mechlorethamine has been researched along with Leukemia, Radiation-Induced in 18 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Leukemia, Radiation-Induced: Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients were randomized in the Southwest Oncology Group (later the Pediatric Oncology Group [POG] to involved-field (IF) radiotherapy alone or IF radiotherapy followed by six courses of mechlorethamine, vincristine, prednisone, and procarbazine (MOPP) chemotherapy; patients in the Children's Cancer Study Group (CCSG) and Cancer and Leukemia Group B (CALGB) were randomized to receive extended-field (EF) radiotherapy or IF radiotherapy followed by six courses of MOPP." | 5.06 | The intergroup Hodgkin's disease in children. A study of stages I and II. ( Fryer, C; Fuller, LM; Gehan, EA; Gilchrist, GS; Hanson, W; Hays, DM; Heller, R; Johnston, J; Kennedy, P; Sullivan, MP, 1990) |
| "Ten patients developed SANLL between the 34th and 123rd month of CR." | 2.38 | Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease. ( Andrieu, JM; Coscas, Y; Fermanian, J; Flandrin, G; Ifrah, N; Payen, C, 1990) |
| "The prognosis of patients with Hodgkin's disease has dramatically improved over the past few decades." | 2.37 | Current management of Hodgkin's disease. ( Behrens, BC; DeVita, VT; Young, RC, 1985) |
| "Risk of leukemia was 0." | 1.30 | The risk of acute leukemia in patients treated for Hodgkin's disease is significantly higher aft [see bined modality programs than after chemotherapy alone and is correlated with the extent of radiotherapy and type and duration of chemotherapy: a case-con ( Anselmo, AP; Baroni, CD; Bernasconi, C; Brusamolino, E; Klersy, C; Lazzarino, M; Lunghi, F; Mandelli, F; Maurizi-Enrici, R; Orlandi, E; Pagnucco, G; Santoro, M, 1998) |
| "A case of Hodgkin's disease with isolated cerebral relapse is reported here." | 1.29 | Meningioma-like cerebral relapse of Hodgkin's disease. ( Catarini, M; Discepoli, G; Leoni, P; Montillo, M; Rychlicki, F; Scarpelli, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Metayer, C | 1 |
| Curtis, RE | 1 |
| Vose, J | 1 |
| Sobocinski, KA | 1 |
| Horowitz, MM | 1 |
| Bhatia, S | 1 |
| Fay, JW | 1 |
| Freytes, CO | 1 |
| Goldstein, SC | 1 |
| Herzig, RH | 1 |
| Keating, A | 1 |
| Miller, CB | 1 |
| Nevill, TJ | 1 |
| Pecora, AL | 1 |
| Rizzo, JD | 1 |
| Williams, SF | 1 |
| Li, CY | 1 |
| Travis, LB | 1 |
| Weisdorf, DJ | 1 |
| DUHIG, JT | 1 |
| Lira, P | 1 |
| Grebe, G | 1 |
| Gomez, GA | 1 |
| Aggarwal, KK | 1 |
| Han, T | 1 |
| Montillo, M | 1 |
| Scarpelli, M | 1 |
| Discepoli, G | 1 |
| Catarini, M | 1 |
| Rychlicki, F | 1 |
| Leoni, P | 1 |
| Valagussa, P | 1 |
| Bonadonna, G | 1 |
| Brusamolino, E | 1 |
| Anselmo, AP | 1 |
| Klersy, C | 1 |
| Santoro, M | 1 |
| Orlandi, E | 1 |
| Pagnucco, G | 1 |
| Lunghi, F | 1 |
| Maurizi-Enrici, R | 1 |
| Baroni, CD | 1 |
| Lazzarino, M | 1 |
| Mandelli, F | 1 |
| Bernasconi, C | 1 |
| Trump, DL | 1 |
| Cowall, DE | 1 |
| Avilés, A | 1 |
| Díaz-Maqueo, JC | 1 |
| Ayala, JR | 1 |
| Cortés, HD | 1 |
| García, EL | 1 |
| Andrieu, JM | 1 |
| Ifrah, N | 1 |
| Payen, C | 1 |
| Fermanian, J | 1 |
| Coscas, Y | 1 |
| Flandrin, G | 1 |
| Gehan, EA | 1 |
| Sullivan, MP | 1 |
| Fuller, LM | 1 |
| Johnston, J | 1 |
| Kennedy, P | 1 |
| Fryer, C | 1 |
| Gilchrist, GS | 1 |
| Hays, DM | 1 |
| Hanson, W | 1 |
| Heller, R | 1 |
| Young, RC | 2 |
| Longo, DL | 1 |
| Glatstein, E | 1 |
| Ihde, DC | 1 |
| Jaffe, ES | 1 |
| DeVita, VT | 2 |
| Iurlo, A | 1 |
| Mecucci, C | 1 |
| Van Orshoven, A | 1 |
| Michaux, JL | 1 |
| Boogaerts, M | 1 |
| Van den Berghe, H | 1 |
| Boccaccio, P | 1 |
| Rosa, F | 1 |
| Casciaro, S | 1 |
| D'Elia, P | 1 |
| Romagnoli, M | 1 |
| Ghio, R | 1 |
| Rowland, KM | 1 |
| Murthy, A | 1 |
| Mauch, PM | 1 |
| Canellos, GP | 1 |
| Rosenthal, DS | 1 |
| Hellman, S | 1 |
| Rosenberg, SA | 1 |
| Kaplan, HS | 1 |
| Behrens, BC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167] | Phase 2 | 1 participants (Actual) | Interventional | 2007-05-31 | Terminated (stopped due to Lack of accrual and interest in study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for mechlorethamine and Leukemia, Radiation-Induced
| Article | Year |
|---|---|
Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Th | 1990 |
Hodgkin's disease: long-term effects of therapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Brain; Female; Genitalia, Fem | 1986 |
Current management of Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; Humans; | 1985 |
4 trials available for mechlorethamine and Leukemia, Radiation-Induced
| Article | Year |
|---|---|
Post-therapeutic acute malignant myeloproliferative syndrome and acute nonlymphocytic leukemia in non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Administration Schedule; Drug | 1982 |
The intergroup Hodgkin's disease in children. A study of stages I and II.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Hodgki | 1990 |
The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Doxorub | 1988 |
The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Combine | 1985 |
11 other studies available for mechlorethamine and Leukemia, Radiation-Induced
| Article | Year |
|---|---|
Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemoth | 2003 |
TUMOR INCIDENCE IN A-STRAIN MICE.
Topics: Cyclophosphamide; Incidence; Leukemia; Leukemia, Radiation-Induced; Lung Neoplasms; Mechlorethamine; | 1965 |
[Acute non-lymphatic leukemia after treatment of Hodgkin's lymphoma with chemotherapy and radiotherapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cytarabine; Dacarbazine; Daunorubi | 1984 |
Meningioma-like cerebral relapse of Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fatal Outcome; Female; Ho | 1994 |
Hodgkin's disease and the risk of acute leukemia in successfully treated patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; D | 1998 |
The risk of acute leukemia in patients treated for Hodgkin's disease is significantly higher aft [see bined modality programs than after chemotherapy alone and is correlated with the extent of radiotherapy and type and duration of chemotherapy: a case-con
Topics: Abdomen; Actuarial Analysis; Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; | 1998 |
Acute myelogenous leukemia as a late complication of the multimodality therapy for Hodgkin's disease.
Topics: Adult; Biopsy; Bone Marrow; Cytarabine; Daunorubicin; Hodgkin Disease; Humans; Leukemia, Myeloid, Ac | 1977 |
Hodgkin's disease and acute leukemia. Is it a true association?
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil | 1992 |
The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Female; Hodgkin Disea | 1988 |
[Acute leukemia in patients treated for Hodgkin's disease].
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Hodgkin Disease; Human | 1988 |
Reduction of fatal complications from combined modality therapy in Hodgkin's disease.
Topics: Actuarial Analysis; Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Pro | 1985 |