mechlorethamine has been researched along with Leukemia P388 in 9 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On a molar basis, TGM was most toxic to normal BALB/c X DBA/2 F1 mice, with a 10% lethal dose (LD10) of 3." | 1.27 | Antitumor activity and bone marrow toxicity of aminoglucose mustard anticancer agents in mice. ( Cantrell, JE; Green, D; Schein, PS, 1986) |
| " Nitrogen mustard [(HN2) NCS-762] and x-rays were selectively toxic to P388/R cells." | 1.27 | Flow cytometric screening for selective toxicity to multidrug-resistant cells. ( Frankfurt, OS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trafalis, D | 1 |
| Geromichalou, E | 1 |
| Dalezis, P | 1 |
| Nikoleousakos, N | 1 |
| Sarli, V | 1 |
| Atwell, GJ | 1 |
| Yaghi, BM | 1 |
| Turner, PR | 1 |
| Boyd, M | 1 |
| O'Connor, CJ | 1 |
| Ferguson, LR | 1 |
| Baguley, BC | 1 |
| Denny, WA | 1 |
| Yang, JM | 1 |
| Yang, GY | 1 |
| Medina, DJ | 1 |
| Vassil, AD | 1 |
| Liao, J | 1 |
| Hait, WN | 1 |
| Indap, MA | 1 |
| Ambaye, RY | 1 |
| Chan, PK | 1 |
| Cantrell, JE | 1 |
| Green, D | 2 |
| Schein, PS | 2 |
| Frankfurt, OS | 1 |
| Bence, J | 1 |
| Somfai-Relle, S | 1 |
| Gáti, E | 1 |
| Dean, SW | 1 |
| McPherson, E | 1 |
9 other studies available for mechlorethamine and Leukemia P388
| Article | Year |
|---|---|
Synthesis and evaluation of new steroidal lactam conjugates with aniline mustards as potential antileukemic therapeutics.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Line, Tumor; Female; Humans; Jurkat Cells; K56 | 2016 |
Synthesis, DNA interactions and biological activity of DNA minor groove targeted polybenzamide-linked nitrogen mustards.
Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Benzamides; DNA; Drug Screeni | 1995 |
Treatment of multidrug resistant (MDR1) murine leukemia with P-glycoprotein substrates accelerates the course of the disease.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Cell Movement; Dise | 1999 |
Methoxyphenyl maleamic acid augments the activity of cytotoxic drugs against murine tumours.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cyclophosphamide; Drug Synergism; | 1991 |
Cross-linkage of nucleophosmin in tumor cells by nitrogen mustard.
Topics: Animals; Cell Nucleus; Cross-Linking Reagents; Hypertrophy; Leukemia P388; Leukemia, Experimental; L | 1989 |
Antitumor activity and bone marrow toxicity of aminoglucose mustard anticancer agents in mice.
Topics: Amino Sugars; Animals; Antineoplastic Agents; Blood Glucose; Bone Marrow; DNA; Leukemia P388; Leukem | 1986 |
Flow cytometric screening for selective toxicity to multidrug-resistant cells.
Topics: Animals; Cell Line; Colony-Forming Units Assay; Combined Modality Therapy; Doxorubicin; Drug Resista | 1987 |
Development and some characteristics of a P388 leukemia strain resistant to 1, 2:5, 6-dianhydrogalactitol.
Topics: Animals; Cell Count; Cell Survival; Cyclophosphamide; Dianhydrogalactitol; Drug Resistance; Female; | 1986 |
6-[Bis(2-chloroethyl)amino]-6-deoxygalactopyranose hydrochloride (C6-galactose mustard), a new alkylating agent with reduced bone marrow toxicity.
Topics: Animals; Bone Marrow; DNA Replication; Drug Evaluation, Preclinical; Female; Galactosamine; Hematopo | 1987 |