Page last updated: 2024-10-30

mechlorethamine and Injuries, Spinal Cord

mechlorethamine has been researched along with Injuries, Spinal Cord in 7 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

ExcerptRelevanceReference
"Melatonin was shown to play an important role in protecting animal cells from neutrophil-induced toxicity and damage by free radicals."1.31Potent protective effects of melatonin on experimental spinal cord injury. ( Fujimoto, T; Ikeda, T; Nakamura, T; Takagi, K, 2000)
"Gabexate mesilate is a synthetic protease inhibitor capable of inhibiting both coagulation and cytokine production by monocytes."1.30Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats. ( Johno, M; Kushimoto, S; Murakami, K; Naruo, M; Okabe, H; Okajima, K; Takatsuki, K; Taoka, Y; Uchiba, M, 1997)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's4 (57.14)18.2507
2000's2 (28.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Taoka, Y5
Okajima, K4
Uchiba, M3
Murakami, K4
Harada, N2
Johno, M4
Naruo, M4
Okabe, H2
Takatsuki, K2
Kushimoto, S1
Fujimoto, T2
Nakamura, T2
Ikeda, T2
Takagi, K2
Makowski, J1
Kiwerski, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432]Phase 240 participants (Anticipated)Interventional2016-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

7 other studies available for mechlorethamine and Injuries, Spinal Cord

ArticleYear
Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog.
    Journal of neurosurgery, 1997, Volume: 86, Issue:6

    Topics: Animals; Epoprostenol; Iloprost; Leukopenia; Male; Mechlorethamine; Peroxidase; Rats; Rats, Wistar;

1997
Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats.
    Critical care medicine, 1997, Volume: 25, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombins; Factor Xa; Gabexate; Hepari

1997
Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Feb-15, Volume: 18, Issue:4

    Topics: Animals; Anticoagulants; Leukocytes; Leukopenia; Male; Mechlorethamine; Peroxidase; Protein C; Rats;

1998
Role of neutrophil elastase in compression-induced spinal cord injury in rats.
    Brain research, 1998, Jul-20, Volume: 799, Issue:2

    Topics: Animals; Cephalosporins; Leukocyte Elastase; Leukopenia; Male; Mechlorethamine; Peroxidase; Proteins

1998
Effects of EPC-K1 on lipid peroxidation in experimental spinal cord injury.
    Spine, 2000, Volume: 25, Issue:1

    Topics: Alkylating Agents; Animals; Ascorbic Acid; Free Radical Scavengers; Leukocyte Count; Lipid Peroxidat

2000
Potent protective effects of melatonin on experimental spinal cord injury.
    Spine, 2000, Apr-01, Volume: 25, Issue:7

    Topics: Animals; Leukopenia; Lipid Peroxidation; Locomotion; Male; Mechlorethamine; Melatonin; Peroxidase; R

2000
[Nitrogen mustard effects in the treatment of spinal cord and peripheral nerve injuries].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1976, Jan-05, Volume: 31, Issue:1

    Topics: Adult; Humans; Male; Mechlorethamine; Middle Aged; Peripheral Nerve Injuries; Spinal Cord Injuries;

1976