mechlorethamine has been researched along with Brain Neoplasms in 40 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma." | 9.08 | Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 8.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity." | 7.68 | Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991) |
| "Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma." | 5.08 | Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 4.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Estramustine phosphate (EMP) is an anti-microtubule agent that induces apoptosis of glioma cells." | 3.71 | Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2. ( Noha, M; Sugisaki, Y; Takahashi, H; Teramoto, A; Watanabe, K; Yoshida, D, 2001) |
| "Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)." | 3.68 | Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992) |
| "Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity." | 3.68 | Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991) |
| "Thirteen patients with advanced (Stage III) malignant melanoma have been treated with high-dose chemotherapy (nitrogen mustard or a combination of BCNU and melphalan) combined with autologous, nonfrozen, bone marrow transplantation." | 3.66 | Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study. ( Dantas, ME; Glode, LM; Koeppler, H; Morton, N; Robinson, WA; Sutherland, J; Thomas, MR, 1982) |
| "Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity." | 1.30 | MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. ( Ater, JL; Bruner, J; Copeland, DR; Moore, B; van Eys, J; Woo, SY, 1997) |
| "7 of 8 with brain metastases treated by the same modality gave complete remission." | 1.27 | [Combination therapy of advanced choriocarcinoma--an analysis of 60 patients]. ( Cai, SM; Ding, YQ; Wang, RY, 1986) |
| "Central nervous system involvement with Hodgkin's disease is extremely rare and is almost always a late complication in patients who have widely disseminated disease in the usual nodal sites." | 1.27 | Hodgkin's disease presenting with isolated craniospinal involvement. ( Bender, BL; Mayernik, DG, 1986) |
| "Five children with brain tumors, who had had no prior chemotherapy, were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, prednisolone (MOPP) and intrathecal methotrexate." | 1.27 | [Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors]. ( Akita, H; Hashimoto, T; Hirose, M; Matsumoto, K; Miki, Y; Miyao, M; Ninomiya, T; Saijo, T; Sato, J, 1986) |
| "Intracranial hodgkin's disease, an extremely uncommon finding, is reported in a 21-year-old man." | 1.27 | Hodgkin's disease, intracranial involvement. Report of a case and review of the literature. ( Enriquez, R; Papac, R; Vera, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (85.00) | 18.7374 |
| 1990's | 5 (12.50) | 18.2507 |
| 2000's | 1 (2.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SOKOL, S | 1 |
| ANDERSON, B | 2 |
| HATIBOGLU, I | 1 |
| OWENS, G | 2 |
| WESTBURY, G | 1 |
| JAVID, R | 1 |
| TALLON, M | 1 |
| STEPANIAN, G | 1 |
| BELMUSTO, L | 1 |
| GONDOS, B | 1 |
| REINGOLD, IM | 1 |
| RATTIGAN, JP | 1 |
| MICHELSON, AL | 1 |
| POMERANTZ, AZ | 1 |
| FRENCH, JD | 1 |
| WEST, PM | 1 |
| VON AMERONGEN, FK | 1 |
| MAGOUN, HW | 1 |
| Moser, K | 1 |
| Pohl, A | 1 |
| Cangir, A | 4 |
| Ragab, AH | 1 |
| Steuber, P | 1 |
| Land, VJ | 1 |
| Berry, DH | 2 |
| Krischer, JP | 1 |
| Schmitt, K | 1 |
| Tulzer, W | 1 |
| Thomas, MR | 1 |
| Robinson, WA | 1 |
| Glode, LM | 1 |
| Dantas, ME | 1 |
| Koeppler, H | 1 |
| Morton, N | 1 |
| Sutherland, J | 1 |
| Shafer, RH | 1 |
| Chase, ES | 1 |
| Ater, JL | 1 |
| van Eys, J | 5 |
| Woo, SY | 1 |
| Moore, B | 1 |
| Copeland, DR | 1 |
| Bruner, J | 1 |
| Galanis, E | 1 |
| Buckner, JC | 1 |
| Burch, PA | 1 |
| Schaefer, PL | 1 |
| Dinapoli, RP | 1 |
| Novotny, PJ | 1 |
| Scheithauer, BW | 1 |
| Rowland, KM | 1 |
| Vukov, AM | 1 |
| Mailliard, JA | 1 |
| Morton, RF | 1 |
| Yoshida, D | 1 |
| Noha, M | 1 |
| Watanabe, K | 1 |
| Takahashi, H | 1 |
| Sugisaki, Y | 1 |
| Teramoto, A | 1 |
| Holoye, PY | 1 |
| Mensi, F | 1 |
| Bombara, R | 1 |
| Massari, A | 1 |
| Sala, F | 1 |
| Visca, U | 1 |
| Hvizdala, E | 1 |
| Morgan, SK | 1 |
| Hayani, A | 1 |
| Mahoney, DH | 1 |
| Taylor, LD | 1 |
| Coyle, T | 1 |
| Bushunow, P | 1 |
| Winfield, J | 1 |
| Wright, J | 1 |
| Graziano, S | 1 |
| Allalunis-Turner, MJ | 1 |
| Day, RS | 1 |
| McKean, JD | 1 |
| Petruk, KC | 1 |
| Allen, PB | 1 |
| Aronyk, KE | 1 |
| Weir, BK | 1 |
| Huyser-Wierenga, D | 1 |
| Fulton, DS | 1 |
| Urtasun, RC | 1 |
| Cai, SM | 1 |
| Wang, RY | 1 |
| Ding, YQ | 1 |
| Evans, CG | 1 |
| Bodell, WJ | 2 |
| Tokuda, K | 1 |
| Doane-Setzer, P | 1 |
| Smith, MT | 1 |
| Takaue, Y | 1 |
| Sullivan, MP | 1 |
| Ramirez, I | 1 |
| Cleary, KR | 1 |
| Stokes, DC | 1 |
| Shenep, JL | 1 |
| Horowitz, ME | 1 |
| Hughes, WT | 1 |
| Baram, TZ | 1 |
| Bruner, JM | 1 |
| Martinez-Prieto, J | 1 |
| Aida, T | 1 |
| Gurney, HP | 1 |
| Phadke, K | 1 |
| Jostes, R | 1 |
| Deen, DF | 1 |
| Bender, BL | 1 |
| Mayernik, DG | 1 |
| Sato, J | 1 |
| Ninomiya, T | 1 |
| Saijo, T | 1 |
| Akita, H | 1 |
| Miki, Y | 1 |
| Hirose, M | 1 |
| Hashimoto, T | 1 |
| Miyao, M | 1 |
| Matsumoto, K | 1 |
| Vera, R | 1 |
| Enriquez, R | 1 |
| Papac, R | 1 |
| Coody, D | 1 |
| Smith, B | 1 |
| Wilson, CB | 1 |
| Hoshino, T | 1 |
| Miller, DR | 1 |
| Sonley, M | 1 |
| Karon, M | 1 |
| Breslow, N | 1 |
| Hammond, D | 1 |
| Mahaley, MS | 2 |
| Woodhall, B | 2 |
| Gaelen, LH | 1 |
| Levitan, S | 1 |
| Sanders, AP | 1 |
2 reviews available for mechlorethamine and Brain Neoplasms
| Article | Year |
|---|---|
[Recent developments in chemotherapy of malignant diseases].
Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 1982 |
Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Hypersensit | 1992 |
1 trial available for mechlorethamine and Brain Neoplasms
| Article | Year |
|---|---|
Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Glioma; | 1998 |
37 other studies available for mechlorethamine and Brain Neoplasms
| Article | Year |
|---|---|
[Treatment of cerebral metastases with oxidized nitrogen mustards].
Topics: Brain; Brain Neoplasms; Mechlorethamine; Nitrogen Mustard Compounds | 1956 |
Necrotizing uveitis incident to perfusion of intractraial malignancies with nitrogen mustard or related compounds.
Topics: Brain Neoplasms; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Perfusion; Uveitis | 1960 |
Results of intermittent, prolonged infusion of nitrogen mustard into the carotid artery in twelve patients with cerebral gliomas.
Topics: Brain Neoplasms; Carotid Arteries; Glioma; Humans; Mechlorethamine; Nitrogen Mustard Compounds | 1961 |
CONTINUOUS INTRA-ARTERIAL INFUSION AND INTERMITTENT INTRA-ARTERIAL INJECTION.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Ethoglucid; Head a | 1963 |
ARTERIAL INFUSION CHEMOTHERAPY OF PRIMARY GLIOMAS.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Glioma; Mechloreth | 1963 |
MEDIASTINAL GANGLIONEUROBLASTOMA METASTASIZING TO SCALENE LYMPH NODES IN AN ADULT. REPORT OF A CASE AND REVIEW OF THE LITERATURE.
Topics: Autopsy; Black People; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Diagnosis, Differential; | 1964 |
Bronchogenic carcinoma with intracranial metastasis (symptomatic improvement following nitrogen mustard therapy.
Topics: Brain; Brain Neoplasms; Carcinoma, Bronchogenic; Lung Neoplasms; Mechlorethamine; Nitrogen Mustard C | 1952 |
Effects of intracarotid administration of nitrogen mustard on normal brain and brain tumors.
Topics: Brain; Brain Neoplasms; Mechlorethamine; Nitrogen Mustard Compounds; Pharmaceutical Preparations | 1952 |
Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Follow-Up | 1984 |
[Second tumor following Hodgkin's disease].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Presc | 1984 |
Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; | 1982 |
DNA damage in rat 9L cells treated with nitrogen mustard and 1,3-bis(2-chloroethyl)-1-nitrosourea assayed by viscoelastometry and S1 nuclease.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Cross-Linking Reagents; Deoxyribonucleases; DNA, Ne | 1980 |
MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, | 1997 |
Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Astrocytes; Brain Neoplasms; Ele | 2001 |
Management of small-cell bronchogenic carcinoma.
Topics: Altretamine; Antibiotics, Antineoplastic; Brain Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide | 1978 |
[The chordoma. Description of 2 clinical cases and results of oncolytic chemotherapy].
Topics: Adult; Aged; Brain Neoplasms; Chordoma; Coccyx; Cyclophosphamide; Humans; Male; Mechlorethamine; Neo | 1979 |
Combination chemotherapy with MOPP in children with recurrent brain tumors.
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combinati | 1978 |
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool | 1992 |
Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Buthionine Sulfoximine; C | 1991 |
[Combination therapy of advanced choriocarcinoma--an analysis of 60 patients].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choriocarcinoma; Combined Modality | 1986 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatograp | 1987 |
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G | 1986 |
Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child, Preschool; Huma | 1988 |
Salvage chemotherapy for recurrent primary brain tumors in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi | 1988 |
[Anticancer drug induced sister chromatid exchange and correlation to cell survival in human brain tumor cells].
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Cisplatin; Glioma; Hum | 1987 |
Hodgkin's disease presenting with central nervous system involvement.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal | 1987 |
Double elution analysis of cross-link formation and repair in cycling and noncycling 9L spheroid cells.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cross-Linking Reagents; Culture Techniques; DNA Repair; DNA, N | 1986 |
Hodgkin's disease presenting with isolated craniospinal involvement.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; D | 1986 |
[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Choroid Pl | 1986 |
Hodgkin's disease, intracranial involvement. Report of a case and review of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal | 1985 |
MOPP regimen as primary chemotherapy for brain tumors in infants.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; | 1985 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
Additive therapy in the maintenance of remission in acute lymphoblastic leukemia of childhood: the effect of the initial leukocyte count.
Topics: Adolescent; Age Factors; Blood; Brain Neoplasms; Child; Child, Preschool; Dactinomycin; Digestive Sy | 1974 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci | 1967 |
Solitary intracranial metastasis by Hodgkin's disease.
Topics: Adult; Brain Neoplasms; Cerebral Angiography; Cerebral Ventriculography; Dura Mater; Female; Hodgkin | 1967 |
Brain perfusion for tumour--the effect of nitrogen mustard on brain adenosine triphosphate.
Topics: Acid Phosphatase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbon I | 1968 |
The in vitro respiration of normal brain and brain tumors.
Topics: Brain; Brain Neoplasms; Cyclophosphamide; Humans; In Vitro Techniques; Mechlorethamine; Methotrexate | 1966 |