mechlorethamine has been researched along with Acute Myelogenous Leukemia in 28 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of morphine and cocaine on the transport of hydrolyzed nitrogen mustard (NH2-OH) and choline by peripheral blood cells of normal subjects and patients with chronic lymphocytic leukemia, acute lymphoblastic leukemia, and acute myeloblastic leukemia was determined." | 3.65 | Drug-induced stimulation of transport of hydrolyzed nitrogen mustard and choline by normal and leukemic human cells in vitro. ( Goldenberg, GJ, 1976) |
| "Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm." | 2.65 | Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease. ( Bartolucci, AA; Durant, JR; Gams, RA; Liu, C, 1983) |
| "Ten patients developed SANLL between the 34th and 123rd month of CR." | 2.38 | Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease. ( Andrieu, JM; Coscas, Y; Fermanian, J; Flandrin, G; Ifrah, N; Payen, C, 1990) |
| "To assess therapy-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/MDS) risk in patients treated for Hodgkin lymphoma (HL) on successive generations of Stanford clinical trials." | 1.39 | Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trials. ( Advani, RH; Balise, R; Greenberg, PL; Hoppe, RT; Horning, SJ; Koontz, MZ; Rosenberg, SA, 2013) |
| "Concerning ANLL, the MOPP regimen was significantly associated with a higher risk: 3." | 1.31 | Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation. ( Andrieu, JM; Colonna, P; Delwail, V; Jais, JP, 2002) |
| "We report a 54-year-old patient with Hodgkin's disease who achieved a complete remission after combined modality treatment." | 1.29 | Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease. ( Bendandi, M; Cantagalli, F; Macchi, S; Mancino, A; Simoncelli, F; Stefanati, V; Tura, S; Visani, G; Zaccaria, A; Zinzani, PL, 1995) |
| "A case of Hodgkin's disease with isolated cerebral relapse is reported here." | 1.29 | Meningioma-like cerebral relapse of Hodgkin's disease. ( Catarini, M; Discepoli, G; Leoni, P; Montillo, M; Rychlicki, F; Scarpelli, M, 1994) |
| "Following irradiation alone, secondary acute nonlymphocytic leukemia (ANLL) is uncommon; following chemotherapy alone, the risk is increased, but not as much as when combined modality treatments are used." | 1.29 | Splenectomy and the increasing risk of secondary acute leukemia in Hodgkin's disease. ( Brusamolino, E; Fiacchini, M; Gobbi, PG; Tura, S; Zinzani, PL, 1993) |
| "20 untreated Hodgkin's disease patients and 1 patient relapsing after radiotherapy (17 stage IIB-IV and 4 stage I-IIA) were given doxorubicin, bleomycin, etoposide and prednisone on a 21-day cycle." | 1.28 | ABEP as primary chemotherapy for Hodgkin's disease. ( Alberto, P; Mermillod, B; Zulian, GB, 1992) |
| "In 1984, the complete remission of malignant lymphoma was observed after MOPP, COPP and VAPP chemotherapies." | 1.28 | [Secondary leukemia (AML) with TcR beta rearrangement]. ( Akiyoshi, T; Hisano, S; Ishibashi, M; Kawara, T; Kikuchi, M; Kimura, N; Kyoshoin, K; Morioka, E; Okumura, M, 1989) |
| "Dissociated cancer cells are exposed to antineoplastic drugs (5 X 10(4) viable cells/drug for 1 hr or continuously) and cultured for 4 to 6 days in liquid medium." | 1.27 | A novel dye exclusion method for testing in vitro chemosensitivity of human tumors. ( Dill, PL; Macaluso, CK; Marsden, JA; Weisenthal, LM, 1983) |
| "A case of Hodgkin's disease is reported in which acute promyelocytic leukaemia developed within 5 months of initiation of chemotherapy." | 1.26 | Hodgkin's disease and acute promyelocytic leukaemia. A case report. ( King, JB; Rosenstrauch, WJ; Steytler, JG; van der Merwe, AM; van Eeden, PJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (53.57) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koontz, MZ | 1 |
| Horning, SJ | 1 |
| Balise, R | 1 |
| Greenberg, PL | 1 |
| Rosenberg, SA | 2 |
| Hoppe, RT | 1 |
| Advani, RH | 1 |
| Ogawa, M | 1 |
| May, JT | 1 |
| Hsu, SD | 1 |
| Costanzi, JJ | 1 |
| Weisenthal, LM | 1 |
| Marsden, JA | 1 |
| Dill, PL | 1 |
| Macaluso, CK | 1 |
| Bartolucci, AA | 1 |
| Liu, C | 1 |
| Durant, JR | 1 |
| Gams, RA | 1 |
| Rosenstrauch, WJ | 1 |
| van der Merwe, AM | 1 |
| King, JB | 1 |
| van Eeden, PJ | 1 |
| Steytler, JG | 1 |
| Lewensohn, R | 1 |
| Ringborg, U | 1 |
| Bendandi, M | 1 |
| Zaccaria, A | 1 |
| Zinzani, PL | 2 |
| Visani, G | 1 |
| Stefanati, V | 1 |
| Cantagalli, F | 1 |
| Mancino, A | 1 |
| Macchi, S | 1 |
| Simoncelli, F | 1 |
| Tura, S | 3 |
| Montillo, M | 1 |
| Scarpelli, M | 1 |
| Discepoli, G | 1 |
| Catarini, M | 1 |
| Rychlicki, F | 1 |
| Leoni, P | 2 |
| Fiacchini, M | 1 |
| Brusamolino, E | 1 |
| Gobbi, PG | 1 |
| Nishikawa, K | 1 |
| Motta, MR | 1 |
| Mangianti, S | 1 |
| Rizzi, S | 1 |
| Ratta, M | 1 |
| Campanini, E | 1 |
| Fortuna, A | 1 |
| Fogli, M | 1 |
| Lemoli, RM | 1 |
| Valagussa, P | 1 |
| Bonadonna, G | 1 |
| Poloni, A | 1 |
| Curzi, L | 1 |
| Cantori, I | 1 |
| Mancini, S | 1 |
| Montanari, M | 1 |
| Masia, MC | 1 |
| Olivieri, A | 1 |
| Delwail, V | 1 |
| Jais, JP | 1 |
| Colonna, P | 1 |
| Andrieu, JM | 2 |
| Trump, DL | 1 |
| Cowall, DE | 1 |
| Sieber, SM | 1 |
| Goldenberg, GJ | 1 |
| Zulian, GB | 1 |
| Mermillod, B | 1 |
| Alberto, P | 1 |
| Ifrah, N | 1 |
| Payen, C | 1 |
| Fermanian, J | 1 |
| Coscas, Y | 1 |
| Flandrin, G | 1 |
| Lavey, RS | 1 |
| Akiyoshi, T | 1 |
| Kimura, N | 1 |
| Hisano, S | 1 |
| Kawara, T | 1 |
| Morioka, E | 1 |
| Ishibashi, M | 1 |
| Kyoshoin, K | 1 |
| Kikuchi, M | 1 |
| Okumura, M | 1 |
| Iurlo, A | 1 |
| Mecucci, C | 1 |
| Van Orshoven, A | 1 |
| Michaux, JL | 1 |
| Boogaerts, M | 1 |
| Van den Berghe, H | 1 |
| Kaplan, HS | 1 |
| Sahakian, GJ | 1 |
| al-Mondhiry, H | 1 |
| Lacher, MJ | 1 |
| Connolly, CE | 1 |
| Focan, C | 1 |
| Bricteux, N | 1 |
| Hugues, J | 1 |
| Jardon-Jeghers, C | 1 |
| Frei, E | 1 |
| Schabel, FM | 1 |
| Goldin, A | 1 |
| Fairley, GH | 1 |
5 reviews available for mechlorethamine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
[Hematologic tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Dacarbazine | 2003 |
[Chemotherapy of relapsed AML and ALL].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Etoposide; Granulocyte Col | 1996 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Th | 1990 |
Combination chemotherapy in malignant diseases.
Topics: Adult; Antineoplastic Agents; Asparaginase; Carmustine; Child; Cyclophosphamide; Cytarabine; Cytosin | 1971 |
2 trials available for mechlorethamine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Female; Hodgkin | 1983 |
The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Combine | 1985 |
21 other studies available for mechlorethamine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trials.
Topics: Academic Medical Centers; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Californ | 2013 |
Acute leukemia following combination chemotherapy for cancer of the lung.
Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Doxorubicin; Drug Therapy, Combination; | 1981 |
A novel dye exclusion method for testing in vitro chemosensitivity of human tumors.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Eosine Y | 1983 |
Hodgkin's disease and acute promyelocytic leukaemia. A case report.
Topics: Adult; Drug Therapy, Combination; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Male; Mechloret | 1980 |
DNA-repair synthesis in blast cells from patients with acute myeloblastic leukaemia.
Topics: Alkylating Agents; Autoradiography; Bone Marrow; Cell Transformation, Neoplastic; DNA; DNA Repair; H | 1982 |
Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Blood Transfusion; Combined Modality | 1995 |
Meningioma-like cerebral relapse of Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fatal Outcome; Female; Ho | 1994 |
Splenectomy and the increasing risk of secondary acute leukemia in Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgkin Di | 1993 |
Pharmacological purging of minimal residual disease from peripheral blood stem cell collections of acute myeloblastic leukemia patients: preclinical studies.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Cyclophosp | 1997 |
Hodgkin's disease and the risk of acute leukemia in successfully treated patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; D | 1998 |
Ex vivo pharmacological purging of leukapheresis collections with nitrogen mustard: amifostine pretreatment improves both early and late peripheral blood progenitor cell recovery.
Topics: Amifostine; Animals; Bone Marrow Purging; Cell Survival; Cells, Cultured; Colony-Forming Units Assay | 1999 |
Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation.
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbaz | 2002 |
Acute myelogenous leukemia as a late complication of the multimodality therapy for Hodgkin's disease.
Topics: Adult; Biopsy; Bone Marrow; Cytarabine; Daunorubicin; Hodgkin Disease; Humans; Leukemia, Myeloid, Ac | 1977 |
Drug-induced stimulation of transport of hydrolyzed nitrogen mustard and choline by normal and leukemic human cells in vitro.
Topics: Biological Transport; Choline; Cocaine; Dose-Response Relationship, Drug; In Vitro Techniques; Leuke | 1976 |
ABEP as primary chemotherapy for Hodgkin's disease.
Topics: Aclarubicin; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cytarabin | 1992 |
Acute nonlymphocytic leukemia after radiation and MOPP chemotherapy for Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; Humans; | 1990 |
[Secondary leukemia (AML) with TcR beta rearrangement].
Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Cyclophosphamide; Female; Gene Rearra | 1989 |
The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Female; Hodgkin Disea | 1988 |
Acute leukemia in Hodgkin's disease.
Topics: Adult; Bleomycin; Carmustine; Chlorambucil; Drug Therapy, Combination; Female; Hodgkin Disease; Huma | 1974 |
[Hodgkin's disease complicated by myeloblastic leukosis].
Topics: Adult; Biopsy; Hodgkin Disease; Humans; Hydrazines; Leukemia, Myeloid, Acute; Lymph Nodes; Male; Mec | 1973 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |