mechlorethamine has been researched along with Anemia, Fanconi in 16 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A total of 271 patients underwent nitrogen mustard (NTM) and diepoxybutane (DEB) tests in our laboratory; baseline chromosomal breakage was studied for all of them." | 7.72 | Differential diagnosis of Fanconi anemia by nitrogen mustard and diepoxybutane. ( Deviren, A; Hacihanefioglu, S; Yalman, N, 2003) |
| " A total of 271 patients underwent nitrogen mustard (NTM) and diepoxybutane (DEB) tests in our laboratory; baseline chromosomal breakage was studied for all of them." | 3.72 | Differential diagnosis of Fanconi anemia by nitrogen mustard and diepoxybutane. ( Deviren, A; Hacihanefioglu, S; Yalman, N, 2003) |
| "Fanconi anemia (FA) is a human autosomal disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinking agents such as mitomycin C and diepoxybutane." | 3.71 | The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. ( Bryant, PE; D'Andrea, AD; Johnson, MA; Jones, NJ; May, S; Meyn, RE; Stuckert, AP; Trueman, KL; Wilson, JB, 2001) |
| "Fanconi anemia (FA) cells are hypersensitive to cytotoxicity, cell cycle arrest, and chromosomal aberrations induced by DNA cross-linking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2)." | 3.69 | The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells. ( Ashmun, RA; Brent, TP; Howell, SR; Marathi, UK, 1996) |
| "Fanconi anemia is a cancer-prone disease characterized by progressive loss of blood cells, skeletal defects and stunted growth." | 1.28 | Alteration of a nuclease in Fanconi anemia. ( Boyd, JB; Buchwald, M; Harris, PV; Ryan, C; Sakaguchi, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voter, AF | 1 |
| Manthei, KA | 1 |
| Keck, JL | 1 |
| Deviren, A | 1 |
| Yalman, N | 1 |
| Hacihanefioglu, S | 1 |
| Cohen, MM | 1 |
| Fruchtman, CE | 1 |
| Simpson, SJ | 1 |
| Martin, AO | 1 |
| Dean, SW | 2 |
| Fox, M | 1 |
| Berger, R | 4 |
| Bernheim, A | 1 |
| Le Coniat, M | 4 |
| Vecchione, D | 1 |
| Schaison, G | 1 |
| Sognier, MA | 1 |
| Hittelman, WN | 1 |
| Gendron, MC | 1 |
| Marathi, UK | 1 |
| Howell, SR | 1 |
| Ashmun, RA | 1 |
| Brent, TP | 1 |
| Stringer, JA | 1 |
| Kirk, SH | 1 |
| Ahmad, SI | 1 |
| Wilson, JB | 1 |
| Johnson, MA | 1 |
| Stuckert, AP | 1 |
| Trueman, KL | 1 |
| May, S | 1 |
| Bryant, PE | 1 |
| Meyn, RE | 1 |
| D'Andrea, AD | 1 |
| Jones, NJ | 1 |
| Sakaguchi, K | 1 |
| Harris, PV | 1 |
| Ryan, C | 1 |
| Buchwald, M | 1 |
| Boyd, JB | 1 |
| Howell, RT | 1 |
| Desangles, F | 1 |
| Miglierina, R | 2 |
| Gendron, M | 1 |
| Sykes, HR | 1 |
| Lehmann, AR | 1 |
16 other studies available for mechlorethamine and Anemia, Fanconi
| Article | Year |
|---|---|
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
Topics: Antineoplastic Agents; DNA Damage; DNA Helicases; DNA Repair; Drug Screening Assays, Antitumor; Fanc | 2016 |
Differential diagnosis of Fanconi anemia by nitrogen mustard and diepoxybutane.
Topics: Alkylating Agents; Chromosome Breakage; Diagnosis, Differential; Epoxy Compounds; Fanconi Anemia; Hu | 2003 |
The cytogenetic response of Fanconi's anemia lymphoblastoid cell lines to various clastogens.
Topics: Adult; Anemia, Aplastic; Ataxia Telangiectasia; Bleomycin; Cell Line; Child; Child, Preschool; Epoxy | 1982 |
Investigation of the cell cycle response of normal and Fanconi's anaemia fibroblasts to nitrogen mustard using flow cytometry.
Topics: Anemia, Aplastic; Cell Cycle; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; | 1983 |
[Effect of chlormethin chlorhydrate on the chromosomes in Fanconi's anemia: application to diagnosis and detection of heterozygotes].
Topics: Anemia, Aplastic; Cells, Cultured; Chromosomes, Human; Fanconi Anemia; Genetic Carrier Screening; Hu | 1980 |
Loss of repairability of DNA interstrand crosslinks in Fanconi's anemia cells with culture age.
Topics: Anemia, Aplastic; Cell Survival; Cells, Cultured; Cross-Linking Reagents; DNA Repair; Fanconi Anemia | 1983 |
Fanconi anemia. Chromosome breakage and cell cycle studies.
Topics: Cell Cycle; Cells, Cultured; Chromosome Aberrations; Cytogenetics; Fanconi Anemia; Flow Cytometry; H | 1993 |
The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells.
Topics: Apoptosis; Cell Cycle; Cell Cycle Proteins; Cross-Linking Reagents; DNA Adducts; DNA Repair; DNA-Bin | 1996 |
Studies on double strand DNA damage, repair and mutagenesis in E coli and the implications to Fanconi's anaemia.
Topics: Amino Acid Sequence; Bacterial Proteins; Cisplatin; DNA Damage; DNA Repair; Escherichia coli; Fancon | 1997 |
The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange.
Topics: Animals; Bleomycin; Cell Line; CHO Cells; Cricetinae; DNA Damage; DNA-Binding Proteins; Epoxy Compou | 2001 |
Alteration of a nuclease in Fanconi anemia.
Topics: Cell Fractionation; Cell Line, Transformed; Deoxyribonucleases; Fanconi Anemia; Fibroblasts; Humans; | 1991 |
Sister chromatid exchange evaluation as an aid to the diagnosis and exclusion of Fanconi's anaemia by induced chromosome damage analysis.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Cross-Linking Reagents; DNA; DNA Damage | 1991 |
[Diagnosis of Fanconi's anemia by nitrogen mustard induction of chromosome breakage in fibroblasts].
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dose-Response Relationship, Drug; Fanconi | 1991 |
A simple diagnostic test for Fanconi anemia by flow cytometry.
Topics: Cell Cycle; Cells, Cultured; Chromosomes; Erythrocytes; Fanconi Anemia; Flow Cytometry; Humans; Mech | 1991 |
Diagnosis of Fanconi's anemia by flow cytometry.
Topics: Cell Cycle; Chromosome Aberrations; DNA; Fanconi Anemia; Flow Cytometry; Heterozygote; Humans; Lymph | 1990 |
Inactivation by nitrogen mustard of plasmids introduced into normal and Fanconi's anaemia cells.
Topics: Acetyltransferases; Anemia, Aplastic; Cell Line, Transformed; Cell Survival; Chloramphenicol O-Acety | 1988 |