, TJ; Golitz, L; Lee, LA; Weston, WL, 1982)
"Despite the dramatic response of Hodgkin's disease to intensive chemotherapy, the skin lesion was rapidly transformed into squamous cell carcinoma in 10 weeks."1.26Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease? ( Poleksic, S; Yeung, KY, 1978)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199030 (78.95)18.7374
1990's8 (21.05)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Portlock, CS1
Jacquillat, C2
Khayat, D1
Desprez-Curely, JP1
Weil, M2
Brocheriou, C1
Auclerc, G2
Chamseddine, N1
Bernard, J1
Schmitt, K1
Tulzer, W1
Gassmann, W1
Schmitz, N1
Kayser, W1
Löffler, H1
Bartolucci, AA1
Liu, C1
Durant, JR1
Gams, RA1
Weiss, VC1
Barsky, GJ1
Solomon, LM1
Auclerc, MF1
Maral, J1
Tawil, E1
Mercier, JP1
Lee, LA1
Fritz, KA1
Golitz, L1
Fritz, TJ1
Weston, WL1
Lichtman, SM1
Brody, J1
Kaplan, MH1
Susin, M1
Koduru, P1
Goh, JC1
Varterasian, ML1
Aref, A1
Karanes, C1
Young, RC3
Anderson, T1
DeVita, VT4
Garrett, MJ1
Das, S1
Smith, JD1
Freedman, LS1
Nissen, NI1
Pajak, TF1
Glidewell, O1
Pedersen-Bjergaard, J1
Stutzman, L1
Falkson, G1
Cuttner, J1
Blom, J1
Leone, L1
Sawitsky, A1
Coleman, M1
Haurani, F1
Spurr, CL1
Harley, JB1
Seligman, B1
Cornell, C1
Henry, P1
Senn, HJ1
Brunner, K1
Martz, G1
Maurice, P1
Bank, A1
Shapiro, L1
James, GW1
Holland, JF1
Poleksic, S1
Yeung, KY1
Klein, E1
Rosner, D1
Holtermann, OA1
Stoll, HL1
Song, SY1
Lokich, JJ1
Viviani, S1
Bonadonna, G1
Santoro, A1
Zanini, M1
Zucali, R1
Negretti, E1
Valagussa, P1
Burgers, JM1
Somers, R1
Henry-Amar, M1
Tarayre, M1
Carde, P1
Thomas, J1
Hagenbeek, A1
Monconduit, M1
de Pauw, BE1
Breed, WP1
Petru, E1
Schmähl, D1
Anderson, H1
Crowther, D1
Deakin, DP1
Ryder, WD1
Radford, JA1
Jenkin, D1
Doyle, J1
Berry, M1
Blanchette, V1
Chan, H1
Doherty, M1
Freedman, M1
Greenberg, M1
Panzarella, T1
Saunders, F1
Longo, DL2
Glatstein, E1
Ihde, DC1
Jaffe, ES1
Straus, DJ1
Zulian, GB1
Mirimanoff, RO1
Bell, BA1
Esseltine, DW1
Freeman, CR1
Takaue, Y1
Sullivan, MP1
Ramirez, I1
Cleary, KR1
van Eys, J1
Hancock, SL1
Hoppe, RT1
Horning, SJ1
Rosenberg, SA1
Zandecki, M1
Dupriez, B1
Laï, JL1
Fenaux, P1
Facon, T1
Lepelley, P1
Estienne, MH1
Huart, JJ1
Jouet, JP1
España, P1
Bonilla, F1
Yebra, M1
Diego, J1
Alvarez de Mon, M1
Marazuela, M1
Durántez, A1
Sans-Sabrafen, J1
Pedro Olivé, C1
Buxó Costa, J1
Pardo Peret, P1
Rodríguez Ferrera, JC1
Woessner, S1
Galofré, M1
Rodríguez Méndez, F1
Eridani, S1
Singh, AK1
Blayney, DW1
Greene, MH1
Hubbard, SM1
Postal, MG1
Duffey, PL1
Perri, RT1
Allen, JI1
Oken, MM1
Limas, C1
Kay, NE1
Musto, P1
Lucchi, T1
Barbieri, D1
Ferraresi, P1
Lanza, F1
Sahakian, GJ1
al-Mondhiry, H1
Lacher, MJ1
Connolly, CE1
Arseneau, JC1
Canellos, GP1
Sherins, RJ1
Chambers, RG1
Alonso, WA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167]Phase 21 participants (Actual)Interventional2007-05-31Terminated (stopped due to Lack of accrual and interest in study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for mechlorethamine and Multiple Primary Neoplasms

ArticleYear
Hodgkin's disease.
    The Medical clinics of North America, 1984, Volume: 68, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cobalt Radioisotopes;

1984
Non-Hodgkin's lymphoma occurring after Hodgkin's disease. Four new cases and a review of the literature.
    Cancer, 1984, Feb-01, Volume: 53, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy;

1984
The treatment of Hodgkin's disease: emphasizing programs at the Clinic Center, National Institutes of Health.
    Current problems in cancer, 1977, Volume: 1, Issue:7

    Topics: Adult; Bleomycin; Bone Marrow; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; H

1977
Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects.
    Neoplasma, 1991, Volume: 38, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Hod

1991
Treatment of advanced Hodgkin's disease.
    Hematology/oncology clinics of North America, 1989, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top

1989
[Acute lymphoblastic leukemia, Burkitt-cell type, after Hodgkin's disease. Study of 2 cases].
    Nouvelle revue francaise d'hematologie, 1987, Volume: 29, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; H

1987
Recently recognized complications of cancer chemotherapy.
    Annals of the New York Academy of Sciences, 1974, Volume: 230

    Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Death, Sudden; Drug Therapy, Combination;

1974

Trials

9 trials available for mechlorethamine and Multiple Primary Neoplasms

ArticleYear
Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease.
    Cancer, 1983, Dec-15, Volume: 52, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Female; Hodgkin

1983
The treatment of Hodgkin's disease: emphasizing programs at the Clinic Center, National Institutes of Health.
    Current problems in cancer, 1977, Volume: 1, Issue:7

    Topics: Adult; Bleomycin; Bone Marrow; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; H

1977
A comparative study of a BCNU containing 4-drug program versus MOPP versus 3-drug combinations in advanced Hodgkin's disease: a cooperative study by the Cancer and Leukemia Group B.
    Cancer, 1979, Volume: 43, Issue:1

    Topics: Adult; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Drug Therapy, Combination; Femal

1979
Alternating versus hybrid MOPP-ABVD in Hodgkin's disease: the Milan experience.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2 Suppl 2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarba

1991
Management of relapse and survival in advanced stage Hodgkin's disease: the EORTC experience.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2 Suppl 2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cause of Death;

1991
A randomised study of adjuvant MVPP chemotherapy after mantle radiotherapy in pathologically staged IA-IIB Hodgkin's disease: 10-year follow-up.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2 Suppl 2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female

1991
The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment.
    Seminars in hematology, 1988, Volume: 25, Issue:2 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Doxorub

1988
Treatment of advanced Hodgkin's disease.
    Hematology/oncology clinics of North America, 1989, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top

1989
Intercurrent death after Hodgkin disease therapy in radiotherapy and adjuvant MOPP trials.
    Annals of internal medicine, 1988, Aug-01, Volume: 109, Issue:3

    Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Cardiovascular Diseases; Clinica

1988

Other Studies

24 other studies available for mechlorethamine and Multiple Primary Neoplasms

ArticleYear
[Second tumor following Hodgkin's disease].
    Padiatrie und Padologie, 1984, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Presc

1984
Hodgkin's disease.
    Cancer treatment reviews, 1984, Volume: 11, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Combined Modality Therapy; Drug Resistanc

1984
Cutaneous T-lymphocyte lymphoma in association with multiple myeloma.
    Archives of dermatology, 1984, Volume: 120, Issue:4

    Topics: Aged; Female; Humans; Lymphoma; Mechlorethamine; Multiple Myeloma; Neoplasms, Multiple Primary; Skin

1984
[Acute leukemias and solid tumors in the course of Hodgkin disease].
    Bulletin du cancer, 1983, Volume: 70, Issue:1

    Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco

1983
Second malignancy complicating Hodgkin's disease.
    Journal of the Canadian Association of Radiologists, 1983, Volume: 34, Issue:2

    Topics: Acute Disease; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cycloph

1983
Second cutaneous malignancies in patients with mycosis fungoides treated with topical nitrogen mustard.
    Journal of the American Academy of Dermatology, 1982, Volume: 7, Issue:5

    Topics: Administration, Topical; Carcinoma, Squamous Cell; Female; Humans; Male; Mechlorethamine; Middle Age

1982
Hodgkin's disease and non-Hodgkin's lymphoma in an HIV positive patient.
    Leukemia & lymphoma, 1993, Volume: 9, Issue:4-5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cyclophosphamide; Dexametha

1993
A blood stem cell transplant in a person with concomitant Hodgkin disease and testicular carcinoma.
    Bone marrow transplantation, 1997, Volume: 19, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Germinoma; Hematopoietic

1997
Long term experience with combination chemotherapy in advanced Hodgkin's disease.
    Clinical oncology, 1977, Volume: 3, Issue:2

    Topics: Adult; Antineoplastic Agents; Bleomycin; Drug Therapy, Combination; Female; Hodgkin Disease; Humans;

1977
Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease?
    Cancer, 1978, Volume: 41, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Therapy, Combination; Hodgkin Disease; Humans;

1978
Nonspecific antigen reactions.
    National Cancer Institute monograph, 1976, Volume: 44

    Topics: Administration, Topical; Antibody Formation; Antigens; Antineoplastic Agents; BCG Vaccine; Breast Ne

1976
Secondary uncommon solid neoplasms in cured Hodgkin's disease and follow-up of the original B-DOPA chemotherapy patient group.
    American journal of clinical oncology, 1990, Volume: 13, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Dacarbaz

1990
Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity.
    Medical and pediatric oncology, 1990, Volume: 18, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali

1990
Ten-year nodular sclerosis Hodgkin's disease and second malignancies.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgkin Di

1989
Hodgkin's disease following Wilms' tumor: a case report.
    Medical and pediatric oncology, 1987, Volume: 15, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgk

1987
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G

1986
[Second tumors in patients treated for Hodgkin's disease].
    Revista clinica espanola, 1988, Volume: 182, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modali

1988
[Hodgkin's disease. Study of 100 cases].
    Medicina clinica, 1987, Feb-07, Volume: 88, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Th

1987
Gastric non-Hodgkin's lymphoma after successful treatment of Hodgkin's disease.
    Oncology, 1986, Volume: 43, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Celiac Disease; Hodgkin Disease; Humans; Immun

1986
Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin's disease.
    The New England journal of medicine, 1987, Mar-19, Volume: 316, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Combined Modality Therapy;

1987
Simultaneous presentation of relapsing Hodgkin's disease and treatment-related non-Hodgkin's lymphoma.
    Medical and pediatric oncology, 1985, Volume: 13, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; Humans;

1985
[Acute lymphoblastic leukemia L3 in Hodgkin's disease in remission: primary or secondary leukosis?].
    Recenti progressi in medicina, 1985, Volume: 76, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Hodgkin Disease; Humans; Karyotyping; Leukemia, Lymp

1985
Acute leukemia in Hodgkin's disease.
    Cancer, 1974, Volume: 33, Issue:5

    Topics: Adult; Bleomycin; Carmustine; Chlorambucil; Drug Therapy, Combination; Female; Hodgkin Disease; Huma

1974
Cutaneous lymphoma complicating basal cell carcinoma of the face.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 91, Issue:4

    Topics: Carcinoma, Basal Cell; Chemotherapy, Cancer, Regional Perfusion; Facial Neoplasms; Humans; Lymphoma;

1970