mechlorethamine has been researched along with Glioma in 14 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma." | 9.08 | Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998) |
| "We undertook a phase II study of combination chemotherapy with mechlorethamine (nitrogen mustard) 6 mg/m2 intravenously day 1 and day 8, vincristine 2 mg intravenously day 1 and day 8, and procarbazine 100 mg/m2 orally days 1 through 14 (MOP) in adults with recurrent high-grade glioma." | 9.06 | Mechlorethamine, vincristine, and procarbazine chemotherapy for recurrent high-grade glioma in adults: a phase II study. ( Baptista, J; Clark, K; Coyle, T; Graziano, S; King, R; Kirshner, J; Newman-Palmer, N; Poiesz, B; Scalzo, A; Winfield, J, 1990) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 8.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity." | 7.68 | Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991) |
| "Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma." | 5.08 | Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998) |
| "We undertook a phase II study of combination chemotherapy with mechlorethamine (nitrogen mustard) 6 mg/m2 intravenously day 1 and day 8, vincristine 2 mg intravenously day 1 and day 8, and procarbazine 100 mg/m2 orally days 1 through 14 (MOP) in adults with recurrent high-grade glioma." | 5.06 | Mechlorethamine, vincristine, and procarbazine chemotherapy for recurrent high-grade glioma in adults: a phase II study. ( Baptista, J; Clark, K; Coyle, T; Graziano, S; King, R; Kirshner, J; Newman-Palmer, N; Poiesz, B; Scalzo, A; Winfield, J, 1990) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 4.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Estramustine phosphate (EMP) is an anti-microtubule agent that induces apoptosis of glioma cells." | 3.71 | Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2. ( Noha, M; Sugisaki, Y; Takahashi, H; Teramoto, A; Watanabe, K; Yoshida, D, 2001) |
| "Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity." | 3.68 | Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HATIBOGLU, I | 1 |
| OWENS, G | 2 |
| JAVID, R | 1 |
| TALLON, M | 1 |
| STEPANIAN, G | 1 |
| BELMUSTO, L | 1 |
| Galanis, E | 1 |
| Buckner, JC | 1 |
| Burch, PA | 1 |
| Schaefer, PL | 1 |
| Dinapoli, RP | 1 |
| Novotny, PJ | 1 |
| Scheithauer, BW | 1 |
| Rowland, KM | 1 |
| Vukov, AM | 1 |
| Mailliard, JA | 1 |
| Morton, RF | 1 |
| Yoshida, D | 1 |
| Noha, M | 1 |
| Watanabe, K | 1 |
| Takahashi, H | 1 |
| Sugisaki, Y | 1 |
| Teramoto, A | 1 |
| Coyle, T | 2 |
| Bushunow, P | 1 |
| Winfield, J | 2 |
| Wright, J | 1 |
| Graziano, S | 2 |
| Allalunis-Turner, MJ | 1 |
| Day, RS | 1 |
| McKean, JD | 1 |
| Petruk, KC | 1 |
| Allen, PB | 1 |
| Aronyk, KE | 1 |
| Weir, BK | 1 |
| Huyser-Wierenga, D | 1 |
| Fulton, DS | 1 |
| Urtasun, RC | 1 |
| Baptista, J | 1 |
| Clark, K | 1 |
| Poiesz, B | 1 |
| Kirshner, J | 1 |
| Scalzo, A | 1 |
| Newman-Palmer, N | 1 |
| King, R | 1 |
| Evans, CG | 1 |
| Bodell, WJ | 3 |
| Tokuda, K | 1 |
| Doane-Setzer, P | 1 |
| Smith, MT | 1 |
| Takaue, Y | 1 |
| Sullivan, MP | 1 |
| Ramirez, I | 1 |
| Cleary, KR | 1 |
| van Eys, J | 2 |
| Baram, TZ | 1 |
| Cangir, A | 1 |
| Bruner, JM | 1 |
| Martinez-Prieto, J | 1 |
| Aida, T | 2 |
| Brdar, B | 1 |
| Mahaley, MS | 1 |
| Woodhall, B | 1 |
1 review available for mechlorethamine and Glioma
| Article | Year |
|---|---|
Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Hypersensit | 1992 |
2 trials available for mechlorethamine and Glioma
| Article | Year |
|---|---|
Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Glioma; | 1998 |
Mechlorethamine, vincristine, and procarbazine chemotherapy for recurrent high-grade glioma in adults: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; G | 1990 |
11 other studies available for mechlorethamine and Glioma
| Article | Year |
|---|---|
Results of intermittent, prolonged infusion of nitrogen mustard into the carotid artery in twelve patients with cerebral gliomas.
Topics: Brain Neoplasms; Carotid Arteries; Glioma; Humans; Mechlorethamine; Nitrogen Mustard Compounds | 1961 |
ARTERIAL INFUSION CHEMOTHERAPY OF PRIMARY GLIOMAS.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Glioma; Mechloreth | 1963 |
Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Astrocytes; Brain Neoplasms; Ele | 2001 |
Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Buthionine Sulfoximine; C | 1991 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatograp | 1987 |
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G | 1986 |
Salvage chemotherapy for recurrent primary brain tumors in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi | 1988 |
Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(II) in human glial-derived cell lines.
Topics: Carmustine; Cell Line; Cell Survival; Cisplatin; DNA; Dose-Response Relationship, Drug; Drug Resista | 1987 |
[Anticancer drug induced sister chromatid exchange and correlation to cell survival in human brain tumor cells].
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Cisplatin; Glioma; Hum | 1987 |
Induction of plasminogen activator by alkylating agents in a repair defective human glioblastoma cell strain.
Topics: Alkylating Agents; Cell Line; Cycloheximide; DNA Repair; Enzyme Induction; Glioma; Humans; Mechloret | 1986 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci | 1967 |