mechlorethamine has been researched along with Ependymoma in 2 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity." | 1.30 | MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. ( Ater, JL; Bruner, J; Copeland, DR; Moore, B; van Eys, J; Woo, SY, 1997) |
| "Five children with brain tumors, who had had no prior chemotherapy, were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, prednisolone (MOPP) and intrathecal methotrexate." | 1.27 | [Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors]. ( Akita, H; Hashimoto, T; Hirose, M; Matsumoto, K; Miki, Y; Miyao, M; Ninomiya, T; Saijo, T; Sato, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ater, JL | 1 |
| van Eys, J | 1 |
| Woo, SY | 1 |
| Moore, B | 1 |
| Copeland, DR | 1 |
| Bruner, J | 1 |
| Sato, J | 1 |
| Ninomiya, T | 1 |
| Saijo, T | 1 |
| Akita, H | 1 |
| Miki, Y | 1 |
| Hirose, M | 1 |
| Hashimoto, T | 1 |
| Miyao, M | 1 |
| Matsumoto, K | 1 |
2 other studies available for mechlorethamine and Ependymoma
| Article | Year |
|---|---|
MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, | 1997 |
[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Choroid Pl | 1986 |