mechlorethamine has been researched along with Disease Models, Animal in 40 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glomerular fibrin deposition is important in the pathogenesis of renal failure and crescent formation in glomerulonephritis." | 7.67 | Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. ( Holdsworth, SR; Tipping, PG, 1985) |
| "Glomerular fibrin deposition is important in the pathogenesis of renal failure and crescent formation in glomerulonephritis." | 3.67 | Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. ( Holdsworth, SR; Tipping, PG, 1985) |
| "Alopecia areata is regarded as a tissue-restricted autoimmune disease of hair follicles in which follicular activity is arrested because of the continued activity of lymphocytic infiltrates." | 2.42 | Old wine in new bottles: reviving old therapies for alopecia areata using rodent models. ( Lui, H; Shapiro, J; Sundberg, JP; Tang, L, 2003) |
| " Peak edema occurred 24-48 h after NM administration using optimized dosing methods and volume." | 1.91 | Depilatory double-disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures. ( Gao, D; Laskin, JD; Li, S; Roldan, TL; Sinko, PJ, 2023) |
| "In the DRS-treated group, the corneal opacity and corneal neovascularization were less severe, and development of iris atrophy was delayed." | 1.39 | Use of amphoteric rinsing solution for treatment of ocular tissues exposed to nitrogen mustard. ( Avni, I; Barkana, Y; Berenshtein, E; Chevion, M; Goldich, Y; Rosner, M; Zadok, D, 2013) |
| "Intervertebral disc degeneration (IDD) is a common and debilitating disorder that results in reduced flexibility of the spine, pain, and reduced mobility." | 1.36 | Accelerated aging of intervertebral discs in a mouse model of progeria. ( Alber, S; Bentley, D; Coehlo, P; Huard, J; Kang, J; Lee, J; Loppini, M; Niedernhofer, LJ; Robbins, PD; Robinson, A; Seo, HY; Sowa, G; Studer, R; Taylor, L; Usas, A; Vo, N; Wang, D; Watkins, SC, 2010) |
| "Melatonin was administered intraperitoneally with two different doses (20mg/kg or 40mg/kg) beginning 1h before HN2 application and continued every 12h for six replications." | 1.34 | Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard. ( Korkmaz, A; Kurt, B; Oter, S; Reiter, RJ; Topal, T; Ucar, M; Yaren, H, 2007) |
| "Treatment with WEB 2086 significantly (P < 0." | 1.30 | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. ( Berend, N; Matheson, MJ; McClean, MA; Rynell, AC, 1997) |
| " From a dose-response showing that the administration of increasing doses of tissue thromboplastin resulted in a subsequent progressive increase of thrombus weight, two concentrations of tissue thromboplastin were chosen: a high dose (550 microL/kg, IV) where thrombus formation was optimal and a concentration (7 microL/kg, IV) where tissue thromboplastin-hypercoagulability was intermediate." | 1.28 | Importance of platelets in experimental venous thrombosis in the rat. ( Bernat, A; Herbert, JM; Maffrand, JP, 1992) |
| "We chose listeriosis because resistance to Listeria monocytogenes occurs in two phases." | 1.27 | Models of T cell deficiency in listeriosis: the effects of cortisone and cyclosporin A on normal and nude BALB/c mice. ( Davis, CE; Douglas, H; Schaffner, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (45.00) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 5 (12.50) | 29.6817 |
| 2010's | 8 (20.00) | 24.3611 |
| 2020's | 5 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Roldan, TL | 1 |
| Li, S | 1 |
| Laskin, JD | 2 |
| Gao, D | 1 |
| Sinko, PJ | 1 |
| Lin, M | 1 |
| Guo, W | 1 |
| Zhang, Z | 1 |
| Zhou, Y | 1 |
| Chen, J | 1 |
| Wang, T | 1 |
| Zhong, X | 1 |
| Lu, Y | 1 |
| Yang, Q | 1 |
| Wei, Q | 1 |
| Han, M | 1 |
| Xu, D | 1 |
| Gao, J | 1 |
| Solopov, P | 1 |
| Biancatelli, RMLC | 1 |
| Marinova, M | 1 |
| Dimitropoulou, C | 1 |
| Catravas, JD | 1 |
| Businaro, R | 1 |
| Maggi, E | 1 |
| Armeli, F | 1 |
| Murray, A | 1 |
| Laskin, DL | 2 |
| Ilhan, A | 1 |
| Yolcu, U | 1 |
| Oztas, E | 1 |
| Erdem, U | 1 |
| Jain, AK | 1 |
| Tewari-Singh, N | 1 |
| Inturi, S | 1 |
| Orlicky, DJ | 1 |
| White, CW | 1 |
| Agarwal, R | 1 |
| Venosa, A | 1 |
| Malaviya, R | 1 |
| Choi, H | 1 |
| Gow, AJ | 1 |
| Vo, N | 1 |
| Seo, HY | 1 |
| Robinson, A | 1 |
| Sowa, G | 1 |
| Bentley, D | 1 |
| Taylor, L | 1 |
| Studer, R | 1 |
| Usas, A | 1 |
| Huard, J | 1 |
| Alber, S | 1 |
| Watkins, SC | 1 |
| Lee, J | 1 |
| Coehlo, P | 1 |
| Wang, D | 1 |
| Loppini, M | 1 |
| Robbins, PD | 1 |
| Niedernhofer, LJ | 1 |
| Kang, J | 1 |
| Całkosiński, I | 2 |
| Rosińczuk-Tonderys, J | 2 |
| Dzierzba, K | 2 |
| Bronowicka-Szydełko, A | 2 |
| Seweryn, E | 1 |
| Majda, J | 2 |
| Całkosińska, M | 2 |
| Gamian, A | 1 |
| Kunak, ZI | 1 |
| Macit, E | 1 |
| Yaren, H | 2 |
| Yaman, H | 1 |
| Cakir, E | 1 |
| Aydin, I | 1 |
| Turker, T | 1 |
| Kurt, YG | 1 |
| Ozcan, A | 1 |
| Uysal, B | 1 |
| Isbilir, S | 1 |
| Akgul, EO | 1 |
| Cayci, T | 1 |
| Korkmaz, A | 2 |
| Kenar, L | 2 |
| Bazan, J | 1 |
| Dobrzyński, M | 1 |
| Goldich, Y | 1 |
| Barkana, Y | 1 |
| Zadok, D | 1 |
| Avni, I | 1 |
| Berenshtein, E | 1 |
| Rosner, M | 1 |
| Chevion, M | 1 |
| Karayilanoğlu, T | 1 |
| Gunhan, O | 1 |
| Kurt, B | 2 |
| Tang, L | 1 |
| Sundberg, JP | 1 |
| Lui, H | 1 |
| Shapiro, J | 1 |
| Busygina, V | 1 |
| Suphapeetiporn, K | 1 |
| Marek, LR | 1 |
| Stowers, RS | 1 |
| Xu, T | 1 |
| Bale, AE | 1 |
| Ucar, M | 1 |
| Reiter, RJ | 1 |
| Oter, S | 1 |
| Topal, T | 1 |
| Cole, DF | 1 |
| Körbling, M | 1 |
| Hunstein, W | 1 |
| Bito, LZ | 1 |
| Lefkowith, JB | 1 |
| Okegawa, T | 1 |
| DeSchryver-Kecskemeti, K | 1 |
| Needleman, P | 1 |
| Keren, G | 1 |
| Wolman, M | 1 |
| Schaffner, A | 1 |
| Douglas, H | 2 |
| Davis, CE | 1 |
| Meisenberg, BR | 1 |
| Melaragno, AJ | 1 |
| Monroy, RL | 1 |
| Matheson, MJ | 1 |
| Rynell, AC | 1 |
| McClean, MA | 1 |
| Berend, N | 1 |
| Liu, W | 1 |
| Okajima, K | 1 |
| Murakami, K | 1 |
| Harada, N | 1 |
| Isobe, H | 1 |
| Irie, T | 1 |
| Wormser, U | 1 |
| Brodsky, B | 1 |
| Reich, R | 1 |
| Ziegler, EJ | 1 |
| Cooke, TD | 1 |
| Richer, S | 1 |
| Hurd, E | 1 |
| Jasin, HE | 1 |
| DeVita, VT | 1 |
| Olenchock, SA | 1 |
| Mentnech, MS | 1 |
| Mull, JC | 1 |
| Gladish, ME | 1 |
| Green, FH | 1 |
| Manor, PC | 1 |
| du Vivier, A | 1 |
| Stoughton, RB | 1 |
| Charache, S | 1 |
| Dreyer, R | 1 |
| Zimmerman, I | 1 |
| Hsu, CK | 1 |
| Herbert, JM | 1 |
| Bernat, A | 1 |
| Maffrand, JP | 1 |
| Holdsworth, SR | 1 |
| Tipping, PG | 1 |
| Wilson, CB | 1 |
| Hoshino, T | 1 |
| Whitaker, AN | 1 |
| Frei, E | 1 |
| Schabel, FM | 1 |
| Goldin, A | 1 |
| Gaynor, E | 1 |
| Maguire, HC | 1 |
5 reviews available for mechlorethamine and Disease Models, Animal
| Article | Year |
|---|---|
Nutraceuticals as potential therapeutics for vesicant-induced pulmonary fibrosis.
Topics: Animals; Chemical Warfare Agents; Dietary Supplements; Disease Models, Animal; Humans; Irritants; Me | 2020 |
Old wine in new bottles: reviving old therapies for alopecia areata using rodent models.
Topics: Alopecia Areata; Animals; Anthralin; Disease Models, Animal; Mechlorethamine; Rodentia | 2003 |
In vitro chemoseparation as part of autologous bone marrow transplantation (ABMT) in hematologic malignancy.
Topics: Acute Disease; Animals; Bone Marrow; Bone Marrow Transplantation; Cyclophosphamide; Disease Models, | 1984 |
Species differences in the responses of the eye to irritation and trauma: a hypothesis of divergence in ocular defense mechanisms, and the choice of experimental animals for eye research.
Topics: Aging; Animals; Anterior Chamber; Aotus trivirgatus; Aqueous Humor; Biological Evolution; Blood; Cat | 1984 |
Human models of human diseases; breast cancer and the lymphomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Disease Models, Animal; Drug Therapy, Combination; | 1979 |
35 other studies available for mechlorethamine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Depilatory double-disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures.
Topics: Acetone; Acetylcholinesterase; Animals; Disease Models, Animal; Female; Irritants; Male; Mechloretha | 2023 |
Reduced Toxicity of Liposomal Nitrogen Mustard Prodrug Formulation Activated by an Intracellular ROS Feedback Mechanism in Hematological Neoplasm Models.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Survival; Disease Models, Animal; Drug Compounding; | 2020 |
The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice.
Topics: Animals; Biomarkers; Disease Models, Animal; Extracellular Matrix Proteins; HSP90 Heat-Shock Protein | 2020 |
Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury.
Topics: Animals; Antioxidants; Burns, Chemical; Chemical Warfare Agents; Disease Models, Animal; Eye Injurie | 2018 |
Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice.
Topics: Animals; Apoptosis; Blister; Cell Proliferation; Chemical Warfare Agents; Dermatitis, Contact; Disea | 2014 |
Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis.
Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Gene Expression Regulation; Inflammation Med | 2016 |
Accelerated aging of intervertebral discs in a mouse model of progeria.
Topics: Aging; Animals; Apoptosis; Cellular Senescence; Disease Models, Animal; DNA-Binding Proteins; Endonu | 2010 |
Estimation of the action of three different mechlorethamine doses on biochemical parameters during experimentally induced pleuritis in rats.
Topics: Acute-Phase Proteins; Alkylating Agents; Animals; Carrageenan; Complement C3; Disease Models, Animal | 2011 |
Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity.
Topics: Animals; Chemical Warfare Agents; Disease Models, Animal; Inflammation; Isothiuronium; Kidney Diseas | 2012 |
Mechlorethamine (NTG) effects on the erythrocytic and leukocytic blood parameters during experimentally induced pleuritis in rats.
Topics: Alkylating Agents; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2012 |
Use of amphoteric rinsing solution for treatment of ocular tissues exposed to nitrogen mustard.
Topics: Animals; Atrophy; Burns, Chemical; Chemical Warfare Agents; Corneal Diseases; Corneal Neovasculariza | 2013 |
The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard.
Topics: Animals; Biopsy; Burns, Chemical; Chemical Warfare Agents; Chlorides; Deferoxamine; Dermatologic Age | 2003 |
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.
Topics: Animals; Cisplatin; Cross-Linking Reagents; Disease Models, Animal; Drosophila; Drosophila Proteins; | 2004 |
Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard.
Topics: Animals; Antioxidants; Biomarkers; Chemical Warfare Agents; Disease Models, Animal; Dose-Response Re | 2007 |
PREVENTION OF EXPERIMENTAL OCULAR HYPERTENSION WITH POLYPHLORETIN PHOSPHATE.
Topics: Alkylating Agents; Animals; Aqueous Humor; Blood Pressure; Disease Models, Animal; Eye Proteins; Int | 1961 |
Macrophage-dependent arachidonate metabolism in hydronephrosis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Chromatography, Thin Layer; Dinop | 1984 |
Can pseudomonas infection in experimental animals mimic Kawasaki's disease?
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Fructose; Guinea Pigs; Humans; Immune System; Inj | 1984 |
Models of T cell deficiency in listeriosis: the effects of cortisone and cyclosporin A on normal and nude BALB/c mice.
Topics: Animals; Bone Marrow; Cortisone; Cyclosporins; Disease Models, Animal; Female; Immunologic Deficienc | 1983 |
Granulocyte colony stimulating factor (G-CSF) for mustard-induced bone marrow suppression.
Topics: Animals; Bone Marrow; Clinical Protocols; Disease Models, Animal; Granulocyte Colony-Stimulating Fac | 1993 |
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azep | 1997 |
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
Topics: Animals; Capillary Permeability; Cephalosporins; Disease Models, Animal; Gastric Mucosa; Glycine; Le | 1998 |
Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity.
Topics: Administration, Topical; Animals; Dermatologic Agents; Disease Models, Animal; Guinea Pigs; Irritant | 2002 |
Pseudomonas aeruginosa vasculitis and bacteremia following conjunctivitis: a simple model of fatal pseudomonas infection in neutropenia.
Topics: Agranulocytosis; Animals; Blood Bactericidal Activity; Conjunctivitis; Disease Models, Animal; Mechl | 1979 |
Localization of antigen-antibody complexes in intraarticular collagenous tissues.
Topics: Adult; Aged; Animals; Antigen-Antibody Complex; Arthritis; Arthritis, Rheumatoid; Arthus Reaction; C | 1975 |
Complement, polymorphonuclear leukocytes and platelets in acute experimental respiratory reactions to Aspergillus.
Topics: Acute Disease; Aerosols; Animals; Antigens, Fungal; Aspergillus; Blood Cell Count; Blood Platelets; | 1979 |
An animal model for screening topical and systemic drugs for potential use in the treatment of psoriasis.
Topics: Administration, Topical; Animals; Cyclophosphamide; Disease Models, Animal; DNA; Drug Evaluation, Pr | 1975 |
Evaluation of extracorporeal alkylation of red cells as a potential treatment for sickle cell anemia.
Topics: Alkylating Agents; Anemia, Sickle Cell; Animals; Disease Models, Animal; Dogs; Erythrocyte Aging; Er | 1976 |
Importance of platelets in experimental venous thrombosis in the rat.
Topics: Animals; Blood Platelets; Clopidogrel; Disease Models, Animal; Heparin; Hirudins; Leukopenia; Male; | 1992 |
Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit.
Topics: Animals; Basement Membrane; Blood Coagulation Tests; Disease Models, Animal; Fibrin; Glomerulonephri | 1985 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
Acute renal failure in disseminated intravascular coagulation. Experimental studies of the induction and prevention of renal fibrin deposition.
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Angiotensin II; Animals; Anticoagulants; Blood Platele | 1974 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
The role of granulocytes in endotoxin-induced vascular injury.
Topics: Agranulocytosis; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Disease Models, Animal | 1973 |
Induction of delayed hypersensitivity to nitrogen mustard in the guinea-pig.
Topics: Allergens; Animals; Biopsy; Dimethyl Sulfoxide; Disease Models, Animal; Erythema; Female; Freund's A | 1974 |