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mechlorethamine and Carcinoma 256, Walker

mechlorethamine has been researched along with Carcinoma 256, Walker in 42 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Carcinoma 256, Walker: A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
" In rats dosed with SR 4233 in vivo, significantly higher levels of 8-hydroxydeoxyguanosine could be detected in liver, compared to vehicle-dosed controls."1.29Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions. ( Cahill, A; Jenkins, TC; Pickering, P; White, IN, 1995)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199040 (95.24)18.7374
1990's2 (4.76)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MCDONALD, GO1
CRUZ, EP1
COLE, WH1
MCNAIR, TJ1
WIBIN, FA1
HOPPE, ET1
SCHMIDT, JL1
DEPEYSTER, JA1
NYHAN, WL1
LOH HOEHN-SARIC, E1
INCH, WR2
McCREDIE, JA2
AGOSTINO, D2
CLIFFTON, EE2
DASGUPTA, T1
PIETRA, G1
SCORTECCI, V1
SICE, J1
IWAMOTO, RH1
ACTON, EM1
ROSS, LO1
SKINNER, WA1
BAKER, BR1
GOODMAN, L4
TSOU, KC1
SU, HC1
MCKIBBIN, B1
DEGRAW, J1
FARPOUR, A1
FISHER, B1
FISHER, ER1
GROSSI, CE1
COLE, DR1
ROUSSELOT, LM1
ZIMMER, H1
SILL, AD1
BURKE, WJ1
BROWN, JE1
WEATHERBEE, C1
CURTIS, DH1
SMITH, HE1
COOK, SL1
ZIMEL, H1
MACRINEANU, A1
MARTINEZ, AP2
LEE, WW2
Cahill, A2
Jenkins, TC1
Pickering, P1
White, IN3
Merriman, RL1
Sladek, NE2
Suzanger, M1
Mattocks, AR1
Bailey, E1
Farmer, PB1
Connors, TA1
Dean, SW2
Johnson, AB1
Tew, KD4
Grunicke, H3
Doppler, W2
Hofmann, J3
Lindner, H1
Maly, K2
Oberhuber, H1
Ringsdorf, H1
Roberts, JJ1
Moy, BC1
Helliger, W2
Hermann, BJ2
Höck, W2
Puschendorf, B2
Buller, AL1
Clapper, ML1
Gibson, NW1
Everett, J1
Goldenberg, GJ1
Sinha, BK1
Terent'eva, TG1
Fomina, IP1
Navashin, SM1
Foster, AB1
Jarman, M1
Ross, WC1
Tisdale, MJ1
Elson, LA1
Cambanis, A1
Dobre, V1
Niculescu-Duvăz, I1
Smith, GM1
Garvie, WH2
Hellmann, K1
Tucker, DF1

Other Studies

42 other studies available for mechlorethamine and Carcinoma 256, Walker

ArticleYear
The effect of cancer inhibitor drugs on the take of Walker carcinosarcoma 256 in rats.
    Surgical forum, 1957, Volume: 7

    Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Mechlorethamine; Neoplasms, Experimental; Nit

1957
Antitumor action of several new piperazine derivatives compared to certain standard anticancer agents.
    The Journal of surgical research, 1963, Volume: 3

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Fluorouracil; Humans; Mechloretham

1963
Effects of nitrogen mustards on the incorporation of amino acids into the proteins of tumors and other tissues; the mustard derivative of serine.
    Biochemical pharmacology, 1963, Volume: 12

    Topics: Amino Acids; Animals; Carcinoma; Carcinoma 256, Walker; Humans; Mechlorethamine; Methionine; Mustard

1963
Effect of aging aqueous nitrogen mustard on white blood cell count, body weight, and Walker 256 tumor in the rat.
    Canadian journal of biochemistry and physiology, 1963, Volume: 41

    Topics: Animals; Body Weight; Carcinoma; Carcinoma 256, Walker; Leukocyte Count; Mechlorethamine; Rats

1963
Effect of wound irrigation with nitrogen mustard or Clorpactin XCB on local recurrence of rat and mouse tumors.
    Cancer, 1963, Volume: 16

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma; Carcinoma 256, Walker; Mechlorethamine

1963
Decrease in pulmonary metastases: potentiation of nitrogen mustard effect by heparin and fibrinolysin.
    Annals of surgery, 1963, Volume: 157

    Topics: Animals; Carcinoma; Carcinoma 256, Walker; Fibrinolysin; Heparin; Lung Neoplasms; Mechlorethamine; N

1963
CARCINOSTATIC PROPERTIES OF MECHLORETHAMINE OXIDE.
    Archives internationales de pharmacodynamie et de therapie, 1964, May-01, Volume: 149

    Topics: Animals; Carcinoma; Carcinoma 256, Walker; Mechlorethamine; Neoplasm Metastasis; Pharmacology; Rats;

1964
POTENTIAL ANTICANCER AGENTS. LXXIX. AROMATIC NITROGEN MUSTARDS DERIVED FROM CYSTEINE.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Cysteine; Mechlo

1963
SYNTHESIS OF POSSIBLE CANCER CHEMOTHERAPEUTIC COMPOUNDS BASED ON ENZYME APPROACH. V. TETRAZOLIUM NITROGEN MUSTARDS.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Animals; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Leukemia; Leukemia, Experiment

1963
DESTRUCTION OF MALIGNANT CELLS IN PERITONEAL CAVITY. EXPERIMENTAL USE OF A CHEMOTHERAPEUTIC AGENT.
    Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 89

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Iatrogenic Disease; Injections; In

1964
ALKYLATING AGENTS DERIVED FROM INDOLES. IV. SYNTHESIS OF THE 5-NITROGEN MUSTARD OF INDOLE-3-CARBOXYLIC ACID.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Alkylating Agents; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Indoles; Mechloretha

1964
TRANSPLANTABLE LUNG CANCER IN RATS. EFFECT OF TREATMENT.
    Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 89

    Topics: Animals; Blood; Carcinoma; Carcinoma 256, Walker; Fibrinolysin; Heparin; Lung Neoplasms; Mechloretha

1964
EFFECT OF EXPERIMENTAL PERFUSION UPON THE BIOLOGIC AND PATHOLOGIC BEHAVIOR OF TUMOR.
    Surgery, 1964, Volume: 56

    Topics: Biological Products; Carcinoma; Carcinoma 256, Walker; Chemotherapy, Cancer, Regional Perfusion; Lun

1964
INTRALUMINAL CHEMOTHERAPY WITH NITROGEN MUSTARD IN SIMULATED CANCER OF THE COLON IN THE RAT.
    The Journal of surgical research, 1964, Volume: 4

    Topics: Absorption; Carcinoma; Carcinoma 256, Walker; Cecal Neoplasms; Colonic Neoplasms; Mechlorethamine; N

1964
POTENTIAL ANTICANCER AGENTS. IV. HETEROCYCLIC PHOSPHORAMIDE NITROGEN MUSTARDS.
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Antineoplastic Agents; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Mechlorethamine; Neoplasms;

1964
CYANO ANALOGS OF PHENOLIC NITROGEN MUSTARDS.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Animals; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Leukemia L1210; Mechlorethamin

1964
ETHYL N-BENZYLLEUCINATE NITROGEN MUSTARD.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Mechlorethamine; Nitrogen Mustard Compo

1964
[RESEARCH ON THE ANTIBLASTIC ACTION OF A NITROGEN MUSTARD OF THE URETHANE TYPE BOUND TO HYDROCORTISONE].
    Studii si cercetari de endocrinologie, 1964, Volume: 15

    Topics: Animals; Carcinoma; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Hydrocortisone; Mammary Neoplas

1964
NITROGEN MUSTARDS DERIVED FROM 3,4-DIHYDRO-2, 4-DIOXO-1(2H)-PYRIMIDINEPROPIONIC AND -BUTYRIC ACIDS.
    Journal of medicinal chemistry, 1965, Volume: 8

    Topics: Butyrates; Carcinoma; Carcinoma 256, Walker; Chemistry, Pharmaceutical; Mechlorethamine; Nitrogen Mu

1965
Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions.
    Chemico-biological interactions, 1995, Mar-30, Volume: 95, Issue:1-2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aerobiosis; Animals; Antineoplastic Agents; Biotransformation; Carcinom

1995
Cytotoxic activity of mechlorethamine and melphalan against cultured tumor cells: potentiation by caffeine.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 206, Issue:2

    Topics: Animals; Antineoplastic Agents; Caffeine; Carcinoma 256, Walker; Cells, Cultured; Drug Synergism; Ly

1978
Reductive activation of N-oxides to cause DNA strand breakage in cell lines in vitro.
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: Aerobiosis; Anaerobiosis; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Line; Cell Tra

1991
Reduction of nitromin to nitrogen mustard: unscheduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines.
    Carcinogenesis, 1989, Volume: 10, Issue:11

    Topics: Aerobiosis; Anaerobiosis; Animals; Antineoplastic Agents; Carcinoma 256, Walker; DNA Repair; In Vitr

1989
A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas.
    Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7

    Topics: Animals; Carcinoma 256, Walker; Cell Line; Cross-Linking Reagents; DNA; Dose-Response Relationship,

1986
Plasma membrane as target of alkylating agents.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Calcium Channel Blockers; Carcinoma 256, Walk

1985
Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines.
    Chemico-biological interactions, 1985, Volume: 54, Issue:2

    Topics: Adenosine Monophosphate; Animals; Antigens, Nuclear; Carcinoma 256, Walker; Cell Line; Chromatograph

1985
Differential sensitivity of histone acetylation in nitrogen-mustard sensitive and resistant cells. Relation to drug uptake, formation and repair of DNA-interstrand cross-links.
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:12

    Topics: Acetylation; Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyclophosphamid

1988
Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.
    Molecular pharmacology, 1987, Volume: 31, Issue:6

    Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Chlorambucil; Cytosol; Drug Resistance; Glutathio

1987
Alkylating antitumor agents reduce histone acetyl-transferase activity.
    Advances in enzyme regulation, 1986, Volume: 25

    Topics: Acetylation; Acetyltransferases; Animals; Butyrates; Butyric Acid; Carcinoma 256, Walker; Carcinoma,

1986
Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity.
    Molecular pharmacology, 1986, Volume: 30, Issue:1

    Topics: Animals; Carcinoma 256, Walker; Cell Line; Dacarbazine; DNA, Neoplasm; Drug Resistance; Mammary Neop

1986
Walker carcinosarcoma 256 in study of anticancer agents. II. Results.
    Cancer research, 1966, Volume: 26, Issue:8 Pt 2

    Topics: Acetates; Animals; Antineoplastic Agents; Azirines; Benzene; Benzoates; Butyrates; Carcinoma 256, Wa

1966
Bioassay and relative cytotoxic potency of cyclophosphamide metabolites generated in vitro and in vivo.
    Cancer research, 1973, Volume: 33, Issue:6

    Topics: Acrolein; Animals; Biological Assay; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Cyclophosph

1973
Nitrogen mustard sensitivity and choline transport in Walker 256 carcinosarcoma cells in vitro.
    Cancer research, 1973, Volume: 33, Issue:11

    Topics: Animals; Binding, Competitive; Biological Transport, Active; Carbon Radioisotopes; Carcinoma 256, Wa

1973
[Experimental study of the antineoplastic effect of the antibiotic polymycin].
    Antibiotiki, 1970, Volume: 15, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Antiviral Agents; As

1970
N-(2-chloroethyl)-N-(2-hydroxyethyl)arylamines. Possible intermediates to potential carcinolytic agents bearing dissimilar reactive functions.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:8

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lethal Dose 50; Mechloreth

1972
DL-willardiine mustard.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Culture Techniques; Leukemia L1210

1968
Growth inhibitory and haematological effects of alkylating agents and attempts at their modification to give greater selectivity of anti-tumour action.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Alkylating Agents; Animals; Body Weight; Carcinoma 256, Walker; Chemical Phenomena; Chemistry; Chlor

1968
Potential anticancer agents. V. New aromatic nitrogen mustards related to 3-[N,N-bis(2-chloroethyl)amino]-4-methylbenzoic acid.
    Journal of medicinal chemistry, 1969, Volume: 12, Issue:1

    Topics: Amides; Animals; Antineoplastic Agents; Benzoates; Carcinoma 256, Walker; Chemical Phenomena; Chemis

1969
A comparison of the effects of cytotoxic agents on the Walker 256 tumour growing in the rat and at the hamster cheek pouch.
    British journal of cancer, 1969, Volume: 23, Issue:1

    Topics: Animals; Carcinoma 256, Walker; Cheek; Cricetinae; Female; Male; Mechlorethamine; Methotrexate; Neop

1969
The action of protamine derivatives and nitrogen mustard on the growth of the Walker 256 rat carcinoma.
    British journal of cancer, 1965, Volume: 19, Issue:3

    Topics: Animals; Carcinoma 256, Walker; Drug Synergism; Injections, Intraperitoneal; Mechlorethamine; Protam

1965
Localization of tumours and drugs on the chorio-allantoic membrane of the chick embryo.
    Nature, 1965, Sep-25, Volume: 207, Issue:5004

    Topics: Animals; Carcinoma 256, Walker; Chick Embryo; Cyclophosphamide; Extraembryonic Membranes; Mechloreth

1965
Studies on induced tumour resistance.
    The British journal of surgery, 1966, Volume: 53, Issue:1

    Topics: Animals; Antibody Formation; Carcinoma 256, Walker; Mechlorethamine; Neoplasms; Rats

1966