Page last updated: 2024-10-30

mechlorethamine and Benign Neoplasms, Brain

mechlorethamine has been researched along with Benign Neoplasms, Brain in 40 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

ExcerptRelevanceReference
"Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma."9.08Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998)
"The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma."8.78Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992)
"Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity."7.68Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991)
"Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma."5.08Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998)
"The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma."4.78Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992)
"Estramustine phosphate (EMP) is an anti-microtubule agent that induces apoptosis of glioma cells."3.71Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2. ( Noha, M; Sugisaki, Y; Takahashi, H; Teramoto, A; Watanabe, K; Yoshida, D, 2001)
"Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)."3.68Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992)
"Biopsy samples and cultured cells derived from them were obtained from 39 patients with malignant glioma and were analyzed for 1) glutathione (GSH) content; 2) sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or nitrogen mustard (HN2) treatment and 3) the effect of buthionine sulfoximine (BSO) treatment on BCNU and/or HN2 cytotoxicity."3.68Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells. ( Allalunis-Turner, MJ; Allen, PB; Aronyk, KE; Day, RS; Fulton, DS; Huyser-Wierenga, D; McKean, JD; Petruk, KC; Urtasun, RC; Weir, BK, 1991)
"Thirteen patients with advanced (Stage III) malignant melanoma have been treated with high-dose chemotherapy (nitrogen mustard or a combination of BCNU and melphalan) combined with autologous, nonfrozen, bone marrow transplantation."3.66Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study. ( Dantas, ME; Glode, LM; Koeppler, H; Morton, N; Robinson, WA; Sutherland, J; Thomas, MR, 1982)
"Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity."1.30MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. ( Ater, JL; Bruner, J; Copeland, DR; Moore, B; van Eys, J; Woo, SY, 1997)
"7 of 8 with brain metastases treated by the same modality gave complete remission."1.27[Combination therapy of advanced choriocarcinoma--an analysis of 60 patients]. ( Cai, SM; Ding, YQ; Wang, RY, 1986)
"Central nervous system involvement with Hodgkin's disease is extremely rare and is almost always a late complication in patients who have widely disseminated disease in the usual nodal sites."1.27Hodgkin's disease presenting with isolated craniospinal involvement. ( Bender, BL; Mayernik, DG, 1986)
"Five children with brain tumors, who had had no prior chemotherapy, were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, prednisolone (MOPP) and intrathecal methotrexate."1.27[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors]. ( Akita, H; Hashimoto, T; Hirose, M; Matsumoto, K; Miki, Y; Miyao, M; Ninomiya, T; Saijo, T; Sato, J, 1986)
"Intracranial hodgkin's disease, an extremely uncommon finding, is reported in a 21-year-old man."1.27Hodgkin's disease, intracranial involvement. Report of a case and review of the literature. ( Enriquez, R; Papac, R; Vera, R, 1985)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199034 (85.00)18.7374
1990's5 (12.50)18.2507
2000's1 (2.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SOKOL, S1
ANDERSON, B2
HATIBOGLU, I1
OWENS, G2
WESTBURY, G1
JAVID, R1
TALLON, M1
STEPANIAN, G1
BELMUSTO, L1
GONDOS, B1
REINGOLD, IM1
RATTIGAN, JP1
MICHELSON, AL1
POMERANTZ, AZ1
FRENCH, JD1
WEST, PM1
VON AMERONGEN, FK1
MAGOUN, HW1
Moser, K1
Pohl, A1
Cangir, A4
Ragab, AH1
Steuber, P1
Land, VJ1
Berry, DH2
Krischer, JP1
Schmitt, K1
Tulzer, W1
Thomas, MR1
Robinson, WA1
Glode, LM1
Dantas, ME1
Koeppler, H1
Morton, N1
Sutherland, J1
Shafer, RH1
Chase, ES1
Ater, JL1
van Eys, J5
Woo, SY1
Moore, B1
Copeland, DR1
Bruner, J1
Galanis, E1
Buckner, JC1
Burch, PA1
Schaefer, PL1
Dinapoli, RP1
Novotny, PJ1
Scheithauer, BW1
Rowland, KM1
Vukov, AM1
Mailliard, JA1
Morton, RF1
Yoshida, D1
Noha, M1
Watanabe, K1
Takahashi, H1
Sugisaki, Y1
Teramoto, A1
Holoye, PY1
Mensi, F1
Bombara, R1
Massari, A1
Sala, F1
Visca, U1
Hvizdala, E1
Morgan, SK1
Hayani, A1
Mahoney, DH1
Taylor, LD1
Coyle, T1
Bushunow, P1
Winfield, J1
Wright, J1
Graziano, S1
Allalunis-Turner, MJ1
Day, RS1
McKean, JD1
Petruk, KC1
Allen, PB1
Aronyk, KE1
Weir, BK1
Huyser-Wierenga, D1
Fulton, DS1
Urtasun, RC1
Cai, SM1
Wang, RY1
Ding, YQ1
Evans, CG1
Bodell, WJ2
Tokuda, K1
Doane-Setzer, P1
Smith, MT1
Takaue, Y1
Sullivan, MP1
Ramirez, I1
Cleary, KR1
Stokes, DC1
Shenep, JL1
Horowitz, ME1
Hughes, WT1
Baram, TZ1
Bruner, JM1
Martinez-Prieto, J1
Aida, T1
Gurney, HP1
Phadke, K1
Jostes, R1
Deen, DF1
Bender, BL1
Mayernik, DG1
Sato, J1
Ninomiya, T1
Saijo, T1
Akita, H1
Miki, Y1
Hirose, M1
Hashimoto, T1
Miyao, M1
Matsumoto, K1
Vera, R1
Enriquez, R1
Papac, R1
Coody, D1
Smith, B1
Wilson, CB1
Hoshino, T1
Miller, DR1
Sonley, M1
Karon, M1
Breslow, N1
Hammond, D1
Mahaley, MS2
Woodhall, B2
Gaelen, LH1
Levitan, S1
Sanders, AP1

Reviews

2 reviews available for mechlorethamine and Benign Neoplasms, Brain

ArticleYear
[Recent developments in chemotherapy of malignant diseases].
    Wiener klinische Wochenschrift, 1982, Dec-10, Volume: 94, Issue:23

    Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy

1982
Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma.
    Cancer, 1992, May-15, Volume: 69, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Hypersensit

1992

Trials

1 trial available for mechlorethamine and Benign Neoplasms, Brain

ArticleYear
Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Glioma;

1998

Other Studies

37 other studies available for mechlorethamine and Benign Neoplasms, Brain

ArticleYear
[Treatment of cerebral metastases with oxidized nitrogen mustards].
    Prensa medica argentina, 1956, Nov-23, Volume: 43, Issue:47

    Topics: Brain; Brain Neoplasms; Mechlorethamine; Nitrogen Mustard Compounds

1956
Necrotizing uveitis incident to perfusion of intractraial malignancies with nitrogen mustard or related compounds.
    Transactions of the American Ophthalmological Society, 1960, Volume: 58

    Topics: Brain Neoplasms; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Perfusion; Uveitis

1960
Results of intermittent, prolonged infusion of nitrogen mustard into the carotid artery in twelve patients with cerebral gliomas.
    Surgical forum, 1961, Volume: 12

    Topics: Brain Neoplasms; Carotid Arteries; Glioma; Humans; Mechlorethamine; Nitrogen Mustard Compounds

1961
CONTINUOUS INTRA-ARTERIAL INFUSION AND INTERMITTENT INTRA-ARTERIAL INJECTION.
    Proceedings of the Royal Society of Medicine, 1963, Volume: 56

    Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Ethoglucid; Head a

1963
ARTERIAL INFUSION CHEMOTHERAPY OF PRIMARY GLIOMAS.
    JAMA, 1963, Nov-23, Volume: 186

    Topics: Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Glioma; Mechloreth

1963
MEDIASTINAL GANGLIONEUROBLASTOMA METASTASIZING TO SCALENE LYMPH NODES IN AN ADULT. REPORT OF A CASE AND REVIEW OF THE LITERATURE.
    The Journal of thoracic and cardiovascular surgery, 1964, Volume: 47

    Topics: Autopsy; Black People; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Diagnosis, Differential;

1964
Bronchogenic carcinoma with intracranial metastasis (symptomatic improvement following nitrogen mustard therapy.
    BMQ; the Boston medical quarterly, 1952, Volume: 3, Issue:1

    Topics: Brain; Brain Neoplasms; Carcinoma, Bronchogenic; Lung Neoplasms; Mechlorethamine; Nitrogen Mustard C

1952
Effects of intracarotid administration of nitrogen mustard on normal brain and brain tumors.
    Journal of neurosurgery, 1952, Volume: 9, Issue:4

    Topics: Brain; Brain Neoplasms; Mechlorethamine; Nitrogen Mustard Compounds; Pharmaceutical Preparations

1952
Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors.
    Medical and pediatric oncology, 1984, Volume: 12, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Follow-Up

1984
[Second tumor following Hodgkin's disease].
    Padiatrie und Padologie, 1984, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Presc

1984
Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Carmustine;

1982
DNA damage in rat 9L cells treated with nitrogen mustard and 1,3-bis(2-chloroethyl)-1-nitrosourea assayed by viscoelastometry and S1 nuclease.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Cross-Linking Reagents; Deoxyribonucleases; DNA, Ne

1980
MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children.
    Journal of neuro-oncology, 1997, Volume: 32, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy,

1997
Induction of apoptosis by estramustine phosphate mediated by phosphorylation of bcl-2.
    Journal of neuro-oncology, 2001, Volume: 54, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Astrocytes; Brain Neoplasms; Ele

2001
Management of small-cell bronchogenic carcinoma.
    Comprehensive therapy, 1978, Volume: 4, Issue:2

    Topics: Altretamine; Antibiotics, Antineoplastic; Brain Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide

1978
[The chordoma. Description of 2 clinical cases and results of oncolytic chemotherapy].
    Minerva medica, 1979, Sep-22, Volume: 70, Issue:40

    Topics: Adult; Aged; Brain Neoplasms; Chordoma; Coccyx; Cyclophosphamide; Humans; Male; Mechlorethamine; Neo

1979
Combination chemotherapy with MOPP in children with recurrent brain tumors.
    Medical and pediatric oncology, 1978, Volume: 4, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combinati

1978
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
    Journal of neuro-oncology, 1992, Volume: 14, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool

1992
Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells.
    Journal of neuro-oncology, 1991, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Buthionine Sulfoximine; C

1991
[Combination therapy of advanced choriocarcinoma--an analysis of 60 patients].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1986, Volume: 8, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choriocarcinoma; Combined Modality

1986
Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.
    Cancer research, 1987, May-15, Volume: 47, Issue:10

    Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Carmustine; Cell Line; Cell Survival; Chromatograp

1987
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G

1986
Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung.
    Chest, 1988, Volume: 94, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child, Preschool; Huma

1988
Salvage chemotherapy for recurrent primary brain tumors in children.
    The Journal of pediatrics, 1988, Volume: 113, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi

1988
[Anticancer drug induced sister chromatid exchange and correlation to cell survival in human brain tumor cells].
    No to shinkei = Brain and nerve, 1987, Volume: 39, Issue:3

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Cisplatin; Glioma; Hum

1987
Hodgkin's disease presenting with central nervous system involvement.
    Australian and New Zealand journal of medicine, 1987, Volume: 17, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal

1987
Double elution analysis of cross-link formation and repair in cycling and noncycling 9L spheroid cells.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Animals; Brain Neoplasms; Cell Cycle; Cross-Linking Reagents; Culture Techniques; DNA Repair; DNA, N

1986
Hodgkin's disease presenting with isolated craniospinal involvement.
    Cancer, 1986, Oct-15, Volume: 58, Issue:8

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; D

1986
[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Choroid Pl

1986
Hodgkin's disease, intracranial involvement. Report of a case and review of the literature.
    American journal of clinical oncology, 1985, Volume: 8, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal

1985
MOPP regimen as primary chemotherapy for brain tumors in infants.
    Journal of neuro-oncology, 1985, Volume: 3, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms;

1985
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
    Journal of neurosurgery, 1969, Volume: 31, Issue:6

    Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis;

1969
Additive therapy in the maintenance of remission in acute lymphoblastic leukemia of childhood: the effect of the initial leukocyte count.
    Cancer, 1974, Volume: 34, Issue:3

    Topics: Adolescent; Age Factors; Blood; Brain Neoplasms; Child; Child, Preschool; Dactinomycin; Digestive Sy

1974
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
    Annals of surgery, 1967, Volume: 166, Issue:2

    Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carci

1967
Solitary intracranial metastasis by Hodgkin's disease.
    Archives of internal medicine, 1967, Volume: 120, Issue:6

    Topics: Adult; Brain Neoplasms; Cerebral Angiography; Cerebral Ventriculography; Dura Mater; Female; Hodgkin

1967
Brain perfusion for tumour--the effect of nitrogen mustard on brain adenosine triphosphate.
    Proceedings of the Australian Association of Neurologists, 1968, Volume: 5, Issue:2

    Topics: Acid Phosphatase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbon I

1968
The in vitro respiration of normal brain and brain tumors.
    Cancer research, 1966, Volume: 26, Issue:2

    Topics: Brain; Brain Neoplasms; Cyclophosphamide; Humans; In Vitro Techniques; Mechlorethamine; Methotrexate

1966