mechlorethamine has been researched along with Burkitt Lymphoma in 24 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We reviewed all reported cases of Burkitt's lymphoma and/or Burkitt's leukemia (BLL) occurring following therapy for Hodgkin's disease." | 2.39 | Burkitt's lymphoma-leukemia in patients treated for Hodgkin's disease. ( Cooper, DL; Levy, A; Salloum, E; Tallini, G, 1996) |
| "Ilmofosine treated CA46 cells failed to accumulate hyperphosphorylated-cdc2/cyclin B1 complexes that are observed when G2-arrest is induced by either nitrogen mustard or ionizing radiation." | 1.29 | The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. ( Grunicke, H; Hofmann, J; Jackman, J; Kohn, KW; O'Connor, PM; Schubert, C; Ueberall, F, 1994) |
| "We surveyed 11 Burkitt's lymphoma cell lines for chemosensitivity to nitrogen mustard (HN2) in order to determine whether any simple correlates to cytotoxic response might be revealed." | 1.28 | Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. ( Bohr, VA; Kohn, KW; Magrath, I; O'Connor, PM; Sarang, M; Wassermann, K, 1991) |
| "A human Burkitt's lymphoma cell line (Raji-HN2) made resistant to nitrogen mustard, a bifunctional alkylating agent, was used to study the mechanism of resistance to nitrogen mustard." | 1.27 | Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells. ( Boyce, RA; Hertzberg, RP; Mattern, MR; Schein, PS; Tan, KB, 1987) |
| "A human Burkitt lymphoma cell line, Raji-HN2, made 10-fold more resistant to nitrogen mustard (HN2) than the parental Raji cell line, exhibited the following characteristics when compared to the parental Raji cells: (i) decreased HN2-induced DNA interstrand crosslinking; (ii) increased (3-fold) DNA topoisomerase II [DNA topoisomerase (ATP-hydrolyzing), EC 5." | 1.27 | Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells. ( Boyce, RA; Mattern, MR; Schein, PS; Tan, KB, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (66.67) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, BE | 1 |
| CLIFFORD, P | 1 |
| Wassermann, K | 2 |
| O'Connor, PM | 5 |
| Jackman, J | 3 |
| May, A | 1 |
| Bohr, VA | 2 |
| Ferris, DK | 1 |
| Hoffmann, I | 1 |
| Draetta, G | 1 |
| Kohn, KW | 4 |
| Fan, S | 1 |
| el-Deiry, WS | 1 |
| Bae, I | 1 |
| Freeman, J | 1 |
| Jondle, D | 1 |
| Bhatia, K | 1 |
| Fornace, AJ | 1 |
| Magrath, I | 3 |
| Hofmann, J | 1 |
| Schubert, C | 1 |
| Ueberall, F | 1 |
| Grunicke, H | 1 |
| Salloum, E | 1 |
| Tallini, G | 1 |
| Levy, A | 1 |
| Cooper, DL | 1 |
| Dubey, SP | 1 |
| Sengupta, SK | 1 |
| Kaleh, LK | 1 |
| Morewaya, JT | 1 |
| Tattersall, MH | 1 |
| Tobias, JS | 1 |
| Henle, W | 1 |
| Owor, R | 1 |
| Olweny, C | 1 |
| Sieber, SM | 1 |
| Wheeler, RH | 2 |
| Dirks, JW | 1 |
| Lunardi, I | 1 |
| Nemiroff, MJ | 1 |
| Sarang, M | 1 |
| Tan, KB | 3 |
| Mattern, MR | 3 |
| Boyce, RA | 3 |
| Hertzberg, RP | 1 |
| Schein, PS | 3 |
| Cuzick, J | 1 |
| Bull, FE | 1 |
| Ruddon, RW | 1 |
| Carbone, PP | 1 |
| Rubin, P | 1 |
| Arseneau, JC | 1 |
| Canellos, GP | 1 |
| DeVita, VT | 1 |
| Sherins, RJ | 1 |
| Ngu, VA | 2 |
| Frei, E | 1 |
3 reviews available for mechlorethamine and Burkitt Lymphoma
| Article | Year |
|---|---|
Burkitt's lymphoma-leukemia in patients treated for Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Burkitt Lymphoma; Cyclophosphamide | 1996 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
Recently recognized complications of cancer chemotherapy.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Death, Sudden; Drug Therapy, Combination; | 1974 |
1 trial available for mechlorethamine and Burkitt Lymphoma
| Article | Year |
|---|---|
How strong is the case for intensive cancer chemotherapy?
Topics: Antineoplastic Agents; Burkitt Lymphoma; Clinical Trials as Topic; Cyclophosphamide; Dose-Response R | 1976 |
20 other studies available for mechlorethamine and Burkitt Lymphoma
| Article | Year |
|---|---|
[Nasopharyngeal carcinoma in sub-Saharan Africa: a tribute to Mr. Peter Clifford].
Topics: Africa South of the Sahara; Antineoplastic Agents, Alkylating; Burkitt Lymphoma; Epstein-Barr Virus | 2009 |
THE MANAGEMENT OF MALIGNANT DISEASE OF THE HEAD AND NECK AREA IN EAST AFRICA.
Topics: Africa; Africa, Eastern; Black People; Burkitt Lymphoma; Busulfan; Carcinoma, Squamous Cell; Child; | 1964 |
Transcription-independent repair of nitrogen mustard-induced N-alkylpurines in the c-myc gene in Burkitt's lymphoma CA46 cells.
Topics: Alkylation; Alleles; Burkitt Lymphoma; DNA Repair; DNA, Neoplasm; Genes, myc; Humans; Mechlorethamin | 1994 |
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.
Topics: Aphidicolin; Burkitt Lymphoma; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Li | 1994 |
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
Topics: Apoptosis; Burkitt Lymphoma; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Topoisom | 1994 |
The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents.
Topics: Alkaloids; Antineoplastic Agents; Burkitt Lymphoma; CDC2 Protein Kinase; Cell Cycle; Cell Line; DNA | 1994 |
Adult head and neck lymphomas in Papua New Guinea: a retrospective study of 70 cases.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Combined Modali | 1999 |
Antibodies to Epstein-Barr-virus antigens before and after the development of Burkitt's lymphoma in a patient treated for Hodgkin's disease.
Topics: Antibodies, Viral; Antigens, Viral; Burkitt Lymphoma; Child; Herpesvirus 4, Human; Hodgkin Disease; | 1975 |
Effect of hyperbaric oxygen on the cytotoxicity of adriamycin and nitrogen mustard in cultured Burkitt's lymphoma cells.
Topics: Burkitt Lymphoma; Cell Survival; Cells, Cultured; Doxorubicin; Hyperbaric Oxygenation; Mechlorethami | 1979 |
Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.
Topics: Alkylation; Burkitt Lymphoma; Cell Cycle; Cell Death; Cross-Linking Reagents; DNA; DNA Damage; DNA R | 1991 |
Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells.
Topics: Amsacrine; Burkitt Lymphoma; Cell Line; Cell Survival; Chromatin; DNA Topoisomerases, Type II; Drug | 1987 |
Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cell Line; DNA Repair; DNA Topoisomerases, Type II; Drug Re | 1987 |
Unique sensitivity of nitrogen mustard-resistant human Burkitt lymphoma cells to novobiocin.
Topics: Burkitt Lymphoma; Cell Line; Cell Survival; Cells, Cultured; DNA Topoisomerases, Type II; Drug Syner | 1988 |
A method for analysing case-control studies with ordinal exposure variables.
Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biometry; Burkitt Lymphoma; Cl | 1985 |
The effect of heparin on the cytotoxicity and uptake of anti-neoplastic drugs in cultured Burkitt lymphoma cells.
Topics: Burkitt Lymphoma; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Hepari | 1974 |
Management of patients with non-Hodgkin's lymphoma.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Hodgkin Disease; Humans; Lymphography; Ly | 1973 |
Updated Hodgkin's disease. C. Advanced disease and special problems. Comment: the non-Hodgkin's lymphomas.
Topics: Burkitt Lymphoma; Cyclophosphamide; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Large B-C | 1973 |
Chemotherapy of Burkitt's tumor at the University of Ibadan, Nigeria.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Follow-Up Studies; Humans; Mechlorethamin | 1972 |
Status and perspectives in chemotherapy of Hodgkin's disease.
Topics: Animals; Antineoplastic Agents; Benzoates; Breast Neoplasms; Burkitt Lymphoma; Cyclophosphamide; Cyt | 1973 |
The treatment of Burkitt tumour.
Topics: Bone Marrow; Burkitt Lymphoma; Cyclophosphamide; Humans; Mechlorethamine; Methotrexate; Nigeria | 1968 |