mechlorethamine has been researched along with Leukemia L 1210 in 38 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiamine is an inhibitor of choline transport by murine L1210 leukemia cells and a protector of these cells from growth inhibition by mechlorethamine in vitro." | 1.26 | Thiamine protection of murine L1210 leukemia cells against mechlorethamine cytotoxicity and its relation to the choline uptake system. ( Naujokaitis, SA, 1981) |
| " The analysis consists of relating survival to the dosage level of each drug in the combination and using response surface techniques to determine the importance of drug interactions and to estimate optimal doses." | 1.26 | An improved method for analyzing survival data from combination chemotherapy experiments. ( Carter, WH; Stablein, DM; Wampler, GL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (86.84) | 18.7374 |
| 1990's | 5 (13.16) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selassie, CD | 1 |
| Hansch, C | 1 |
| Khwaja, TA | 1 |
| FURMAN, GJ | 1 |
| ACKERMAN, GA | 3 |
| COHEN, C | 1 |
| FRIEDMAN, OM | 1 |
| BOGER, E | 1 |
| GRUBLIAUSKAS, V | 1 |
| SOMMER, H | 1 |
| BURKE, WJ | 1 |
| BROWN, JE | 1 |
| WEATHERBEE, C | 1 |
| CURTIS, DH | 1 |
| Wilkoff, LJ | 1 |
| Dixon, GJ | 1 |
| Dulmadge, EA | 1 |
| Schabel, FM | 2 |
| Naujokaitis, SA | 5 |
| Fisher, JM | 3 |
| Rabinovitz, M | 3 |
| Ritter, C | 1 |
| Iyengar, CL | 1 |
| Rutman, RJ | 2 |
| Li, Y | 1 |
| Eiseman, JL | 1 |
| Sentz, DL | 1 |
| Rogers, FA | 1 |
| Pan, SS | 1 |
| Hu, LT | 1 |
| Egorin, MJ | 1 |
| Callery, PS | 1 |
| Zhou, GH | 1 |
| Teicher, BA | 1 |
| Frei, E | 2 |
| Ronen, SM | 1 |
| DiStefano, F | 1 |
| McCoy, CL | 1 |
| Robertson, D | 1 |
| Smith, TA | 1 |
| Al-Saffar, NM | 1 |
| Titley, J | 1 |
| Cunningham, DC | 1 |
| Griffiths, JR | 1 |
| Leach, MO | 1 |
| Clarke, PA | 1 |
| Ewig, RA | 3 |
| Kohn, KW | 8 |
| Carter, WH | 1 |
| Stablein, DM | 1 |
| Wampler, GL | 1 |
| Zwelling, LA | 1 |
| Filipski, J | 1 |
| Surya, YA | 1 |
| Rosenfeld, JM | 1 |
| Hillcoat, BL | 1 |
| Ross, WE | 1 |
| Thomas, CB | 1 |
| Bonner, WM | 1 |
| Ritter, CA | 1 |
| Avadhani, NG | 1 |
| Hansel, J | 1 |
| Takamizawa, A | 1 |
| Matsumoto, S | 1 |
| Iwata, T | 1 |
| Tochino, Y | 1 |
| Katagiri, K | 1 |
| Yamaguchi, K | 1 |
| Kremkau, FW | 1 |
| Kaufmann, JS | 1 |
| Walker, MM | 1 |
| Burch, PG | 1 |
| Spurr, CL | 1 |
| O'Connor, PM | 1 |
| Wilcock, C | 1 |
| Chahwala, SB | 1 |
| Hickman, JA | 1 |
| Kann, HE | 2 |
| Fraser, I | 1 |
| Goldin, A | 1 |
| Goodman, MT | 2 |
| Folk, RM | 1 |
| Snyder, AL | 1 |
| Benckhuijsen, C | 1 |
| DeVita, VT | 1 |
| Carbone, PP | 1 |
| Martinez, AP | 1 |
| Lee, WW | 1 |
| Goodman, L | 1 |
| Kessel, D | 1 |
| Myers, M | 1 |
| Wodinsky, I | 2 |
| Kensler, CJ | 1 |
| Palm, PE | 1 |
| Day, HM | 1 |
| Battista, SP | 1 |
| Rogers, WI | 1 |
| Yesair, DW | 1 |
| Cutts, JH | 1 |
| Walker, IG | 1 |
1 review available for mechlorethamine and Leukemia L 1210
| Article | Year |
|---|---|
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; | 1969 |
1 trial available for mechlorethamine and Leukemia L 1210
| Article | Year |
|---|---|
Chemotherapeutic implications of staging in Hodgkin's disease.
Topics: Animals; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Combinations; Follow-Up Stud | 1971 |
36 other studies available for mechlorethamine and Leukemia L 1210
| Article | Year |
|---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; | 1990 |
Effects of nitrogen mustard on the histochemistry of mouse lymphocytic leukaemia L 1210.
Topics: Animals; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocytes; Mechlorethamine; M | 1961 |
SYNTHESIS OF N-PHOSPHORYLATED DERIVATIVES OF NITROGEN MUSTARDS WITH LATENT CYTOTOXICITY.
Topics: Animals; Chemistry, Pharmaceutical; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymp | 1963 |
CYANO ANALOGS OF PHENOLIC NITROGEN MUSTARDS.
Topics: Animals; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Leukemia L1210; Mechlorethamin | 1964 |
Effect of 1,3-bis(2-chlorethyl)-1-nitrosourea (NSC-409962) and nitrogen mustard (NSC-762) on kinetic behavior of cultured L1210 leukemic cells.
Topics: Alkylating Agents; Animals; Biological Assay; Culture Techniques; Kinetics; Leukemia L1210; Mechlore | 1967 |
Protection of murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine and inhibition of choline uptake as a structure-activity relationship of 2-dimethylaminoethanol and its analogues.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Choline; De | 1984 |
Tetraalkylammonium ions: protection of murine L1210 leukemia and bone marrow progenitor cells in vitro against mechlorethamine cytotoxicity and inhibition of the choline transport system.
Topics: Animals; Biological Transport, Active; Cell Survival; Choline; Clone Cells; Colony-Forming Units Ass | 1982 |
Differential enhancement of antitumor effectiveness by phospholipid vesicles (liposomes).
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Carmustine; Cell Line; Cell Membran | 1981 |
Thiamine protection of murine L1210 leukemia cells against mechlorethamine cytotoxicity and its relation to the choline uptake system.
Topics: Animals; Biological Transport; Choline; Leukemia L1210; Male; Mechlorethamine; Melphalan; Mice; Thia | 1981 |
Ethanol mustard cytotoxicity in vitro toward murine leukemia and bone marrow progenitor cells.
Topics: Animals; Bone Marrow Cells; Cell Survival; Cells, Cultured; Choline; Colony-Forming Units Assay; Hem | 1981 |
Cain's quinolinium (NSC 176319): protection of murine L1210 leukemia cells and bone marrow progenitor cells against mechlorethamine cytotoxicity and its application to combination chemotherapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Clone Cells; Colony-Forming Units As | 1981 |
Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane.
Topics: Animals; Antineoplastic Agents; Aziridines; Cross-Linking Reagents; DNA; Electrophoresis, Agar Gel; | 1996 |
Postlabeling detection of DNA adducts of antitumor alkylating agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Autoradiography; Base Sequence; Benzofurans; Chromatogra | 1996 |
Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Caspases; Cell Survival; Colorectal Neoplasms | 1999 |
DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.
Topics: Animals; Carmustine; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; Endopeptidases; | 1978 |
An improved method for analyzing survival data from combination chemotherapy experiments.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; | 1979 |
Effect of thiourea on survival and DNA cross-link formation in cells treated with platinum(II) complexes, L-phenylalanine mustard, and bis(2-chloroethyl)methylamine.
Topics: Animals; Cell Survival; Cells, Cultured; Cisplatin; Cross-Linking Reagents; DNA, Neoplasm; Leukemia | 1979 |
DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; DNA Repair; DNA, | 1977 |
Cross-linking of DNA in L1210 cells and nuclei treated with cyclophosphamide and phosphoramide mustard.
Topics: Alkylation; Animals; Cell Nucleus; Cells, Cultured; Cyclophosphamide; DNA, Neoplasm; In Vitro Techni | 1978 |
Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.
Topics: Animals; Cell Survival; Cells, Cultured; DNA Repair; DNA, Neoplasm; DNA, Single-Stranded; Leukemia L | 1978 |
Characterization of DNA-protein cross-links formed by treatment of L1210 cells and nuclei with bis(2-chloroethyl)methylamine (nitrogen mustard).
Topics: Alkylation; Animals; Cell Nucleus; DNA, Neoplasm; Kinetics; Leukemia L1210; Mechlorethamine; Neoplas | 1978 |
Liposomal potentiation of the antitumor activity of alkylating drugs.
Topics: Alkylating Agents; Animals; Carcinoma, Ehrlich Tumor; Carmustine; Drug Synergism; Leukemia L1210; Li | 1976 |
Studies on cyclophosphamide metabolites and their related compounds. 2. Preparation of an active species of cyclophosphamide and related compounds.
Topics: Acetals; Animals; Body Weight; Cyclophosphamide; HeLa Cells; Lethal Dose 50; Leukemia L1210; Magneti | 1975 |
Ultrasonic enhancement of nitrogen mustard cytotoxicity in mouse leukemia.
Topics: Animals; Cell Survival; Cells, Cultured; Leukemia L1210; Mechlorethamine; Mice; Mice, Inbred DBA; Ne | 1976 |
Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards.
Topics: Animals; Colony-Forming Units Assay; Computer Simulation; Crossing Over, Genetic; DNA Damage; In Vit | 1990 |
Selective inhibition by bis(2-chloroethyl)methylamine (nitrogen mustard) of the Na+/K+/Cl- cotransporter of murine L1210 leukemia cells.
Topics: Adenosine Triphosphate; Alkylating Agents; Animals; Biological Transport; Carrier Proteins; Chloride | 1988 |
Effects of deoxyribonucleic acid-reactive drugs on ribonucleic acid synthesis in leukemia L1210 cells.
Topics: Acridines; Acrylamides; Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benz | 1972 |
The effect of mechlorethamine and cyclophosphamide on the nicotinamide-adenine dinucleotide glycohydrolase activity in Ehrlich ascites cells and L1210 leukemia cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cyclophosphamide; In Vitro Techniques; Leukemia L1210; Mechloreth | 1965 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Effects of antileukemic agents on the respiratory activity of murine lymphocytic Leukemia L1210.
Topics: Animals; Buffers; Busulfan; Cell Adhesion; Cell Survival; Chlorambucil; Cyclophosphamide; Cytoplasm; | 1973 |
The effects of antineoplastic agents on the respiratory activity of murine lymphocytic leukemia L1210.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chlorambucil; Dactinomycin; Dose-Response Relations | 1973 |
Size distributions of high molecular weight RNA synthesized by L1210 cells. Effects of DNA-reactive drugs.
Topics: Acrylamides; Animals; Benzodiazepinones; Carbon Radioisotopes; Cell Line; Cell Nucleolus; Cell Nucle | 1973 |
DL-willardiine mustard.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Culture Techniques; Leukemia L1210 | 1968 |
Accumulation of two alkylating agents, nitrogen mustard and busulfan, by murine leukemia cells in vitro.
Topics: Amines; Animals; Busulfan; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Mechloretham | 1969 |
Toxicology of anti-leukemic agents with special reference to phthalanilide derivatives.
Topics: Anilides; Animals; Cyclophosphamide; Leukemia L1210; Mechlorethamine; Mice | 1965 |
The effect of pH upon the antitumor activity and toxicity of nitrogen mustard.
Topics: Animals; Carcinoma, Ehrlich Tumor; Culture Techniques; Hydrogen-Ion Concentration; L Cells; Leukemia | 1966 |