mechlorethamine has been researched along with Benign Neoplasms, Brain in 40 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma." | 9.08 | Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 8.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity." | 7.68 | Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991) |
| "Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma." | 5.08 | Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 4.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Estramustine phosphate (EMP) is an anti-microtubule agent that induces apoptosis of glioma cells." | 3.71 | Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2. ( Noha, M; Sugisaki, Y; Takahashi, H; Teramoto, A; Watanabe, K; Yoshida, D, 2001) |
| "Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)." | 3.68 | Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992) |
| "Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity." | 3.68 | Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991) |
| "Thirteen patients with advanced (Stage III) malignant melanoma have been treated with high-dose chemotherapy (nitrogen mustard or a combination of BCNU and melphalan) combined with autologous, nonfrozen, bone marrow transplantation." | 3.66 | Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study. ( Dantas, ME; Glode, LM; Koeppler, H; Morton, N; Robinson, WA; Sutherland, J; Thomas, MR, 1982) |
| "Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity." | 1.30 | MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. ( Ater, JL; Bruner, J; Copeland, DR; Moore, B; van Eys, J; Woo, SY, 1997) |
| "7 of 8 with brain metastases treated by the same modality gave complete remission." | 1.27 | [Combination therapy of advanced choriocarcinoma--an analysis of 60 patients]. ( Cai, SM; Ding, YQ; Wang, RY, 1986) |
| "Central nervous system involvement with Hodgkin's disease is extremely rare and is almost always a late complication in patients who have widely disseminated disease in the usual nodal sites." | 1.27 | Hodgkin's disease presenting with isolated craniospinal involvement. ( Bender, BL; Mayernik, DG, 1986) |
| "Five children with brain tumors, who had had no prior chemotherapy, were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, prednisolone (MOPP) and intrathecal methotrexate." | 1.27 | [Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors]. ( Akita, H; Hashimoto, T; Hirose, M; Matsumoto, K; Miki, Y; Miyao, M; Ninomiya, T; Saijo, T; Sato, J, 1986) |
| "Intracranial hodgkin's disease, an extremely uncommon finding, is reported in a 21-year-old man." | 1.27 | Hodgkin's disease, intracranial involvement. Report of a case and review of the literature. ( Enriquez, R; Papac, R; Vera, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (85.00) | 18.7374 |
| 1990's | 5 (12.50) | 18.2507 |
| 2000's | 1 (2.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SOKOL, S | 1 |
| ANDERSON, B | 2 |
| HATIBOGLU, I | 1 |
| OWENS, G | 2 |
| WESTBURY, G | 1 |
| JAVID, R | 1 |
| TALLON, M | 1 |
| STEPANIAN, G | 1 |
| BELMUSTO, L | 1 |
| GONDOS, B | 1 |
| REINGOLD, IM | 1 |
| RATTIGAN, JP | 1 |
| MICHELSON, AL | 1 |
| POMERANTZ, AZ | 1 |
| FRENCH, JD | 1 |
| WEST, PM | 1 |
| VON AMERONGEN, FK | 1 |
| MAGOUN, HW | 1 |
| Moser, K | 1 |
| Pohl, A | 1 |
| Cangir, A | 4 |
| Ragab, AH | 1 |
| Steuber, P | 1 |
| Land, VJ | 1 |
| Berry, DH | 2 |
| Krischer, JP | 1 |
| Schmitt, K | 1 |
| Tulzer, W | 1 |
| Thomas, MR | 1 |
| Robinson, WA | 1 |
| Glode, LM | 1 |
| Dantas, ME | 1 |
| Koeppler, H | 1 |
| Morton, N | 1 |
| Sutherland, J | 1 |
| Shafer, RH | 1 |
| Chase, ES | 1 |
| Ater, JL | 1 |
| van Eys, J | 5 |
| Woo, SY | 1 |
| Moore, B | 1 |
| Copeland, DR | 1 |
| Bruner, J | 1 |
| Galanis, E | 1 |
| Buckner, JC | 1 |
| Burch, PA | 1 |
| Schaefer, PL | 1 |
| Dinapoli, RP | 1 |
| Novotny, PJ | 1 |
| Scheithauer, BW | 1 |
| Rowland, KM | 1 |
| Vukov, AM | 1 |
| Mailliard, JA | 1 |
| Morton, RF | 1 |
| Yoshida, D | 1 |
| Noha, M | 1 |
| Watanabe, K | 1 |
| Takahashi, H | 1 |
| Sugisaki, Y | 1 |
| Teramoto, A | 1 |
| Holoye, PY | 1 |
| Mensi, F | 1 |
| Bombara, R | 1 |
| Massari, A | 1 |
| Sala, F | 1 |
| Visca, U | 1 |
| Hvizdala, E | 1 |
| Morgan, SK | 1 |
| Hayani, A | 1 |
| Mahoney, DH | 1 |
| Taylor, LD | 1 |
| Coyle, T | 1 |
| Bushunow, P | 1 |
| Winfield, J | 1 |
| Wright, J | 1 |
| Graziano, S | 1 |
| Allalunis-Turner, MJ | 1 |
| Day, RS | 1 |
| McKean, JD | 1 |
| Petruk, KC | 1 |
| Allen, PB | 1 |
| Aronyk, KE | 1 |
| Weir, BK | 1 |
| Huyser-Wierenga, D | 1 |
| Fulton, DS | 1 |
| Urtasun, RC | 1 |
| Cai, SM | 1 |
| Wang, RY | 1 |
| Ding, YQ | 1 |
| Evans, CG | 1 |
| Bodell, WJ | 2 |
| Tokuda, K | 1 |
| Doane-Setzer, P | 1 |
| Smith, MT | 1 |
| Takaue, Y | 1 |
| Sullivan, MP | 1 |
| Ramirez, I | 1 |
| Cleary, KR | 1 |
| Stokes, DC | 1 |
| Shenep, JL | 1 |
| Horowitz, ME | 1 |
| Hughes, WT | 1 |
| Baram, TZ | 1 |
| Bruner, JM | 1 |
| Martinez-Prieto, J | 1 |
| Aida, T | 1 |
| Gurney, HP | 1 |
| Phadke, K | 1 |
| Jostes, R | 1 |
| Deen, DF | 1 |
| Bender, BL | 1 |
| Mayernik, DG | 1 |
| Sato, J | 1 |
| Ninomiya, T | 1 |
| Saijo, T | 1 |
| Akita, H | 1 |
| Miki, Y | 1 |
| Hirose, M | 1 |
| Hashimoto, T | 1 |
| Miyao, M | 1 |
| Matsumoto, K | 1 |
| Vera, R | 1 |
| Enriquez, R | 1 |
| Papac, R | 1 |
| Coody, D | 1 |
| Smith, B | 1 |
| Wilson, CB | 1 |
| Hoshino, T | 1 |
| Miller, DR | 1 |
| Sonley, M | 1 |
| Karon, M | 1 |
| Breslow, N | 1 |
| Hammond, D | 1 |
| Mahaley, MS | 2 |
| Woodhall, B | 2 |
| Gaelen, LH | 1 |
| Levitan, S | 1 |
| Sanders, AP | 1 |
2 reviews available for mechlorethamine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
[Recent developments in chemotherapy of malignant diseases].
Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 1982 |
Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Hypersensit | 1992 |
1 trial available for mechlorethamine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Glioma; | 1998 |
37 other studies available for mechlorethamine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
[Treatment of cerebral metastases with oxidized nitrogen mustards].
Topics: Brain; Brain Neoplasms; Mechlorethamine; Nitrogen Mustard Compounds | 1956 |
Necrotizing uveitis incident to perfusion of intractraial malignancies with nitrogen mustard or related compounds.
Topics: Brain Neoplasms; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Perfusion; Uveitis | 1960 |
Results of intermittent, prolonged infusion of nitrogen mustard into the carotid artery in twelve patients with cerebral gliomas.
Topics: Brain Neoplasms; Carotid Arteries; Glioma; Humans; Mechlorethamine; Nitrogen Mustard Compounds | 1961 |
CONTINUOUS INTRA-ARTERIAL INFUSION AND INTERMITTENT INTRA-ARTERIAL INJECTION.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Ethoglucid; Head a | 1963 |
ARTERIAL INFUSION CHEMOTHERAPY OF PRIMARY GLIOMAS.
Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Glioma; Mechloreth | 1963 |
MEDIASTINAL GANGLIONEUROBLASTOMA METASTASIZING TO SCALENE LYMPH NODES IN AN ADULT. REPORT OF A CASE AND REVIEW OF THE LITERATURE.
Topics: Autopsy; Black People; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Diagnosis, Differential; | 1964 |
Bronchogenic carcinoma with intracranial metastasis (symptomatic improvement following nitrogen mustard therapy.
Topics: Brain; Brain Neoplasms; Carcinoma, Bronchogenic; Lung Neoplasms; Mechlorethamine; Nitrogen Mustard C | 1952 |
Effects of intracarotid administration of nitrogen mustard on normal brain and brain tumors.
Topics: Brain; Brain Neoplasms; Mechlorethamine; Nitrogen Mustard Compounds; Pharmaceutical Preparations | 1952 |
Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Follow-Up | 1984 |
[Second tumor following Hodgkin's disease].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Presc | 1984 |
Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; | 1982 |
DNA damage in rat 9L cells treated with nitrogen mustard and 1,3-bis(2-chloroethyl)-1-nitrosourea assayed by viscoelastometry and S1 nuclease.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Cross-Linking Reagents; Deoxyribonucleases; DNA, Ne | 1980 |
MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, | 1997 |
Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Astrocytes; Brain Neoplasms; Ele | 2001 |
Management of small-cell bronchogenic carcinoma.
Topics: Altretamine; Antibiotics, Antineoplastic; Brain Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide | 1978 |
[The chordoma. Description of 2 clinical cases and results of oncolytic chemotherapy].
Topics: Adult; Aged; Brain Neoplasms; Chordoma; Coccyx; Cyclophosphamide; Humans; Male; Mechlorethamine; Neo | 1979 |
Combination chemotherapy with MOPP in children with recurrent brain tumors.
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combinati | 1978 |
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool | 1992 |
Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Buthionine Sulfoximine; C | 1991 |
[Combination therapy of advanced choriocarcinoma--an analysis of 60 patients].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choriocarcinoma; Combined Modality | 1986 |
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatograp | 1987 |
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G | 1986 |
Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child, Preschool; Huma | 1988 |
Salvage chemotherapy for recurrent primary brain tumors in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi | 1988 |
[Anticancer drug induced sister chromatid exchange and correlation to cell survival in human brain tumor cells].
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Cisplatin; Glioma; Hum | 1987 |
Hodgkin's disease presenting with central nervous system involvement.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal | 1987 |
Double elution analysis of cross-link formation and repair in cycling and noncycling 9L spheroid cells.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cross-Linking Reagents; Culture Techniques; DNA Repair; DNA, N | 1986 |
Hodgkin's disease presenting with isolated craniospinal involvement.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; D | 1986 |
[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Choroid Pl | 1986 |
Hodgkin's disease, intracranial involvement. Report of a case and review of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal | 1985 |
MOPP regimen as primary chemotherapy for brain tumors in infants.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; | 1985 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
Additive therapy in the maintenance of remission in acute lymphoblastic leukemia of childhood: the effect of the initial leukocyte count.
Topics: Adolescent; Age Factors; Blood; Brain Neoplasms; Child; Child, Preschool; Dactinomycin; Digestive Sy | 1974 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci | 1967 |
Solitary intracranial metastasis by Hodgkin's disease.
Topics: Adult; Brain Neoplasms; Cerebral Angiography; Cerebral Ventriculography; Dura Mater; Female; Hodgkin | 1967 |
Brain perfusion for tumour--the effect of nitrogen mustard on brain adenosine triphosphate.
Topics: Acid Phosphatase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbon I | 1968 |
The in vitro respiration of normal brain and brain tumors.
Topics: Brain; Brain Neoplasms; Cyclophosphamide; Humans; In Vitro Techniques; Mechlorethamine; Methotrexate | 1966 |