mechlorethamine has been researched along with Medulloblastoma in 12 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age." | 9.07 | Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study. ( Boyett, JM; Camitta, B; Cornell, CJ; Kim, TH; Krischer, JP; Kun, L; Laurent, JP; Link, M; Luthy, AR; Ragab, AH, 1991) |
| "In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age." | 5.07 | Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study. ( Boyett, JM; Camitta, B; Cornell, CJ; Kim, TH; Krischer, JP; Kun, L; Laurent, JP; Link, M; Luthy, AR; Ragab, AH, 1991) |
| "Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)." | 3.68 | Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992) |
| "Medulloblastoma is a rare tumor in adult." | 2.39 | High dose chemotherapy with stem-cell transplantation in a metastatic medulloblastoma in an adult: a case report and review of the literature. ( Cottu, PH; Epardeau, B; Espie, M; Extra, JM; Giacchetti, S; Marty, M; Mignot, L; Visot, B, 1994) |
| "Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity." | 1.30 | MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. ( Ater, JL; Bruner, J; Copeland, DR; Moore, B; van Eys, J; Woo, SY, 1997) |
| "Five children with brain tumors, who had had no prior chemotherapy, were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, prednisolone (MOPP) and intrathecal methotrexate." | 1.27 | [Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors]. ( Akita, H; Hashimoto, T; Hirose, M; Matsumoto, K; Miki, Y; Miyao, M; Ninomiya, T; Saijo, T; Sato, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandes, AA | 1 |
| Ermani, M | 1 |
| Amista, P | 1 |
| Basso, U | 1 |
| Vastola, F | 1 |
| Gardiman, M | 1 |
| Iuzzolino, P | 1 |
| Turazzi, S | 1 |
| Rotilio, A | 1 |
| Volpin, L | 1 |
| Mazza, C | 1 |
| Sainati, L | 1 |
| Ammannati, F | 1 |
| Berti, F | 1 |
| Cangir, A | 4 |
| Ragab, AH | 2 |
| Steuber, P | 1 |
| Land, VJ | 1 |
| Berry, DH | 1 |
| Krischer, JP | 2 |
| Cottu, PH | 1 |
| Giacchetti, S | 1 |
| Mignot, L | 1 |
| Epardeau, B | 1 |
| Visot, B | 1 |
| Extra, JM | 1 |
| Espie, M | 1 |
| Marty, M | 1 |
| Ater, JL | 1 |
| van Eys, J | 4 |
| Woo, SY | 1 |
| Moore, B | 1 |
| Copeland, DR | 1 |
| Bruner, J | 1 |
| Hayani, A | 1 |
| Mahoney, DH | 1 |
| Taylor, LD | 1 |
| Kun, L | 1 |
| Kim, TH | 1 |
| Laurent, JP | 1 |
| Boyett, JM | 1 |
| Cornell, CJ | 1 |
| Link, M | 1 |
| Luthy, AR | 1 |
| Camitta, B | 1 |
| Kretschmar, CS | 2 |
| Tarbell, NJ | 2 |
| Kupsky, W | 1 |
| Lavally, BL | 2 |
| Loeffler, JS | 2 |
| Wolfe, L | 1 |
| Strand, R | 1 |
| Scott, RM | 1 |
| Sallan, SE | 2 |
| Winston, KR | 1 |
| Fischer, EG | 1 |
| Baram, TZ | 2 |
| Bruner, JM | 2 |
| Martinez-Prieto, J | 1 |
| Dowell, RE | 1 |
| Pack, B | 1 |
| Sato, J | 1 |
| Ninomiya, T | 1 |
| Saijo, T | 1 |
| Akita, H | 1 |
| Miki, Y | 1 |
| Hirose, M | 1 |
| Hashimoto, T | 1 |
| Miyao, M | 1 |
| Matsumoto, K | 1 |
| Coody, D | 1 |
| Smith, B | 1 |
1 review available for mechlorethamine and Medulloblastoma
| Article | Year |
|---|---|
High dose chemotherapy with stem-cell transplantation in a metastatic medulloblastoma in an adult: a case report and review of the literature.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplant | 1994 |
1 trial available for mechlorethamine and Medulloblastoma
| Article | Year |
|---|---|
Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms | 1991 |
10 other studies available for mechlorethamine and Medulloblastoma
| Article | Year |
|---|---|
The treatment of adults with medulloblastoma: a prospective study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Disease-Free Survival; | 2003 |
Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Follow-Up | 1984 |
MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, | 1997 |
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool | 1992 |
Pre-irradiation chemotherapy for infants and children with medulloblastoma: a preliminary report.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Child; Child, Pres | 1989 |
Pre-radiation chemotherapy for infants and poor prognosis children with medulloblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Child; Child, Pres | 1988 |
Salvage chemotherapy for recurrent primary brain tumors in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi | 1988 |
Survival and neurologic outcome of infants with medulloblastoma treated with surgery and MOPP chemotherapy. A preliminary report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Child, Preschool; Combined Mod | 1987 |
[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Choroid Pl | 1986 |
MOPP regimen as primary chemotherapy for brain tumors in infants.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; | 1985 |