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mechlorethamine and Abnormalities, Autosome

mechlorethamine has been researched along with Abnormalities, Autosome in 38 studies

nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.

Research Excerpts

ExcerptRelevanceReference
"Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)."3.68Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992)
"Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate."1.43PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome. ( Advani, RH; Armand, P; Chapuy, B; Connelly, CF; Daadi, SE; de Jong, D; Freeman, GJ; Homer, H; Hoppe, RT; Ligon, AH; Natkunam, Y; Neuberg, DS; Redd, RA; Rodig, SJ; Roemer, MG; Shipp, MA; Sun, HH, 2016)
"The frequency of chromosome aberrations in the peripheral blood of patients successfully treated for Hodgkin's disease (HD) and non-Hodgkin's lymphoma is compared with that seen in age-matched haematologically normal subjects."1.28Chromosome aberrations following cytotoxic therapy in patients in complete remission from lymphoma. ( Clark, RE; Jacobs, A; Jones, BM; White, AD, 1992)
"In oocytes chromosome aberrations detected as half-translocations or dominant lethals depend on a repair system which in a number of genetically nonrelated strains shows different repair capacities."1.26Mutation induction in repair-deficient strains of Drosophila. ( Graf, U; Würgler, FE, 1980)
"Stage II Hodgkin's disease probably should be divided into two substages requiring different treatment."1.26[The current state of curability of Hodgkin's disease]. ( Streuli, RA; Ultmann, JE, 1981)
" On the other hand, acrolein was most toxic to cell proliferation and most active in inducing chromosome breakage."1.26Cytogenetic toxicity of cyclophosphamide and its metabolites in vitro. ( Arrighi, FE; Au, W; Kopnin, B; Sokova, OI, 1980)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199027 (71.05)18.7374
1990's8 (21.05)18.2507
2000's1 (2.63)29.6817
2010's2 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Roemer, MG1
Advani, RH1
Ligon, AH1
Natkunam, Y1
Redd, RA1
Homer, H1
Connelly, CF1
Sun, HH1
Daadi, SE1
Freeman, GJ1
Armand, P1
Chapuy, B1
de Jong, D1
Hoppe, RT1
Neuberg, DS1
Rodig, SJ1
Shipp, MA1
KAUFMANN, BP1
GAY, H2
Salas, C1
Niembro, A1
Lozano, V1
Gallardo, E1
Molina, B1
Sánchez, S1
Ramos, S1
Carnevale, A1
Pérez-Vera, P1
Rivera Luna, R1
Frias, S1
STEVENSON, KG1
CURTIS, HJ1
FRIEDMAN, BI1
SAENGER, EL1
KREINDLER, MS1
RIEGER, R1
MICHAELIS, A1
Kneller, A1
Cohen, N1
Berkowicz, M1
Reichart, M1
Rosner, E1
Sokolovski, M1
Nagler, A1
Rechavi, G1
Amariglio, N1
Trakhtenbrot, L1
GOLDACRE, RJ1
LOVELESS, A1
ROSS, WC1
KAUFMAN, BP1
ROTHBERG, H1
Soukup, S1
Takacs, E1
Warkany, J1
Sen, P1
Hittelman, WN2
Meyne, J1
Legator, MS1
Würgler, FE1
Graf, U1
Fox, M1
Scott, D1
Streuli, RA1
Ultmann, JE1
Dolfini, E1
Ghersa, P1
Barbieri, B1
Donelli, MG1
Conti, AM1
Au, W1
Sokova, OI1
Kopnin, B1
Arrighi, FE1
Wiencke, JK1
Kelsey, KT1
Brandriff, BF1
Meistrich, ML1
Gordon, LA1
Carrano, AV1
Liang, JC1
Berger, R2
Le Coniat, M2
Gendron, MC1
Winkelmann, RK1
Caro, WA1
Tsutsui, T1
Umeda, M1
Maizumi, H1
Saito, M1
Sotomayor, RE1
Sega, GA1
Cumming, RB1
Wobus, AM2
Schöneich, J2
Thieme, R1
Hayani, A1
Mahoney, DH1
Taylor, LD1
White, AD1
Jones, BM1
Clark, RE1
Jacobs, A1
Howell, RT1
Desangles, F1
Miglierina, R1
Gendron, M1
Fingert, HJ1
Chang, JD1
Pardee, AB1
Iurlo, A1
Mecucci, C1
Van Orshoven, A1
Michaux, JL1
Boogaerts, M1
Van den Berghe, H1
Sasaki, MS1
Tonomura, A1
Shevchenko, VV1
Protopopova, EM1
Grigor'eva, GA1
Bolotova, TK1
Rao, PN1
Kovaleva, TA1
Shamina, ZB1
Butenko, RG1
Nawar, MM1
Konzak, CF1
Nilan, RA1
Dubinin, NP1
Shcherbakov, VK1
Kesler, GN1
Baburina, ND1

Reviews

2 reviews available for mechlorethamine and Abnormalities, Autosome

ArticleYear
The genetic toxicology of nitrogen and sulphur mustard.
    Mutation research, 1980, Volume: 75, Issue:2

    Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Bacteria; Cells, Cultured; Chromosome Aberrations;

1980
Current problems in mycosis fungoides and Sézary syndrome.
    Annual review of medicine, 1977, Volume: 28

    Topics: B-Lymphocytes; Blood Cell Count; Chromosome Aberrations; Dermatitis, Exfoliative; Humans; Immunoglob

1977

Other Studies

36 other studies available for mechlorethamine and Abnormalities, Autosome

ArticleYear
PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, 08-10, Volume: 34, Issue:23

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Bleomycin; C

2016
Effect of near infrared radiation on the production of chromosome rearrangements in Drosophila by nitrogen mustard.
    The Anatomical record, 1948, Volume: 101, Issue:4

    Topics: Animals; Chromosome Aberrations; Chromosomes; Drosophila; Infrared Rays; Mechlorethamine; Radiation

1948
Persistent genomic instability in peripheral blood lymphocytes from Hodgkin lymphoma survivors.
    Environmental and molecular mutagenesis, 2012, Volume: 53, Issue:4

    Topics: Adult; Aneuploidy; Case-Control Studies; Chromosomal Instability; Chromosome Aberrations; Chromosome

2012
Chromosomal aberrations in irradiated and nitrogen mustard-treated mice.
    Radiation research, 1961, Volume: 15

    Topics: Animals; Chromosome Aberrations; Chromosomes; Mechlorethamine; Mice; Nitrogen Mustard Compounds; Rad

1961
ENDOREDUPLICATION IN LEUCOCYTE CHROMOSOMES. PRELIMINARY REPORT OF ITS RELATION TO CANCER AND WHOLE-BODY IRRADIATION.
    Lancet (London, England), 1964, Sep-05, Volume: 2, Issue:7358

    Topics: Breast Neoplasms; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cobalt Isotopes; Coloni

1964
ON THE DISTRIBUTION AMONGST CELLS OF CHEMICALLY INDUCED CHROMATID ABERRATIONS IN ROOT TIP MERISTEMS OF VICIA FABA.
    Mutation research, 1964, Volume: 106

    Topics: Chromatids; Chromosome Aberrations; Cyclophosphamide; Diploidy; Ethanol; Ethers; Glycerophosphates;

1964
Acquisition of a Ph chromosome with minor BCR/ABL fusion in treatment-related myelodysplastic syndrome with chromosome 7 abnormalities in a patient treated for Hodgkin disease.
    Cancer genetics and cytogenetics, 2005, Volume: 159, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Chromosome

2005
Mode of production of chromosome abnormalities by the nitrogen mustards; the possible role of cross-linking.
    Nature, 1949, Apr-30, Volume: 163, Issue:4148

    Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Ethylamines; Genetic Phenomena; Heredity;

1949
The influence of near infrared radiation on the production by nitrogen mustard of chromosome rearrangements in Drosophila.
    The Journal of experimental zoology, 1949, Volume: 111, Issue:3

    Topics: Animals; Chromosome Aberrations; Chromosomes; Drosophila; Heredity; Infrared Rays; Mechlorethamine;

1949
Chromosome changes in embryos treated with various teratogens.
    Journal of embryology and experimental morphology, 1967, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure

1967
Induction of chromosome damage by Neurospora endonuclease in repair-inhibited quiescent normal human fibroblasts.
    Mutation research, 1984, Volume: 129, Issue:3

    Topics: Cell Line; Chromosome Aberrations; Cytarabine; DNA Repair; Endonucleases; Fibroblasts; HeLa Cells; H

1984
Clastogenic effects of transplacental exposure of mouse embryos to nitrogen mustard or cyclophosphamide.
    Teratogenesis, carcinogenesis, and mutagenesis, 1983, Volume: 3, Issue:3

    Topics: Animals; Chromosome Aberrations; Cyclophosphamide; Female; Maternal-Fetal Exchange; Mechlorethamine;

1983
Mutation induction in repair-deficient strains of Drosophila.
    Basic life sciences, 1980, Volume: 15

    Topics: Alkylating Agents; Animals; Chromosome Aberrations; DNA Repair; Drosophila melanogaster; Female; Gen

1980
[The current state of curability of Hodgkin's disease].
    Schweizerische medizinische Wochenschrift, 1981, Sep-05, Volume: 111, Issue:36

    Topics: Chromosome Aberrations; Drug Therapy, Combination; Hodgkin Disease; Humans; Leukemia; Mechlorethamin

1981
Cytotoxic and cytogenetic effect of nitrogen mustard on EUE cells pretreated with sodium warfarin.
    European journal of cancer, 1980, Volume: 16, Issue:1

    Topics: Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes, Human; Drug Synergism; Humans; Mechlo

1980
Cytogenetic toxicity of cyclophosphamide and its metabolites in vitro.
    Cytogenetics and cell genetics, 1980, Volume: 26, Issue:2-4

    Topics: Acrolein; Aldehydes; Animals; Biotransformation; Cell Division; Cell Line; Chromosome Aberrations; C

1980
Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes.
    IARC scientific publications, 1993, Issue:127

    Topics: Butadienes; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Epoxy Compoun

1993
Chromosomal damage in sperm of patients surviving Hodgkin's disease following MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) therapy with and without radiotherapy.
    Human genetics, 1994, Volume: 93, Issue:3

    Topics: Adolescent; Adult; Aneuploidy; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromosome A

1994
Fanconi anemia. Chromosome breakage and cell cycle studies.
    Cancer genetics and cytogenetics, 1993, Volume: 69, Issue:1

    Topics: Cell Cycle; Cells, Cultured; Chromosome Aberrations; Cytogenetics; Fanconi Anemia; Flow Cytometry; H

1993
Comparison of mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations in cultured mouse cells by potent mutagens.
    Gan, 1977, Volume: 68, Issue:5

    Topics: 4-Nitroquinoline-1-oxide; Animals; Azaguanine; Cell Line; Centrifugation, Density Gradient; Chromoso

1977
Unscheduled DNA synthesis in spermatogenic cells of mice treated in vivo with the indirect alkylating agents cyclophosphamide and mitomen.
    Mutation research, 1978, Volume: 50, Issue:2

    Topics: Animals; Chromosome Aberrations; Chromosomes; Cyclophosphamide; DNA Repair; Ethyl Methanesulfonate;

1978
The effect of the mode of administration of nitrogen mustard and cytosine arabinoside on the production of chromosomal aberrations in mouse bone marrow and ascites tumour cells.
    Mutation research, 1978, Volume: 58, Issue:1

    Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Chromosome Aberrations; Chromosomes; Cytarabine; Fem

1978
[A cytological test system for the routine determination of mutagenicity].
    Die Pharmazie, 1977, Volume: 32, Issue:3

    Topics: Ascitic Fluid; Caffeine; Cells, Cultured; Chromosome Aberrations; Cytarabine; Hydrazines; Isonicotin

1977
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
    Journal of neuro-oncology, 1992, Volume: 14, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool

1992
Chromosome aberrations following cytotoxic therapy in patients in complete remission from lymphoma.
    Carcinogenesis, 1992, Volume: 13, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cells, Cultured; Chromosome Aberrations

1992
Sister chromatid exchange evaluation as an aid to the diagnosis and exclusion of Fanconi's anaemia by induced chromosome damage analysis.
    Journal of medical genetics, 1991, Volume: 28, Issue:7

    Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Cross-Linking Reagents; DNA; DNA Damage

1991
[Diagnosis of Fanconi's anemia by nitrogen mustard induction of chromosome breakage in fibroblasts].
    Pathologie-biologie, 1991, Volume: 39, Issue:2

    Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dose-Response Relationship, Drug; Fanconi

1991
Diagnosis of Fanconi's anemia by flow cytometry.
    Nouvelle revue francaise d'hematologie, 1990, Volume: 32, Issue:6

    Topics: Cell Cycle; Chromosome Aberrations; DNA; Fanconi Anemia; Flow Cytometry; Heterozygote; Humans; Lymph

1990
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosom

1986
The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients.
    Cancer genetics and cytogenetics, 1988, Volume: 36, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Female; Hodgkin Disea

1988
A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.
    Cancer research, 1973, Volume: 33, Issue:8

    Topics: Alkanesulfonates; Alkylating Agents; Anemia, Aplastic; Antimetabolites; Caffeine; Cell Division; Cel

1973
Change in the activity of chemical mutagens during their interaction with seed metabolites.
    Soviet genetics, 1971, Volume: 7, Issue:4

    Topics: Chromosome Aberrations; Dimethoate; Ethylenes; Hydrazines; Imines; Maleates; Mechlorethamine; Mesyla

1971
Premature chromosome condensation. II. The nature of chromosome gaps produced by alkylating agents and ultraviolet light.
    Mutation research, 1974, Volume: 23, Issue:2

    Topics: Animals; Cell Fusion; Cell Line; Cell Nucleus; Chromatin; Chromosome Aberrations; Chromosomes; Crice

1974
Effects of nitrogen mustard on a culture of isolated tissues of Rauwolfia serpentina Benth.
    Soviet genetics, 1974, Apr-01, Volume: 8, Issue:2

    Topics: Chromosome Aberrations; Culture Techniques; Mechlorethamine; Mitosis; Mutagens; Mutation; Plants, Me

1974
Comparative studies of the biological effectiveness of nitrogen mustards, ethyleneimine and gamma-rays.
    Mutation research, 1971, Volume: 11, Issue:3

    Topics: Azirines; Chlorophyll; Chromosome Aberrations; Edible Grain; Ethylamines; Fertility; Mechlorethamine

1971
[Effect of alkylating agents on chromosomes in stages prior to DNA synthesis].
    Doklady Akademii nauk SSSR, 1966, Jun-01, Volume: 168, Issue:4

    Topics: Alkylating Agents; Chromosome Aberrations; DNA; Mechlorethamine; Mutation; Phosphinic Acids; Plants

1966