mechlorethamine and Bright Disease studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Bright Disease: A historical classification which is no longer used. It described acute glomerulonephritis, acute nephritic syndrome, or acute nephritis. Named for Richard Bright.

Research Excerpts

Excerpt	Relevance	Reference
"Glomerular fibrin deposition is important in the pathogenesis of renal failure and crescent formation in glomerulonephritis."	7.67	Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. ( Holdsworth, SR; Tipping, PG, 1985)
"Glomerular fibrin deposition is important in the pathogenesis of renal failure and crescent formation in glomerulonephritis."	3.67	Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. ( Holdsworth, SR; Tipping, PG, 1985)
"Children with systemic lupus erythematosus and nephritis may benefit from the addition of cytotoxic agents to their corticosteroid regime, although the indications for this are not clear, and controlled evidence is lacking."	2.36	Immunosuppressive agents in the treatment of the nephrotic syndrome and glomerulonephritis in children. ( Cameron, JS, 1979)
"This case shows that relapse of Hodgkin's disease may occur after a 10 year interval and furthermore it may preceded by nephrotic syndrome."	1.27	Glomerulonephritis preceding late relapse of Hodgkin's disease. ( Lynn, WA; Marcus, RE, 1988)
"Malignant myelosclerosis or acute myelofibrosis is a rare acute myeloproliferative disorder characterized by pancytopenia, myeloblastosis and marrow fibrosis."	1.26	Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy. ( Ali, NO; Janes, WO, 1979)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (97.06)	18.7374
1990's	1 (2.94)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
LANGE, K	1
SLOBODY, L	1
CRAIG, F	1
OGUR, G	1
OBERMAN, J	1
LOCASTO, F	1
BALDWIN, DS	3
McLEAN, PG	1
CHASIS, H	3
GOLDRING, W	3
WU, C	2
BARIETY, J	4
LAGRUE, G	4
SAFAR, M	1
HESSE, JC	1
MILLIEZ, P	4
COCHRANE, CG	1
UNANUE, ER	1
DIXON, FJ	1
TAYLOR, RD	2
FRITEL, D	2
TCHERDAKOFF, P	1
SAMARCQ, P	2
CORCORAN, AC	1
PAGE, IH	1
NAVA, G	1
CHINI, A	1
Holdsworth, SR	2
Wallace, DJ	1
Metzger, AL	1
Germuth, FG	1
Rodriguez, E	1
Shah, HJ	1
Lorelle, K	1
McGee, S	1
Milano, L	1
Wise, O	1
Cameron, JS	3
Ali, NO	1
Janes, WO	1
Wagner, L	1
Pollak, VE	3
Dillard, MG	3
Tillman, RL	1
Sampson, CC	1
Lynn, WA	1
Marcus, RE	1
West, CD	1
Tipping, PG	1
Boulton-Jones, M	1
Robinson, R	1
Ogg, C	1
Pirani, CL	2
Dujovne, I	2
Wojnarowski, M	2
Wyszyńska, T	2
Habib, R	1
Levy, M	1
Rorive, G	1
Hiernaux, M	1
Rowecka-Trzebicka, K	1
Nowak, S	1
Bodalski, J	1
Margolis, A	1
Michalak, A	1
Jacquillat, C	1

Article	Year
Immunosuppressive agents in the treatment of the nephrotic syndrome and glomerulonephritis in children. Paediatrician, 1979, Volume: 8, Issue:5-6 Topics: Azathioprine; Child; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive A	1979
Immunosuppressive agents in lupus nephritis: a critical analysis. Medicine, 1976, Volume: 55, Issue:3 Topics: Azathioprine; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney; Lupus	1976
[Indications for immunosuppressive treatment in kidney diseases of children]. Pediatria polska, 1969, Volume: 44, Issue:5 Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Azathioprine; Chil	1969
Immunosuppressant agents in the treatment of glomerulonephritis. 2. Cytotoxic drugs. Journal of the Royal College of Physicians of London, 1971, Volume: 5, Issue:4 Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antilymphocyte Serum; Antineoplastic Agents; Azath	1971

Article	Year
The influence of ACTH and nitrogen mustard therapy on serum complement of patients in the nephrotic stage. Bulletin. New York Medical College, 1951, Volume: 14 Topics: Adrenocorticotropic Hormone; Complement System Proteins; Glomerulonephritis; Mechlorethamine; Nitrog	1951
Effect of nitrogen mustard on clinical course of glomerulonephritis. A.M.A. archives of internal medicine, 1953, Volume: 92, Issue:2 Topics: Glomerulonephritis; Humans; Mechlorethamine; Nitrogen Mustard Compounds	1953
[Nitrogen mustard in the treatment of the nephrotic syndrome of chronic glomerulonephritis]. Zhonghua nei ke za zhi, 1959, Volume: 7 Topics: Chronic Disease; Glomerulonephritis; Mechlorethamine; Nephrotic Syndrome; Nitrogen Mustard Compounds	1959
[Nitrogen mustard in treatment of nephrotic syndrome of chronic glomerulonephritis]. Zhonghua nei ke za zhi, 1959, Volume: 7 Topics: Chronic Disease; Glomerulonephritis; Mechlorethamine; Nephrotic Syndrome; Nitrogen Mustard Compounds	1959
[THE NEPHROTIC SYNDROME OF "RHEUMATOID PURPURA"]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, May-14, Volume: 40 Topics: Abdomen; Abdomen, Acute; Abdominal Cavity; Child; Chlorambucil; Diagnosis; Glomerulonephritis; Hemat	1964
A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS. The Journal of experimental medicine, 1965, Jul-01, Volume: 122 Topics: Animals; Antibodies; Basement Membrane; Complement System Proteins; Electrons; Glomerulonephritis; K	1965
Nephrotic syndrome: treatment with ACTH and nitrogen mustard. The Medical clinics of North America, 1955, Volume: Cleveland No. Topics: Adrenocorticotropic Hormone; Glomerulonephritis; Humans; Mechlorethamine; Nephrosis; Nephrotic Syndr	1955
[Trial treatment of various glomerular nephropathies with nitrogen mustards]. La Semaine des hopitaux: therapeutique, 1962, Volume: 38 Topics: Glomerulonephritis; Kidney Diseases; Kidney Glomerulus; Mechlorethamine; Nitrogen Mustard Compounds	1962
Treatment of the nephrotic syndrome with nitrogen mustard. The Journal of laboratory and clinical medicine, 1950, Volume: 36, Issue:6 Topics: Glomerulonephritis; Mechlorethamine; Nephrotic Syndrome; Nitrogen Mustard Compounds	1950
[Nitrogen mustard in chronic glomerulonephritis]. Il Policlinico. Sezione pratica, 1951, Dec-03, Volume: 58, Issue:49 Topics: Chronic Disease; Glomerulonephritis; Humans; Mechlorethamine; Nitrogen Mustard Compounds	1951
The effect of nitrogen mustard on renal manifestations of human glomerulonephritis. The Journal of clinical investigation, 1950, Volume: 29, Issue:6 Topics: Glomerulonephritis; Humans; Kidney; Mechlorethamine; Nephritis; Nitrogen Mustard Compounds	1950
Effect of febrile plasma, typhoid vaccine and nitrogen mustard on renal manifestations of human glomerulonephritis. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:4 Topics: Fever; Glomerulonephritis; Humans; Kidney; Kidney Glomerulus; Mechlorethamine; Typhoid-Paratyphoid V	1949
Fc dependence of macrophage accumulation and subsequent injury in experimental glomerulonephritis. Journal of immunology (Baltimore, Md. : 1950), 1983, Volume: 130, Issue:2 Topics: Animals; Complement System Proteins; Fluorescent Antibody Technique; Glomerulonephritis; Kidney; Kid	1983
Successful use of nitrogen mustard for cyclophosphamide resistant diffuse proliferative lupus glomerulonephritis: report of 2 cases. The Journal of rheumatology, 1995, Volume: 22, Issue:4 Topics: Adolescent; Adult; Cyclophosphamide; Drug Resistance; Female; Glomerulonephritis; Humans; Lupus Neph	1995
Antibasement membrane disease. II. Mechanism of glomerular injury in an accelerated model of Masugi nephritis. Laboratory investigation; a journal of technical methods and pathology, 1978, Volume: 39, Issue:5 Topics: Animals; Antibodies, Anti-Idiotypic; Antigen-Antibody Complex; Autoantibodies; Autoimmune Diseases;	1978
Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy. Cancer, 1979, Volume: 43, Issue:4 Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Glom	1979
Treatment of lupus nephritis. Advances in nephrology from the Necker Hospital, 1976, Volume: 6 Topics: Adrenal Cortex Hormones; Adult; Animals; Antibody Formation; Azathioprine; Chlorambucil; Cyclophosph	1976
Lupus Nephritis. Correlations between the clinical course and presence of electron-dense deposits. Laboratory investigation; a journal of technical methods and pathology, 1975, Volume: 32, Issue:3 Topics: Adolescent; Adult; Basement Membrane; Biopsy; Endothelium; Epithelial Cells; Epithelium; Female; Glo	1975
Glomerulonephritis preceding late relapse of Hodgkin's disease. Postgraduate medical journal, 1988, Volume: 64, Issue:751 Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Glomerulonephritis; Glomerulosclerosis, Foca	1988
Childhood membranoproliferative glomerulonephritis: an approach to management. Kidney international, 1986, Volume: 29, Issue:5 Topics: Aspirin; Azathioprine; Child; Cyclophosphamide; Dipyridamole; Drug Administration Schedule; Drug The	1986
Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. The Journal of clinical investigation, 1985, Volume: 76, Issue:4 Topics: Animals; Basement Membrane; Blood Coagulation Tests; Disease Models, Animal; Fibrin; Glomerulonephri	1985
Treatment of lupus nephritis with cyclophosphamide. Lancet (London, England), 1970, Oct-24, Volume: 2, Issue:7678 Topics: Adolescent; Adult; Age Factors; Azathioprine; Biopsy; Chlorambucil; Cortisone; Cyclophosphamide; Fem	1970
The clinical course of lupus nephritis: relationship to the renal histologic findings. Perspectives in nephrology and hypertension, 1973, Volume: 1 Pt 2, Issue:0 Topics: Antigen-Antibody Complex; Complement System Proteins; Drug Therapy, Combination; gamma-Globulins; Gl	1973
[Nephropathies of rheumatoid purpura in children. Clinical and anatomical study of 60 cases]. Archives francaises de pediatrie, 1972, Volume: 29, Issue:3 Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Diagnosis, Differential; Female; Fluorescent Anti	1972
[Recovery of normal ultrastructure in 2 cases of primary glomerulonephritis with diffuse extra-membranous deposits]. La Presse medicale, 1968, Nov-27, Volume: 76, Issue:46 Topics: Adult; Basement Membrane; Biopsy; Chlorambucil; Female; Glomerulonephritis; Glucocorticoids; Hematur	1968
[On the use of antimitotic and immunosuppressive agents in nephrology]. Revue medicale de Liege, 1969, Oct-01, Volume: 24, Issue:19 Topics: Azathioprine; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Diseases; Mechlorethamine	1969
[Results of immunosuppressive treatment of diseases of renal glomerulus in children]. Pediatria polska, 1969, Volume: 44, Issue:5 Topics: Azathioprine; Child; Child, Preschool; Chlorambucil; Chronic Disease; Female; Glomerulonephritis; Hu	1969
[Attempts of the use of cytostatic agents in some forms of glomerulonephritis in children]. Pediatria polska, 1969, Volume: 44, Issue:5 Topics: Adolescent; Antineoplastic Agents; Azathioprine; Child; Child, Preschool; Chlorambucil; Chronic Dise	1969
[Extended chemotherapy of nephrotic syndromes and of certain glomerular nephropathies]. Semaine therapeutique, 1965, Volume: 41, Issue:3 Topics: Chlorambucil; Glomerulonephritis; Humans; Mechlorethamine; Nephrotic Syndrome	1965

mechlorethamine and Bright Disease

Research Excerpts

Research

Studies (34)

Authors

Reviews

Trials

Other Studies