mechlorethamine has been researched along with Experimental Leukemia in 41 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On a molar basis, TGM was most toxic to normal BALB/c X DBA/2 F1 mice, with a 10% lethal dose (LD10) of 3." | 1.27 | Antitumor activity and bone marrow toxicity of aminoglucose mustard anticancer agents in mice. ( Cantrell, JE; Green, D; Schein, PS, 1986) |
| " Nitrogen mustard [(HN2) NCS-762] and x-rays were selectively toxic to P388/R cells." | 1.27 | Flow cytometric screening for selective toxicity to multidrug-resistant cells. ( Frankfurt, OS, 1987) |
| " The dose-response relationship for the potentiation was defined for DMSO." | 1.27 | Potentiation of nitrogen mustard cytotoxicity to leukemia cells by sulfur-containing compounds administered in vivo. ( Grates, HE; Valeriote, F, 1986) |
| "Amphotericin B (AmB) has been shown to potentiate the cytotoxicity of several different anticancer agents in AKR mice." | 1.26 | Potentiation of anticancer agents by amphotericin B. ( Dieckman, J; Medoff, G; Valeriote, F, 1981) |
| " The analysis consists of relating survival to the dosage level of each drug in the combination and using response surface techniques to determine the importance of drug interactions and to estimate optimal doses." | 1.26 | An improved method for analyzing survival data from combination chemotherapy experiments. ( Carter, WH; Stablein, DM; Wampler, GL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| TOKUOKA, S | 1 |
| ALEXANDER, P | 3 |
| MIKULSKI, ZB | 1 |
| FURMAN, GJ | 1 |
| ACKERMAN, GA | 2 |
| COHEN, C | 1 |
| TRAMS, EG | 1 |
| NADKARNI, MV | 1 |
| SMITH, PK | 1 |
| ARMAGHAN, V | 1 |
| GERHARTZ, H | 1 |
| WIEDEMANN, H | 1 |
| JEN, YF | 1 |
| DUNNING, WF | 1 |
| CURTIS, MR | 1 |
| FRIEDMAN, OM | 1 |
| BOGER, E | 1 |
| GRUBLIAUSKAS, V | 1 |
| SOMMER, H | 1 |
| TSOU, KC | 1 |
| SU, HC | 1 |
| CORREA, JN | 1 |
| ANDREWS, JR | 1 |
| NEMETH, L | 1 |
| GAL, F | 1 |
| SKIPPER, HE | 1 |
| BENNETT, LL | 1 |
| LANGHAM, WH | 1 |
| Valeriote, F | 4 |
| Tolen, S | 1 |
| Grunicke, H | 1 |
| Putzer, H | 1 |
| Scheidl, F | 1 |
| Wolff-Schreiner, E | 1 |
| Grünewald, K | 1 |
| Medoff, G | 1 |
| Dieckman, J | 1 |
| Yerushalmi, A | 1 |
| Yagil, G | 1 |
| Perito, S | 1 |
| Cenci, E | 1 |
| Sbaraglia, G | 1 |
| Vecchiarelli, A | 1 |
| Carter, WH | 1 |
| Stablein, DM | 1 |
| Wampler, GL | 1 |
| Wrathmell, AB | 1 |
| Goldenberg, GJ | 5 |
| Ujházy, V | 1 |
| Kolarov, J | 1 |
| Kuzela, S | 1 |
| Krempaský, V | 1 |
| Bohunická, E | 1 |
| Grates, HE | 2 |
| Chan, PK | 1 |
| DeNeve, WJ | 1 |
| Everett, CK | 1 |
| Suminski, JE | 1 |
| Valeriote, FA | 1 |
| Cantrell, JE | 1 |
| Green, D | 2 |
| Schein, PS | 2 |
| Frankfurt, OS | 1 |
| Bence, J | 1 |
| Somfai-Relle, S | 1 |
| Gáti, E | 1 |
| Dean, SW | 1 |
| McPherson, E | 1 |
| Frei, E | 1 |
| Schabel, FM | 1 |
| Goldin, A | 1 |
| Sinha, BK | 1 |
| Wodinsky, I | 2 |
| Swiniarski, J | 1 |
| Kensler, CJ | 1 |
| Venditti, JM | 1 |
| Cook, ES | 1 |
| Nutini, LG | 1 |
| Hazlett, LD | 1 |
| Terent'eva, TG | 1 |
| Fomina, IP | 1 |
| Navashin, SM | 1 |
| Kieler, J | 1 |
| Gromek, A | 1 |
| Nissen, NI | 1 |
| Kessel, D | 1 |
| Myers, M | 1 |
41 other studies available for mechlorethamine and Experimental Leukemia
| Article | Year |
|---|---|
[Leukemia-like changes in mice administered with nitrogen mustard N-oxide (nitromin)].
Topics: Animals; Leukemia; Leukemia, Experimental; Mechlorethamine; Mice; Nitrogen Mustard Compounds | 1955 |
Differences in the response of leukaemia cells in tissue culture to nitrogen mustard and to dimethyl myleran.
Topics: Animals; Busulfan; Leukemia, Experimental; Mechlorethamine; Nitrogen Mustard Compounds; Research Des | 1961 |
Effects of nitrogen mustard on the histochemistry of mouse lymphocytic leukaemia L 1210.
Topics: Animals; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocytes; Mechlorethamine; M | 1961 |
On the mechanism of action of the alkylating agents. II. Effects of nitrogen mustard, Myleran, and x-radiation on nucleic acid biosynthesis.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Busulfan; Leukemia, Experimental; Mechlorethamine | 1961 |
The effect of mustargen mixed with urethan in the treatment of IRC leukemia in Fischer rats.
Topics: Animals; Leukemia; Leukemia, Experimental; Mechlorethamine; Nitrogen Mustard Compounds; Rats; Rats, | 1961 |
[Alteration of experimental mouse leukemia with nitrogen mustard phosphamide esters].
Topics: Animals; Dimethoate; Esters; Leukemia; Leukemia, Experimental; Mechlorethamine; Mice | 1961 |
[TUMOUR CHEMOTHERAPY. IX. NITROGEN MUSTARDS OF PHOSPHORAMIDE, PHOSPHORAMIDE ESTER AND THIOESTER].
Topics: Animals; Fibrosarcoma; Leukemia; Leukemia, Experimental; Mechlorethamine; Mice; Neoplasms; Nitrogen | 1962 |
COMPARATIVE RESPONSE OF A SPECTRUM OF TRANSPLANTABLE RAT NEOPLASMS TO NITROGEN MUSTARD, TRIETHYLENEMELAMINE, AND A GROUP OF BENZALDEHYDE MUSTARD DERIVATIVES.
Topics: Animals; Benzaldehydes; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Female; Humans; Injectio | 1964 |
SYNTHESIS OF N-PHOSPHORYLATED DERIVATIVES OF NITROGEN MUSTARDS WITH LATENT CYTOTOXICITY.
Topics: Animals; Chemistry, Pharmaceutical; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymp | 1963 |
SYNTHESIS OF POSSIBLE CANCER CHEMOTHERAPEUTIC COMPOUNDS BASED ON ENZYME APPROACH. V. TETRAZOLIUM NITROGEN MUSTARDS.
Topics: Animals; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Leukemia; Leukemia, Experiment | 1963 |
MODIFICATION OF THE RADIATION EFFECT ON ASCITIC TUMOUR CELLS BY PHARMACOLOGICAL AGENTS INJECTED INTRAVENOUSLY.
Topics: beta-Aminoethyl Isothiourea; Glutathione; Injections; Injections, Intravenous; Leukemia; Leukemia, E | 1964 |
[Comparative studies on the effect of dimethanesulfonyl-D-mannitol and mannitol mustard on animal leukemia].
Topics: Leukemia; Leukemia, Experimental; Mannitol; Mannomustine; Mechlorethamine; Nitrogen Mustard Compound | 1962 |
Over-all tracer studies with C14 labeled nitrogen mustard in normal and leukemic mice.
Topics: Animals; Leukemia, Experimental; Mechlorethamine; Mice; Nitrogen Mustard Compounds; Research | 1951 |
Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721.
Topics: Amifostine; Animals; Cell Survival; Drug Interactions; Drug Synergism; Hematopoietic Stem Cells; Leu | 1982 |
Inhibition of tumor growth by alkylation of the plasma membrane.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Membrane; Drug Resistance; Leukemia, Experime | 1982 |
Potentiation of anticancer agents by amphotericin B.
Topics: Amphotericin B; Animals; Antineoplastic Agents; Carmustine; Cell Survival; Colony-Forming Units Assa | 1981 |
The interaction of chromatin with alkylating agents. The monofunctional action of bis(2-chloroethyl)methylamine.
Topics: Animals; Cattle; Chromatin; DNA; DNA, Neoplasm; Hydrogen-Ion Concentration; Kinetics; Leukemia L5178 | 1980 |
[The use of BCG as immunoadjuvant in combination with antitumor drugs in a virus induced leukemia. II].
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; BCG Vaccine; Cyclophosphamide; Dimethoate; F | 1980 |
An improved method for analyzing survival data from combination chemotherapy experiments.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; | 1979 |
Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
Topics: Animals; Antibody Formation; Antigens, Neoplasm; BCG Vaccine; Immunization; Leukemia, Experimental; | 1976 |
The role of drug transport in resistance to nitrogen mustard and other alkylating agents in L518Y lymphoblsts.
Topics: Alkylating Agents; Animals; Binding, Competitive; Biological Transport; Carmustine; Cell Line; Chlor | 1975 |
Different inhibitory effect of nitrogen mustard (HN2) and TS-160 (HN3) on choline transport in L 5178Y lymphoblasts.
Topics: Alkylating Agents; Amines; Animals; Binding, Competitive; Biological Transport; Choline; Leukemia, E | 1975 |
Potentiation of nitrogen mustard cytotoxicity by disulfiram, diethyldithiocarbamic acid, and diethylamine in mice.
Topics: Animals; Diethylamines; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Drug Synergism; Leu | 1989 |
Cross-linkage of nucleophosmin in tumor cells by nitrogen mustard.
Topics: Animals; Cell Nucleus; Cross-Linking Reagents; Hypertrophy; Leukemia P388; Leukemia, Experimental; L | 1989 |
Influence of WR2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo.
Topics: Amifostine; Animals; Bone Marrow; DNA; DNA Damage; Female; Leukemia, Experimental; Male; Mechloretha | 1988 |
Antitumor activity and bone marrow toxicity of aminoglucose mustard anticancer agents in mice.
Topics: Amino Sugars; Animals; Antineoplastic Agents; Blood Glucose; Bone Marrow; DNA; Leukemia P388; Leukem | 1986 |
Flow cytometric screening for selective toxicity to multidrug-resistant cells.
Topics: Animals; Cell Line; Colony-Forming Units Assay; Combined Modality Therapy; Doxorubicin; Drug Resista | 1987 |
Potentiation of nitrogen mustard cytotoxicity to leukemia cells by sulfur-containing compounds administered in vivo.
Topics: Amino Acids; Animals; Drug Synergism; Female; Hematopoietic Stem Cells; Leukemia, Experimental; Male | 1986 |
Development and some characteristics of a P388 leukemia strain resistant to 1, 2:5, 6-dianhydrogalactitol.
Topics: Animals; Cell Count; Cell Survival; Cyclophosphamide; Dianhydrogalactitol; Drug Resistance; Female; | 1986 |
6-[Bis(2-chloroethyl)amino]-6-deoxygalactopyranose hydrochloride (C6-galactose mustard), a new alkylating agent with reduced bone marrow toxicity.
Topics: Animals; Bone Marrow; DNA Replication; Drug Evaluation, Preclinical; Female; Galactosamine; Hematopo | 1987 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Drug-induced stimulation of nitrogen mustard and choline transport and other systems in L5178Y lymphoblasts in vitro.
Topics: Amino Acids; Aminoisobutyric Acids; Aminolevulinic Acid; Animals; Atropine; Biological Transport; Ce | 1974 |
Protection of L5178Y lymphoblasts by choline and ethanolamine against cytocidal effect of nitrogen mustard in vitro.
Topics: Animals; Binding, Competitive; Choline; Ethanolamines; Female; Hydrolysis; Injections, Intraperitone | 1973 |
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouraci | 1974 |
Counteraction of leukopenia caused by mechlorethamine and azathioprine.
Topics: Animals; Antineoplastic Agents; Azathioprine; Dogs; Erythrocyte Count; Female; Kidney Transplantatio | 1971 |
Short-term effects of actinomycin D and nitrogen mustard on murine lymphocytic leukemia P388.
Topics: Animals; Cell Nucleolus; Dactinomycin; Depression, Chemical; Glucosephosphate Dehydrogenase; Histocy | 1971 |
[Experimental study of the antineoplastic effect of the antibiotic polymycin].
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Antiviral Agents; As | 1970 |
Studies on the antineoplastic effect of vanadium salts.
Topics: Animals; Carcinoma, Ehrlich Tumor; Leukemia, Experimental; Mechlorethamine; Mice; Sarcoma, Experimen | 1965 |
Accumulation of two alkylating agents, nitrogen mustard and busulfan, by murine leukemia cells in vitro.
Topics: Amines; Animals; Busulfan; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Mechloretham | 1969 |
The effects of nitrogen mustard and dimethyl myleran on murine leukemia cell lines of different radiosensitivity in vitro.
Topics: Animals; Busulfan; Culture Techniques; Leukemia, Experimental; Mechlorethamine; Mice; Nitrogen Musta | 1965 |
Comparison of direct and indirect effects of alkylating agents and radiation on murine leukaemia cells in vitro.
Topics: Animals; Busulfan; Cell Division; Culture Techniques; Leukemia, Experimental; Lymphocytes; Mechloret | 1966 |