mechlorethamine has been researched along with Lupus Erythematosus, Systemic in 20 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with systemic lupus erythematosus and nephritis may benefit from the addition of cytotoxic agents to their corticosteroid regime, although the indications for this are not clear, and controlled evidence is lacking." | 2.36 | Immunosuppressive agents in the treatment of the nephrotic syndrome and glomerulonephritis in children. ( Cameron, JS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (95.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ROHN, RJ | 1 |
| BOND, WH | 1 |
| DUBOIS, EL | 2 |
| DYK, T | 1 |
| BERSANI, A | 1 |
| STANCARI, V | 1 |
| WILSON, RM | 1 |
| MAHER, JF | 1 |
| SCHREINER, GE | 1 |
| KELLUM, RE | 1 |
| HASERICK, JR | 2 |
| PLAZA DE LOS REYES, M | 1 |
| MONSALVE, J | 1 |
| ANTILLO, A | 1 |
| Wallace, DJ | 1 |
| Podell, TE | 1 |
| Weiner, JM | 1 |
| Cox, MB | 1 |
| Klinenberg, JR | 1 |
| Forouzesh, S | 1 |
| Fox, DA | 1 |
| McCune, WJ | 1 |
| Cameron, JS | 3 |
| Wagner, L | 1 |
| Pollak, VE | 3 |
| Clough, JD | 1 |
| Dillard, MG | 3 |
| Tillman, RL | 1 |
| Sampson, CC | 1 |
| Quismorio, FP | 1 |
| Tay, A | 1 |
| Boulton-Jones, M | 1 |
| Robinson, R | 1 |
| Ogg, C | 1 |
| Pirani, CL | 2 |
| Dujovne, I | 2 |
4 reviews available for mechlorethamine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Immunosuppressive drug therapy of systemic lupus erythematosus.
Topics: Azathioprine; Cyclophosphamide; Cyclosporine; Humans; Immunosuppressive Agents; Leukocyte Count; Lup | 1994 |
Immunosuppressive agents in the treatment of the nephrotic syndrome and glomerulonephritis in children.
Topics: Azathioprine; Child; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive A | 1979 |
Immunosuppressive agents in lupus nephritis: a critical analysis.
Topics: Azathioprine; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney; Lupus | 1976 |
Immunosuppressant agents in the treatment of glomerulonephritis. 2. Cytotoxic drugs.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antilymphocyte Serum; Antineoplastic Agents; Azath | 1971 |
1 trial available for mechlorethamine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
The effect of treatment with prednisone and nitrogen mustard on the renal lesions and life span of patients with lupus glomerulonephritis.
Topics: Acute Kidney Injury; Adolescent; Adult; Autopsy; Biopsy; Clinical Trials as Topic; Drug Synergism; F | 1973 |
15 other studies available for mechlorethamine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Some effects of nitrogen mustard and triethylene melamine in acute disseminated lupus erythematosus.
Topics: Humans; Lupus Erythematosus, Systemic; Mechlorethamine; Nitrogen Mustard Compounds; Triethylenemelam | 1953 |
Nitrogen mustard in treatment of systemic lupus erythematosus.
Topics: Humans; Lupus Erythematosus, Systemic; Mechlorethamine; Nitrogen Mustard Compounds | 1954 |
[A case of acute systemic lupus erythematosus; resistance of the lupus nephropathy to combined treatment with prednisone, nivaquine and nitrogranulogen].
Topics: Chloroquine; Humans; Kidney; Kidney Diseases; Lupus Erythematosus, Systemic; Mechlorethamine; Nitrog | 1958 |
[A case of subacute erythematovisceritis clinically cured by azoiprite treatment].
Topics: Humans; Lupus Erythematosus, Systemic; Mechlorethamine; Nitrogen Mustard Compounds | 1959 |
Lupus nephritis. Clinical and histologic survey.
Topics: Adrenocorticotropic Hormone; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Mechlorethamine | 1963 |
Mechlorethamine therapy for systemic lupus nephropathy. Analysis and review of ten years experience and a clinical study of 211 cases including 81 patients treated with mechlorethamine.
Topics: Humans; Kidney Diseases; Lupus Erythematosus, Systemic; Mechlorethamine | 1963 |
[Two cases of generalized lupus erythematosus treated with nitrogen mustards].
Topics: Humans; Lupus Erythematosus, Systemic; Mechlorethamine; Nitrogen Mustard Compounds | 1952 |
Lupus nephritis. Experience with 230 patients in a private practice from 1950 to 1980.
Topics: Adolescent; Adult; Biopsy; Blood Pressure; Creatinine; Female; Humans; Kidney; Lupus Erythematosus, | 1982 |
Treatment of lupus nephritis.
Topics: Adrenal Cortex Hormones; Adult; Animals; Antibody Formation; Azathioprine; Chlorambucil; Cyclophosph | 1976 |
Therapy in lupus erythematosus.
Topics: Drug Therapy, Combination; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mechlore | 1976 |
Acute systemic lupus erythematosus in IgA deficiency. Mechlorethamine hydrochloride therapy.
Topics: Acute Disease; Adolescent; Antibodies, Antinuclear; Dysgammaglobulinemia; Humans; Immunoglobulin A; | 1975 |
Lupus Nephritis. Correlations between the clinical course and presence of electron-dense deposits.
Topics: Adolescent; Adult; Basement Membrane; Biopsy; Endothelium; Epithelial Cells; Epithelium; Female; Glo | 1975 |
Axillary vein thrombosis after nitrogen mustard therapy for SLE.
Topics: Adult; Axillary Vein; Female; Humans; Lupus Erythematosus, Systemic; Mechlorethamine; Thrombosis | 1988 |
Treatment of lupus nephritis with cyclophosphamide.
Topics: Adolescent; Adult; Age Factors; Azathioprine; Biopsy; Chlorambucil; Cortisone; Cyclophosphamide; Fem | 1970 |
The clinical course of lupus nephritis: relationship to the renal histologic findings.
Topics: Antigen-Antibody Complex; Complement System Proteins; Drug Therapy, Combination; gamma-Globulins; Gl | 1973 |