Page last updated: 2024-10-30

mechlorethamine and Malignant Melanoma

mechlorethamine has been researched along with Malignant Melanoma in 55 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

ExcerptRelevanceReference
"Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models."7.83Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. ( Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME, 2016)
"In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time."7.67Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. ( Parsons, PG, 1984)
"The formation and removal of nitrogen mustard (HN2)- and melphalan-induced DNA cross-links (DNA interstrand and DNA-protein cross-links) in a human melanoma cell line (RPMI 8322), as determined by alkaline elution of DNA, was compared and related to the cytotoxic effect of each drug."7.67Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells. ( Hansson, J; Lewensohn, R; Nilsson, B; Ringborg, U, 1987)
"Forty-two patients with intransit metastases of melanoma in a limb were treated by isolated regional perfusion chemotherapy using mechlorethamine (nitrogen mustard)."7.67Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard). ( Fortner, JG; Gould-Rossbach, P; Guerra, J; Horowitz, G; Knapper, WH; Ray, C; Schnog, J; Shiu, MH; Yeh, S, 1986)
" The additional use of mechlorethamine or oral psoralen plus UV-A, but not radiation, was significantly associated with the development of basal cell carcinoma and squamous cell carcinoma, but not malignant melanoma."4.79Malignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. The influence of additional therapy after total skin electron beam radiation. ( Braverman, IM; Feldman, AM; Kacinski, BM; Licata, AG; Wilson, LD, 1995)
"Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models."3.83Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. ( Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME, 2016)
"The cytotoxic effects of the bifunctional DNA-reactive drugs cisplatin, mustine and melphalan were studied in two human melanoma cell lines, RPMI 8322 and A 375."3.68Comparative study of two human melanoma cell lines with different sensitivities to mustine and cisplatin. ( Edgren, M; Fichtinger-Schepman, AM; Hansson, J; Ringborg, U, 1991)
"In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time."3.67Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. ( Parsons, PG, 1984)
"The formation and removal of nitrogen mustard (HN2)- and melphalan-induced DNA cross-links (DNA interstrand and DNA-protein cross-links) in a human melanoma cell line (RPMI 8322), as determined by alkaline elution of DNA, was compared and related to the cytotoxic effect of each drug."3.67Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells. ( Hansson, J; Lewensohn, R; Nilsson, B; Ringborg, U, 1987)
"Forty-two patients with intransit metastases of melanoma in a limb were treated by isolated regional perfusion chemotherapy using mechlorethamine (nitrogen mustard)."3.67Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard). ( Fortner, JG; Gould-Rossbach, P; Guerra, J; Horowitz, G; Knapper, WH; Ray, C; Schnog, J; Shiu, MH; Yeh, S, 1986)
"Thirteen patients with advanced (Stage III) malignant melanoma have been treated with high-dose chemotherapy (nitrogen mustard or a combination of BCNU and melphalan) combined with autologous, nonfrozen, bone marrow transplantation."3.66Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study. ( Dantas, ME; Glode, LM; Koeppler, H; Morton, N; Robinson, WA; Sutherland, J; Thomas, MR, 1982)
" It is the authors' conclusion that the portable isolated limb perfusion system achieved all of the required parameters to provide safe and effective treatment for this type of melanoma."1.29Safe, compact and portable system for regional chemotherapeutic hyperthermic perfusion procedures. ( Faddis, D; Fried, SJ; Miller, R; Weaver, FA, 1993)
" Cytostatics are dosed per liter of perfused extremity."1.27[Technic of isolated perfusion of the extremities. Experience with 171 cases]. ( Aigner, K; Schwemmle, K, 1983)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199046 (83.64)18.7374
1990's7 (12.73)18.2507
2000's0 (0.00)29.6817
2010's2 (3.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lyons, AB1
Mitchell, DA1
Moy, RL2
Nath, K1
Nelson, DS1
Putt, ME1
Leeper, DB1
Garman, B1
Nathanson, KL1
Glickson, JD1
LUCK, JM1
CREECH, O4
RYAN, RF4
KREMENTZ, ET5
HOLLAND, JF1
REGELSON, W2
WESTBURY, G1
HUMBLE, JG1
NEWTON, KA1
SKINNER, ME1
PEGG, DE1
IRVINE, WT1
NOON, CF1
MANIZADE, D1
SALEPCIOGLU, A1
AKTAN, K1
ARIEL, IM1
PACK, GT1
KENNEDY, BJ1
ZELICKSON, AS1
CALCUTT, G1
CONNORS, TA1
BRINDLEY, CO1
SALVIN, LG1
POTEE, KG1
LIPOWSKA, B1
SHNIDER, BI1
COLSKY, J1
BOGUSZ, J1
BUTELSKI, W1
SYCH, M1
THIELE, EH1
ARISON, RN1
BOXER, GE1
MAUER, AM1
KRILL, CE1
VIGI, F1
SHINGLETON, WW1
PARKER, RT1
DOWD, JE1
DIPAOLO, JA1
WATNE, AL1
FRIEDMAN, BI1
SAENGER, EL1
KREINDLER, MS1
DECOSSE, JJ1
ROGERS, LS1
LAWRENCE, W1
TAYAO, MS1
MAHAJAN, RD1
PAGE, R1
MILLER, DG1
CLAPP, P1
KONDO, T1
ICHIHASHI, H1
BIRINGER, A1
HOLAN, J1
MEDLA, F1
JONES, KO1
REEVE, TS1
PIPER, DW1
CUMBERLAND, VH1
Markman, M1
Aigner, K2
Schwemmle, K1
Cosnes, A1
Revuz, J1
Wechsler, J1
Touraine, R1
Parsons, PG1
Thomas, MR1
Robinson, WA2
Glode, LM2
Dantas, ME1
Koeppler, H1
Morton, N1
Sutherland, J1
Hofer, D2
Dubitsky, AM1
Reïlly, P2
Santoro, MG3
Jaffe, BM3
Dubitsky, A1
Marti, J1
Hild, P1
Hundeiker, M1
Hartmann, DW1
Morton, NJ1
Mangalik, A1
Leport, P1
Favalli, C1
Rinaldi, C1
Licata, AG1
Wilson, LD1
Braverman, IM1
Feldman, AM1
Kacinski, BM1
Quinn, TD1
Polk, HC1
Edwards, MJ1
Carter, RD1
Sutherland, CM1
Muchmore, JH1
Lamb, PM1
Menaker, GM1
Amichai, B1
Grunwald, MH1
Goldstein, J1
Finkelstein, E1
Halevy, S1
Fried, SJ1
Miller, R1
Weaver, FA1
Faddis, D1
Klein, E1
Rosner, D1
Holtermann, OA1
Stoll, HL1
Song, SY1
Hansson, J2
Fichtinger-Schepman, AM1
Edgren, M1
Ringborg, U2
Lewensohn, R1
Nilsson, B1
Shiu, MH1
Knapper, WH1
Fortner, JG1
Yeh, S1
Horowitz, G1
Schnog, J1
Guerra, J1
Gould-Rossbach, P1
Ray, C1
Helman, P1
Sealy, R1
Malherbe, E1
Anderson, J1
Anderson, CB1
Philpott, GW1
Ferguson, TB1
Hill, GJ1
Larsen, RR1
Hersh, EM1
McBride, CM2
Gschwind, C1
Mahaley, MS1
Woodhall, B1
Jelicić, I1
Pasini, M1
Prpić, I1
Relja-Vladović, T1
Hancević, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Melphalan Intra-arterial Chemotherapy for Choroidal Melanoma Chemoreduction - a Phase I Clinical Trial[NCT05893654]Phase 1/Phase 210 participants (Anticipated)Interventional2021-05-01Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for mechlorethamine and Malignant Melanoma

ArticleYear
Malignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. The influence of additional therapy after total skin electron beam radiation.
    Archives of dermatology, 1995, Volume: 131, Issue:4

    Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Electrons; Female; Humans; Lymphoma, T

1995

Trials

1 trial available for mechlorethamine and Malignant Melanoma

ArticleYear
Newer techniques in cancer chemotherapy.
    Disease-a-month : DM, 1984, Volume: 30, Issue:10

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Ce

1984

Other Studies

53 other studies available for mechlorethamine and Malignant Melanoma

ArticleYear
Topical chemotherapy for numerous superficial basal cell carcinomas years after isolated limb perfusion for melanoma.
    Cutis, 2019, Volume: 103, Issue:5

    Topics: Administration, Cutaneous; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents

2019
Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell S

2016
The action of the phenylalanine mustards and of several homologs on mouse melanoma.
    Cancer research, 1957, Volume: 17, Issue:11

    Topics: Animals; Mechlorethamine; Melanoma; Melphalan; Neoplasms, Experimental; Nitrogen Mustard Compounds

1957
Treatment of melanoma by isolation-perfusion technique.
    Journal of the American Medical Association, 1959, Jan-24, Volume: 169, Issue:4

    Topics: Humans; Leg; Mechlorethamine; Melanoma; Neoplasms; Nitrogen Mustard Compounds; Perfusion; Phenylalan

1959
Studies of phenylalanine nitrogen mustard (CB 3025) in metastatic malignant melanoma of man.
    Annals of the New York Academy of Sciences, 1958, Apr-24, Volume: 68, Issue:3

    Topics: Humans; Mechlorethamine; Melanoma; Nitrogen Mustard Compounds; Phenylalanine

1958
A CLINICAL study of the comparative effect of nitrogen mustard and DON in patients with bronchogenic carcinoma, Hodgkin's disease, lymphosarcoma, and melanoma.
    Journal of the National Cancer Institute, 1959, Volume: 22, Issue:2

    Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Hodgkin Disease; Humans; Leucine; Lymphoma; Lymphoma

1959
Disseminated malignant melanoma: response to treatment by massive dosage of a cytotoxic agent combined with autogenous marrow replacement.
    Lancet (London, England), 1959, May-09, Volume: 1, Issue:7080

    Topics: Antineoplastic Agents; Bone Marrow; Cytotoxins; Mannitol; Mechlorethamine; Melanoma; Nitrogen Mustar

1959
The treatment of malignant melanoma by perfusion techniques.
    Proceedings of the Royal Society of Medicine, 1961, Volume: 54

    Topics: Humans; Mechlorethamine; Melanoma; Nitrogen Mustard Compounds; Perfusion

1961
[A case of malignant melanoma of the leg treated by isolated perfusion of nitrogen mustard].
    Turk Tip Cemiyeti mecmuasi, 1960, Volume: 26

    Topics: Extracorporeal Circulation; Humans; Leg; Mechlorethamine; Melanoma; Nitrogen Mustard Compounds; Perf

1960
Treatment of disseminated melanoma with phenylalanine mustard (melphelan) and autogenous bone marrow transplants.
    Surgery, 1962, Volume: 51

    Topics: Bone Marrow; Bone Marrow Transplantation; Humans; Mechlorethamine; Melanoma; Melphalan; Nitrogen Mus

1962
Chemotherapy of melanoma of the extremities by isolated perfusion.
    Cancer chemotherapy reports, 1962, Volume: 16

    Topics: Antineoplastic Agents; Extremities; Mechlorethamine; Melanoma; Neoplasms; Nitrogen Mustard Compounds

1962
MELANOMA IN AN ALBINO.
    JAMA, 1963, Nov-30, Volume: 186

    Topics: Albinism; Electrons; Mechlorethamine; Melanins; Melanoma; Microscopy; Microscopy, Electron; Neoplasm

1963
TUMOUR SULPHYDRYL LEVELS AND SENSITIVITY TO THE NITROGEN MUSTARD MEROPHAN.
    Biochemical pharmacology, 1963, Volume: 12

    Topics: Animals; Lymphoma; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mechlorethamine; Mela

1963
FURTHER COMPARATIVE TRIAL OF TRIETHYLENE THIOPHOSPHORAMIDE AND MECHLORETHAMINE IN PATIENTS WITH MELANOMA AND HODGKIN'S DISEASE.
    Journal of chronic diseases, 1964, Volume: 17

    Topics: District of Columbia; Hodgkin Disease; Mechlorethamine; Melanoma; New York; Thiotepa; Toxicology

1964
[RESULTS IN THE CHEMOTHERAPY OF MALIGNANT NEOPLASMS USING THE APPARATUS FOR EXTRACORPOREAL CIRCULATION].
    Polski przeglad chirurgiczny, 1963, Volume: 35

    Topics: Chemotherapy, Cancer, Regional Perfusion; Extracorporeal Circulation; Heart, Artificial; Humans; Leg

1963
ONCOLYSIS BY CLOSTRIDIA. III. EFFECTS OF CLOSTRIDIA AND CHEMOTHERAPEUTIC AGENTS ON RODENT TUMORS.
    Cancer research, 1964, Volume: 24

    Topics: Adenocarcinoma; Animals; Antimetabolites; Antineoplastic Agents; Aziridines; Bacteriological Techniq

1964
A STUDY OF THE MECHANISMS OF GRANULOCYTOPENIA.
    Annals of the New York Academy of Sciences, 1964, Feb-28, Volume: 113

    Topics: Agranulocytosis; Anemia; Anemia, Macrocytic; Carcinoma; Carcinoma, Bronchogenic; Child; Hodgkin Dise

1964
[ANTINEOPLASTIC PREPARATIONS USED AS A MEANS OF PROTECTION AGAINST THE FREE ELEMENTS IN THE BLOOD AND CONTAMINATION BY NEOPLASTIC CELLS, IN OPERATIVE INTERVENTIONS].
    Minerva medica, 1963, Nov-03, Volume: 54

    Topics: Antineoplastic Agents; Carcinoma; Cyclophosphamide; Hodgkin Disease; Humans; Mechlorethamine; Melano

1963
REGIONAL PERFUSION IN MELANOMA OF LIMBS.
    JAMA, 1964, Jun-08, Volume: 188

    Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Extremities; Humans; Mechlorethamin

1964
ABDOMINAL PERFUSION FOR CANCER CHEMOTHERAPY USING HYPOTHERMIA AND HYPERTHERMIA.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Abdomen; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Cycloph

1964
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop

1964
ENDOREDUPLICATION IN LEUCOCYTE CHROMOSOMES. PRELIMINARY REPORT OF ITS RELATION TO CANCER AND WHOLE-BODY IRRADIATION.
    Lancet (London, England), 1964, Sep-05, Volume: 2, Issue:7358

    Topics: Breast Neoplasms; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cobalt Isotopes; Coloni

1964
EFFECT OF HYPERBARIC OXYGEN AND CANCER CHEMOTHERAPY ON GROWTH OF ANIMAL TUMORS.
    Surgical forum, 1964, Volume: 15

    Topics: Animals; Cricetinae; Humans; Hyperbaric Oxygenation; Injections, Intraperitoneal; Lung Neoplasms; Me

1964
SYSTEMIC THIOSULFATE PROTECTION DURING FRACTIONATED REGIONAL NITROGEN MUSTARD THERAPY.
    The Journal of surgical research, 1964, Volume: 4

    Topics: Biomedical Research; Carcinoma; Carcinoma, Squamous Cell; Dogs; Geriatrics; Infusions, Parenteral; I

1964
[INDUCTION OF METASTASES BY TREATMENT WITH CARCINOSTATIC AGENTS. II. DEPRESSION OF HOST RESISTANCE AND ANTIBODY PRODUCTION].
    Gan, 1964, Volume: 55

    Topics: Animals; Anti-Bacterial Agents; Antibody Formation; Cattle; Chemotherapy, Cancer, Regional Perfusion

1964
OUR EXPERIENCES WITH CYTOSTATIC PERFUSIONS OF THE EXTREMITIES IN THE TREATMENT OF MALIGNANT TUMORS.
    Neoplasma, 1964, Volume: 11

    Topics: Animals; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Dogs; Drug Ther

1964
Disseminated abdominal melanoma treated by massive dosage of nitrogen mustard and autogenous bone-marrow replacement.
    The Medical journal of Australia, 1960, Jul-09, Volume: 47(2)

    Topics: Bone Marrow; Bone Marrow Transplantation; Humans; Mechlorethamine; Medical Records; Melanoma; Nitrog

1960
[Technic of isolated perfusion of the extremities. Experience with 171 cases].
    Langenbecks Archiv fur Chirurgie, 1983, Volume: 359, Issue:2

    Topics: Arm; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dacarbazine; Drug Therapy, Combination; Ex

1983
[Melanoma and dysplastic nevus after 8 years of topical Caryolysine].
    Annales de dermatologie et de venereologie, 1984, Volume: 111, Issue:2

    Topics: Administration, Topical; Female; Humans; Mechlorethamine; Melanoma; Middle Aged; Nevus, Pigmented; P

1984
Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines.
    Cancer research, 1984, Volume: 44, Issue:7

    Topics: Caffeine; Cell Line; Cell Survival; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Ho

1984
Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Carmustine;

1982
The interactions between indomethacin and cytotoxic drugs in mice bearing B-16 melanomas.
    Prostaglandins, 1980, Volume: 20, Issue:6

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Cell Count; Cell Division; Doxorubicin; Female; Fluorouraci

1980
Prostaglandin E augments the effect of chemotherapy on B-16 melanoma in vivo.
    The Journal of surgical research, 1982, Volume: 32, Issue:6

    Topics: Animals; Antineoplastic Agents; Dopamine; Doxorubicin; Drug Therapy, Combination; Female; Fluorourac

1982
[New modifications in isolated extremity perfusion ].
    Zeitschrift fur Hautkrankheiten, 1982, Jul-15, Volume: 57, Issue:14

    Topics: Antineoplastic Agents; Arm; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dacarbazine; Dactin

1982
High-dose nitrogen mustard (HN2) with autologous nonfrozen bone marrow transplantation in advanced malignant melanoma. A phase I trial.
    Blut, 1981, Volume: 42, Issue:4

    Topics: Adolescent; Bone Marrow Transplantation; Drug Evaluation; Female; Humans; Hypocalcemia; Male; Mechlo

1981
PGE restores the immune response in chemotherapy-treated, tumor-bearing mice.
    Life sciences, 1982, Apr-05, Volume: 30, Issue:14

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Antibody Formation; Doxorubicin; Drug Therapy, Combination;

1982
Hyperthermic isolated limb perfusion increases circulating levels of inflammatory cytokines.
    Cancer immunology, immunotherapy : CII, 1995, Volume: 40, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Cancer, Regional Perfusion; Combined M

1995
Regional chemotherapy for melanoma. A 35-year experience.
    Annals of surgery, 1994, Volume: 220, Issue:4

    Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Clinical Trials as Topic; Combined Modality T

1994
Multiple basal cell carcinomas of the limb after adjuvant treatment of melanoma with isolated limb perfusion.
    Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:5 Pt 1

    Topics: Antineoplastic Agents, Alkylating; Carcinoma, Basal Cell; Chemotherapy, Adjuvant; Chemotherapy, Canc

1998
Small malignant melanoma in patients with mycosis fungoides.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 1998, Volume: 11, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Humans; Male; Mechlorethamine; Melanoma; Middle Aged; Myco

1998
Safe, compact and portable system for regional chemotherapeutic hyperthermic perfusion procedures.
    The journal of extra-corporeal technology, 1993, Volume: 25, Issue:1

    Topics: Adult; Aged; Arm; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Dactinomycin;

1993
Nonspecific antigen reactions.
    National Cancer Institute monograph, 1976, Volume: 44

    Topics: Administration, Topical; Antibody Formation; Antigens; Antineoplastic Agents; BCG Vaccine; Breast Ne

1976
Comparative study of two human melanoma cell lines with different sensitivities to mustine and cisplatin.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:8

    Topics: Cell Line; Cell Survival; Cisplatin; DNA, Neoplasm; Glutathione; Humans; Mechlorethamine; Melanoma;

1991
Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells.
    Cancer research, 1987, May-15, Volume: 47, Issue:10

    Topics: Cell Line; Cell Survival; DNA; Humans; Mathematics; Mechlorethamine; Melanoma; Melphalan; Neoplastic

1987
Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:12

    Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Humans; Hyperthermia, In

1986
Intra-arterial cytotoxic therapy and x-ray therapy for cancer of the head and neck.
    Lancet (London, England), 1965, Jan-16, Volume: 1, Issue:7377

    Topics: Adenoma, Pleomorphic; Carcinoma, Squamous Cell; Facial Neoplasms; Fibrosarcoma; Head; Head and Neck

1965
The treatment of malignant pleural effusions.
    Cancer, 1974, Volume: 33, Issue:4

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamou

1974
Chemotherapy of melanoma of the extremities by perfusion: fourteen years clinical experience.
    Annals of surgery, 1972, Volume: 175, Issue:6

    Topics: Adult; Aged; Arm; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Leg; Male; Mechlorethami

1972
Cancer chemotherapy. I. Methods, agents and overall results in 400 patients.
    Oncology, 1972, Volume: 26, Issue:2

    Topics: Adenocarcinoma; Amides; Androgens; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Estrogens;

1972
Local and systemic immunologic effects of perfusion therapy for malignant melanoma.
    Surgery, gynecology & obstetrics, 1973, Volume: 137, Issue:3

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; E

1973
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
    Annals of surgery, 1967, Volume: 166, Issue:2

    Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci

1967
[Regional perfusion with nitrogen mustard in the treatment of malignant tumors of the lower extremities].
    Lijecnicki vjesnik, 1969, Volume: 91, Issue:12

    Topics: Adolescent; Adult; Angiokeratoma; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion

1969
Advanced melanoma of the extremities.
    Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:2

    Topics: Adolescent; Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Child; Dactinomycin; Female; Huma

1970