Page last updated: 2024-10-30

mechlorethamine and Head and Neck Neoplasms

mechlorethamine has been researched along with Head and Neck Neoplasms in 31 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Research Excerpts

ExcerptRelevanceReference
" In the absence of evidence of a dose-response curve for platinum, the lower dosage schedules that can be used with acceptable toxicity on an outpatient basis should be selected."3.75Chemotherapy for squamous cell carcinoma of the head and neck: a progress report. ( Glick, JH; Taylor, SG; Zehngebot, LM, 1980)
"Thirty-four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five-drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus bacillus Calmette-Gu erin (BCG) by scarification (20 patients)."2.64Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study. ( Gutterman, JU; Hersh, EM; Livingston, RB; Richman, SP; Suen, JY, 1976)
"Besides human 2008 ovarian cancer cells we also found that human lung (A549) and head and neck cancer cells (SCC 25) were transiently sensitized by cisplatin."1.29Factors influencing the drug sensitization of human tumor cells for in situ lipofection. ( Huang, L; Son, K, 1996)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199028 (90.32)18.7374
1990's2 (6.45)18.2507
2000's0 (0.00)29.6817
2010's1 (3.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fenn, JE1
Udelsman, R1
CLIFFORD, P1
CLIFT, RA2
DUFF, JK1
HENRY, J1
LEBRUN, J1
SIMON, S1
SMETS, W1
MALHERBE, E2
SEALY, R2
HELMAN, P2
ANDERSON, J2
WESTBURY, G1
HARRIES, JR2
BROWN, F1
BEECHER, JL1
OETTGEN, HF1
HANNA, DC1
GAISFORD, JC1
GOLDWYN, RM1
APPAIX, A1
DEVIN, R1
PECH, A1
GARCIN, M2
SPITALIER, JM2
BEAHRS, OH1
CALDAROLA, VT1
HARRISON, EG1
CLAPP, P1
TAYAO, MS1
MILLER, DG1
LAWRENCE, W1
AMALRIC, R1
ROUX, G1
DUMOULIN, H1
DESGEORGE, Y1
HARTUNG, L1
KLOPP, CT1
SMITH, DF1
ALFORD, TC1
Glick, JH1
Zehngebot, LM1
Taylor, SG1
Bartual, J1
Roquette, J1
Gil, M1
Magro, E1
Bascuas, JL1
Wade, PM1
Smith, RE1
Johns, ME1
Son, K1
Huang, L1
Dubey, SP1
Sengupta, SK1
Kaleh, LK1
Morewaya, JT1
Richman, SP1
Livingston, RB1
Gutterman, JU1
Suen, JY1
Hersh, EM1
Tattersall, MH1
Tobias, JS1
Takaue, Y1
Sullivan, MP1
Ramirez, I1
Cleary, KR1
van Eys, J1
Donegan, WL1
Harris, HS1
Srivastava, SP1
Asopa, HS1
Agarwal, HS1
Gogoi, BN1
Kenis, Y1
Lawhorn, TI1
Stone, HH1
Martin, JD1
Hill, GJ1
Larsen, RR1
Pommatau, E1
Brunat, M1
Mayer, H1
Dargent, M1
Garas, J1
Nikolaides, G1
Ramantanis, G1
Tourlas, G1
Geogakas, A1
Tsatsaris, S1
Spanoudanis, C1
Politis, A1
Yonemoto, RH1
Byron, RL1
Riihimaki, DU1
Keating, JL1

Reviews

4 reviews available for mechlorethamine and Head and Neck Neoplasms

ArticleYear
Chemotherapy for squamous cell carcinoma of the head and neck: a progress report.
    American journal of otolaryngology, 1980, Volume: 1, Issue:4

    Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil; Clinical Trials as Topic;

1980
Response of esthesioneuroblastoma to chemotherapy. Report of five cases and review of the literature.
    Cancer, 1984, Mar-01, Volume: 53, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy;

1984
Chemotherapy of residual disease in solid tumours.
    Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1971, Volume: 16, Issue:2

    Topics: Colonic Neoplasms; Cyclophosphamide; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Lun

1971
Chemotherapy in solid tumors of childhood.
    Oncology, 1972, Volume: 26, Issue:2

    Topics: Abdominal Neoplasms; Adolescent; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Eye Neopla

1972

Trials

3 trials available for mechlorethamine and Head and Neck Neoplasms

ArticleYear
Chemotherapy for squamous cell carcinoma of the head and neck: a progress report.
    American journal of otolaryngology, 1980, Volume: 1, Issue:4

    Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil; Clinical Trials as Topic;

1980
Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study.
    Cancer treatment reports, 1976, Volume: 60, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; BCG Vaccine; Bleomycin; Carcinoma, Squamous Cell; Doxorubicin; F

1976
How strong is the case for intensive cancer chemotherapy?
    Lancet (London, England), 1976, Nov-13, Volume: 2, Issue:7994

    Topics: Antineoplastic Agents; Burkitt Lymphoma; Clinical Trials as Topic; Cyclophosphamide; Dose-Response R

1976

Other Studies

25 other studies available for mechlorethamine and Head and Neck Neoplasms

ArticleYear
First use of intravenous chemotherapy cancer treatment: rectifying the record.
    Journal of the American College of Surgeons, 2011, Volume: 212, Issue:3

    Topics: Antineoplastic Agents; Head and Neck Neoplasms; History, 20th Century; Humans; Infusions, Intravenou

2011
Nitrogen-mustard therapy combined with autologous marrow infusion.
    Lancet (London, England), 1961, Apr-01, Volume: 1, Issue:7179

    Topics: Bone Marrow; Bone Marrow Transplantation; Head and Neck Neoplasms; Mechlorethamine; Mustard Plant; N

1961
[Regional intraarterial perfusion of nitrogen mustard and simultaneous irradiation of extensive cancers of the head and neck].
    Acta chirurgica Belgica, 1960, Volume: 59

    Topics: Head and Neck Neoplasms; Humans; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds

1960
Contributions to the treatment of cancer of the head and neck. Nitrogen mustard toxicity and bone marrow infusion.
    East African medical journal, 1961, Volume: 38

    Topics: Bone Marrow; Bone Marrow Transplantation; Head; Head and Neck Neoplasms; Humans; Mechlorethamine; Ne

1961
Intraarterial chemotherapy and x-ray therapy in cancer of the head and neck. Technique, methods, results and complications.
    Clinical radiology, 1963, Volume: 14

    Topics: Head; Head and Neck Neoplasms; Humans; Mechlorethamine; Methotrexate; Neck; Neoplasms; Thiotepa; X-R

1963
CONTINUOUS INTRA-ARTERIAL INFUSION AND INTERMITTENT INTRA-ARTERIAL INJECTION.
    Proceedings of the Royal Society of Medicine, 1963, Volume: 56

    Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Ethoglucid; Head a

1963
HAEMODYNAMIC EFFECTS OF OCCLUSION OF ABDOMINAL AORTA DURING NITROGEN MUSTARD THERAPY.
    British medical journal, 1963, Sep-28, Volume: 2, Issue:5360

    Topics: Aorta; Aorta, Abdominal; Black People; Chemotherapy, Cancer, Regional Perfusion; Head; Head and Neck

1963
INTRA-ARTERIAL NITROGEN MUSTARD FOR CONTROL OF PAIN IN HEAD AND NECK CANCER.
    American journal of surgery, 1963, Volume: 106

    Topics: Head; Head and Neck Neoplasms; Injections; Injections, Intra-Arterial; Mechlorethamine; Neoplasms; P

1963
[REGIONAL CHEMOTHERAPY OF HEAD AND NECK CANCER (APROPOS OF 24 INFUSIONS AND 19 REGIONAL ARTERIAL PERFUSIONS)].
    La Presse medicale, 1963, Sep-21, Volume: 71

    Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Facial Neoplasms; Head; Head and Ne

1963
TREATMENT OF CANCER OF THE HEAD AND NECK BY CHEMOTHERAPY.
    JAMA, 1964, Sep-07, Volume: 189

    Topics: Alopecia; Diarrhea; Erythema; Head; Head and Neck Neoplasms; Injections, Intra-Arterial; Leukopenia;

1964
RESULTS OF REGIONAL CHEMOTHERAPY OF NEOPLASMS OF THE UPPER BODY BY TEMPORARY MID-TORSO VASCULAR OCCLUSION.
    Cancer, 1964, Volume: 17

    Topics: Alkylating Agents; Bone Marrow; Breast Neoplasms; Catheterization; Chemotherapy, Cancer, Regional Pe

1964
HEMODYNAMIC EFFECTS OF OCCLUSION OF THE ABDOMINAL AORTA DURING NITROGEN-MUSTARD THERAPY.
    American heart journal, 1964, Volume: 68

    Topics: Aorta; Aorta, Abdominal; Blood Pressure Determination; Blood Volume Determination; Chemotherapy, Can

1964
[APROPOS OF TREATMENT OF ADVANCED TUMORS OF THE HEAD AND NECK BY SIMULTANEOUS COMBINED RADIATION-ARTERIAL INFUSIONS OF NITROGEN MUSTARD].
    Journal de radiologie, d'electrologie, et de medecine nucleaire, 1964, Volume: 45

    Topics: Drug Therapy; Facial Neoplasms; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Mandibu

1964
Palliation achieved in carcinoma of the head and neck with intra-arterial chemotherapy.
    American journal of surgery, 1961, Volume: 102

    Topics: Head and Neck Neoplasms; Humans; Mechlorethamine; Neck; Nitrogen Mustard Compounds; Palliative Care

1961
Twelve years of experience with cytotoxic therapy in malignant tumors of the neck and head.
    Archives of oto-rhino-laryngology, 1982, Volume: 234, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide;

1982
Factors influencing the drug sensitization of human tumor cells for in situ lipofection.
    Gene therapy, 1996, Volume: 3, Issue:7

    Topics: Animals; Antineoplastic Agents; Bleomycin; Cation Exchange Resins; Chloramphenicol O-Acetyltransfera

1996
Adult head and neck lymphomas in Papua New Guinea: a retrospective study of 70 cases.
    The Australian and New Zealand journal of surgery, 1999, Volume: 69, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Combined Modali

1999
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G

1986
Factors influencing the success of arterial infusion chemotherapy for cancer of the head and neck.
    American journal of surgery, 1972, Volume: 123, Issue:5

    Topics: Age Factors; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell

1972
Intra-arterial cytotoxic therapy and x-ray therapy for cancer of the head and neck.
    Lancet (London, England), 1965, Jan-16, Volume: 1, Issue:7377

    Topics: Adenoma, Pleomorphic; Carcinoma, Squamous Cell; Facial Neoplasms; Fibrosarcoma; Head; Head and Neck

1965
The use and efficacy of intra--arterial injections of chemotherapeutic drugs in advanced cases of oral carcinomas.
    Indian journal of cancer, 1967, Volume: 4, Issue:3

    Topics: Cyclophosphamide; Facial Neoplasms; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Mec

1967
Cancer chemotherapy. I. Methods, agents and overall results in 400 patients.
    Oncology, 1972, Volume: 26, Issue:2

    Topics: Adenocarcinoma; Amides; Androgens; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Estrogens;

1972
Complete regression of metastatic tumors of the adult with antimitotic treatment.
    Journal of surgical oncology, 1974, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; F

1974
Surgical chemotherapy for treatment of experimental tumors (animals) and far advanced tumors (humans).
    International surgery, 1972, Volume: 57, Issue:8

    Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Head and Neck Neoplasms; Humans; Injections, Intr

1972
Historic and current intra-arterial chemotherapy.
    Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Catheterization; Chemotherapy, Cancer, Regional Per

1970