mechlorethamine has been researched along with Agranulocytosis in 31 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We subjected nine dogs with severe granulocytopenia 4 days after the administration of mechlorethamine to 1 hour of cerebral ischemia induced by the controlled, incremental injection of air into the internal carotid artery." | 3.67 | Influence of granulocytopenia on canine cerebral ischemia induced by air embolism. ( Dutka, AJ; Hallenbeck, JM; Kochanek, PM, 1989) |
| "Eighteen patients with advanced Hodgkin's disease, refractory to combination chemotherapy with nitrogen mustard, vincristine, prednisone, and procarbazine (MOPP), were treated with vinblastine, doxorubicin (Adriamycin), bleomycin, CCNU, and dacarbazine (DTIC) (VABCD)." | 2.65 | Treatment of MOPP-refractory Hodgkin's disease with vinblastine, doxorubicin, bleomycin, CCNU, and dacarbazine. ( Bond, WH; Chenoweth, L; Einhorn, LH; Stevens, EE; Williams, SD, 1983) |
| "All rabbits died of respiratory failure with pulmonary edema, and although chemotherapy decreased the number of neutrophils in the lungs by greater than 90%, it did not influence survival time or extravascular lung water content." | 1.27 | Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs. ( Bland, RD; Hazinski, TA; Raj, JU, 1985) |
| "Acute edematous lung injury is associated with a marked increase in the number of granulocytes in the alveoli and microvasculature of the lung." | 1.26 | Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. ( McMurtry, I; Repine, JE; Shasby, DM; Shasby, SS; Tate, RM; Vanbenthuysen, KM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BENNETT, IL | 1 |
| WAGNER, RR | 1 |
| MAUER, AM | 1 |
| KRILL, CE | 1 |
| ALLEN, IV | 1 |
| DE VANNA, F | 1 |
| Einhorn, LH | 1 |
| Williams, SD | 1 |
| Stevens, EE | 1 |
| Bond, WH | 1 |
| Chenoweth, L | 1 |
| Nugent, KM | 1 |
| Onofrio, JM | 1 |
| Issekutz, AC | 1 |
| Ripley, M | 1 |
| Rochon, Y | 1 |
| Pi-Jimenez, E | 1 |
| Wright, B | 1 |
| Weitberg, AB | 1 |
| Harmon, DC | 1 |
| Raj, JU | 2 |
| Bland, RD | 2 |
| Henderson, DK | 1 |
| Hockey, LJ | 1 |
| Vukalcic, LJ | 1 |
| Edwards, JE | 1 |
| Yersin, BR | 1 |
| Glauser, MP | 1 |
| Freedman, LR | 1 |
| Shasby, DM | 1 |
| Vanbenthuysen, KM | 1 |
| Tate, RM | 1 |
| Shasby, SS | 1 |
| McMurtry, I | 1 |
| Repine, JE | 1 |
| Meddens, MJ | 1 |
| Thompson, J | 1 |
| Eulderink, F | 1 |
| Bauer, WC | 1 |
| Mattie, H | 1 |
| van Furth, R | 1 |
| Kernoff, L | 1 |
| Colman, J | 1 |
| Ziegler, EJ | 1 |
| Douglas, H | 1 |
| Viollier, AF | 1 |
| Senn, HJ | 1 |
| de Kreek, EJ | 1 |
| Sybesma, HB | 1 |
| Dutka, AJ | 1 |
| Kochanek, PM | 1 |
| Hallenbeck, JM | 1 |
| Laughlin, MJ | 1 |
| Wild, L | 1 |
| Nickerson, PA | 1 |
| Matalon, S | 1 |
| Hazinski, TA | 1 |
| Lerner, RG | 1 |
| Wiener, J | 1 |
| Goldstein, R | 1 |
| Gaynor, E | 1 |
| Lippman, ME | 1 |
| Finch, SC | 2 |
| Skjorten, F | 1 |
| Evensen, SA | 1 |
| Fairley, GH | 1 |
| DeConti, RC | 1 |
| Kaplan, SR | 1 |
| Calabresi, P | 1 |
| Guckian, JC | 1 |
| Morrey, BF | 1 |
| Kirby, HB | 1 |
| Fink, ME | 1 |
| Fieschi, A | 1 |
| Sacchetti, C | 1 |
| Forman, EN | 1 |
| Abildgaard, CF | 1 |
| Bolger, JF | 1 |
| Johnson, CA | 1 |
| Schulman, I | 1 |
| Boggs, DR | 1 |
| Cartwright, GE | 1 |
| Wintrobe, MM | 1 |
1 trial available for mechlorethamine and Agranulocytosis
| Article | Year |
|---|---|
Treatment of MOPP-refractory Hodgkin's disease with vinblastine, doxorubicin, bleomycin, CCNU, and dacarbazine.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 1983 |
30 other studies available for mechlorethamine and Agranulocytosis
| Article | Year |
|---|---|
Production of fever by influenzal viruses. V. Effect of nitrogen mustard (HN2).
Topics: Agranulocytosis; Fever; Humans; Influenza, Human; Mechlorethamine; Nitrogen Mustard Compounds; Virus | 1955 |
A STUDY OF THE MECHANISMS OF GRANULOCYTOPENIA.
Topics: Agranulocytosis; Anemia; Anemia, Macrocytic; Carcinoma; Carcinoma, Bronchogenic; Child; Hodgkin Dise | 1964 |
THE EFFECT OF GRANULOCYTOPENIA ON EXPERIMENTAL TUBERCULIN FEVER.
Topics: Agranulocytosis; Fever; Hypersensitivity; Hypersensitivity, Delayed; Leukopenia; Lipopolysaccharides | 1965 |
[Experimental agranulocytosis].
Topics: Agranulocytosis; Mechlorethamine; Nitrogen Mustard Compounds | 1952 |
Pulmonary clearance of Candida albicans in neutropenic mice.
Topics: Agranulocytosis; Animals; Candida albicans; Candidiasis; Kidney; Lung; Mechlorethamine; Mice; Neutro | 1984 |
A role for hemolysin in Escherichia coli-induced inflammation in granulocytopenic rabbits.
Topics: Agranulocytosis; Animals; Blood Platelets; Capillary Permeability; Escherichia coli Infections; Fema | 1984 |
Autoimmune neutropenia, hemolytic anemia, and reticulocytopenia in Hodgkin's disease.
Topics: Adult; Agranulocytosis; Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocol | 1984 |
Neutrophil depletion does not prevent oxygen-induced lung injury in rabbits.
Topics: Agranulocytosis; Animals; Hemodynamics; Mechlorethamine; Neutropenia; Oxygen; Pulmonary Edema; Rabbi | 1983 |
Effect of immunosuppression on the development of experimental hematogenous Candida endophthalmitis.
Topics: Agranulocytosis; Animals; Candidiasis; Endophthalmitis; Immunosuppression Therapy; Leukocyte Count; | 1980 |
Effect of nitrogen mustard on natural history of right-sided streptococcal endocarditis in rabbits: role for cellular host defenses.
Topics: Agranulocytosis; Animals; Endocarditis, Bacterial; Granulocytes; Leukocytes; Leukopenia; Mechloretha | 1982 |
Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.
Topics: Agranulocytosis; Animals; Free Radicals; Granulocytes; Granulomatous Disease, Chronic; Lung; Lung In | 1982 |
Role of granulocytes in experimental Streptococcus sanguis endocarditis.
Topics: Agranulocytosis; Animals; Endocarditis, Bacterial; Endocardium; Granulocytes; Male; Mechlorethamine; | 1982 |
Neutropenia fails to prevent the acute phase stimulation of fibrinogen synthesis.
Topics: Agranulocytosis; Animals; Carbon Radioisotopes; Fibrinogen; Liver; Male; Mechlorethamine; Neutropeni | 1982 |
Pseudomonas aeruginosa vasculitis and bacteremia following conjunctivitis: a simple model of fatal pseudomonas infection in neutropenia.
Topics: Agranulocytosis; Animals; Blood Bactericidal Activity; Conjunctivitis; Disease Models, Animal; Mechl | 1979 |
[Curative aspects of modern combination chemotherapy in generalized malignant lymphomas].
Topics: Agranulocytosis; Cyclophosphamide; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Life | 1976 |
[From tumors to scales].
Topics: Agranulocytosis; Humans; Immunologic Deficiency Syndromes; Leg Ulcer; Leukopenia; Male; Mechloretham | 1975 |
Influence of granulocytopenia on canine cerebral ischemia induced by air embolism.
Topics: Agranulocytosis; Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Dogs; Emboli | 1989 |
Effects of hyperoxia on alveolar permeability of neutropenic rabbits.
Topics: Agranulocytosis; Animals; Epithelium; Lung Diseases; Mechlorethamine; Neutropenia; Neutrophils; Oxyg | 1986 |
Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs.
Topics: Agranulocytosis; Animals; Blood Pressure; Capillary Permeability; Cardiac Output; Hydroxyurea; Lung; | 1985 |
Experimental venous thrombosis in agranulocytic rabbits.
Topics: Agranulocytosis; Animals; Blood Cell Count; Blood Platelets; Female; Fibrin; Fibrinogen; Iodine Radi | 1974 |
The role of granulocytes in endotoxin-induced vascular injury.
Topics: Agranulocytosis; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Disease Models, Animal | 1973 |
A quantitative study of muramidase distribution in normal and nitrogen mustard-treated rats.
Topics: Agranulocytosis; Animals; Bone Marrow; Bone Marrow Cells; Kidney; Leukocytes; Lung; Male; Mechloreth | 1972 |
Disseminated intravascular coagulation induced by liquoid in normal, thrombocytopenic and granulocytopenic rabbits. Light and electron microscope studies.
Topics: Agranulocytosis; Animals; Blood Cell Count; Blood Platelets; Blood Proteins; Busulfan; Capillaries; | 1972 |
The treatment of Hodgkin's disease.
Topics: Agranulocytosis; Antineoplastic Agents; Bone Marrow Diseases; Chlorambucil; Drug Combinations; Hodgk | 1972 |
Endotoxin stimulation in patients with lymphoma: correlation with the myelosuppressive effects of alkylating agents.
Topics: Agranulocytosis; Alkylating Agents; Bone Marrow Cells; Bone Marrow Examination; Cyclophosphamide; En | 1972 |
Role of lysosomes and cathepsin inhibitor in plasma during pneumococcal infection.
Topics: Agranulocytosis; Animals; Antimetabolites; Cardiac Output; Cathepsins; Hydrogen-Ion Concentration; L | 1970 |
Serum muramidase and granulocyte turnover.
Topics: Agranulocytosis; Immune Sera; Leukocytes; Leukopenia; Mechlorethamine; Muramidase; Time Factors | 1968 |
Evaluation of the granulopoiesis during antiblastic treatment.
Topics: Agranulocytosis; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Endotoxins; Hem | 1968 |
Generalized Shwartzman reaction: role of the granulocyte in intravascular coagulation and renal cortical necrosis.
Topics: Agranulocytosis; Animals; Blood Cell Count; Endotoxins; Fibrinogen; Kidney Cortex Necrosis; Leukocyt | 1969 |
Neutrophilia-inducing activity in plasma of dogs recovering from drug-induced myelotoxicity.
Topics: Agranulocytosis; Animals; Dogs; Endotoxins; Kinetics; Leukocyte Count; Mechlorethamine; Neutrophils; | 1966 |