mechlorethamine and Cancer of Skin studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

Excerpt	Relevance	Reference
"In total, 260 patients with stage IA to IIA mycosis fungoides who had not used topical mechlorethamine within 2 years and were naive to prior use of topical carmustine therapy."	9.17	Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. ( Adelson, DM; Duvic, M; Guitart, J; Hull, CM; Kim, EJ; Kim, YH; Kimball, AB; Knobler, EH; Lessin, SR; Naylor, MF; Olsen, EA; Pandya, AG; Rook, AH; Strober, BE; Sundram, U; Wood, GS; Wu, H, 2013)
"To determine if a therapeutic regimen of twice-weekly applications of mechlorethamine hydrochloride and betamethasone dipropionate cream is effective in the treatment of early-stage mycosis fungoides while increasing cutaneous tolerance."	9.11	Treatment of early-stage mycosis fungoides with twice-weekly applications of mechlorethamine and topical corticosteroids: a prospective study. ( Bagot, M; Bernard, P; Beylot-Barry, M; Cordel, N; Courville, P; D'Incan, M; de Quatrebarbes, J; Delaunay, M; Estève, E; Joly, P; Souteyrand, P; Vaillant, L, 2005)
"Topical mechlorethamine hydrochloride is commonly used in the treatment of mycosis fungoides and has been formulated in both aqueous and ointment vehicles."	9.07	Topical mechlorethamine in the treatment of mycosis fungoides. Uniformity of application and potential for environmental contamination. ( Ballman, EA; Blumsack, RF; Breneman, DL; Breneman, JC; Davis, M; Nartker, AL; Pruemer, JM, 1991)
"Of 42 patients who had mycosis fungoides (MF) confined to the skin with or without dermatopathic lymphadenopathy, 21 were treated with topically applied mechlorethamine hydrochloride and 21 with total-skin electron-beam irradiation."	9.05	Treatment of mycosis fungoides: total-skin electron-beam irradiation vs topical mechlorethamine therapy. ( Hamminga, B; Noordijk, EM; van Vloten, WA, 1982)
"The feasibility of employing adjuvant topical mechlorethamine after electron beam therapy in the treatment of patients with mycosis fungoides is demonstrated."	9.04	The treatment of mycosis fungoides: adjuvant topical mechlorethamine after electron beam therapy. ( Constantine, VS; Farber, EM; Fuks, ZY; Hoppe, RT; Price, NM, 1977)
"The pivotal 201 Study investigated chlormethine/mechlorethamine gel treatment for patients with early stage disease mycosis fungoides and demonstrated the treatment was not inferior to chlormethine ointment."	8.02	Evaluating the Treatment Patterns of Chlormethine/Mechlorethamine Gel in Patients With Stage I-IIA Mycosis Fungoides: By-time Reanalysis of a Randomized Controlled Phase 2 Study. ( Angello, JT; Geskin, LJ; Kim, EJ; Kim, YH, 2021)
"Chlormethine/mechlorethamine gel is a skin-directed therapy for patients with mycosis fungoides cutaneous T-cell lymphoma."	8.02	The PROVe Study: US Real-World Experience with Chlormethine/Mechlorethamine Gel in Combination with Other Therapies for Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma. ( Akilov, OE; Angello, JT; Bailey, WL; Geskin, LJ; Girardi, M; Guitart, J; Kim, EJ; Musiek, A; Querfeld, C, 2021)
" We report the case of a follicular mycosis fungoides in a lung transplant recipient who was successfully treated with topical mechlorethamine, prior to subsequent renal transplantation."	7.74	Mycosis fungoides in a lung transplant recipient with advanced ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation. ( Aubert, JD; Duchosal, MA; Laffitte, E; Panizzon, RG; Pascual, M; Venetz, JP, 2008)
"Mechlorethamine therapy is a cost-effective and easily administered treatment for cutaneous T-cell lymphomas."	7.70	A prospective study of cutaneous intolerance to topical mechlorethamine therapy in patients with cutaneous T-cell lymphomas. French Study Group of Cutaneous Lymphomas. ( Avril, MF; Bagot, M; Beylot-Barry, M; Delaunay, M; Estève, E; Grange, F; Joly, P; Laroche, L; Souteyrand, P; Thomine, E; Vaillant, L; Wechsler, J, 1999)
"Two patients with histologically proven mycosis fungoides, a malignancy of phenotypically mature T cells, received a topical challenge with mechlorethamine to areas of clinically uninvolved skin to exclude possible hypersensitivity reactions to this chemotherapeutic agent."	7.69	Detection of low-level tumor cells in allergic contact dermatitis induced by mechlorethamine in patients with mycosis fungoides. ( Sklar, JL; Veelken, H; Wood, GS, 1996)
"One hundred seventeen patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride."	7.67	Topical mechlorethamine therapy for early stage mycosis fungoides. ( Halperin, PS; Ramsay, DL; Zeleniuch-Jacquotte, A, 1988)
"Forty-two patients with intransit metastases of melanoma in a limb were treated by isolated regional perfusion chemotherapy using mechlorethamine (nitrogen mustard)."	7.67	Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard). ( Fortner, JG; Gould-Rossbach, P; Guerra, J; Horowitz, G; Knapper, WH; Ray, C; Schnog, J; Shiu, MH; Yeh, S, 1986)
"Ten patients with advanced stage (TNM IIB-IVB) mycosis fungoides were treated with a combination chemotherapy program consisting of bleomycin and methotrexate weekly, doxorubicin every 3 weeks, and topical nitrogen mustard daily (BAM-M)."	7.67	Treatment of advanced stage mycosis fungoides with bleomycin, doxorubicin, and methotrexate with topical nitrogen mustard (BAM-M). ( Adelstein, DJ; Davis, BR; Hines, JD; Zakem, MH, 1986)
"Complete responses lasting from 4 to 14 years were documented in 65 of 331 (20%) patients with cutaneous T cell lymphoma treated with topical mechlorethamine (HN2) between 1968 and 1982."	7.67	Long-term efficacy, curative potential, and carcinogenicity of topical mechlorethamine chemotherapy in cutaneous T cell lymphoma. ( Kantor, AF; Micaily, B; Shrager, L; Tan, ET; Van Scott, EJ; Vonderheid, EC, 1989)
"A six-year experience in 20 patients with advanced mycosis fungoides treated with combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides showed initial complete remissions in 16 patients (85%)."	7.67	Combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides: a six-year experience. ( Thestrup-Pedersen, K; Zachariae, H, 1987)
"Seventy-six patients with mycosis fungoides (MF) were given topical mechlorethamine hydrochloride therapy."	7.67	Response of mycosis fungoides to topical chemotherapy with mechlorethamine. ( Dubin, N; Parnes, RE; Ramsay, DL, 1984)
"A group of 243 patients with mycosis fungoides (MF) received treatment with topical applications of dilute aqueous solutions of mechlorethamine and/or systemic chemotherapy over the past 10 years."	7.66	A 10-year experience with topical mechlorethamine for mycosis fungoides: comparison with patients treated by total-skin electron-beam radiation therapy. ( Johnson, WC; Van Scott, EJ; Vonderheid, EC; Wallner, PE, 1979)
"Patients with limited skin involvement by mycosis fungoides were treated with daily topical mechlorethamine."	7.65	Topical mechlorethamine therapy for mycosis fungoides. ( Constantine, VS; Farber, EM; Fuks, ZY; Hoppe, RT; Price, NM, 1977)
"Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years."	7.65	Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration. ( Price, NM, 1977)
"The cutaneous manifestations of mycosis fungoides have been successfully treated in nine patients for 16 to 28 months with oral methoxsalen and subsequent irradiation with longwave ultraviolet light."	7.65	Oral methoxsalen photochemotherapy of mycosis fungoides. ( Fitzpatrick, TB; Gilchrest, BA; Haynes, HA; Parrish, JA; Tanenbaum, L, 1976)
" Off-label dosing modifications, as well as co-administration of topical steroids and an aggressive moisturization regimen, can be used to reduce these side-effects."	5.62	Management of Mycosis Fungoides with Topical Chlormethine/Mechlorethamine Gel: A Columbia University Cutaneous Lymphoma Center Experience. ( Garcia-Saleem, TJ; Geskin, LJ; Khaleel, AE; Stonesifer, CJ, 2021)
"In total, 260 patients with stage IA to IIA mycosis fungoides who had not used topical mechlorethamine within 2 years and were naive to prior use of topical carmustine therapy."	5.17	Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. ( Adelson, DM; Duvic, M; Guitart, J; Hull, CM; Kim, EJ; Kim, YH; Kimball, AB; Knobler, EH; Lessin, SR; Naylor, MF; Olsen, EA; Pandya, AG; Rook, AH; Strober, BE; Sundram, U; Wood, GS; Wu, H, 2013)
"To determine if a therapeutic regimen of twice-weekly applications of mechlorethamine hydrochloride and betamethasone dipropionate cream is effective in the treatment of early-stage mycosis fungoides while increasing cutaneous tolerance."	5.11	Treatment of early-stage mycosis fungoides with twice-weekly applications of mechlorethamine and topical corticosteroids: a prospective study. ( Bagot, M; Bernard, P; Beylot-Barry, M; Cordel, N; Courville, P; D'Incan, M; de Quatrebarbes, J; Delaunay, M; Estève, E; Joly, P; Souteyrand, P; Vaillant, L, 2005)
" Six of these patients showed allergic contact dermatitis to mechlorethamine after a mean period of 9."	5.10	Evaluation of a 1-h exposure time to mechlorethamine in patients undergoing topical treatment. ( Dalac, S; Delaunay, M; Dréno, B; Evrard, V; Foulc, P; Guillot, B; Verret, JL, 2002)
"Topical mechlorethamine hydrochloride is commonly used in the treatment of mycosis fungoides and has been formulated in both aqueous and ointment vehicles."	5.07	Topical mechlorethamine in the treatment of mycosis fungoides. Uniformity of application and potential for environmental contamination. ( Ballman, EA; Blumsack, RF; Breneman, DL; Breneman, JC; Davis, M; Nartker, AL; Pruemer, JM, 1991)
"Of 42 patients who had mycosis fungoides (MF) confined to the skin with or without dermatopathic lymphadenopathy, 21 were treated with topically applied mechlorethamine hydrochloride and 21 with total-skin electron-beam irradiation."	5.05	Treatment of mycosis fungoides: total-skin electron-beam irradiation vs topical mechlorethamine therapy. ( Hamminga, B; Noordijk, EM; van Vloten, WA, 1982)
"The feasibility of employing adjuvant topical mechlorethamine after electron beam therapy in the treatment of patients with mycosis fungoides is demonstrated."	5.04	The treatment of mycosis fungoides: adjuvant topical mechlorethamine after electron beam therapy. ( Constantine, VS; Farber, EM; Fuks, ZY; Hoppe, RT; Price, NM, 1977)
" The additional use of mechlorethamine or oral psoralen plus UV-A, but not radiation, was significantly associated with the development of basal cell carcinoma and squamous cell carcinoma, but not malignant melanoma."	4.79	Malignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. The influence of additional therapy after total skin electron beam radiation. ( Braverman, IM; Feldman, AM; Kacinski, BM; Licata, AG; Wilson, LD, 1995)
"The two major topical treatment modalities for cutaneous T-cell lymphoma (CTCL) are mechlorethamine (nitrogen mustard) and topical carmustine (BCNU)."	4.79	Topical treatment of early cutaneous T-cell lymphoma. ( Meller, JA; Ramsay, DL; Zackheim, HS, 1995)
"The pivotal 201 Study investigated chlormethine/mechlorethamine gel treatment for patients with early stage disease mycosis fungoides and demonstrated the treatment was not inferior to chlormethine ointment."	4.02	Evaluating the Treatment Patterns of Chlormethine/Mechlorethamine Gel in Patients With Stage I-IIA Mycosis Fungoides: By-time Reanalysis of a Randomized Controlled Phase 2 Study. ( Angello, JT; Geskin, LJ; Kim, EJ; Kim, YH, 2021)
"Chlormethine/mechlorethamine gel is a skin-directed therapy for patients with mycosis fungoides cutaneous T-cell lymphoma."	4.02	The PROVe Study: US Real-World Experience with Chlormethine/Mechlorethamine Gel in Combination with Other Therapies for Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma. ( Akilov, OE; Angello, JT; Bailey, WL; Geskin, LJ; Girardi, M; Guitart, J; Kim, EJ; Musiek, A; Querfeld, C, 2021)
" We report the case of a follicular mycosis fungoides in a lung transplant recipient who was successfully treated with topical mechlorethamine, prior to subsequent renal transplantation."	3.74	Mycosis fungoides in a lung transplant recipient with advanced ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation. ( Aubert, JD; Duchosal, MA; Laffitte, E; Panizzon, RG; Pascual, M; Venetz, JP, 2008)
"Mechlorethamine therapy is a cost-effective and easily administered treatment for cutaneous T-cell lymphomas."	3.70	A prospective study of cutaneous intolerance to topical mechlorethamine therapy in patients with cutaneous T-cell lymphomas. French Study Group of Cutaneous Lymphomas. ( Avril, MF; Bagot, M; Beylot-Barry, M; Delaunay, M; Estève, E; Grange, F; Joly, P; Laroche, L; Souteyrand, P; Thomine, E; Vaillant, L; Wechsler, J, 1999)
"Eleven patients with mycosis fungoides had X-ray examinations of their lungs before, during and after topical treatment with mechlorethamine."	3.69	Long-term topical nitrogen mustard treatment does not induce pulmonary fibrosis in MF patients. ( Knudsen, N; Nielsen, M; Rasmussen, K; Thestrup-Pedersen, K, 1994)
"Two patients with histologically proven mycosis fungoides, a malignancy of phenotypically mature T cells, received a topical challenge with mechlorethamine to areas of clinically uninvolved skin to exclude possible hypersensitivity reactions to this chemotherapeutic agent."	3.69	Detection of low-level tumor cells in allergic contact dermatitis induced by mechlorethamine in patients with mycosis fungoides. ( Sklar, JL; Veelken, H; Wood, GS, 1996)
"Patients with mycosis fungoides (n = 23) or Sézary syndrome (n = 5) were treated with 4 months of recombinant interferon alfa together with isotretinoin, followed by total skin electron beam therapy alone (for stage I to II disease) or preceded by chemotherapy (for stage III to IV disease)."	3.69	Combined modality therapy for cutaneous T-cell lymphoma. ( Cabanillas, FF; Duvic, M; Eifel, PJ; Kurzrock, R; Lemak, NA; Redman, JR; Tucker, SL, 1996)
"Seventy-six patients with mycosis fungoides (MF) were given topical mechlorethamine hydrochloride therapy."	3.67	Response of mycosis fungoides to topical chemotherapy with mechlorethamine. ( Dubin, N; Parnes, RE; Ramsay, DL, 1984)
"Ten patients with advanced stage (TNM IIB-IVB) mycosis fungoides were treated with a combination chemotherapy program consisting of bleomycin and methotrexate weekly, doxorubicin every 3 weeks, and topical nitrogen mustard daily (BAM-M)."	3.67	Treatment of advanced stage mycosis fungoides with bleomycin, doxorubicin, and methotrexate with topical nitrogen mustard (BAM-M). ( Adelstein, DJ; Davis, BR; Hines, JD; Zakem, MH, 1986)
"A six-year experience in 20 patients with advanced mycosis fungoides treated with combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides showed initial complete remissions in 16 patients (85%)."	3.67	Combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides: a six-year experience. ( Thestrup-Pedersen, K; Zachariae, H, 1987)
"Complete responses lasting from 4 to 14 years were documented in 65 of 331 (20%) patients with cutaneous T cell lymphoma treated with topical mechlorethamine (HN2) between 1968 and 1982."	3.67	Long-term efficacy, curative potential, and carcinogenicity of topical mechlorethamine chemotherapy in cutaneous T cell lymphoma. ( Kantor, AF; Micaily, B; Shrager, L; Tan, ET; Van Scott, EJ; Vonderheid, EC, 1989)
"One hundred seventeen patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride."	3.67	Topical mechlorethamine therapy for early stage mycosis fungoides. ( Halperin, PS; Ramsay, DL; Zeleniuch-Jacquotte, A, 1988)
"Twenty-one patients with tumor stage mycosis fungoides (MF) with or without lymph node (LN) involvement, were treated with total skin electron beam irradiation (TSEB) followed by six monthly cycles of systemic chemotherapy (CT) of either mechlorethamine (HN2) or cyclophosphamide (CTX) with vincristine (VCR), procarbazine, and prednisone (PRD) (COPP or MOPP)."	3.67	Combined modality therapy for tumor stage mycosis fungoides: results of a 10-year follow-up. ( Baron, JM; Griem, ML; Griem, SF; Hallahan, DE; Lorincz, AL; Medenica, M; Soltani, K, 1988)
"Specific treatments for mycosis fungoides, including electron beam irradiation, topical mechlorethamine, and psoralen plus ultraviolet A (PUVA) may be associated with the development of skin cancers after a variable latency period."	3.67	Cutaneous malignancies and metastatic squamous cell carcinoma following topical therapies for mycosis fungoides. ( Abel, EA; Hoppe, RT; Sendagorta, E, 1986)
"Forty-two patients with intransit metastases of melanoma in a limb were treated by isolated regional perfusion chemotherapy using mechlorethamine (nitrogen mustard)."	3.67	Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard). ( Fortner, JG; Gould-Rossbach, P; Guerra, J; Horowitz, G; Knapper, WH; Ray, C; Schnog, J; Shiu, MH; Yeh, S, 1986)
"A group of 243 patients with mycosis fungoides (MF) received treatment with topical applications of dilute aqueous solutions of mechlorethamine and/or systemic chemotherapy over the past 10 years."	3.66	A 10-year experience with topical mechlorethamine for mycosis fungoides: comparison with patients treated by total-skin electron-beam radiation therapy. ( Johnson, WC; Van Scott, EJ; Vonderheid, EC; Wallner, PE, 1979)
"Eleven mycosis fungoides patients were phototested on apparently normal skin before treatment with mechlorethamine, topically in 8 patients and with methoxsypsoralen followed by longwave ultraviolet light (PUVA) in 3 patients."	3.66	Normalized light reactions in mycosis fungoides patients after complete remission of skin lesions. ( Volden, G, 1980)
"The cutaneous manifestations of mycosis fungoides have been successfully treated in nine patients for 16 to 28 months with oral methoxsalen and subsequent irradiation with longwave ultraviolet light."	3.65	Oral methoxsalen photochemotherapy of mycosis fungoides. ( Fitzpatrick, TB; Gilchrest, BA; Haynes, HA; Parrish, JA; Tanenbaum, L, 1976)
"Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years."	3.65	Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration. ( Price, NM, 1977)
"Twenty-six patients with mycosis fungoides were treated topically with three nitrosourea compounds: carmustine (BCNU), lomustine (CCNU), and 1-methyl-1-nitrosourea."	3.65	Treatment of mycosis fungoides with topical nitrosourea compounds: Further studies. ( Epstein, EH; Zackheim, HS, 1975)
"Patients with limited skin involvement by mycosis fungoides were treated with daily topical mechlorethamine."	3.65	Topical mechlorethamine therapy for mycosis fungoides. ( Constantine, VS; Farber, EM; Fuks, ZY; Hoppe, RT; Price, NM, 1977)
"A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years."	3.65	Topical chemotherapy and immunotherapy of mycosis fungoides: intermediate-term results. ( Asbell, SO; Grekin, DA; Johnson, WC; Van Scott, EJ; Vonderheid, EC, 1977)
" However, the optimal regimen regarding frequency and dosing as well as combination and maintenance therapy is not well established."	2.82	The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region). ( Assaf, C; Booken, N; Dippel, E; Guenova, E; Jonak, C; Klemke, CD; Nicolay, JP; Schlaak, M; Trautinger, F; Wobser, M, 2022)
" CL gel has a manageable safety profile, with most adverse events being mild and skin related."	2.82	Chlormethine Gel for Patients with Mycosis Fungoides Cutaneous T Cell Lymphoma: A Review of Efficacy and Safety in Clinical Trial and Real-World Settings. ( Ardigò, M; Nikbakht, N; Papadavid, E; Querfeld, C; Wehkamp, U, 2022)
"The cause of mycosis fungoides is unknown and, with the possible exception of very early stage disease, no cure is available."	2.43	Treatment of cutaneous T-cell lymphoma/mycosis fungoides. ( Bradley, B; Parker, SR, 2006)
"Follicular mycosis fungoides is an unusual variant of mycosis fungoides (MF)."	2.41	Follicular mycosis fungoides: a case report and review of the literature. ( DeBloom, J; Gaspari, A; Scott, G; Severson, J, 2001)
" However, most workers in the field acknowledge that issues of optimal dosing and curative potency remain unresolved."	2.38	Total skin electron irradiation: efficacy in early mycosis fungoides. ( Dale, J; Kuten, A; Leviov, M; Rosenblatt, E; Tatcher, M, 1993)
" Adverse events (AE) were recorded in 43."	1.72	Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions. ( Dalamaga, M; Koumourtzis, M; Lampadaki, K; Papadavid, E, 2022)
"Chlormethine gel was approved for treatment of mycosis fungoides, the most common cutaneous T-cell lymphoma, on the basis of results from study 201 and study 202."	1.72	Chlormethine Gel Versus Chlormethine Ointment for Treatment of Patients with Mycosis Fungoides: A Post-Hoc Analysis of Clinical Trial Data. ( Assaf, C; Guitart, J; Hodak, E; Kim, YH; Quaglino, P; Querfeld, C; Scarisbrick, JJ, 2022)
" Off-label dosing modifications, as well as co-administration of topical steroids and an aggressive moisturization regimen, can be used to reduce these side-effects."	1.62	Management of Mycosis Fungoides with Topical Chlormethine/Mechlorethamine Gel: A Columbia University Cutaneous Lymphoma Center Experience. ( Garcia-Saleem, TJ; Geskin, LJ; Khaleel, AE; Stonesifer, CJ, 2021)
" Chlormethine gel could be combined with other skin-directed or systemic therapies for optimal benefit."	1.62	Chlormethine Gel in Combination with Other Therapies in the Treatment of Patients with Mycosis Fungoides Cutaneous T Cell Lymphoma: Three Case Reports. ( Karagianni, F; Koumourtzis, M; Lampadaki, K; Marinos, L; Papadavid, E, 2021)
"Hypopigmented mycosis fungoides is characterized by early onset, occurrence in dark-skinned individuals, and good response to therapy."	1.31	Hypopigmented mycosis fungoides: treatment and a 6(1/2)-year follow-up of 9 patients. ( Akaraphanth, R; Douglass, MC; Lim, HW, 2000)
"Although effective at treating mycosis fungoides (MF), nitrogen mustard (HN(2)) creates potential exposure risks to those who administer it, including health care workers and family members."	1.31	Exposure at home to airborne concentrations of nitrogen mustard during topical application for the treatment of mycosis fungoides: a case study. ( Lewis-Younger, C; Lillquist, DR; Snell, J; Wallace, DO, 2000)
"Clinical features predictive of disease progression include initial lymphadenopathy (stage IIA) and lack of complete response to initial treatment."	1.30	Clinical characteristics and long-term outcome of patients with generalized patch and/or plaque (T2) mycosis fungoides. ( Chow, S; Hoppe, RT; Kim, YH; Varghese, A, 1999)
"Clinical course or treatment for granulomatous fungoides mycosis or classical fungoid mycosis."	1.30	[Granulomatous mycosis fungoides histologically simulating cutaneous sarcoidosis]. ( Croué, A; François, S; Maillard, H; Verret, JL, 1998)
"Side effects in the treatment of mycosis fungoides with topical nitrogen mustard include allergic contact dermatitis, hyperpigmentation, urticaria, and erythema multiforme-like dermatitis."	1.29	Atypical cutaneous changes after topical treatment with nitrogen mustard in patients with mycosis fungoides. ( Garcia, JA; Kamino, H; Ramsay, D; Reddy, VB, 1996)
"Skin involvement with Hodgkin's disease is rare."	1.28	Cutaneous Hodgkin's disease in a patient with human immunodeficiency virus infection. ( Jacobs, SR; Shaw, MT, 1989)
"HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series."	1.26	Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice. ( Smuckler, EA; Zackheim, HS, 1980)
"We present a case of Hodgkin's disease and extensive skin infiltration with a favorable outcome."	1.26	Skin infiltration in Hodgkin's disease. ( Abt, AB; Gordon, RA; Lookingbill, DP, 1980)
"Four lesions were squamous cell carcinomas and two were basal cell carcinomas."	1.26	Second cutaneous malignancies in patients with mycosis fungoides treated with topical nitrogen mustard. ( Fritz, KA; Fritz, TJ; Golitz, L; Lee, LA; Weston, WL, 1982)
"Mycosis fungoides is a cutaneously-derived malignant lymphoma which, without effective treatment, may run an unrelenting, rapidly lethal course."	1.26	Mycosis fungoides: clinical and therapeutic review. ( Basler, RS; Lynch, PJ, 1979)
"Mycosis fungoides is a T-cell lymphoma which is often localized to the skin in the early stages."	1.26	Topical chemotherapy of mycosis fungoides. ( Epstein, EH; Grekin, DA; Zackheim, HS, 1979)
"Despite the dramatic response of Hodgkin's disease to intensive chemotherapy, the skin lesion was rapidly transformed into squamous cell carcinoma in 10 weeks."	1.26	Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease? ( Poleksic, S; Yeung, KY, 1978)
"Two cases of advanced Kaposi sarcoma are reviewed to illustrate a chemotherapeutic approach to patients with this disease."	1.25	Chemotherapy for advanced Kaposi sarcoma. ( Campos, LT; Lanzotti, VJ; Samuels, ML; Sinkovics, JG, 1975)

Research

Studies (203)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Percent of Participants Achieving at Least 50% Improvement of Severity Weighted Assessment Tool (SWAT)

Timeframe	Studies, this research(%)	All Research%
pre-1990	110 (54.19)	18.7374
1990's	38 (18.72)	18.2507
2000's	19 (9.36)	29.6817
2010's	14 (6.90)	24.3611
2020's	22 (10.84)	2.80

Authors	Studies
Koumourtzis, M	3
Lampadaki, K	3
Dalamaga, M	2
Papadavid, E	5
Correia, E	1
Krishnasamy, S	1
Suriano, JG	1
Shi, W	1
Alpdogan, SO	1
Sahu, J	1
Porcu, P	1
Nikbakht, N	2
Assaf, C	4
Booken, N	1
Dippel, E	1
Guenova, E	3
Jonak, C	1
Klemke, CD	1
Nicolay, JP	1
Schlaak, M	1
Wobser, M	1
Trautinger, F	1
Nikolaou, V	1
Marinos, L	2
Patsatsi, A	1
Georgiou, E	1
Stratigos, A	1
Querfeld, C	11
Scarisbrick, JJ	4
Kim, YH	10
Guitart, J	5
Quaglino, P	4
Hodak, E	3
Laghi, A	1
Franceschini, C	1
Mandel, VD	1
Teoli, M	1
Musicco, F	1
Sansone, M	1
La Malfa, AM	1
Ardigò, M	2
Wehkamp, U	2
Scandurra, M	1
Turini, M	1
Gniadecki, R	1
Paron, E	1
Ortiz-Romero, PL	3
Poligone, B	1
Malachowski, SJ	1
Sun, J	1
Chen, PL	1
Seminario-Vidal, L	1
Kim, EJ	5
Geskin, L	1
Girardi, M	2
Musiek, A	2
Mink, DR	1
Williams, MJ	1
Angello, JT	4
Bailey, WL	2
Trager, MH	2
Chen, C	1
Husain, S	1
Geskin, LJ	7
Akilov, OE	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
An Open Label Study to Evaluate the Safety and Efficacy of Nitrogen Mustard (Mechlorethamine - MCH) 0.04% Formulation in Patients With Stage I-IIA Mycosis Fungoides Who Have Completed 12 Months Treatment Without a Complete Response[NCT00535470]	Phase 2	100 participants (Actual)	Interventional	2007-07-31	Completed
A Phase II Pivotal Trial to Evaluate the Safety and Efficacy of Nitrogen Mustard (NM) 0.02% Ointment Formulations in Patients With Stage I or IIA Mycosis Fungoides (MF)[NCT00168064]	Phase 2	260 participants (Actual)	Interventional	2006-05-31	Completed
Treatments and Outcomes in Patients With Primary Cutaneous Lymphoma: a Nationwide Multi-center Prospective Study in China[NCT05518851]		3,000 participants (Anticipated)	Observational	2022-08-01	Recruiting
Valchlor Therapy in Conjunction With Triamcinolone 0.1% Ointment for the Treatment of Contact Dermatitis in Patients With Early Stage Cutaneous T-cell Lymphoma (Mechlorethamine Induced Dermatitis Avoidance Study)[NCT03380026]	Phase 2	28 participants (Actual)	Interventional	2017-12-13	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Assessment of lesion distribution and severity. A responder analysis was performed on whether subject achieved at least 50% improvement on scale. This had to be confirmed on at least one visit at least 4 weeks apart. (NCT00168064)
Timeframe: Baseline to end of therapy

Ratio of Response Rates Based on CAILS

Intervention	Percent of participants (Number)
PG -Mechlorethamine-MCH (Nitrogen Mustard) 0.02% PG Gel	61
AP- Mechlorethamine-MCH (NM) 0.02% Compounded in Aquaphor	60

The ratio of the response rate of the patients treated with the PG formulation to the response rate of the patients treated with the AP formulation. Skin response determined by at least a 50% reduction from baseline in the Composite Assessment of Index Lesion Severity (CAILS) following up to 12 months of treatment (NCT00168064)
Timeframe: Assessment made at Day 1 and every subsequent visit during treatment

Incidence of Moderate to Severe Contact Dermatitis by SCORD Scoring

Intervention	percentage of participants (Number)
PG- Mechlorethamine-MCH (Nitrogen Mustard) 0.02% Gel	76
AP- Aquaphor Formulation Mechlorethamine-MCH (NM) 0.02%	62

Incidence of moderate to severe contact dermatitis in patients treated concurrently with Triamcinolone 0.1% ointment versus those that are not. Dermatitis will be defined as a finding of cutaneous inflammatory reaction occurring as a result of treatment. This will be assessed by the SCORD (SCORing Dermatitis) tool and may be confirmed by biopsy of the specimen. Moderate to Severe Contact dermatitis is defined as >25 by SCORD. (NCT03380026)
Timeframe: 4 months

Severity of Dermatitis

Intervention	patients (Number)
Valchlor 0.016% Topical Gel	16
Valchlor Plus Triamcinolone	11

"Scoring Atopic Dermatitis (SCORAD) differences between lesions treated with Valchlor and Triamcinolone versus lesions treated with Valchlor only. SCORAD measures the extent and severity of dermatitis. The percentage of total body surface area (0-100) covered by a lesion is measured by an investigator, and this number corresponds to score A. The intensity criteria are met by scoring erythema, edema/papulation, oozing/crusting, excoriation, xerosis, and thickness on a scale of 0-3 (0=none, 1=mild, 2=Moderate, 3=Severe). These values are summed to give a total score, B. Subjective symptoms of pruritus and insomnia are then scored using visual analogue scales ranging from 0-10 (0=none, 10=worst imaginable), and the result of each is summed to give score C. The final score is then calculated by the formula A/5 + 7B/2 + C. The lowest possible score is 0, and the highest possible score is 103. A higher score indicates a worse outcome.~A lower score would be a better outcome." (NCT03380026)
Timeframe: 4 months

Efficacy of Valchlor vs Valchlor Plus Triamcinolone

Intervention	score on a scale (Mean)
Valchlor 0.016% Topical Gel	24.8
Valchlor Plus Triamcinolone	12.7

Efficacy of Valchlor therapy with Triamcinolone compared to Valchlor using a composite assessment of index lesion severity (CAILS). CAILS is an objective, quantitative, method to assess the extent of skin lesions. Skin lesions and erythema will be evaluated using CAILS. A Composite Assessment will be generated for each time point by a summation of the grades for each index lesion's erythema, scaling, plaque elevation, hypopigmentation or hyperpigmentation, and area of involvement. The index lesion grade at baseline will be divided into the grade at each subsequent study visit to determine the subject's response to treatment. Any ratio of the grade obtained at the visit vs. the one obtained at baseline that is >1.0 will indicate worsening of disease. (NCT03380026)
Timeframe: 4 months

Intervention	CAILS score (Mean)
	Average CAILS score at Baseline	Average CAILS score at Month 4
Valchlor 0.016% Topical Gel	8.6	11.4
Valchlor Plus Triamcinolone	7.0	12.0

Article	Year
The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region). Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2022, Volume: 20, Issue:5 Topics: Austria; Cyclohexylamines; Dermatitis, Contact; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neo	2022
Topical chlormethine gel in the treatment of mycosis fungoides: A single-center real-life experience and systematic review of the literature. Dermatologic therapy, 2022, Volume: 35, Issue:9 Topics: Aged; Gels; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	2022
Chlormethine Gel for Patients with Mycosis Fungoides Cutaneous T Cell Lymphoma: A Review of Efficacy and Safety in Clinical Trial and Real-World Settings. Advances in therapy, 2022, Volume: 39, Issue:9 Topics: Clinical Trials as Topic; Gels; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Mycosis Fungoi	2022
Mechanism of action of chlormethine gel in mycosis fungoides. Journal of the European Academy of Dermatology and Venereology : JEADV, 2023, Volume: 37, Issue:9 Topics: Humans; Mechlorethamine; Mustard Gas; Mycosis Fungoides; Quality of Life; Skin Neoplasms; Tumor Micr	2023
Diagnosis and Management of Cutaneous B-Cell Lymphomas. Dermatologic clinics, 2019, Volume: 37, Issue:4 Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; An	2019
Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data. Drug design, development and therapy, 2018, Volume: 12 Topics: Administration, Cutaneous; Antineoplastic Agents, Alkylating; Drug Eruptions; Gels; Humans; Mechlore	2018
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions. Journal of the American Academy of Dermatology, 2014, Volume: 70, Issue:2 Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Combined Modality Therapy; Dermatologic Agents;	2014
In brief: mechlorethamine gel (Valchlor) for cutaneous T-Cell lymphoma. The Medical letter on drugs and therapeutics, 2015, Apr-27, Volume: 57, Issue:1467 Topics: Administration, Cutaneous; Animals; Antineoplastic Agents, Alkylating; Gels; Humans; Lymphoma, T-Cel	2015
Cutaneous T-cell lymphoma: a review of current therapies and the future therapeutic implications of chemokine biology. Journal of drugs in dermatology : JDD, 2009, Volume: 8, Issue:12 Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Chemokines; Humans; Lymphoma, T-Cell, Cutaneous;	2009
Treatment of cutaneous T-cell lymphoma/mycosis fungoides. Dermatology nursing, 2006, Volume: 18, Issue:6 Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Antineoplastic Agents; Bexarotene; Biopsy; Cost	2006
Systemic monotherapy vs combination therapy for CTCL: rationale and future strategies. Oncology (Williston Park, N.Y.), 2007, Volume: 21, Issue:2 Suppl 1 Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antine	2007
Topical mechlorethamine chemotherapy. Considerations on its use in mycosis fungoides. International journal of dermatology, 1984, Volume: 23, Issue:3 Topics: Administration, Topical; Dermatitis, Contact; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neopl	1984
Evaluation and treatment of mycosis fungoides lymphoma. International journal of dermatology, 1980, Volume: 19, Issue:4 Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Furocoumarins; Humans; Mechlorethamine; Mycosis Fung	1980
Total skin electron irradiation: efficacy in early mycosis fungoides. Leukemia & lymphoma, 1993, Volume: 10, Issue:4-5 Topics: Adult; Aged; Aged, 80 and over; Child; Clinical Trials as Topic; Combined Modality Therapy; Electron	1993
Malignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. The influence of additional therapy after total skin electron beam radiation. Archives of dermatology, 1995, Volume: 131, Issue:4 Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Electrons; Female; Humans; Lymphoma, T	1995
Treatment of cutaneous T-cell lymphoma. Seminars in dermatology, 1994, Volume: 13, Issue:3 Topics: Carmustine; Combined Modality Therapy; Humans; Interferon-alpha; Lymphoma, T-Cell, Cutaneous; Mechlo	1994
Therapeutic approaches in cutaneous lymphoma. Dermatologic clinics, 1994, Volume: 12, Issue:2 Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Interferon-alpha; Lymphoma, T-Cell, Cutane	1994
Treatment of cutaneous T-cell lymphoma: an update. The Journal of the American Osteopathic Association, 1993, Volume: 93, Issue:5 Topics: Antineoplastic Agents; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Photochemotherapy; Reti	1993
Topical treatment of early cutaneous T-cell lymphoma. Hematology/oncology clinics of North America, 1995, Volume: 9, Issue:5 Topics: Administration, Topical; Antineoplastic Agents, Alkylating; Carmustine; History, 20th Century; Human	1995
Mycosis fungoides and total skin electron beam radiation. Blood, 1997, Apr-15, Volume: 89, Issue:8 Topics: Antineoplastic Agents, Alkylating; Chemotherapy, Adjuvant; Disease-Free Survival; Electrons; Humans;	1997
[Mycosis fungoides]. Annales de dermatologie et de venereologie, 1997, Volume: 124, Issue:1 Topics: Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Humans; Mechlorethamine; Mycosis Fungo	1997
Cutaneous T cell lymphoma: update of treatment. Dermatology (Basel, Switzerland), 1999, Volume: 199, Issue:2 Topics: Administration, Topical; Adrenal Cortex Hormones; Antineoplastic Agents, Alkylating; Beta Particles;	1999
Hypopigmented mycosis fungoides: a report of 7 cases and review of the literature. Cutis, 2001, Volume: 67, Issue:2 Topics: Adult; Antineoplastic Agents, Alkylating; Black or African American; Female; Humans; Hypopigmentatio	2001
Follicular mycosis fungoides: a case report and review of the literature. Journal of cutaneous pathology, 2001, Volume: 28, Issue:6 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Biomark	2001
Current concepts in mycosis fungoides: its nosology, diagnosis and treatment. International journal of dermatology, 1976, Volume: 15 Topics: Humans; Immunotherapy; Lymph Nodes; Lymphoma; Mechlorethamine; Mycosis Fungoides; Nitrosourea Compou	1976
Current problems in mycosis fungoides and Sézary syndrome. Annual review of medicine, 1977, Volume: 28 Topics: B-Lymphocytes; Blood Cell Count; Chromosome Aberrations; Dermatitis, Exfoliative; Humans; Immunoglob	1977
Therapeutic alternatives in cutaneous T-cell lymphoma. Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:3 Topics: Combined Modality Therapy; Humans; Interferons; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Neopla	1992
Mycosis fungoides: time to define the best therapy. Journal of the National Cancer Institute, 1990, Feb-07, Volume: 82, Issue:3 Topics: Humans; Interferons; Mechlorethamine; Mycosis Fungoides; PUVA Therapy; Skin Neoplasms	1990
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Article	Year
Chlormethine gel is effective for the treatment of skin lesions in patients with early- and late-stage mycosis fungoides in clinical practice. Journal of the European Academy of Dermatology and Venereology : JEADV, 2022, Volume: 36, Issue:10 Topics: Combined Modality Therapy; Humans; Mechlorethamine; Mycosis Fungoides; Skin Diseases; Skin Neoplasms	2022
Prior Bexarotene or Phototherapy Does Not Affect Response to Chlormethine Gel: Post Hoc Analysis of a Pivotal Trial. Acta dermato-venereologica, 2023, 02-07, Volume: 103 Topics: Bexarotene; Humans; Mechlorethamine; Phototherapy; Skin Neoplasms	2023
Lack of Systemic Absorption of Topical Mechlorethamine Gel in Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma. The Journal of investigative dermatology, 2021, Volume: 141, Issue:6 Topics: Absorption, Physiological; Administration, Cutaneous; Adult; Aged; Female; Gels; Humans; Male; Mechl	2021
Post hoc Analysis of a Randomized, Controlled, Phase 2 Study to Assess Response Rates with Chlormethine/Mechlorethamine Gel in Patients with Stage IA-IIA Mycosis Fungoides. Dermatology (Basel, Switzerland), 2022, Volume: 238, Issue:2 Topics: Antineoplastic Agents, Alkylating; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Mycosis Fun	2022
Use of chlormethine 0.04% gel for mycosis fungoides after treatment with topical chlormethine 0.02% gel: A phase 2 extension study. Journal of the American Academy of Dermatology, 2022, Volume: 87, Issue:1 Topics: Gels; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	2022
Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. JAMA dermatology, 2013, Volume: 149, Issue:1 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkyla	2013
Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. JAMA dermatology, 2013, Volume: 149, Issue:1 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkyla	2013
Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. JAMA dermatology, 2013, Volume: 149, Issue:1 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkyla	2013
Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. JAMA dermatology, 2013, Volume: 149, Issue:1 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkyla	2013
Evaluation of a 1-h exposure time to mechlorethamine in patients undergoing topical treatment. The British journal of dermatology, 2002, Volume: 147, Issue:5 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dermatit	2002
Treatment of early-stage mycosis fungoides with twice-weekly applications of mechlorethamine and topical corticosteroids: a prospective study. Archives of dermatology, 2005, Volume: 141, Issue:9 Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylati	2005
Transfer factor therapy in mycosis fungoides: a double-blind study. Acta dermato-venereologica, 1982, Volume: 62, Issue:1 Topics: Administration, Topical; Aged; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Male;	1982
Treatment of mycosis fungoides: total-skin electron-beam irradiation vs topical mechlorethamine therapy. Archives of dermatology, 1982, Volume: 118, Issue:3 Topics: Administration, Topical; Adult; Aged; Female; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fu	1982
[Topical chemotherapy in mycosis fungoides (author's transl)]. Dermatologica, 1978, Volume: 157, Issue:6 Topics: Administration, Topical; Clinical Trials as Topic; Drug Evaluation; Humans; Injections, Intravenous;	1978
The treatment of mycosis fungoides: adjuvant topical mechlorethamine after electron beam therapy. Cancer, 1977, Volume: 40, Issue:6 Topics: Administration, Topical; Dermatitis, Contact; Female; Humans; Male; Mechlorethamine; Middle Aged; My	1977
Topical mechlorethamine in the treatment of mycosis fungoides. Uniformity of application and potential for environmental contamination. Journal of the American Academy of Dermatology, 1991, Volume: 25, Issue:6 Pt 1 Topics: Administration, Cutaneous; Adult; Aged; Arm; Back; Body Surface Area; Clothing; Environmental Exposu	1991

Article	Year
Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions. Acta dermato-venereologica, 2022, Jun-09, Volume: 102 Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Humans; Mechlorethamine; Mycosis Fungoides	2022
Response to Chlormethine/Mechlorethamine gel Maintenance Treatment Regimen in Patients With Mycosis Fungoides: A Single-center Retrospective Study. Clinical lymphoma, myeloma & leukemia, 2022, Volume: 22, Issue:8 Topics: Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Mycosis Fungoides; Retrospective Studies; Skin	2022
Chlormethine Gel Versus Chlormethine Ointment for Treatment of Patients with Mycosis Fungoides: A Post-Hoc Analysis of Clinical Trial Data. American journal of clinical dermatology, 2022, Volume: 23, Issue:4 Topics: Clinical Trials as Topic; Dermatitis, Contact; Gels; Humans; Mechlorethamine; Mycosis Fungoides; Oin	2022
Chlormethine Gel Versus Chlormethine Ointment for Treatment of Patients with Mycosis Fungoides: A Post-Hoc Analysis of Clinical Trial Data. American journal of clinical dermatology, 2022, Volume: 23, Issue:4 Topics: Clinical Trials as Topic; Dermatitis, Contact; Gels; Humans; Mechlorethamine; Mycosis Fungoides; Oin	2022
Chlormethine Gel Versus Chlormethine Ointment for Treatment of Patients with Mycosis Fungoides: A Post-Hoc Analysis of Clinical Trial Data. American journal of clinical dermatology, 2022, Volume: 23, Issue:4 Topics: Clinical Trials as Topic; Dermatitis, Contact; Gels; Humans; Mechlorethamine; Mycosis Fungoides; Oin	2022
Chlormethine Gel Versus Chlormethine Ointment for Treatment of Patients with Mycosis Fungoides: A Post-Hoc Analysis of Clinical Trial Data. American journal of clinical dermatology, 2022, Volume: 23, Issue:4 Topics: Clinical Trials as Topic; Dermatitis, Contact; Gels; Humans; Mechlorethamine; Mycosis Fungoides; Oin	2022
Chlormethine Gel for the Treatment of Mycosis Fungoides (Cutaneous T-cell Lymphoma) in Canada. Skin therapy letter, 2023, Volume: 28, Issue:2 Topics: Adult; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Mycosis Fungoides; Skin; Skin Neoplasms	2023
Real-world experience with mechlorethamine gel in patients with mycosis fungoides-cutaneous lymphoma: Preliminary findings from a prospective observational study. Journal of the American Academy of Dermatology, 2020, Volume: 83, Issue:3 Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Drug E	2020
Nitrogen mustard gel-induced inflammation triggers lymphomatoid papulosis in patients with mycosis fungoides. The Journal of dermatology, 2020, Volume: 47, Issue:5 Topics: Administration, Cutaneous; Adult; Aged; Antineoplastic Agents, Alkylating; Female; Gels; Humans; Ki-	2020
Evaluating the Treatment Patterns of Chlormethine/Mechlorethamine Gel in Patients With Stage I-IIA Mycosis Fungoides: By-time Reanalysis of a Randomized Controlled Phase 2 Study. Clinical lymphoma, myeloma & leukemia, 2021, Volume: 21, Issue:2 Topics: Antineoplastic Agents, Alkylating; Clinical Trials, Phase II as Topic; Gels; Humans; Mechlorethamine	2021
The PROVe Study: US Real-World Experience with Chlormethine/Mechlorethamine Gel in Combination with Other Therapies for Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma. American journal of clinical dermatology, 2021, Volume: 22, Issue:3 Topics: Administration, Cutaneous; Administration, Oral; Aged; Antineoplastic Agents, Alkylating; Antineopla	2021
Chlormethine Gel in Combination with Other Therapies in the Treatment of Patients with Mycosis Fungoides Cutaneous T Cell Lymphoma: Three Case Reports. Advances in therapy, 2021, Volume: 38, Issue:6 Topics: Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Mycosis Fungoides; Quality of Life; Skin Neopl	2021
Management of chlormethine gel treatment in mycosis fungoides patients in two German skin lymphoma centers. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2021, Volume: 19, Issue:7 Topics: Humans; Lymphoma, Non-Hodgkin; Mechlorethamine; Mycosis Fungoides; Neoplasms, Connective Tissue; Ski	2021
Jak-STAT Inhibition Mediates Romidepsin and Mechlorethamine Synergism in Cutaneous T-Cell Lymphoma. The Journal of investigative dermatology, 2021, Volume: 141, Issue:12 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Depsipeptides; Drug Syner	2021
Real-life experience with chlormethine gel for early-stage mycosis fungoides with emphasis on types and management of cutaneous side-effects The Journal of dermatological treatment, 2022, Volume: 33, Issue:4 Topics: Adult; Dermatitis, Contact; Dermatologic Agents; Drug-Related Side Effects and Adverse Reactions; Hu	2022
Management of Mycosis Fungoides with Topical Chlormethine/Mechlorethamine Gel: A Columbia University Cutaneous Lymphoma Center Experience. Acta dermato-venereologica, 2021, Sep-08, Volume: 101, Issue:9 Topics: Antineoplastic Agents, Alkylating; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms; Unive	2021
Topical chemotherapy for numerous superficial basal cell carcinomas years after isolated limb perfusion for melanoma. Cutis, 2019, Volume: 103, Issue:5 Topics: Administration, Cutaneous; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents	2019
Secondary cancers, comorbidities and mortality associated with nitrogen mustard therapy in patients with mycosis fungoides: a 30-year population-based cohort study. The British journal of dermatology, 2014, Volume: 170, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Cause of Death; Cohor	2014
Nitrogen mustard revisited. The British journal of dermatology, 2014, Volume: 170, Issue:3 Topics: Antineoplastic Agents, Alkylating; Female; Humans; Male; Mechlorethamine; Mycosis Fungoides; Neoplas	2014
Mechlorethamine gel for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma. Expert review of clinical pharmacology, 2014, Volume: 7, Issue:5 Topics: Administration, Cutaneous; Antineoplastic Agents, Alkylating; Clinical Trials as Topic; Drug Approva	2014
Novel therapeutic combination demonstrates more than additive effects in cutaneous T-cell lymphoma. Leukemia & lymphoma, 2015, Volume: 56, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Depsipeptides; DNA Damage; Human	2015
An Elderly Man With New Skin Plaques Consistent With Cutaneous T-Cell Lymphoma. Oncology (Williston Park, N.Y.), 2016, 10-15, Volume: 30, Issue:10 Topics: Administration, Cutaneous; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor;	2016
Clinicopathologic features and treatment outcomes in Woringer-Kolopp disease. Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:4 Topics: Adolescent; Adult; Aged; Biopsy; Child; Diagnosis, Differential; Female; Hand Dermatoses; Humans; In	2008
Nitrogen mustard therapy for blastomatous skin disease (transl.). Medizinische Nachrichten aus den Vereinigten Staaten, 1948, Apr-19, Volume: 51 Topics: Mechlorethamine; Neoplasms; Skin; Skin Neoplasms	1948
Specific nail alterations in cutaneous T-cell lymphoma: successful treatment with topical mechlorethamine. Archives of dermatology, 2010, Volume: 146, Issue:11 Topics: Administration, Topical; Aged, 80 and over; Gene Rearrangement, T-Lymphocyte; Humans; Lymphocytes; M	2010
The Stanford University experience with conventional-dose, total skin electron-beam therapy in the treatment of generalized patch or plaque (T2) and tumor (T3) mycosis fungoides. Archives of dermatology, 2011, Volume: 147, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemotherapy, Adjuvant; Female; H	2011
Erythema gyratum repens-like eruptions with large cell transformation in a patient with mycosis fungoides. International journal of dermatology, 2012, Volume: 51, Issue:10 Topics: Aged; Antineoplastic Agents; Bexarotene; Combined Modality Therapy; Electrons; Erythema; Humans; Mal	2012
Topical nitrogen mustard in the management of mycosis fungoides: update of the Stanford experience. Archives of dermatology, 2003, Volume: 139, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Biopsy, Needle; Child; Cohort S	2003
The effect of intra-arterial nitrogen-mustard therapy on human skin. Cancer, 1953, Volume: 6, Issue:2 Topics: Humans; Mechlorethamine; Mustard Plant; Nitrogen; Nitrogen Mustard Compounds; Skin Neoplasms	1953
[Malignant lymphogranulomatosis (Hodgkin's diseases) with cutaneous initiation: total remission under combined treatment with radio-therapy and nitrogen mustard]. Prensa medica argentina, 1954, Feb-19, Volume: 41, Issue:8 Topics: Combined Modality Therapy; Hodgkin Disease; Manipulation, Osteopathic; Mechlorethamine; Nitrogen Mus	1954
Nitromin effect on epidermal carcinogenesis with methylcholanthrene; preliminary report. Gan, 1954, Volume: 45, Issue:2-3 Topics: Animals; Carcinogenesis; Epidermis; Mechlorethamine; Methylcholanthrene; Neoplasms, Experimental; Ni	1954
[Effect of Gordeev solution No. 2 on morphological tissue changes in the treatment of skin & lip cancer]. Voprosy onkologii, 1958, Volume: 4, Issue:2 Topics: Humans; Lip; Lip Neoplasms; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Skin; Skin Neopl	1958
[Cutaneous lymphosis with elements simulating the sarcoids of Besnier-Boeck-Schaumann disease treated by surgical excision & oral nitrogen mustards]. Lyon medical, 1958, Jul-27, Volume: 90, Issue:30 Topics: Diagnosis, Differential; Humans; Lymphoid Tissue; Mechlorethamine; Medical Records; Neoplasms; Nitro	1958
Topical nitrogen mustard in cutaneous lymphosarcoma (mycosis fungoides). Canadian Medical Association journal, 1962, Dec-15, Volume: 87 Topics: Humans; Lymphoma, Non-Hodgkin; Mechlorethamine; Musculoskeletal Diseases; Mycosis Fungoides; Skin Ne	1962
MELANOMA IN AN ALBINO. JAMA, 1963, Nov-30, Volume: 186 Topics: Albinism; Electrons; Mechlorethamine; Melanins; Melanoma; Microscopy; Microscopy, Electron; Neoplasm	1963
[A CASE OF LEUKEMIA CUTIS]. Hifuka kiyo. Acta dermatologica, 1963, Volume: 58 Topics: Dactinomycin; Dermatology; Humans; Leukemia; Mechlorethamine; Pathology; Prednisolone; Skin; Skin Ne	1963
STUDIES ON TOPICAL CHEMOTHERAPY OF TUMOR-CONTAMINATED SURGICAL WOUNDS. American journal of surgery, 1963, Volume: 106 Topics: Carcinoma, Ehrlich Tumor; Carcinoma, Squamous Cell; Chlorine; Laryngeal Neoplasms; Mechlorethamine;	1963
STUDIES ON REGIONAL PERFUSION AND INTRA-ARTERIAL INFUSION FOR CANCER CHEMOTHERAPY. Surgery, 1964, Volume: 55 Topics: Antineoplastic Agents; Breast Neoplasms; Celiac Artery; Chemotherapy, Cancer, Regional Perfusion; Co	1964
[On nitrogen mustard therapy of skin tumors]. Archiv fur Dermatologie und Syphilis, 1951, Volume: 192, Issue:2 Topics: Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Skin; Skin Neoplasms	1951
Milia in regressing plaques of mycosis fungoides: provoked by topical nitrogen mustard or not? International journal of dermatology, 2004, Volume: 43, Issue:12 Topics: Administration, Cutaneous; Antineoplastic Agents, Alkylating; Epidermal Cyst; Female; Follow-Up Stud	2004
Benign pleural schwannoma secondary to radiotherapy for Hodgkin disease. American journal of clinical oncology, 2005, Volume: 28, Issue:6 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Basal Cell; Combin	2005
[Local treatments of cutaneous T-cell lymphomas]. Annales de dermatologie et de venereologie, 2005, Volume: 132 Spec No 2 Topics: Administration, Topical; Antineoplastic Agents, Alkylating; Humans; Lymphoma, T-Cell, Cutaneous; Mec	2005
Topical mechlorethamine and clobetasol in multifocal primary cutaneous marginal zone-B cell lymphoma. The British journal of dermatology, 2006, Volume: 154, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Clobetasol; Humans; Lymphoma, B-Cell; Lymphom	2006
Eruptive cherry angiomas associated with vitiligo: provoked by topical nitrogen mustard? The Journal of dermatology, 2006, Volume: 33, Issue:12 Topics: Adult; Alkylating Agents; Capillaries; Dermatologic Agents; Hemangioma; Humans; Male; Mechlorethamin	2006
Mycosis fungoides. Dermatology nursing, 2007, Volume: 19, Issue:4 Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Carmustine; Causality; Humans; Mechlore	2007
Treatment of cutaneous blastomas and other diseases with nitrogen mustard. Archives of dermatology and syphilology, 1949, Volume: 60, Issue:2 Topics: Administration, Cutaneous; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Skin; Skin Neopla	1949
[Chlormethine (Caryolysine), carmustine (Bicnu)]. Annales de dermatologie et de venereologie, 2007, Volume: 134, Issue:12 Topics: Antineoplastic Agents, Alkylating; Carmustine; Humans; Mechlorethamine; Skin Neoplasms	2007
Mycosis fungoides in a lung transplant recipient with advanced ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation. Dermatology (Basel, Switzerland), 2008, Volume: 217, Issue:1 Topics: Administration, Topical; Adult; Antineoplastic Agents; Betamethasone Valerate; Cyclosporine; Humans;	2008
Aspects of the treatment of mycosis fungoides. A report from the Scandinavian Mycosis Fungoides Study Group. Cutis, 1980, Volume: 25, Issue:2 Topics: Bleomycin; Electrons; Ficusin; Humans; Mechlorethamine; Methotrexate; Mycosis Fungoides; Neoplasm St	1980
Normalized light reactions in mycosis fungoides patients after complete remission of skin lesions. Acta dermato-venereologica, 1980, Volume: 60, Issue:2 Topics: Aged; Female; Humans; Light; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Photochemotherap	1980
Focal contact sensitivity to nitrogen mustard in lesions of cutaneous T-cell lymphoma (mycosis fungoides). Acta dermato-venereologica, 1981, Volume: 61, Issue:2 Topics: Administration, Topical; Dermatitis, Contact; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fu	1981
Remission of lesions in mycosis fungoides following topical application of nitrogen mustard. By John R. Haserick, Joseph H. Richardson, and Douglas J. Grant. Cleveland Clinic quarterly, 1983,Summer, Volume: 50, Issue:2 Topics: Adult; Dermatology; History, 20th Century; Humans; Male; Mechlorethamine; Mycosis Fungoides; Skin Ne	1983
Combined moderate dose electron beam radiotherapy and topical chemotherapy for cutaneous T-Cell lymphoma. International journal of radiation oncology, biology, physics, 1983, Volume: 9, Issue:4 Topics: Administration, Topical; Adult; Aged; Electrons; Female; Humans; Male; Mechlorethamine; Middle Aged;	1983
Cutaneous T-cell lymphomas. Seminars in oncology, 1980, Volume: 7, Issue:3 Topics: Administration, Topical; Adult; Antineoplastic Agents; Electrons; Female; Furocoumarins; Humans; Imm	1980
Prolonged remission of tumor-stage mycosis fungoides by topical immunotherpay. Archives of dermatology, 1981, Volume: 117, Issue:9 Topics: Administration, Topical; Adult; Drug Eruptions; Female; Humans; Immunotherapy; Mechlorethamine; Myco	1981
Nitrogen mustard (mechlorethamine) and UVB photocarcinogenesis: a dose response effect. The Journal of investigative dermatology, 1984, Volume: 83, Issue:5 Topics: Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Mechlorethamine; Mice; Mice, Ha	1984
Response of mycosis fungoides to topical chemotherapy with mechlorethamine. Archives of dermatology, 1984, Volume: 120, Issue:12 Topics: Administration, Topical; Adolescent; Adult; Aged; Child; Drug Hypersensitivity; Female; Humans; Hype	1984
Effects of mechlorethamine (HN2, nitrogen mustard) on UV-induced carcinogenesis in hairless mouse skin. Journal of the National Cancer Institute, 1984, Volume: 72, Issue:2 Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Mechlorethamine; Mice; Mice, Hairless; Neoplasm	1984
Cutaneous T-lymphocyte lymphoma in association with multiple myeloma. Archives of dermatology, 1984, Volume: 120, Issue:4 Topics: Aged; Female; Humans; Lymphoma; Mechlorethamine; Multiple Myeloma; Neoplasms, Multiple Primary; Skin	1984
Commentary and update: topical chemotherapy with mechlorethamine for mycosis fungoides. Cleveland Clinic quarterly, 1983,Summer, Volume: 50, Issue:2 Topics: Administration, Topical; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	1983
[Melanoma and dysplastic nevus after 8 years of topical Caryolysine]. Annales de dermatologie et de venereologie, 1984, Volume: 111, Issue:2 Topics: Administration, Topical; Female; Humans; Mechlorethamine; Melanoma; Middle Aged; Nevus, Pigmented; P	1984
Combination topical nitrogen mustard and photochemotherapy for mycosis fungoides. Clinical and experimental dermatology, 1984, Volume: 9, Issue:3 Topics: Administration, Topical; Adult; Aged; Drug Therapy, Combination; Female; Humans; Male; Mechlorethami	1984
Treatment of cutaneous T-cell lymphoma. The Journal of dermatologic surgery and oncology, 1980, Volume: 6, Issue:5 Topics: Antineoplastic Agents; Drug Therapy, Combination; Electrons; Humans; Lymphoma; Mechlorethamine; Neop	1980
Clinicopathologic relationships, survival, and therapy in 59 patients with observations on occupation as a new prognostic factor. Cancer, 1980, Dec-15, Volume: 46, Issue:12 Topics: Adolescent; Adult; Aged; Biopsy; Female; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoid	1980
Cutaneous T-cell lymphoma: clinicopathological relationships, therapy and survival in ninety-two patients. The British journal of dermatology, 1982, Volume: 107, Issue:2 Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyc	1982
Prolonged topical maintenance therapy for mycosis fungoides. Journal of the American Academy of Dermatology, 1983, Volume: 8, Issue:4 Topics: Animals; Carmustine; Humans; Mechlorethamine; Mice; Mycosis Fungoides; Skin Neoplasms	1983
[Modern therapy of mycosis fungoides]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1983, Volume: 34, Issue:6 Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluocinolone Acetonide; Humans; Mechlorethamine; M	1983
Granulomatous mycosis fungoides. A 14-year follow-up of a case. The American Journal of dermatopathology, 1983, Volume: 5, Issue:2 Topics: Follow-Up Studies; Granuloma; Humans; Male; Mechlorethamine; Methotrexate; Middle Aged; Mycosis Fung	1983
[New modifications in isolated extremity perfusion ]. Zeitschrift fur Hautkrankheiten, 1982, Jul-15, Volume: 57, Issue:14 Topics: Antineoplastic Agents; Arm; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dacarbazine; Dactin	1982
Topical mechlorethamine therapy for mycosis fungoides. Proposed schedule to overcome drug resistance. Archives of dermatology, 1982, Volume: 118, Issue:2 Topics: Administration, Topical; Aged; Drug Administration Schedule; Drug Resistance; Humans; Male; Mechlore	1982
Canine cutaneous lymphoma. Journal of the American Veterinary Medical Association, 1982, Mar-01, Volume: 180, Issue:5 Topics: Animals; Cyclophosphamide; Dog Diseases; Dogs; Female; Lymphocytes; Male; Mechlorethamine; Mycosis F	1982
Failure of periodic ultraviolet radiation treatments to prevent sensitization to nitrogen mustard: a case report. The British journal of dermatology, 1982, Volume: 106, Issue:3 Topics: Cell Count; Dermatitis, Contact; Humans; Langerhans Cells; Male; Mechlorethamine; Middle Aged; Mycos	1982
Precautions for personnel applying topical nitrogen mustard to patients with mycosis fungoides. Dermatologica, 1982, Volume: 165, Issue:2 Topics: Accidents, Occupational; Administration, Topical; Health Occupations; Humans; Mechlorethamine; Mycos	1982
Second cutaneous malignancies in patients with mycosis fungoides treated with topical nitrogen mustard. Journal of the American Academy of Dermatology, 1982, Volume: 7, Issue:5 Topics: Administration, Topical; Carcinoma, Squamous Cell; Female; Humans; Male; Mechlorethamine; Middle Age	1982
Mycosis fungoides. Current problems in cancer, 1981, Volume: 6, Issue:3 Topics: Adult; Female; Humans; Lymph Nodes; Lymphocytes; Male; Mechlorethamine; Middle Aged; Mycosis Fungoid	1981
Photochemotherapy and topical nitrogen mustard in the treatment of mycosis fungoides. The British journal of dermatology, 1980, Volume: 102, Issue:3 Topics: Administration, Topical; Female; Humans; Male; Mechlorethamine; Mycosis Fungoides; Photochemotherapy	1980
Skin infiltration in Hodgkin's disease. Archives of dermatology, 1980, Volume: 116, Issue:9 Topics: Adult; Drug Therapy, Combination; Hodgkin Disease; Humans; Male; Mechlorethamine; Prednisone; Procar	1980
Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice. Experientia, 1980, Oct-15, Volume: 36, Issue:10 Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Lomustine; Mechlorethamine; Mice; Neopla	1980
Treatment of mycosis fungoides with photochemotherapy (PUVA): long-term follow-up. Journal of the American Academy of Dermatology, 1995, Volume: 33, Issue:2 Pt 1 Topics: Biopsy; Carmustine; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Mechlorethamine; Middle	1995
Photopheresis in the red man or pre-Sézary syndrome. Dermatology (Basel, Switzerland), 1995, Volume: 190, Issue:2 Topics: Acitretin; Aged; Dermatitis, Exfoliative; Follow-Up Studies; Humans; Male; Mechlorethamine; Middle A	1995
Long-term topical nitrogen mustard treatment does not induce pulmonary fibrosis in MF patients. Acta dermato-venereologica, 1994, Volume: 74, Issue:1 Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Lung; Male; M	1994
Regional chemotherapy for melanoma. A 35-year experience. Annals of surgery, 1994, Volume: 220, Issue:4 Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Clinical Trials as Topic; Combined Modality T	1994
Cutaneous T cell lymphomas. BMJ (Clinical research ed.), 1994, Feb-26, Volume: 308, Issue:6928 Topics: Administration, Topical; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Methoxsalen; Randomiz	1994
Risk of secondary cutaneous malignancies in patients with long-standing mycosis fungoides. Journal of the American Academy of Dermatology, 1994, Volume: 30, Issue:2 Pt 1 Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Follow-Up Studies; H	1994
Detection of low-level tumor cells in allergic contact dermatitis induced by mechlorethamine in patients with mycosis fungoides. The Journal of investigative dermatology, 1996, Volume: 106, Issue:4 Topics: Adult; Aged; Dermatitis, Allergic Contact; Female; Gene Rearrangement, gamma-Chain T-Cell Antigen Re	1996
Combined modality therapy for cutaneous T-cell lymphoma. Journal of the American Academy of Dermatology, 1996, Volume: 34, Issue:6 Topics: Administration, Cutaneous; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Ca	1996
[Mycosis fungoides in the child. Three cases]. Annales de dermatologie et de venereologie, 1995, Volume: 122, Issue:10 Topics: Antigens, CD; Child; Child, Preschool; Humans; Mechlorethamine; Mycosis Fungoides; PUVA Therapy; Rem	1995
Atypical cutaneous changes after topical treatment with nitrogen mustard in patients with mycosis fungoides. The American Journal of dermatopathology, 1996, Volume: 18, Issue:1 Topics: Administration, Topical; Aged; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Precan	1996
Stevens-Johnson syndrome associated with topical nitrogen mustard therapy. Journal of the American Academy of Dermatology, 1997, Volume: 36, Issue:1 Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Female	1997
[Mustine: work environment--insecurity never ceases]. Sygeplejersken, 1997, May-16, Volume: 97, Issue:20 Topics: Humans; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Nursing Staff, Hospital; Occupationa	1997
Mycosis fungoides in young patients: clinical characteristics and outcome. Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:5 Pt 1 Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Case-Control Studies; Cause of De	1998
Multiple basal cell carcinomas of the limb after adjuvant treatment of melanoma with isolated limb perfusion. Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:5 Pt 1 Topics: Antineoplastic Agents, Alkylating; Carcinoma, Basal Cell; Chemotherapy, Adjuvant; Chemotherapy, Canc	1998
The prognostic significance of delayed hypersensitivity to dinitrochlorobenzene and mechlorethamine hydrochloride in cutaneous T cell lymphoma. The Journal of investigative dermatology, 1998, Volume: 110, Issue:6 Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Dinitrochlorobenzene; Disease P	1998
Small malignant melanoma in patients with mycosis fungoides. Journal of the European Academy of Dermatology and Venereology : JEADV, 1998, Volume: 11, Issue:2 Topics: Adult; Antineoplastic Agents, Alkylating; Humans; Male; Mechlorethamine; Melanoma; Middle Aged; Myco	1998
Prognostic significance of a polymerase chain reaction-detectable dominant T-lymphocyte clone in cutaneous lesions of patients with mycosis fungoides. Blood, 1998, Nov-01, Volume: 92, Issue:9 Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antineoplastic A	1998
[Granulomatous mycosis fungoides histologically simulating cutaneous sarcoidosis]. Annales de dermatologie et de venereologie, 1998, Volume: 125, Issue:12 Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Diagnosis,	1998
Clinical characteristics and long-term outcome of patients with generalized patch and/or plaque (T2) mycosis fungoides. Archives of dermatology, 1999, Volume: 135, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Cause of Death; Disease Progression; Female; Humans; Lymph Nodes; Ly	1999
Total skin electron beam therapy with or without adjuvant topical nitrogen mustard or nitrogen mustard alone as initial treatment of T2 and T3 mycosis fungoides. International journal of radiation oncology, biology, physics, 1999, Mar-15, Volume: 43, Issue:5 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Cause of	1999
A prospective study of cutaneous intolerance to topical mechlorethamine therapy in patients with cutaneous T-cell lymphomas. French Study Group of Cutaneous Lymphomas. Archives of dermatology, 1999, Volume: 135, Issue:11 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkyla	1999
Hypopigmented mycosis fungoides: treatment and a 6(1/2)-year follow-up of 9 patients. Journal of the American Academy of Dermatology, 2000, Volume: 42, Issue:1 Pt 1 Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Asian People; Black People; Child; Female; Fol	2000
Exposure at home to airborne concentrations of nitrogen mustard during topical application for the treatment of mycosis fungoides: a case study. Dermatology (Basel, Switzerland), 2000, Volume: 200, Issue:2 Topics: Administration, Topical; Air Pollution, Indoor; Antineoplastic Agents, Alkylating; Environmental Exp	2000
Letter: Hyperpigmentation after cancer chemotherapy. Lancet (London, England), 1975, Aug-23, Volume: 2, Issue:7930 Topics: Humans; Mechlorethamine; Melanocytes; Mycosis Fungoides; Organoids; Pigmentation Disorders; Skin Neo	1975
Chemotherapy for advanced Kaposi sarcoma. Archives of dermatology, 1975, Volume: 111, Issue:10 Topics: Aged; Bleomycin; Dacarbazine; Dactinomycin; Doxorubicin; Humans; Male; Mechlorethamine; Middle Aged;	1975
[Treatment of mycosis fungoides--an internordic project]. Nordisk medicin, 1976, Volume: 91, Issue:4 Topics: Bleomycin; Humans; Mechlorethamine; Methotrexate; Mycosis Fungoides; Palliative Care; Scandinavian a	1976
Mycosis fungoides plaque stage treated with topical nitrogen mustard with and without attempts at tolerance induction: report from the Scandinavian mycosis fungoides study group. Acta dermato-venereologica, 1979, Volume: 59, Issue:1 Topics: Administration, Topical; Adult; Aged; Drug Eruptions; Drug Evaluation; Female; Follow-Up Studies; Hu	1979
Occurrence of immunoglobulins and complement in the skin of patients undergoing topical treatment of mycosis fungoides. Acta dermato-venereologica, 1979, Volume: 59, Issue:2 Topics: Complement System Proteins; Fluorescent Antibody Technique; Humans; Immunoglobulin A; Immunoglobulin	1979
Total skin electron beam therapy in mycosis fungoides. Cancer, 1978, Volume: 42, Issue:3 Topics: Administration, Topical; Adult; Aged; Erythema; Female; Humans; Male; Mechlorethamine; Methods; Midd	1978
A 10-year experience with topical mechlorethamine for mycosis fungoides: comparison with patients treated by total-skin electron-beam radiation therapy. Cancer treatment reports, 1979, Volume: 63, Issue:4 Topics: Administration, Topical; Adolescent; Adult; Aged; Child; Female; Humans; Male; Mechlorethamine; Midd	1979
Electron-beam therapy for mycosis fungoides: the Stanford University experience. Cancer treatment reports, 1979, Volume: 63, Issue:4 Topics: Adult; Aged; Female; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Neoplasm Staging	1979
PUVA-induced suppression of contact sensitivity to mustine hydrochloride in mycosis fungoides. British medical journal, 1978, Sep-23, Volume: 2, Issue:6141 Topics: Aged; Drug Eruptions; Furocoumarins; Humans; Mechlorethamine; Middle Aged; Mycosis Fungoides; Photoc	1978
Mycosis fungoides: clinical and therapeutic review. The Journal of family practice, 1979, Volume: 8, Issue:2 Topics: Humans; Lymphoma; Mechlorethamine; Methoxsalen; Mycosis Fungoides; Photochemotherapy; Sezary Syndrom	1979
Scandinavian mycosis fungoides trial. Cancer treatment reports, 1979, Volume: 63, Issue:4 Topics: Administration, Topical; Antineoplastic Agents; Female; Humans; Male; Mechlorethamine; Methoxsalen;	1979
Topical chemotherapy of mycosis fungoides. Cutis, 1979, Volume: 24, Issue:5 Topics: Administration, Topical; Carmustine; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	1979
Topical mechlorethamine therapy for mycosis fungoides. The British journal of dermatology, 1977, Volume: 97, Issue:5 Topics: Administration, Topical; Dermatitis, Contact; Desensitization, Immunologic; Female; Humans; Male; Me	1977
[Mycosis fungoides]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1977, Nov-20, Volume: 97, Issue:32 Topics: Administration, Topical; Adult; Aged; Dermatitis, Contact; Humans; Mechlorethamine; Middle Aged; Myc	1977
Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease? Cancer, 1978, Volume: 41, Issue:1 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Therapy, Combination; Hodgkin Disease; Humans;	1978
Mycosis fungoides, nitrogen mustard and skin cancer. The British journal of dermatology, 1978, Volume: 99, Issue:1 Topics: Administration, Topical; Aged; Female; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides	1978
Nonspecific antigen reactions. National Cancer Institute monograph, 1976, Volume: 44 Topics: Administration, Topical; Antibody Formation; Antigens; Antineoplastic Agents; BCG Vaccine; Breast Ne	1976
Oral methoxsalen photochemotherapy of mycosis fungoides. Cancer, 1976, Volume: 38, Issue:2 Topics: Administration, Oral; Aged; Female; Humans; Male; Mechlorethamine; Methoxsalen; Middle Aged; Mycosis	1976
Topical chemotherapy and immunotherapy of mycosis fungoides: intermediate-term results. Archives of dermatology, 1977, Volume: 113, Issue:4 Topics: Administration, Topical; Aged; Desensitization, Immunologic; Dinitrochlorobenzene; Drug Hypersensiti	1977
Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration. Archives of dermatology, 1977, Volume: 113, Issue:10 Topics: Administration, Topical; Biopsy; Dermatitis, Contact; DNA; Humans; Mechlorethamine; Mycosis Fungoide	1977
Failure to induce tolerance to mechlorethamine hydrochloride. Archives of dermatology, 1977, Volume: 113, Issue:10 Topics: Dermatitis, Contact; Dinitrochlorobenzene; Humans; Immune Tolerance; Mechlorethamine; Mycosis Fungoi	1977
Topical chemotherapy in mycosis fungoides. Bulletin du cancer, 1977, Volume: 64, Issue:2 Topics: Administration, Topical; Antibiotics, Antineoplastic; Humans; Mechlorethamine; Mycosis Fungoides; Sk	1977
[From tumors to scales]. Nederlands tijdschrift voor geneeskunde, 1975, Jul-26, Volume: 119, Issue:30 Topics: Agranulocytosis; Humans; Immunologic Deficiency Syndromes; Leg Ulcer; Leukopenia; Male; Mechloretham	1975
Frequent low doses of intravenous mechlorethamine for late-stage mycosis fungoides lymphoma. Cancer, 1975, Volume: 36, Issue:5 Topics: Adult; Aged; Female; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Remission, Spont	1975
Melanogenesis from topical mechlorethamine and analogues in skin of hairless mice and in vitiligo. The Journal of investigative dermatology, 1975, Volume: 65, Issue:5 Topics: Administration, Topical; Aged; Animals; Female; Humans; Male; Mechlorethamine; Melanins; Mice; Mice,	1975
Treatment of mycosis fungoides with topical nitrosourea compounds: Further studies. Archives of dermatology, 1975, Volume: 111, Issue:12 Topics: Administration, Topical; Adult; Aged; Bone Marrow; Carmustine; Cross Reactions; Drug Hypersensitivit	1975
Carcinogenicity of topical mechlorethamine in mice. Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:4 Topics: Administration, Cutaneous; Animals; Carcinogens; Carcinoma, Squamous Cell; Mechlorethamine; Mice; Sk	1992
Topical mechlorethamine in the treatment of mycosis fungoides. Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:5 Pt 1 Topics: Administration, Cutaneous; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	1992
Soluble IL2 receptor serum levels and epidermal cytokines in mycosis fungoides and related disorders. Acta dermato-venereologica, 1991, Volume: 71, Issue:6 Topics: Aged; Aged, 80 and over; Chemotaxis; Cytokines; Female; Humans; Male; Mechlorethamine; Middle Aged;	1991
Eruptive epidermal cysts and multiple squamous cell carcinomas after therapy for cutaneous T-cell lymphoma. Journal of the American Academy of Dermatology, 1991, Volume: 25, Issue:5 Pt 2 Topics: Administration, Cutaneous; Carcinoma, Squamous Cell; Epidermal Cyst; Humans; Lymphoma, T-Cell, Cutan	1991
International symposium on cutaneous T cell lymphoma. Chicago, Illinois, Oct. 19-21, 1989. Journal of the American Academy of Dermatology, 1991, Volume: 24, Issue:1 Topics: Chicago; Humans; Interferon alpha-2; Interferon-alpha; Lymphoma, T-Cell, Cutaneous; Mechlorethamine;	1991
Treatment of advanced stage mycosis fungoides with bleomycin, doxorubicin, and methotrexate with topical nitrogen mustard (BAM-M). Cancer, 1986, Dec-15, Volume: 58, Issue:12 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Li	1986
Combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides: a six-year experience. Acta dermato-venereologica, 1987, Volume: 67, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophos	1987
Long-term efficacy, curative potential, and carcinogenicity of topical mechlorethamine chemotherapy in cutaneous T cell lymphoma. Journal of the American Academy of Dermatology, 1989, Volume: 20, Issue:3 Topics: Administration, Cutaneous; Age Factors; Aged; Female; Follow-Up Studies; Humans; Lymphoma; Male; Mec	1989
Topical nitrogen mustard in early mycosis fungoides. A 12-year experience. Acta dermato-venereologica, 1985, Volume: 65, Issue:1 Topics: Administration, Topical; Adult; Aged; Female; Follow-Up Studies; Humans; Male; Mechlorethamine; Midd	1985
Cutaneous Hodgkin's disease in a patient with human immunodeficiency virus infection. Cancer, 1989, Dec-15, Volume: 64, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; H	1989
Topical mechlorethamine therapy for early stage mycosis fungoides. Journal of the American Academy of Dermatology, 1988, Volume: 19, Issue:4 Topics: Administration, Topical; Adult; Aged; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delay	1988
Acanthosis nigricans associated with mycosis fungoides. Journal of the American Academy of Dermatology, 1988, Volume: 19, Issue:5 Pt 2 Topics: Acanthosis Nigricans; Adult; Humans; Male; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	1988
No detectable increase in sister chromatid exchanges in lymphocytes from mycosis fungoides patients after topical treatment with nitrogen mustard. The British journal of dermatology, 1988, Volume: 119, Issue:6 Topics: Aged; Aged, 80 and over; Female; Humans; Lymphocytes; Male; Mechlorethamine; Middle Aged; Mycosis Fu	1988
Combined modality therapy for tumor stage mycosis fungoides: results of a 10-year follow-up. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:7 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophospha	1988
Mycosis fungoides: management with topical nitrogen mustard. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Female; Humans; Lymphatic Metastasis; Male; Mechlor	1987
Cutaneous malignancies and metastatic squamous cell carcinoma following topical therapies for mycosis fungoides. Journal of the American Academy of Dermatology, 1986, Volume: 14, Issue:6 Topics: Administration, Topical; Aged; Biopsy; Carcinoma, Squamous Cell; Female; Humans; Male; Mechlorethami	1986
Regional isolated limb perfusion of melanoma intransit metastases using mechlorethamine (nitrogen mustard). Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:12 Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Humans; Hyperthermia, In	1986
Skin lesions in chronic granulocytic leukemia. Treatment of a patient with topical nitrogen mustard. Cancer, 1985, Jun-01, Volume: 55, Issue:11 Topics: Administration, Topical; Aged; Female; Humans; Leukemia, Myeloid; Mechlorethamine; Skin Neoplasms	1985
[Histiocytosis X with perianovulvar eosinophilic granuloma. Favorable effect of the local application of nitrogen mustard onto anovulvar lesions]. Annales de dermatologie et de venereologie, 1985, Volume: 112, Issue:2 Topics: Administration, Topical; Aged; Anus Diseases; Eosinophilic Granuloma; Female; Histiocytosis, Langerh	1985
Histiocytosis X of the scalp and face responding to topical nitrogen mustard. Journal of the Royal Society of Medicine, 1985, Volume: 78 Suppl 11 Topics: Administration, Topical; Adult; Facial Neoplasms; Histiocytosis, Langerhans-Cell; Humans; Male; Mech	1985
Topical nitrogen mustard in mycosis fungoides. International journal of clinical pharmacology research, 1985, Volume: 5, Issue:3 Topics: Administration, Topical; Adult; Aged; Female; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fu	1985
Factors influencing the success of arterial infusion chemotherapy for cancer of the head and neck. American journal of surgery, 1972, Volume: 123, Issue:5 Topics: Age Factors; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell	1972
The treatment of malignant pleural effusions. Cancer, 1974, Volume: 33, Issue:4 Topics: Adenocarcinoma; Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamou	1974
Mycosis fungoides lymphoma. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:5 Part 2 Topics: Administration, Topical; Antineoplastic Agents; Humans; Lymphoma; Mechlorethamine; Mycosis Fungoides	1974
Subcutaneous metastasis following needle biopsy of the pleura. The Journal of the American Osteopathic Association, 1974, Volume: 73, Issue:7 Topics: Biopsy, Needle; Carcinoma, Bronchogenic; Female; Humans; Mechlorethamine; Middle Aged; Neoplasm Meta	1974
Complete remissions of mycosis fungoides lymphoma induced by topical nitrogen mustard (HN2). Control of delayed hypersensitivity to HN2 by desensitization and by induction of specific immunologic tolerance. Cancer, 1973, Volume: 32, Issue:1 Topics: Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Immune Tolerance; Immunologic Tech	1973
Complete regressions of mycosis fungoides with topical mechlorethamine hydrochloride. JAMA, 1972, Nov-27, Volume: 222, Issue:9 Topics: Humans; Mechlorethamine; Mycosis Fungoides; Remission, Spontaneous; Skin Neoplasms; Solutions	1972
Mucha-Habermann disease mistaken for reticulum cell sarcoma. Archives of dermatology, 1971, Volume: 103, Issue:4 Topics: Aged; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differential; Female; Humans; Hypothyroidism; Lympho	1971
Mycosis fungoides bullosa. Archives of dermatology, 1971, Volume: 104, Issue:4 Topics: Biopsy; Blister; Cyclophosphamide; Female; Fluorescent Antibody Technique; Humans; Mechlorethamine;	1971
Mycosis fungoides. Archives of dermatology, 1972, Volume: 105, Issue:5 Topics: Aged; Betamethasone; Humans; Male; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms	1972
[Mycosis fungoides. A form of pleuropulmonary origin with cutaneous sclerodermiform manifestations. Treatment by application of nitrogen mustard]. Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1971, Volume: 78, Issue:6 Topics: Chlorambucil; Cortisone; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Skin Neoplas	1971
Cutaneous lymphoma complicating basal cell carcinoma of the face. Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 91, Issue:4 Topics: Carcinoma, Basal Cell; Chemotherapy, Cancer, Regional Perfusion; Facial Neoplasms; Humans; Lymphoma;	1970
Advanced melanoma of the extremities. Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:2 Topics: Adolescent; Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Child; Dactinomycin; Female; Huma	1970
Responses of mycosis fungoides to intensive external treatment with nitrogen mustard. Archives of dermatology, 1970, Volume: 102, Issue:5 Topics: Adult; Aged; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Leukocyte Count; Male	1970
[Treatment of malignant reticulohemopathies with limewashing using mechlorethamin]. Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1970, Volume: 77, Issue:6 Topics: Adult; Aged; Female; Humans; Lymphoma; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Sarcom	1970
Lymphatic extension of carcinoma of the lung to the anterior chest wall. American journal of surgery, 1965, Volume: 110, Issue:6 Topics: Biopsy; Carcinoma, Squamous Cell; Cobalt Isotopes; Humans; Lung Neoplasms; Lymph Node Excision; Lymp	1965
Treatment of a giant cutaneous hemangioma by intra-arterial injection of nitrogen mustard: case report. Annals of surgery, 1966, Volume: 164, Issue:5 Topics: Angiography; Erythema; Facial Neoplasms; Female; Hemangioma; Humans; Infant; Injections, Intra-Arter	1966

mechlorethamine and Cancer of Skin