Page last updated: 2024-10-30

mechlorethamine and Leucocythaemia

mechlorethamine has been researched along with Leucocythaemia in 184 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

ExcerptRelevanceReference
"In the last two decades, it has become evident that secondary leukemias after Hodgkin's disease (HD) are mainly caused by the treatment with alkylating agents, especially mechlorethamine."9.08Low risk of secondary leukemias after chemotherapy without mechlorethamine in childhood Hodgkin's disease. German-Austrian Pediatric Hodgkin's Disease Group. ( Creutzig, U; Gadner, H; Harbott, J; Mann, G; Riepenhausen, M; Ritter, J; Schellong, G, 1997)
"Among these, leukemia is extremely common, and thus, developing novel drugs to combat leukemia is crucial."5.72Novel nitrogen mustard-artemisinin hybrids with potent anti-leukemia action through DNA damage and activation of GPx. ( Chen, H; Cui, J; Dai, T; Lin, L; Liu, Y; Lu, W; Sun, D; Yang, L; Yang, X, 2022)
"In the last two decades, it has become evident that secondary leukemias after Hodgkin's disease (HD) are mainly caused by the treatment with alkylating agents, especially mechlorethamine."5.08Low risk of secondary leukemias after chemotherapy without mechlorethamine in childhood Hodgkin's disease. German-Austrian Pediatric Hodgkin's Disease Group. ( Creutzig, U; Gadner, H; Harbott, J; Mann, G; Riepenhausen, M; Ritter, J; Schellong, G, 1997)
" Patients were randomized in the Southwest Oncology Group (later the Pediatric Oncology Group [POG] to involved-field (IF) radiotherapy alone or IF radiotherapy followed by six courses of mechlorethamine, vincristine, prednisone, and procarbazine (MOPP) chemotherapy; patients in the Children's Cancer Study Group (CCSG) and Cancer and Leukemia Group B (CALGB) were randomized to receive extended-field (EF) radiotherapy or IF radiotherapy followed by six courses of MOPP."5.06The intergroup Hodgkin's disease in children. A study of stages I and II. ( Fryer, C; Fuller, LM; Gehan, EA; Gilchrist, GS; Hanson, W; Hays, DM; Heller, R; Johnston, J; Kennedy, P; Sullivan, MP, 1990)
" After a median follow-up of more than 6 years following MOPP (mechlorethamine/vincristine/procarbazine/prednisone) chemotherapy with or without radiotherapy, 5% of patients with Hodgkin's disease developed second primaries, 60% of which were leukemias."4.78Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects. ( Petru, E; Schmähl, D, 1991)
" The risk of treatment-induced acute leukemias as well as sterility can be avoided or greatly decreased with drug combinations not including procarbazine HCI and alkylating agents."4.77Chemotherapy of malignant lymphomas. ( Bonadonna, G, 1985)
"In addition to mechlorethamine, lomustine and teniposide combinations were also linked to an elevated risk of developing leukemia."3.69Leukemia risk following Hodgkin's disease: relation to cumulative dose of alkylating agents, treatment with teniposide combinations, number of episodes of chemotherapy, and bone marrow damage. ( Chorus, AM; Hagenbeek, A; Noyon, R; Pinedo, HM; Somers, R; van den Belt-Dusebout, AW; van Kerkhoff, EH; van Leeuwen, FE, 1994)
" Human chronic myelogenous leukemia K-562 cells were efficiently transduced with the N2Yc retrovirus vector and showed a significant increase in the 50% inhibitory concentration of chlorambucil (3."3.69Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells. ( Cournoyer, D; Greenbaum, M; Letourneau, S, 1996)
"The effect of morphine and cocaine on the transport of hydrolyzed nitrogen mustard (NH2-OH) and choline by peripheral blood cells of normal subjects and patients with chronic lymphocytic leukemia, acute lymphoblastic leukemia, and acute myeloblastic leukemia was determined."3.65Drug-induced stimulation of transport of hydrolyzed nitrogen mustard and choline by normal and leukemic human cells in vitro. ( Goldenberg, GJ, 1976)
"Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe."2.82Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy. ( Karati, D; Kumar, D; Mahadik, KR; Trivedi, P, 2022)
"Most patients with early-stage Hodgkin's disease can now be cured by one of several therapeutic approaches."2.37Early-stage Hodgkin's disease: current approaches to treatment. ( MacKenzie, R; Rusthoven, JJ, 1985)
"The prognosis of patients with Hodgkin's disease has dramatically improved over the past few decades."2.37Current management of Hodgkin's disease. ( Behrens, BC; DeVita, VT; Young, RC, 1985)
"Among these, leukemia is extremely common, and thus, developing novel drugs to combat leukemia is crucial."1.72Novel nitrogen mustard-artemisinin hybrids with potent anti-leukemia action through DNA damage and activation of GPx. ( Chen, H; Cui, J; Dai, T; Lin, L; Liu, Y; Lu, W; Sun, D; Yang, L; Yang, X, 2022)
"Concerning ANLL, the MOPP regimen was significantly associated with a higher risk: 3."1.31Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation. ( Andrieu, JM; Colonna, P; Delwail, V; Jais, JP, 2002)
"Patients treated for Hodgkin's disease have an increased risk of developing subsequent acute leukemia."1.30The risk of acute leukemia in patients treated for Hodgkin's disease is significantly higher aft [see bined modality programs than after chemotherapy alone and is correlated with the extent of radiotherapy and type and duration of chemotherapy: a case-con ( Anselmo, AP; Baroni, CD; Bernasconi, C; Brusamolino, E; Klersy, C; Lazzarino, M; Lunghi, F; Mandelli, F; Maurizi-Enrici, R; Orlandi, E; Pagnucco, G; Santoro, M, 1998)
" All other disease stages will require a different strategy that should consist of radiotherapy combined with short-term effective regimens, such as ABVD (doxorubicin, bleomycin, vinblastine and decarbazine) or VBM (vinblastine, bleomycin and methotrexate) to reduce the incidence of MOPP-associated gonadal dysfunction and leukaemogenesis."1.28Early stage Hodgkin's disease: ten-year results of a non-randomised study with radiotherapy alone or combined with MOPP. ( Banfi, A; Bonadonna, G; Bonfante, V; Devizzi, L; Santoro, A; Tesoro Tess, JD; Valagussa, P; Viviani, S; Zanini, M; Zucali, R, 1992)
"3 microM, ethacrynic acid was toxic to 8 of 24 (33%) tumor specimens studied."1.28Enhancement of anthracycline and alkylator cytotoxicity by ethacrynic acid in primary cultures of human tissues. ( Kern, DH; Messenger, JC; Nagourney, RA; Weisenthal, LM, 1990)
"Thirty-four subsequent second malignant neoplasms were observed in 33 patients among those treated for Hodgkin's disease."1.27Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience. ( DeVita, VT; Glatstein, E; Kelley, PA; Kinsella, TJ; Makuch, RW; Tester, WJ; Waller, B, 1984)
"Patients who had a relapse of Hodgkin's disease did not have an increased incidence of second malignancy."1.27Second malignancy complicating Hodgkin's disease. ( Mercier, JP; Tawil, E, 1983)
"Menadiol was tested alone and in combination with standard antineoplastic agents."1.27Selective enhancement by menadiol of in vitro drug activity in human lymphatic neoplasms. ( Dill, PL; Duarte, TE; Su, YZ; Weisenthal, LM, 1987)
"Of 602 patients treated for non-Hodgkin's lymphomas, 9 developed overt acute nonlymphocytic leukemia or preleukemia with refractory cytopenia and cytogenetic abnormalities of the bone marrow."1.27Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents. ( Ersbøll, J; Keiding, N; Larsen, MS; Larsen, SO; Nissen, NI; Pedersen-Bjergaard, J; Philip, P; Schultz, H; Sørensen, HM, 1985)
"Stage II Hodgkin's disease probably should be divided into two substages requiring different treatment."1.26[The current state of curability of Hodgkin's disease]. ( Streuli, RA; Ultmann, JE, 1981)
"We studied 680 patients with Hodgkin's disease, treated at Stanford University Medical Center from July 1, 1968, through December 31, 1975, to determine the risk of development of hematologic neoplasia."1.26Hematologic neoplasia in patients treated for Hodgkin's disease. ( Coleman, CN; Flint, A; Glatstein, EJ; Kaplan, HS; Rosenberg, SA; Williams, CJ, 1977)
"Urethane is the best treatment available for multiple myeloma."1.23New therapy for leukemia, polycythemia, and lymphoma. ( BARTLETT, GR; MARLOW, AA, 1953)

Research

Studies (184)

TimeframeStudies, this research(%)All Research%
pre-1990165 (89.67)18.7374
1990's14 (7.61)18.2507
2000's3 (1.63)29.6817
2010's0 (0.00)24.3611
2020's2 (1.09)2.80

Authors

AuthorsStudies
Dai, T1
Lin, L1
Chen, H1
Lu, W1
Yang, X1
Yang, L1
Liu, Y1
Cui, J1
Sun, D1
Karati, D1
Mahadik, KR1
Trivedi, P1
Kumar, D1
ERSLEV, A1
WINTROBE, MM4
HUGULEY, CM3
BURCHENAL, JH5
LESTER, RA1
GOODMAN, LS2
SYKES, MP1
IRWIN, GE1
MARLOW, AA1
BARTLETT, GR1
RUNDLES, RW1
BARTON, WB1
COONRAD, EV1
KLIMA, R1
HORNISCHER, R1
HOLY, J1
SUCHAN, M1
MORELLI, A1
MAUREA, C1
KUROYANAGI, S1
INTROZZI, P2
MARINONE, G2
HOLTHAUS, JM1
BEATTIE, JW1
HOWELLS, LH1
CAKMAKCI, A1
RAMIOUL, H1
TOKUOKA, S1
SELLEI, C2
ECKHARDT, S2
HARTAI, F1
DUMBOVICH, B1
BERNARD, J2
MATHE, G2
WEIL, M3
HANSEN, PB1
HORLIN, W1
SCHMITT, W1
HELLENDOORN, HB1
PELT, M1
GERBRANDY, J1
LAMY, P1
REMIGY, E1
STEHLIN, H1
KRAKOFF, IH1
KARNOFSKY, DA2
ZULIK, R1
LOVISETTO, P1
CASTELLANO, M1
SCHREK, R2
FRIEDMAN, IA1
LEITHOLD, L1
SZENTKLARAY, J1
CHILOV, K2
IVANOV, S2
KIRCHEV, P1
BLOCK, M2
MOKEEVA, RA1
VISHNIAKOVA, EG1
DIAMOND, HD1
DOAN, CA1
WISEMAN, BK1
BOURONCLE, BA1
LAWKOWICZ, W1
BECALSKI, J1
BARLOW, AM1
LEEMING, JT1
WILKINSON, JF3
GALTON, DA1
WILTSHAW, E1
SZUR, L1
DACIE, JV1
PISANI, A2
POGGI, C2
MEARDI, G2
ARMAGHAN, V1
GERHARTZ, H1
WIEDEMANN, H1
SPRAGUE, CC1
THEOLOGIDES, A1
KENNEDY, BJ1
HARRINGTON, WJ2
HALLORAN, MJ1
KIRCHOFF, VG1
REINHARD, EH1
GROSSMAN, R1
WHITE, B1
HILGER, E1
SAMPEY, JR6
KOJIMA, M1
NAKAMOTO, S1
KOLFF, WJ1
EVANS, AM1
RIEKHOF, P1
IMAMURA, S1
NAKAKUKI, K1
KATCHMAN, BJ1
ZIPF, RE1
MURPHY, JP1
JEN, YF1
STEFANI, S1
DOCTOR, VM1
DE BERGSAGEL, DE1
SHULLENBERGER, CC1
ADAMS, JL1
MATSUOKA, M1
CREPALDI, G1
PARPAJOLA, A1
BURNINGHAM, RA1
RESTREPO, A1
PUGH, RP1
BROWN, EB1
SCHLOSSMAN, SF1
KHURI, PD1
LESSNER, HE1
DIAMANDOPOULOS, GT1
SMITH, EB1
DUNNING, WF1
CURTIS, MR1
DOWD, JE1
DIPAOLO, JA1
WATNE, AL1
IRIARTE, P1
JAGASIA, H1
THURMAN, WG2
FRIEDMAN, OM1
BOGER, E1
GRUBLIAUSKAS, V1
SOMMER, H1
HUTCHISON, JL1
TSOU, KC1
SU, HC1
CORREA, JN1
ANDREWS, JR1
DUHIG, JT1
KEIDAN, SE1
MAINWARING, D1
SMITH, JC1
BOLANDE, RP1
CONKLIN, JW1
UPTON, AC1
CHRISTENBERRY, KW1
GREEN, RA1
DIXON, H1
MORROW, LB1
ANDERSON, RE1
VESIN, S1
LIBANSKY, J1
CHUDOMEL, V1
BRABEC, V1
SOCHMAN, J1
SANDOR, L1
CERNY, V1
UJHAZY, V1
WINKLER, A1
NEMETH, L1
GAL, F1
PORTER, FS1
HOLOWACH, J1
RUNDLES, W1
GRIZZLE, J1
BONO, VH1
JONSSON, U1
CORLEY, CC1
WEICKER, H1
LINDEMANN, M1
GUMMEL, H1
GARDIKAS, C2
BURCHENAL, JR1
JOHNSTON, SF1
SIEBEROVA-KLIMOVA, R1
NINNI, M1
LEVI, M1
MENE, G1
FERRI, A1
CAPPELLO, F1
de LORENZO, J1
JANNINI, P1
ABOU SINNA, I1
SZREDER, W1
MIGDALSKA, Z1
KIELER, J1
TAZAKI, Y1
FUCHIGAMI, A1
OOTA, K1
INGRASSIA, G1
VASILE, B1
MELICK, RA1
STORTI, E1
KEIBL, E1
SPITZY, KH1
STORCH, L1
JANBON, M1
BERTRAND, L1
PEDERSEN, E1
PAVAN, S1
MATTHEWS, WB1
SPURR, CL2
SMITH, TR1
JACOBSON, LO1
von KRESS, H1
Johnson, EP1
MYERS, WP1
BEN-ASHER, S1
LEVIN, WC1
HOLT, JG1
Valagussa, P2
Santoro, A3
Fossati Bellani, F1
Franchi, F1
Banfi, A2
Bonadonna, G4
Freireich, EJ1
Keating, M1
Cabanillas, F1
Barlogie, B1
Dameshek, W1
Goodman, MJ1
Gilman, A1
McLennan, MT1
Körbling, M1
Hunstein, W1
Vorob'ev, AI1
Brilliant, MD1
Voltarelli, JC1
Falcão, RP1
Bottura, C1
Tester, WJ1
Kinsella, TJ1
Waller, B1
Makuch, RW1
Kelley, PA1
Glatstein, E2
DeVita, VT5
Jacquillat, C1
Auclerc, G1
Auclerc, MF1
Maral, J1
Tawil, E1
Mercier, JP1
Aisenberg, AC1
Gassmann, W1
Schmitz, N1
Löffler, H1
Gomez, GA1
Aggarwal, KK1
Han, T1
Streuli, RA1
Ultmann, JE1
Nagourney, RA2
Evans, SS1
Messenger, JC2
Su, YZ2
Weisenthal, LM3
van Leeuwen, FE1
Chorus, AM1
van den Belt-Dusebout, AW1
Hagenbeek, A2
Noyon, R1
van Kerkhoff, EH1
Pinedo, HM1
Somers, R1
Fabbri, S1
Prontera, C1
Broggini, M1
D'Incalci, M1
Letourneau, S1
Greenbaum, M1
Cournoyer, D1
Schellong, G1
Riepenhausen, M1
Creutzig, U1
Ritter, J1
Harbott, J1
Mann, G1
Gadner, H1
Brusamolino, E1
Anselmo, AP1
Klersy, C1
Santoro, M1
Orlandi, E1
Pagnucco, G1
Lunghi, F1
Maurizi-Enrici, R1
Baroni, CD1
Lazzarino, M1
Mandelli, F1
Bernasconi, C1
Cellai, E1
Magrini, SM1
Masala, G1
Alterini, R1
Costantini, AS1
Rigacci, L1
Olmastroni, L1
Papi, MG1
Spediacci, MA1
Innocenti, F1
Bellesi, G1
Ferrini, PR1
Biti, G1
Avilés, A3
Neri, N1
Delwail, V1
Jais, JP1
Colonna, P1
Andrieu, JM1
Garrett, MJ1
Das, S1
Smith, JD1
Freedman, LS1
Nissen, NI2
Pajak, TF1
Glidewell, O1
Pedersen-Bjergaard, J2
Stutzman, L1
Falkson, G1
Cuttner, J1
Blom, J1
Leone, L1
Sawitsky, A1
Coleman, M1
Haurani, F1
Harley, JB1
Seligman, B1
Cornell, C1
Henry, P1
Senn, HJ1
Brunner, K1
Martz, G1
Maurice, P1
Bank, A1
Shapiro, L1
James, GW1
Holland, JF1
Coleman, CN1
Williams, CJ1
Flint, A1
Glatstein, EJ1
Rosenberg, SA1
Kaplan, HS1
Goldenberg, GJ1
Díaz-Maqueo, JC2
Ayala, JR1
Cortés, HD1
García, EL2
Hall, AG1
Tilby, MJ1
Bonfante, V1
Viviani, S1
Zucali, R1
Devizzi, L1
Zanini, M1
Tesoro Tess, JD1
Kern, DH1
Talavera, A1
Guzmán, R1
Longo, DL3
Duffey, PL2
Wiernik, PH1
Hubbard, SM2
Phares, JC1
Bastian, AW1
Jaffe, ES2
Young, RC4
Petru, E1
Schmähl, D1
Gehan, EA1
Sullivan, MP1
Fuller, LM1
Johnston, J1
Kennedy, P1
Fryer, C1
Gilchrist, GS1
Hays, DM1
Hanson, W1
Heller, R1
Lowenthal, RM1
Jestrimski, KW1
Sagher, D1
Karrison, T1
Schwartz, JL1
Larson, R1
Meier, P1
Strauss, B1
Ihde, DC1
Straus, DJ1
Boccaccio, P1
Rosa, F1
Casciaro, S1
D'Elia, P1
Romagnoli, M1
Ghio, R1
España, P1
Bonilla, F1
Yebra, M1
Diego, J1
Alvarez de Mon, M1
Marazuela, M1
Durántez, A1
Rowland, KM1
Murthy, A1
Duarte, TE1
Dill, PL1
Sizoo, W1
Löwenberg, B1
Blayney, DW1
Greene, MH1
Postal, MG1
Rusthoven, JJ1
MacKenzie, R1
Virgolini, L1
Behrens, BC1
Ersbøll, J1
Sørensen, HM1
Keiding, N1
Larsen, SO1
Philip, P1
Larsen, MS1
Schultz, H1
Carbone, PP1
Trepel, F1
Stockhusen, G1
Rastetter, J1
Begemann, H1
Frei, E2
Schabel, FM1
Goldin, A1
Rubin, P1
Pruzanski, W1
Saito, S1
Benckhuijsen, C1
Silber, R1
Unger, KW1
Ellman, L1
Berceanu, S1
Gociu, M1
Geib, R1
Sighetea, E1
Dăncescu, I1
Segal, E1
Tănăsescu, C1
Leikin, S1
Brubaker, C1
Hartmann, J1
Murphy, ML1
Wolff, J1
Fennelly, JJ1
Bishop, RC1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Maternal Cancer Diagnosis and Treatment During Pregnancy:a Registry for Maternal, Fetal, and Neonatal Outcomes With Longitudinal Follow up of Child Development and Maternal Psychological Well Being[NCT02749474]400 participants (Anticipated)Observational [Patient Registry]2003-07-31Recruiting
(PRO#11307) Phase III Randomized Study of Autologous Stem Cell Transplantation With High-dose Melphalan Versus High-dose Melphalan and Bortezomib in Patients With Multiple Myeloma 65 Year or Older[NCT01453088]Phase 263 participants (Actual)Interventional2010-06-24Terminated (stopped due to Lack of Accrual)
Tandem Autologous Hematopoietic Stem Cell Transplant With Melphalan Followed by Melphalan and Bortezomib in Patients With Multiple Myeloma[NCT01241708]Phase 3146 participants (Actual)Interventional2010-04-08Completed
A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167]Phase 21 participants (Actual)Interventional2007-05-31Terminated (stopped due to Lack of accrual and interest in study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Survival Rate

(NCT01453088)
Timeframe: 1 year

InterventionParticipants (Count of Participants)
Auto Transplant High Dose Melphalan27
Auto Transplant High Dose Melphalan+Bortezomib27

Progression Free Survival Rate

Progression free survival of elderly patients with multiple myeloma treated with either high-dose melphalan versus high-dose melphalan and bortezomib at 3 years (NCT01453088)
Timeframe: Participants will be followed post transplant for a minimum of 3 years, and after that may be monitored as part of the study indefinitely

InterventionParticipants (Count of Participants)
Auto Transplant High Dose Melphalan13
Auto Transplant High Dose Melphalan+Bortezomib11

Reviews

14 reviews available for mechlorethamine and Leucocythaemia

ArticleYear
Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:8

    Topics: Alkylating Agents; Antineoplastic Agents; Antineoplastic Agents, Alkylating; DNA; Humans; Leukemia;

2022
ABVD chemotherapy in the treatment of Hodgkin's disease.
    Cancer treatment reviews, 1982, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Bleomycin; Clinical Trials as Topic; Dacarbazine; Doxorubicin; Drug Resistanc

1982
The hematologic malignancies. Leukemia, lymphoma, and myeloma.
    Cancer, 1984, Dec-01, Volume: 54, Issue:11 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cyclophosphamide; Doxor

1984
In vitro chemoseparation as part of autologous bone marrow transplantation (ABMT) in hematologic malignancy.
    Blut, 1984, Volume: 48, Issue:4

    Topics: Acute Disease; Animals; Bone Marrow; Bone Marrow Transplantation; Cyclophosphamide; Disease Models,

1984
Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies.
    Blood reviews, 1992, Volume: 6, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; DNA Damage; DNA, Neoplasm; Drug Design; Drug Resi

1992
Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies.
    Blood reviews, 1992, Volume: 6, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; DNA Damage; DNA, Neoplasm; Drug Design; Drug Resi

1992
Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies.
    Blood reviews, 1992, Volume: 6, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; DNA Damage; DNA, Neoplasm; Drug Design; Drug Resi

1992
Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies.
    Blood reviews, 1992, Volume: 6, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; DNA Damage; DNA, Neoplasm; Drug Design; Drug Resi

1992
Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects.
    Neoplasma, 1991, Volume: 38, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Hod

1991
Corticosteroid drugs: their role in oncological practice.
    The Medical journal of Australia, 1986, Jan-20, Volume: 144, Issue:2

    Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast

1986
Chemotherapy of malignant lymphomas.
    Seminars in oncology, 1985, Volume: 12, Issue:4 Suppl 6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin; Drug Resistance

1985
Treatment of advanced Hodgkin's disease.
    Hematology/oncology clinics of North America, 1989, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top

1989
Hodgkin's disease: long-term effects of therapy.
    Medical and pediatric oncology, 1986, Volume: 14, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Brain; Female; Genitalia, Fem

1986
Early-stage Hodgkin's disease: current approaches to treatment.
    Canadian Medical Association journal, 1985, Aug-01, Volume: 133, Issue:3

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fem

1985
[Neutrophil leukemia. Review of the literature].
    Minerva medica, 1985, Oct-27, Volume: 76, Issue:41

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Examination; Busulfan; Fema

1985
Current management of Hodgkin's disease.
    Drugs, 1985, Volume: 30, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; Humans;

1985
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
    Folia medica Neerlandica, 1969, Dec-02, Volume: 12, Issue:2

    Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans;

1969

Trials

8 trials available for mechlorethamine and Leucocythaemia

ArticleYear
ABVD chemotherapy in the treatment of Hodgkin's disease.
    Cancer treatment reviews, 1982, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Bleomycin; Clinical Trials as Topic; Dacarbazine; Doxorubicin; Drug Resistanc

1982
Post-therapeutic acute malignant myeloproliferative syndrome and acute nonlymphocytic leukemia in non-Hodgkin's lymphoma.
    Cancer, 1982, Dec-01, Volume: 50, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Administration Schedule; Drug

1982
Low risk of secondary leukemias after chemotherapy without mechlorethamine in childhood Hodgkin's disease. German-Austrian Pediatric Hodgkin's Disease Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:6

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Child

1997
A comparative study of a BCNU containing 4-drug program versus MOPP versus 3-drug combinations in advanced Hodgkin's disease: a cooperative study by the Cancer and Leukemia Group B.
    Cancer, 1979, Volume: 43, Issue:1

    Topics: Adult; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Drug Therapy, Combination; Femal

1979
Treatment of advanced-stage Hodgkin's disease: alternating noncrossresistant MOPP/CABS is not superior to MOPP.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dose-Re

1991
The intergroup Hodgkin's disease in children. A study of stages I and II.
    Cancer, 1990, Mar-15, Volume: 65, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Hodgki

1990
The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment.
    Seminars in hematology, 1988, Volume: 25, Issue:2 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Doxorub

1988
Treatment of advanced Hodgkin's disease.
    Hematology/oncology clinics of North America, 1989, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top

1989

Other Studies

164 other studies available for mechlorethamine and Leucocythaemia

ArticleYear
Novel nitrogen mustard-artemisinin hybrids with potent anti-leukemia action through DNA damage and activation of GPx.
    European journal of medicinal chemistry, 2022, Dec-15, Volume: 244

    Topics: Antineoplastic Agents; Apoptosis; Artemisinins; Cell Line, Tumor; DNA Damage; Glutathione Peroxidase

2022
Treatment Of Malignant Blood Diseases and Cancer With Nitrogen Mustard Gas In U.S.A.; Review Article.
    Ugeskrift for laeger, 1948, Feb-12, Volume: 110, Issue:7

    Topics: Leukemia; Mechlorethamine

1948
Nitrogen-mustard therapy for Hodgkin's disease, lymphosarcoma, the leukemias, and other disorders.
    Cancer, 1948, Volume: 1, Issue:3

    Topics: Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Mustard Plant; Nitrogen

1948
Studies on the chemotherapy of leukemia; effect of certain nitrogen mustards and carbamates on transmitted mouse leukemia.
    Cancer, 1948, Volume: 1, Issue:3

    Topics: Anti-Anxiety Agents; Carbamates; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1948
The newer nitrogen mustards in the treatment of leukemia.
    Radiology, 1948, Volume: 50, Issue:4

    Topics: Ethylamines; Leukemia; Mechlorethamine

1948
Nitrogen mustard as a therapeutic agent for Hodgkin's disease, lymphosarcoma and leukemia.
    Annals of internal medicine, 1947, Volume: 27, Issue:4

    Topics: Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine

1947
Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.
    Journal of the American Medical Association, 1946, Sep-21, Volume: 132

    Topics: Amines; Gas Poisoning; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mechloret

1946
Treatment of the leukemias and lymphomas; current trends.
    Journal of the American Medical Women's Association, 1952, Volume: 7, Issue:9

    Topics: Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compounds; Triethylenemelamine

1952
Recent advances in treatment of leukemias and lymphomas.
    The West Virginia medical journal, 1952, Volume: 48, Issue:9

    Topics: Humans; Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compounds

1952
New therapy for leukemia, polycythemia, and lymphoma.
    California medicine, 1953, Volume: 78, Issue:2

    Topics: Aminopterin; Chronic Disease; Hodgkin Disease; Humans; Leukemia; Lymphoma; Mechlorethamine; Multiple

1953
The role of chemotherapy in the management of malignant lymphomas and leukemias.
    Southern medical journal, 1953, Volume: 46, Issue:3

    Topics: Adrenocorticotropic Hormone; Cortisone; Disease Management; Folic Acid Antagonists; Humans; Leukemia

1953
[Nitrogen mustard therapy of proliferative blood diseases; methods, experiences as well as application possibilities in therapy of carcinoma].
    Wiener medizinische Wochenschrift (1946), 1953, Jan-03, Volume: 103, Issue:1

    Topics: Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymp

1953
[Therapeutic effect of small doses of chloroethylaminohydrochloride associated with roentgenotherapy in blastomatosis].
    Casopis lekaru ceskych, 1953, Mar-06, Volume: 92, Issue:10

    Topics: Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds; Radiotherapy; X-Ray Therapy

1953
[Eosinophilic leukemia].
    Haematologica, 1953, Volume: 37, Issue:5

    Topics: Adrenocorticotropic Hormone; Hypereosinophilic Syndrome; Leukemia; Mechlorethamine; Nitrogen Mustard

1953
[A case of chronic myelogenous leucaemia treated with nitrogen mustard N-oxide].
    Gan, 1953, Volume: 44, Issue:2-3

    Topics: Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Mechlorethamine; Nitr

1953
[Role of chemical cytostatic treatment in therapy of hemopathies producing chronic malignant conditions].
    Haematologica, 1953, Volume: 37, Issue:11

    Topics: Ethylamines; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma,

1953
Chemotherapy of lymphomas and leukemia.
    The Nebraska state medical journal, 1954, Volume: 39, Issue:5

    Topics: Adrenocorticotropic Hormone; Cortisone; Folic Acid Antagonists; Humans; Leukemia; Lymphoma; Mechlore

1954
Biological actions and therapeutic applications of nitrogen mustard.
    The Quarterly journal of medicine, 1954, Volume: 23, Issue:90

    Topics: Hodgkin Disease; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Nitr

1954
[Triethylene melamine treatment of leukemia and lymphogranulomatosis].
    Turk Tip Cemiyeti mecmuasi, 1954, Volume: 20, Issue:6

    Topics: Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds; Sarcoidosis; Triethylenemela

1954
Indication of the use of beta-naphthyl-di-2-chloroethylamine, in Hodgkin's disease and Leukemia.
    Acta - Unio Internationalis Contra Cancrum, 1955, Volume: 11, Issue:2

    Topics: Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1955
[Leukemia-like changes in mice administered with nitrogen mustard N-oxide (nitromin)].
    Gan, 1955, Volume: 46, Issue:2-3

    Topics: Animals; Leukemia; Leukemia, Experimental; Mechlorethamine; Mice; Nitrogen Mustard Compounds

1955
Clinical trial of a new nitrogen-mustard compound.
    Lancet (London, England), 1956, May-26, Volume: 270, Issue:6926

    Topics: Hodgkin Disease; Leukemia; Lung Neoplasms; Mechlorethamine; Nitrogen; Nitrogen Mustard Compounds

1956
[Trials of treatment by p-(di-2-chloroethylamino)phenylbutyric acid in Hodgkin's disease, chronic lymphoid leukemia and different sarcomas of lymphatic tissue; study of one hundred cases].
    Revue francaise d'etudes cliniques et biologiques, 1956, Volume: 1, Issue:10

    Topics: Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoid Tiss

1956
Clinical experience with CB 1348 (NN-di(2-chloroethyl, -P-aminophenylbutyric acid) in the treatment of chronic lymphatic leukaemia.
    Acta radiologica, 1957, Volume: 47, Issue:3

    Topics: Chlorambucil; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Mechlorethamine;

1957
[Treatment of hematologic neoplasms with nitrogen oxide mustards].
    Deutsche medizinische Wochenschrift (1946), 1957, Feb-15, Volume: 82, Issue:7

    Topics: Hematologic Neoplasms; Hodgkin Disease; Leukemia; Lymphoma; Mechlorethamine; Mustard Plant; Nitrogen

1957
[Treatment of Hodgkin's disease, chronic lymphoid leukosis and various lymphosarcomas with p-(di-2-chloroethyl) aminophenylbutyric acid].
    Le Sang, 1957, Volume: 28, Issue:1

    Topics: Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Nit

1957
[Biochemical changes in induced cytolysis].
    Nederlands tijdschrift voor geneeskunde, 1957, Jun-01, Volume: 101, Issue:22

    Topics: Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Radiotherapy

1957
[Severe terminal purpura during CB 1348 therapy of chronic lymphoid leukemia].
    Revue medicale de Nancy, 1957, Volume: 82

    Topics: Chlorambucil; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Mechlorethamine;

1957
Remissions induced by chlorambucil in chronic granulocytic leukemia.
    Journal of the American Medical Association, 1958, Feb-08, Volume: 166, Issue:6

    Topics: Chlorambucil; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mechlorethamine; Neoplasms

1958
[Therapy of malignant diseases of the lymphatic and reticular systems with a nitrogen mustard derivative].
    Arzneimittel-Forschung, 1958, Volume: 8, Issue:6

    Topics: Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Mannitol; Mechlorethamine; Neoplasms; Nitrogen Mustar

1958
[P-bis-(beta-chloroethyl) aminophenylalanine (sarcolysin) in antiblastic chemotherapy with special reference to lymphatic blood diseases].
    Haematologica, 1958, Volume: 43, Issue:4

    Topics: Hodgkin Disease; Humans; Leukemia; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechloret

1958
Variability of the in vitro sensitivity of human leukemic lymphocytes to x-rays and chemotherapeutic agents.
    Journal of the National Cancer Institute, 1958, Volume: 20, Issue:6

    Topics: Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mechlorethamine; Nitrogen Mu

1958
[Therapeutic procedures for ambulatory treatment of hemoblastosis and malignant neoplasms].
    Neoplasma, 1958, Volume: 5, Issue:1

    Topics: Ascorbic Acid; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Vitamin A

1958
[Trial therapy of leukoses, lymphogranulomas & malignant tumors with urethane, chloroethylamine & other clinical compounds].
    Izvestiia na meditsinskite instituti. [Bulletin des instituts de medecine]. Bulgarska akademiia na naukite. Otdelenie za biologicheski i meditsinski nauki, 1957, Volume: 14

    Topics: Antineoplastic Agents; Hodgkin Disease; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compo

1957
Histopathologic effects of x-rays, radiophosphorus, nitrogen mustard, urethane, and steroids upon the spleen in leukemias and lymphomas.
    Radiology, 1958, Volume: 71, Issue:4

    Topics: Adrenocorticotropic Hormone; Cortisone; Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compou

1958
[Result of use of dopan in treatment of chronic myeloleukosis].
    Sovetskaia meditsina, 1958, Volume: 22, Issue:9

    Topics: Humans; Leukemia; Leukemia, Myeloid; Mechlorethamine; Nitrogen Mustard Compounds; Uracil; Uracil Mus

1958
[Lymphoid leukemia treated by the combination of cortisone, CB 1348 & transfusions].
    Journal de medecine de Bordeaux et du Sud-Ouest, 1958, Volume: 135, Issue:12

    Topics: Blood Transfusion; Chlorambucil; Cortisone; Leukemia; Leukemia, Lymphoid; Mechlorethamine; Nitrogen

1958
[First results of dopane therapy of chronic myeloid leukemia and of certain malignant tumors].
    Voprosy onkologii, 1958, Volume: 4, Issue:5

    Topics: Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Mechlorethami

1958
Clinical indications for the use of nitrogen mustard and triethylene melamine in malignant lymphomas and leukemias.
    Annals of the New York Academy of Sciences, 1958, Apr-24, Volume: 68, Issue:3

    Topics: Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compounds; Triethylenemelamine

1958
Clinical evaluation of CB 1348 in leukemias and lymphomas.
    Annals of the New York Academy of Sciences, 1958, Apr-24, Volume: 68, Issue:3

    Topics: Chlorambucil; Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compounds

1958
[Observations on the application of CB-1348 in lymphatic leukemias].
    Polskie Archiwum Medycyny Wewnetrznej, 1959, Volume: 29, Issue:3

    Topics: Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Mechlorethamine; Nitrogen Mustard Compounds

1959
Mannomustine in treatment of leukaemias, polycythaemia, and malignant disorders.
    British medical journal, 1959, Aug-22, Volume: 2, Issue:5146

    Topics: Leukemia; Mannitol; Mannomustine; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Polycythem

1959
The use of chlorambucil and steroids in the treatment of chronic lymphocytic leukaemia.
    British journal of haematology, 1961, Volume: 7

    Topics: Adrenal Cortex Hormones; Chlorambucil; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leu

1961
[The effect of nitrogen mustard on the oxygen consumption of the leukocytes in chronic myeloid leukemia].
    Bollettino della Societa italiana di biologia sperimentale, 1960, Aug-15, Volume: 36

    Topics: Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukocytes; M

1960
[The effect of nitrogen mustard on the oxygen consumption of the leukocytes in chronic lymphatic leukemia].
    Bollettino della Societa italiana di biologia sperimentale, 1960, Aug-15, Volume: 36

    Topics: Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes; Mechlorethamine; Nitrogen Must

1960
The effect of mustargen mixed with urethan in the treatment of IRC leukemia in Fischer rats.
    Cancer chemotherapy reports, 1961, Volume: 14

    Topics: Animals; Leukemia; Leukemia, Experimental; Mechlorethamine; Nitrogen Mustard Compounds; Rats; Rats,

1961
[Alteration of experimental mouse leukemia with nitrogen mustard phosphamide esters].
    Folia haematologica; internationales Magazin fur Blutforschung, 1961, Volume: 6

    Topics: Animals; Dimethoate; Esters; Leukemia; Leukemia, Experimental; Mechlorethamine; Mice

1961
[5-year clinical experience with Degranol].
    Orvosi hetilap, 1962, Jun-24, Volume: 103

    Topics: Leukemia; Mannomustine; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds

1962
Evaluation of the effectiveness of radioactive phosphorus and chlorambucil in patients with chronic lymphocytic leukemia.
    Cancer chemotherapy reports, 1962, Volume: 16

    Topics: Chlorambucil; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Mec

1962
Effect of uracil mustard in malignant lymphoma and chronic lymphatic leukemia.
    Minnesota medicine, 1962, Volume: 45

    Topics: Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Minnesota; Nitrogen Mustard Compounds; Urac

1962
Some immunologic aspects of the evolution and treatment of leukemia.
    Transactions of the Association of American Physicians, 1962, Volume: 75

    Topics: Animals; Biological Products; Busulfan; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compound

1962
[Forms of leukosis and their therapy].
    Therapeutische Umschau. Revue therapeutique, 1963, Volume: 20

    Topics: Adrenocorticotropic Hormone; Antineoplastic Agents; Busulfan; Colchicine; Folic Acid Antagonists; Go

1963
Nitrogen mustards in the management of Hodgkin's disease and the leukemias. IX. Further clinical reports, 1960-1962.
    Journal of the South Carolina Medical Association, 1963, Volume: 59

    Topics: Disease Management; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1963
Nitrogen mustards in the management of Hodgkin's disease and the leukemias. VII. Clinical reports, 1959-62.
    American journal of pharmacy and the sciences supporting public health, 1962, Volume: 134

    Topics: Disease Management; Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1962
[TUMOR-FORMING LEUKEMIA (INCLUDING CHLOROMA)].
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1963, Volume: 26

    Topics: Adolescent; Alanine; Antineoplastic Agents; Child; Dexamethasone; Humans; Leukemia; Mechlorethamine;

1963
THE URIC ACID ANURIA OF LEUKEMIA TREATED BY DIALYSIS.
    The Ohio State medical journal, 1963, Volume: 59

    Topics: Adolescent; Anuria; Chlorambucil; Fluid Therapy; Humans; Kidney; Kidneys, Artificial; Leukemia; Mech

1963
LEUKEMIA. AN ANALYSIS OF 209 CASES FROM THE ELLIS FISCHEL STATE CANCER HOSPITAL.
    Missouri medicine, 1963, Volume: 60

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Cancer Care Facilit

1963
[A CASE OF LEUKEMIA CUTIS].
    Hifuka kiyo. Acta dermatologica, 1963, Volume: 58

    Topics: Dactinomycin; Dermatology; Humans; Leukemia; Mechlorethamine; Pathology; Prednisolone; Skin; Skin Ne

1963
THE EFFECT OF CHEMOTHERAPEUTIC AGENTS UPON THE METABOLISM OF INTACT HUMAN CANCER CELLS: AN IN VITRO TECHNIC FOR CELL SENSITIVITY.
    Clinical chemistry, 1963, Volume: 102

    Topics: Aminopterin; Antineoplastic Agents; Azaguanine; Carbohydrate Metabolism; In Vitro Techniques; Lactat

1963
[TUMOUR CHEMOTHERAPY. IX. NITROGEN MUSTARDS OF PHOSPHORAMIDE, PHOSPHORAMIDE ESTER AND THIOESTER].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1962, Volume: 9

    Topics: Animals; Fibrosarcoma; Leukemia; Leukemia, Experimental; Mechlorethamine; Mice; Neoplasms; Nitrogen

1962
RESISTANCE OF PHYTOHAEMAGGLUTININ-TREATED LYMPHOCYTES TO X-RAYS AND NITROGEN MUSTARD.
    Nature, 1963, Nov-02, Volume: 200

    Topics: Antibodies; Biochemical Phenomena; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mechlorethamin

1963
EFFECT OF ADMINISTRATION OF ALKYLATING AGENTS OR 6-MERCAPTOPURINE ON SERUM LEVEL OF DEOXYRIBONUCLEASE I IN LEUKEMIA PATIENTS.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1963, Volume: 114

    Topics: Alkylating Agents; Blood Chemical Analysis; Busulfan; Deoxyribonuclease I; DNA; Humans; Leukemia; Le

1963
CHRONIC LYMPHATIC LEUKAEMIA AND ITS MANAGEMENT.
    The New Zealand medical journal, 1963, Volume: 62

    Topics: Adrenal Cortex Hormones; Chlorambucil; Geriatrics; Humans; Leukemia; Leukemia, Lymphoid; Mechloretha

1963
[IMPROVEMENT AND EXACERBATION IN LEUKEMIA].
    [Sogo rinsho] Clinic all-round, 1963, Volume: 12

    Topics: Aminocaproates; Aminocaproic Acid; Anemia; Antineoplastic Agents; Blood Transfusion; Busulfan; Centr

1963
EXCRETION OF TRYPTOPHAN METABOLITES IN DIFFERENT FORMS OF HAEMOBLASTOSIS.
    Clinica chimica acta; international journal of clinical chemistry, 1964, Volume: 9

    Topics: Cortisone; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Kynurenic Acid; Ky

1964
WEEKLY HIGH-DOSAGE GLUCOCORTICOSTEROID TREATMENT OF LYMPHOCYTIC LEUKEMIAS AND LYMPHOMAS.
    The New England journal of medicine, 1964, May-28, Volume: 270

    Topics: Anemia; Anemia, Hemolytic; Betamethasone; Chlorambucil; Dexamethasone; Geriatrics; Humans; Leukemia;

1964
PHAGOCYTOSIS IN RETICULUM CELL SARCOMA.
    Cancer, 1964, Volume: 17

    Topics: Adolescent; Black People; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Leukemia;

1964
COMPARATIVE RESPONSE OF A SPECTRUM OF TRANSPLANTABLE RAT NEOPLASMS TO NITROGEN MUSTARD, TRIETHYLENEMELAMINE, AND A GROUP OF BENZALDEHYDE MUSTARD DERIVATIVES.
    Cancer chemotherapy reports, 1964, Volume: 36

    Topics: Animals; Benzaldehydes; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Female; Humans; Injectio

1964
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop

1964
LYMPHANGIOGRAPHY FOR MALIGNANT DISEASES IN CHILDREN.
    JAMA, 1964, May-11, Volume: 188

    Topics: Adolescent; Child; Hodgkin Disease; Humans; Infant; Leukemia; Leukemia, Myeloid; Lymph Nodes; Lympha

1964
SYNTHESIS OF N-PHOSPHORYLATED DERIVATIVES OF NITROGEN MUSTARDS WITH LATENT CYTOTOXICITY.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Animals; Chemistry, Pharmaceutical; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymp

1963
THE MANAGEMENT OF LEUKEMIA AND LYMPHOMA.
    Applied therapeutics, 1964, Volume: 6

    Topics: Adrenal Cortex Hormones; Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Hodgkin Disease; Human

1964
SYNTHESIS OF POSSIBLE CANCER CHEMOTHERAPEUTIC COMPOUNDS BASED ON ENZYME APPROACH. V. TETRAZOLIUM NITROGEN MUSTARDS.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Animals; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Leukemia; Leukemia, Experiment

1963
MODIFICATION OF THE RADIATION EFFECT ON ASCITIC TUMOUR CELLS BY PHARMACOLOGICAL AGENTS INJECTED INTRAVENOUSLY.
    Nature, 1964, Jul-11, Volume: 203

    Topics: beta-Aminoethyl Isothiourea; Glutathione; Injections; Injections, Intravenous; Leukemia; Leukemia, E

1964
TUMOR INCIDENCE IN A-STRAIN MICE.
    Archives of pathology, 1965, Volume: 79

    Topics: Cyclophosphamide; Incidence; Leukemia; Leukemia, Radiation-Induced; Lung Neoplasms; Mechlorethamine;

1965
ASSOCIATION OF HERPES ZOSTER WITH LEUKEMIA AND LYMPHOMA IN CHILDREN.
    Clinical pediatrics, 1965, Volume: 4

    Topics: Adrenal Cortex Hormones; Alkylating Agents; Child; Cyclophosphamide; Drug Therapy; Herpes Zoster; Ho

1965
RADIATION AND DRUG INDUCED HYALINIZATION OF THE STOMACH.
    Archives of pathology, 1965, Volume: 79

    Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Drug Therapy; Ganglioneuroma; Gastroin

1965
FURTHER OBSERVATIONS ON LATE SOMATIC EFFECTS OF RADIOMIMETIC CHEMICALS AND X-RAYS IN MICE.
    Cancer research, 1965, Volume: 25

    Topics: Aging; Busulfan; Cataract; Female; Humans; Leukemia; Leukemia, Myeloid; Longevity; Lung Neoplasms; L

1965
EXPECTANCY FOR LIFE IN CHRONIC LYMPHATIC LEUKEMIA.
    Blood, 1965, Volume: 25

    Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Child; Chlorambucil; Cyclophospha

1965
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
    Archives of pathology, 1965, Volume: 79

    Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leu

1965
[Combination of microdosage of chloralkylamines with roentgen irradiation in the treatment of hemoblastoses and hemoblastomas].
    Casopis lekaru ceskych, 1952, Nov-14, Volume: 91, Issue:45-46

    Topics: Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphatic Vessels; Mechlorethamine

1952
Treatment of malignant lymphomas and lymphadenoses with leukeran.
    Neoplasma, 1959, Volume: 6

    Topics: Chlorambucil; Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Nitrogen Mus

1959
CB 1348 therapy in leukemia and allied diseases.
    American practitioner and digest of treatment, 1959, Volume: 10

    Topics: Arylsulfonates; Chlorambucil; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1959
New nitrogen mustards in the control of leukemia.
    American journal of pharmacy and the sciences supporting public health, 1959, Volume: 131

    Topics: Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1959
Clinical evaluation of the effect of degranol.
    Neoplasma, 1959, Volume: 6

    Topics: Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mannitol; Mannomustine; Mechlorethamine;

1959
[Comparative studies on the effect of dimethanesulfonyl-D-mannitol and mannitol mustard on animal leukemia].
    Arzneimittel-Forschung, 1962, Volume: 12

    Topics: Leukemia; Leukemia, Experimental; Mannitol; Mannomustine; Mechlorethamine; Nitrogen Mustard Compound

1962
Uracil mustard therapy in acute leukemia in children.
    Cancer chemotherapy reports, 1962, Volume: 18

    Topics: Acute Disease; Child; Infant; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds; Uracil Mustard

1962
Comparison of CB-1348 (chlorambucil, leukeran) and CB-1364.
    Cancer chemotherapy reports, 1962, Volume: 16

    Topics: Antineoplastic Agents; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mechlo

1962
Current control of the chronic leukemias with nitrogen mustards.
    American journal of pharmacy and the sciences supporting public health, 1961, Volume: 133

    Topics: Chronic Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1961
Management of human leukemias and Hodgkin's disease with Dopan (uracil mustard).
    Journal of the South Carolina Medical Association, 1962, Volume: 58

    Topics: Disease Management; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds;

1962
Nitrogen mustards in the treatment of neoplastic disease.
    Advances in internal medicine, 1950, Volume: 4

    Topics: Hodgkin Disease; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Mycosis

1950
[Efficacy and limitations of karyoklastic therapy of leukosis, lymphogranulomatosis, and malignant tumors in childhood].
    Kinderarztliche Praxis, 1950, Volume: 18

    Topics: Hodgkin Disease; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Sarcoidosis; Uret

1950
[Nitrogen mustard therapy of malignant tumors].
    Das Deutsche Gesundheitswesen, 1950, Nov-30, Volume: 5, Issue:48

    Topics: Carcinoma; Hodgkin Disease; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds

1950
Trial of beta-naphthyl-di-2-chloroethylamine in leukaemia, Hodgkin's disease, and allied disorders.
    Lancet (London, England), 1951, Jan-20, Volume: 1, Issue:6647

    Topics: Arylsulfonates; Ethylamines; Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1951
Chemotherapy of leukemia. III. Further studies on the effect of nitrogen mustards and related compounds on transmitted mouse leukemia.
    Cancer, 1951, Volume: 4, Issue:2

    Topics: Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1951
[Clinical experiences with nitrogen mustards].
    Casopis lekaru ceskych, 1951, May-04, Volume: 90, Issue:18

    Topics: Erythema; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds

1951
[Chloronaphthylamine in the treatment of malignant lymphogranuloma and chronic leukemia].
    Haematologica, 1950, Volume: 34, Issue:10

    Topics: Chronic Disease; Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1950
[Effect of methyl-bis (beta-chloroethyl)amine hydrochloride on Hodgkin's disease, lymphosarcoma, leukemia and neoplasms].
    Rivista di patologia e clinica, 1951, Volume: 6, Issue:1

    Topics: Amines; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Neoplas

1951
[Multiple successive and simultaneous treatment in a case of chronic myeloid leukemia].
    Il Progresso medico, 1951, Apr-30, Volume: 7, Issue:8

    Topics: Chloramines; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Mechlore

1951
[Nitrogen mustard in the treatment of Hodgkin's disease, lymphosarcoma, leukemia and related diseases].
    Arquivos de clinica, 1951, Volume: 12, Issue:3

    Topics: Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Nitrogen Mustard Compou

1951
The principles of radiation therapy of lymphoblastoma.
    The Journal of the Egyptian Medical Association, 1951, Volume: 34, Issue:5

    Topics: Hodgkin Disease; Leukemia; Lymphoma, Non-Hodgkin; Mechlorethamine; Nitrogen Mustard Compounds; Sarco

1951
[Preliminary results of combined urethane, nitrogen mustard and Delbet's vaccine therapy of chronic myelocytic leukemias].
    Polski tygodnik lekarski, 1951, May-07, Volume: 6, Issue:18-19

    Topics: Humans; Immunotherapy, Active; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia,

1951
Nitrogen mustard therapy in Hodgkin's disease, lympho-reticulosarcomatosis and lymphatic leukaemia.
    Acta radiologica, 1951, Volume: 36, Issue:6

    Topics: Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Nit

1951
Precipitous leucopenia in a N-mustard treated leukemia; (an autopsy case).
    Gan, 1951, Volume: 42, Issue:2-4

    Topics: Autopsy; Humans; Leukemia; Leukemia, Myeloid; Leukopenia; Mechlorethamine; Mustard Plant; Nitrogen M

1951
[Nitrogen mustard therapy of malignant granuloma, leukemia and neoplasms].
    Haematologica, 1951, Volume: 35, Issue:10

    Topics: Hodgkin Disease; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds

1951
[Chloroalkylamines and acute leukemia; clinical and histopathological study of methyl-bis (beta chloroethyl) amine hydrochloride in acute hemocytoblastic leukosis].
    Haematologica, 1951, Volume: 35, Issue:11

    Topics: Amines; Humans; Leukemia; Leukocytes; Mechlorethamine; Nitrogen Mustard Compounds

1951
Chemotherapy in the reticuloses.
    The Medical journal of Australia, 1952, Jan-12, Volume: 1, Issue:2

    Topics: Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compounds; Peptide Nucleic Acids; Phosphorus;

1952
[Treatment of malignant lymphogranuloma and chronic leukemia with chloroethylnaphthylamine].
    Radioterapia, radiobiologia e fisica medica, 1951, Volume: 7

    Topics: Chronic Disease; Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1951
[Treatment of leukemia with urethane and nitrogen mustards].
    Izvestiia na meditsinskite instituti. [Bulletin des instituts de medecine]. Bulgarska akademiia na naukite. Otdelenie za biologicheski i meditsinski nauki, 1951, Volume: 4-5

    Topics: Humans; Leukemia; Leukemia, Myeloid; Mechlorethamine; Nitrogen Mustard Compounds; Urethane

1951
Alkylamines in the treatment of leukaemia.
    Lancet (London, England), 1952, Jul-26, Volume: 2, Issue:6726

    Topics: Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1952
[Problems of leucocyte metabolism. III. Effects of nitrogen mustard and nitrogen mustard in combination with urethan on the metabolism of cells of myeloid leukemia].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1952, Volume: 214, Issue:5

    Topics: Humans; Leukemia; Leukemia, Myeloid; Leukocytes; Mechlorethamine; Nitrogen Mustard Compounds; Uretha

1952
Leukemic lymphosarcoma, lymphosarcomatosis; remarkable but transitory efficiency of the nitrided perite.
    Le Sang, 1949, Volume: 20, Issue:8

    Topics: Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Sarcoma

1949
On treatment of spontaneous leukemia in mice with nitrogenized mustard gas.
    Acta pathologica et microbiologica Scandinavica, 1950, Volume: 27, Issue:1

    Topics: Animals; Leukemia; Mechlorethamine; Mice; Mustard Gas; Nitrogen Mustard Compounds

1950
[Action of chloramine in two cases of leukemic myelosis and in a case of malignant lymphogranuloma].
    Minerva medica, 1949, Sep-08, Volume: 40, Issue:44 Pt 2

    Topics: Chloramines; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1949
A trial of beta-naphthyldi-2-chloroethylamine in leukemia, Hodgkin's disease, and allied diseases.
    Lancet (London, England), 1950, May-13, Volume: 1, Issue:6611

    Topics: Arylsulfonates; Ethylamines; Hodgkin Disease; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds;

1950
The role of nitrogen mustard therapy in the treatment of lymphomas and leukemias.
    The American journal of medicine, 1950, Volume: 8, Issue:6

    Topics: Hodgkin Disease; Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Sarcoma

1950
[Malignant growth and pharmacotherapy].
    Arztliche Wochenschrift, 1950, Jun-16, Volume: 5, Issue:23

    Topics: Leukemia; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Sarcoma; Urethane

1950
Nitrogen Mustards in Fowl Leucosis.
    Science (New York, N.Y.), 1948, Jan-09, Volume: 107, Issue:2767

    Topics: Animals; Birds; Humans; Leukemia; Meat; Mechlorethamine; Nitrogen Mustard Compounds

1948
The nitrogen mustards in the treatment of leukemia.
    Cancer, 1949, Volume: 2, Issue:1

    Topics: Ethylamines; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1949
Nitrogen mustard therapy; the use of methyl bis (B chloroethyl) amine hydrochloride in Hodgkin's disease, leukemia, lymphosarcoma and cancer of the lung.
    The American journal of the medical sciences, 1949, Volume: 217, Issue:2

    Topics: Amines; Ethylamines; Hodgkin Disease; Humans; Leukemia; Lung Diseases; Lung Neoplasms; Lymphoma; Lym

1949
Nitrogen mustard in treatment of leukemias.
    Texas state journal of medicine, 1949, Volume: 45, Issue:8

    Topics: Leukemia; Mechlorethamine; Nitrogen Mustard Compounds

1949
Absence of treatment-induced second neoplasms after ABVD in Hodgkin's disease.
    Blood, 1982, Volume: 59, Issue:3

    Topics: Actuarial Analysis; Acute Disease; Adolescent; Adult; Aged; Bleomycin; Child; Child, Preschool; Daca

1982
Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders.
    JAMA, 1984, May-04, Volume: 251, Issue:17

    Topics: History, 20th Century; Hodgkin Disease; Humans; Leukemia; Lymphoma, Non-Hodgkin; Mechlorethamine; Ne

1984
[Various disputable problems of ambulatory treatment of tumors of the blood system].
    Terapevticheskii arkhiv, 1984, Volume: 56, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Doxorubicin; Hodgkin

1984
Antibody-dependent cellular cytotoxicity in some lymphoreticular diseases.
    Tumori, 1984, Feb-29, Volume: 70, Issue:1

    Topics: Antibody-Dependent Cell Cytotoxicity; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphami

1984
Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combine

1984
[Acute leukemias and solid tumors in the course of Hodgkin disease].
    Bulletin du cancer, 1983, Volume: 70, Issue:1

    Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco

1983
Second malignancy complicating Hodgkin's disease.
    Journal of the Canadian Association of Radiologists, 1983, Volume: 34, Issue:2

    Topics: Acute Disease; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cycloph

1983
Acute nonlymphocytic leukemia after treatment for Hodgkin's disease.
    The American journal of medicine, 1983, Volume: 75, Issue:3

    Topics: Acute Disease; Adult; Age Factors; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy

1983
[10 years of DeVita protocol].
    Deutsche medizinische Wochenschrift (1946), 1982, Jul-09, Volume: 107, Issue:27

    Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Therapy, Combination; Hodgkin Disease; Humans;

1982
[The current state of curability of Hodgkin's disease].
    Schweizerische medizinische Wochenschrift, 1981, Sep-05, Volume: 111, Issue:36

    Topics: Chromosome Aberrations; Drug Therapy, Combination; Hodgkin Disease; Humans; Leukemia; Mechlorethamin

1981
2 chlorodeoxyadenosine activity and cross resistance patterns in primary cultures of human hematologic neoplasms.
    British journal of cancer, 1993, Volume: 67, Issue:1

    Topics: Cladribine; Cytarabine; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leuk

1993
Leukemia risk following Hodgkin's disease: relation to cumulative dose of alkylating agents, treatment with teniposide combinations, number of episodes of chemotherapy, and bone marrow damage.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:5

    Topics: Adult; Aged; Alkylating Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Case-Co

1994
Differential inhibition of the DNA binding of transcription factors NF kappa B and OTF-1 by nitrogen mustard and quinacrine mustard: transcriptional implications.
    Carcinogenesis, 1993, Volume: 14, Issue:9

    Topics: Base Composition; Base Sequence; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; HIV Long

1993
Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells.
    Human gene therapy, 1996, May-01, Volume: 7, Issue:7

    Topics: Alkylating Agents; Animals; Blotting, Southern; Blotting, Western; Bone Marrow Transplantation; Chlo

1996
The risk of acute leukemia in patients treated for Hodgkin's disease is significantly higher aft [see bined modality programs than after chemotherapy alone and is correlated with the extent of radiotherapy and type and duration of chemotherapy: a case-con
    Haematologica, 1998, Volume: 83, Issue:9

    Topics: Abdomen; Actuarial Analysis; Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over;

1998
The risk of second malignant tumors and its consequences for the overall survival of Hodgkin's disease patients and for the choice of their treatment at presentation: analysis of a series of 1524 cases consecutively treated at the Florence University Hosp
    International journal of radiation oncology, biology, physics, 2001, Apr-01, Volume: 49, Issue:5

    Topics: Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Confidence Intervals; F

2001
Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero.
    Clinical lymphoma, 2001, Volume: 2, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Bleomyci

2001
Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation.
    British journal of haematology, 2002, Volume: 118, Issue:1

    Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbaz

2002
Long term experience with combination chemotherapy in advanced Hodgkin's disease.
    Clinical oncology, 1977, Volume: 3, Issue:2

    Topics: Adult; Antineoplastic Agents; Bleomycin; Drug Therapy, Combination; Female; Hodgkin Disease; Humans;

1977
Hematologic neoplasia in patients treated for Hodgkin's disease.
    The New England journal of medicine, 1977, Dec-08, Volume: 297, Issue:23

    Topics: Adult; Child; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Leukemia; Male; Mechloreth

1977
Drug-induced stimulation of transport of hydrolyzed nitrogen mustard and choline by normal and leukemic human cells in vitro.
    Cancer research, 1976, Volume: 36, Issue:3

    Topics: Biological Transport; Choline; Cocaine; Dose-Response Relationship, Drug; In Vitro Techniques; Leuke

1976
Hodgkin's disease and acute leukemia. Is it a true association?
    Archives of medical research, 1992,Spring, Volume: 23, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil

1992
Early stage Hodgkin's disease: ten-year results of a non-randomised study with radiotherapy alone or combined with MOPP.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 29A, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy;

1992
Enhancement of anthracycline and alkylator cytotoxicity by ethacrynic acid in primary cultures of human tissues.
    Cancer chemotherapy and pharmacology, 1990, Volume: 26, Issue:5

    Topics: Cell Survival; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Ethacrynic Acid; Human

1990
Growth and development of children of mothers treated with chemotherapy during pregnancy: current status of 43 children.
    American journal of hematology, 1991, Volume: 36, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Bleomyci

1991
Low O6-alkylguanine DNA alkyltransferase activity in the peripheral blood lymphocytes of patients with therapy-related acute nonlymphocytic leukemia.
    Cancer research, 1988, Jun-01, Volume: 48, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin; Hodgkin Disease

1988
[Acute leukemia in patients treated for Hodgkin's disease].
    Recenti progressi in medicina, 1988, Volume: 79, Issue:1

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Hodgkin Disease; Human

1988
[Second tumors in patients treated for Hodgkin's disease].
    Revista clinica espanola, 1988, Volume: 182, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modali

1988
Selective enhancement by menadiol of in vitro drug activity in human lymphatic neoplasms.
    Cancer treatment reports, 1987, Volume: 71, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colony-Forming Units Assay; D

1987
[Myelodysplastic syndromes: a group of preleukemic disorders].
    Nederlands tijdschrift voor geneeskunde, 1987, Sep-19, Volume: 131, Issue:38

    Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leukemia

1987
Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin's disease.
    The New England journal of medicine, 1987, Mar-19, Volume: 316, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Combined Modality Therapy;

1987
Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents.
    Annals of internal medicine, 1985, Volume: 103, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Combined Chemotherapy Prot

1985
International Symposium on Hodgkin's Disease. Session 4. Small group workshops. Report on workshop: Chemotherapy.
    National Cancer Institute monograph, 1973, Volume: 36

    Topics: Antineoplastic Agents; Bleomycin; Carmustine; Doxorubicin; Drug Therapy, Combination; Hodgkin Diseas

1973
[Cytostatic effects on nucleic acid- and protein synthesis of benign and malignant lymphomas].
    Chemotherapy, 1967, Volume: 12, Issue:3

    Topics: Amides; Antineoplastic Agents; Dactinomycin; DNA, Neoplasm; Hodgkin Disease; Humans; Hydralazine; In

1967
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
    Cancer research, 1974, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara

1974
Updated Hodgkin's disease. C. Advanced disease and special problems. Comment: the non-Hodgkin's lymphomas.
    JAMA, 1973, Jan-08, Volume: 223, Issue:2

    Topics: Burkitt Lymphoma; Cyclophosphamide; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Large B-C

1973
Influence of chemotherapeutic agents on the antibacterial activity of normal and leukemic sera.
    Journal of the National Cancer Institute, 1974, Volume: 52, Issue:3

    Topics: Antineoplastic Agents; Blood Bactericidal Activity; Carmustine; Cell Membrane; Complement System Pro

1974
Combination chemotherapy of acute leukemia and Hodgkin's disease.
    JAMA, 1972, Nov-27, Volume: 222, Issue:9

    Topics: Antineoplastic Agents; Drug Combinations; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Predni

1972
RNA metabolism in normal and leukaemic leucocytes: further studies on RNA synthesis.
    British journal of haematology, 1968, Volume: 14, Issue:3

    Topics: Antimetabolites; Busulfan; Carbon Isotopes; Chromatography; Humans; Leukemia; Leukemia, Lymphoid; Le

1968
[Results and current biological bases of therapy of malignant hemoreticulopathies].
    Studii si cercetari de medicina interna, 1971, Volume: 12, Issue:3

    Topics: Antineoplastic Agents; Chlorambucil; Cortisone; Cyclophosphamide; Humans; Hydrazines; Leukemia; Lymp

1971
The use of combination therapy in leukemia remission.
    Cancer, 1969, Volume: 24, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Central Nervous System Diseases; Child; Dactinomycin; Humans; Leu

1969
Drugs and their abuse no. V--misuse of cytotoxic drugs.
    Journal of the Irish Medical Association, 1971, Jul-22, Volume: 64, Issue:416

    Topics: Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Humans; Leukemia; Mechlorethamine; Melphalan;

1971
Chemotherapy of Hodgkin's disease, lymphoma, and leukemia.
    Radiologic clinics of North America, 1968, Volume: 6, Issue:1

    Topics: Adult; Antineoplastic Agents; Busulfan; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Lymphoma; M

1968