mechlorethamine has been researched along with Abnormalities, Autosome in 38 studies
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)." | 3.68 | Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992) |
| "Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate." | 1.43 | PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome. ( Advani, RH; Armand, P; Chapuy, B; Connelly, CF; Daadi, SE; de Jong, D; Freeman, GJ; Homer, H; Hoppe, RT; Ligon, AH; Natkunam, Y; Neuberg, DS; Redd, RA; Rodig, SJ; Roemer, MG; Shipp, MA; Sun, HH, 2016) |
| "The frequency of chromosome aberrations in the peripheral blood of patients successfully treated for Hodgkin's disease (HD) and non-Hodgkin's lymphoma is compared with that seen in age-matched haematologically normal subjects." | 1.28 | Chromosome aberrations following cytotoxic therapy in patients in complete remission from lymphoma. ( Clark, RE; Jacobs, A; Jones, BM; White, AD, 1992) |
| "In oocytes chromosome aberrations detected as half-translocations or dominant lethals depend on a repair system which in a number of genetically nonrelated strains shows different repair capacities." | 1.26 | Mutation induction in repair-deficient strains of Drosophila. ( Graf, U; Würgler, FE, 1980) |
| "Stage II Hodgkin's disease probably should be divided into two substages requiring different treatment." | 1.26 | [The current state of curability of Hodgkin's disease]. ( Streuli, RA; Ultmann, JE, 1981) |
| " On the other hand, acrolein was most toxic to cell proliferation and most active in inducing chromosome breakage." | 1.26 | Cytogenetic toxicity of cyclophosphamide and its metabolites in vitro. ( Arrighi, FE; Au, W; Kopnin, B; Sokova, OI, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (71.05) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roemer, MG | 1 |
| Advani, RH | 1 |
| Ligon, AH | 1 |
| Natkunam, Y | 1 |
| Redd, RA | 1 |
| Homer, H | 1 |
| Connelly, CF | 1 |
| Sun, HH | 1 |
| Daadi, SE | 1 |
| Freeman, GJ | 1 |
| Armand, P | 1 |
| Chapuy, B | 1 |
| de Jong, D | 1 |
| Hoppe, RT | 1 |
| Neuberg, DS | 1 |
| Rodig, SJ | 1 |
| Shipp, MA | 1 |
| KAUFMANN, BP | 1 |
| GAY, H | 2 |
| Salas, C | 1 |
| Niembro, A | 1 |
| Lozano, V | 1 |
| Gallardo, E | 1 |
| Molina, B | 1 |
| Sánchez, S | 1 |
| Ramos, S | 1 |
| Carnevale, A | 1 |
| Pérez-Vera, P | 1 |
| Rivera Luna, R | 1 |
| Frias, S | 1 |
| STEVENSON, KG | 1 |
| CURTIS, HJ | 1 |
| FRIEDMAN, BI | 1 |
| SAENGER, EL | 1 |
| KREINDLER, MS | 1 |
| RIEGER, R | 1 |
| MICHAELIS, A | 1 |
| Kneller, A | 1 |
| Cohen, N | 1 |
| Berkowicz, M | 1 |
| Reichart, M | 1 |
| Rosner, E | 1 |
| Sokolovski, M | 1 |
| Nagler, A | 1 |
| Rechavi, G | 1 |
| Amariglio, N | 1 |
| Trakhtenbrot, L | 1 |
| GOLDACRE, RJ | 1 |
| LOVELESS, A | 1 |
| ROSS, WC | 1 |
| KAUFMAN, BP | 1 |
| ROTHBERG, H | 1 |
| Soukup, S | 1 |
| Takacs, E | 1 |
| Warkany, J | 1 |
| Sen, P | 1 |
| Hittelman, WN | 2 |
| Meyne, J | 1 |
| Legator, MS | 1 |
| Würgler, FE | 1 |
| Graf, U | 1 |
| Fox, M | 1 |
| Scott, D | 1 |
| Streuli, RA | 1 |
| Ultmann, JE | 1 |
| Dolfini, E | 1 |
| Ghersa, P | 1 |
| Barbieri, B | 1 |
| Donelli, MG | 1 |
| Conti, AM | 1 |
| Au, W | 1 |
| Sokova, OI | 1 |
| Kopnin, B | 1 |
| Arrighi, FE | 1 |
| Wiencke, JK | 1 |
| Kelsey, KT | 1 |
| Brandriff, BF | 1 |
| Meistrich, ML | 1 |
| Gordon, LA | 1 |
| Carrano, AV | 1 |
| Liang, JC | 1 |
| Berger, R | 2 |
| Le Coniat, M | 2 |
| Gendron, MC | 1 |
| Winkelmann, RK | 1 |
| Caro, WA | 1 |
| Tsutsui, T | 1 |
| Umeda, M | 1 |
| Maizumi, H | 1 |
| Saito, M | 1 |
| Sotomayor, RE | 1 |
| Sega, GA | 1 |
| Cumming, RB | 1 |
| Wobus, AM | 2 |
| Schöneich, J | 2 |
| Thieme, R | 1 |
| Hayani, A | 1 |
| Mahoney, DH | 1 |
| Taylor, LD | 1 |
| White, AD | 1 |
| Jones, BM | 1 |
| Clark, RE | 1 |
| Jacobs, A | 1 |
| Howell, RT | 1 |
| Desangles, F | 1 |
| Miglierina, R | 1 |
| Gendron, M | 1 |
| Fingert, HJ | 1 |
| Chang, JD | 1 |
| Pardee, AB | 1 |
| Iurlo, A | 1 |
| Mecucci, C | 1 |
| Van Orshoven, A | 1 |
| Michaux, JL | 1 |
| Boogaerts, M | 1 |
| Van den Berghe, H | 1 |
| Sasaki, MS | 1 |
| Tonomura, A | 1 |
| Shevchenko, VV | 1 |
| Protopopova, EM | 1 |
| Grigor'eva, GA | 1 |
| Bolotova, TK | 1 |
| Rao, PN | 1 |
| Kovaleva, TA | 1 |
| Shamina, ZB | 1 |
| Butenko, RG | 1 |
| Nawar, MM | 1 |
| Konzak, CF | 1 |
| Nilan, RA | 1 |
| Dubinin, NP | 1 |
| Shcherbakov, VK | 1 |
| Kesler, GN | 1 |
| Baburina, ND | 1 |
2 reviews available for mechlorethamine and Abnormalities, Autosome
| Article | Year |
|---|---|
The genetic toxicology of nitrogen and sulphur mustard.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Bacteria; Cells, Cultured; Chromosome Aberrations; | 1980 |
Current problems in mycosis fungoides and Sézary syndrome.
Topics: B-Lymphocytes; Blood Cell Count; Chromosome Aberrations; Dermatitis, Exfoliative; Humans; Immunoglob | 1977 |
36 other studies available for mechlorethamine and Abnormalities, Autosome
| Article | Year |
|---|---|
PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Bleomycin; C | 2016 |
Effect of near infrared radiation on the production of chromosome rearrangements in Drosophila by nitrogen mustard.
Topics: Animals; Chromosome Aberrations; Chromosomes; Drosophila; Infrared Rays; Mechlorethamine; Radiation | 1948 |
Persistent genomic instability in peripheral blood lymphocytes from Hodgkin lymphoma survivors.
Topics: Adult; Aneuploidy; Case-Control Studies; Chromosomal Instability; Chromosome Aberrations; Chromosome | 2012 |
Chromosomal aberrations in irradiated and nitrogen mustard-treated mice.
Topics: Animals; Chromosome Aberrations; Chromosomes; Mechlorethamine; Mice; Nitrogen Mustard Compounds; Rad | 1961 |
ENDOREDUPLICATION IN LEUCOCYTE CHROMOSOMES. PRELIMINARY REPORT OF ITS RELATION TO CANCER AND WHOLE-BODY IRRADIATION.
Topics: Breast Neoplasms; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cobalt Isotopes; Coloni | 1964 |
ON THE DISTRIBUTION AMONGST CELLS OF CHEMICALLY INDUCED CHROMATID ABERRATIONS IN ROOT TIP MERISTEMS OF VICIA FABA.
Topics: Chromatids; Chromosome Aberrations; Cyclophosphamide; Diploidy; Ethanol; Ethers; Glycerophosphates; | 1964 |
Acquisition of a Ph chromosome with minor BCR/ABL fusion in treatment-related myelodysplastic syndrome with chromosome 7 abnormalities in a patient treated for Hodgkin disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Chromosome | 2005 |
Mode of production of chromosome abnormalities by the nitrogen mustards; the possible role of cross-linking.
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Ethylamines; Genetic Phenomena; Heredity; | 1949 |
The influence of near infrared radiation on the production by nitrogen mustard of chromosome rearrangements in Drosophila.
Topics: Animals; Chromosome Aberrations; Chromosomes; Drosophila; Heredity; Infrared Rays; Mechlorethamine; | 1949 |
Chromosome changes in embryos treated with various teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure | 1967 |
Induction of chromosome damage by Neurospora endonuclease in repair-inhibited quiescent normal human fibroblasts.
Topics: Cell Line; Chromosome Aberrations; Cytarabine; DNA Repair; Endonucleases; Fibroblasts; HeLa Cells; H | 1984 |
Clastogenic effects of transplacental exposure of mouse embryos to nitrogen mustard or cyclophosphamide.
Topics: Animals; Chromosome Aberrations; Cyclophosphamide; Female; Maternal-Fetal Exchange; Mechlorethamine; | 1983 |
Mutation induction in repair-deficient strains of Drosophila.
Topics: Alkylating Agents; Animals; Chromosome Aberrations; DNA Repair; Drosophila melanogaster; Female; Gen | 1980 |
[The current state of curability of Hodgkin's disease].
Topics: Chromosome Aberrations; Drug Therapy, Combination; Hodgkin Disease; Humans; Leukemia; Mechlorethamin | 1981 |
Cytotoxic and cytogenetic effect of nitrogen mustard on EUE cells pretreated with sodium warfarin.
Topics: Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes, Human; Drug Synergism; Humans; Mechlo | 1980 |
Cytogenetic toxicity of cyclophosphamide and its metabolites in vitro.
Topics: Acrolein; Aldehydes; Animals; Biotransformation; Cell Division; Cell Line; Chromosome Aberrations; C | 1980 |
Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes.
Topics: Butadienes; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Epoxy Compoun | 1993 |
Chromosomal damage in sperm of patients surviving Hodgkin's disease following MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) therapy with and without radiotherapy.
Topics: Adolescent; Adult; Aneuploidy; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromosome A | 1994 |
Fanconi anemia. Chromosome breakage and cell cycle studies.
Topics: Cell Cycle; Cells, Cultured; Chromosome Aberrations; Cytogenetics; Fanconi Anemia; Flow Cytometry; H | 1993 |
Comparison of mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations in cultured mouse cells by potent mutagens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azaguanine; Cell Line; Centrifugation, Density Gradient; Chromoso | 1977 |
Unscheduled DNA synthesis in spermatogenic cells of mice treated in vivo with the indirect alkylating agents cyclophosphamide and mitomen.
Topics: Animals; Chromosome Aberrations; Chromosomes; Cyclophosphamide; DNA Repair; Ethyl Methanesulfonate; | 1978 |
The effect of the mode of administration of nitrogen mustard and cytosine arabinoside on the production of chromosomal aberrations in mouse bone marrow and ascites tumour cells.
Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Chromosome Aberrations; Chromosomes; Cytarabine; Fem | 1978 |
[A cytological test system for the routine determination of mutagenicity].
Topics: Ascitic Fluid; Caffeine; Cells, Cultured; Chromosome Aberrations; Cytarabine; Hydrazines; Isonicotin | 1977 |
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool | 1992 |
Chromosome aberrations following cytotoxic therapy in patients in complete remission from lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cells, Cultured; Chromosome Aberrations | 1992 |
Sister chromatid exchange evaluation as an aid to the diagnosis and exclusion of Fanconi's anaemia by induced chromosome damage analysis.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Cross-Linking Reagents; DNA; DNA Damage | 1991 |
[Diagnosis of Fanconi's anemia by nitrogen mustard induction of chromosome breakage in fibroblasts].
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Dose-Response Relationship, Drug; Fanconi | 1991 |
Diagnosis of Fanconi's anemia by flow cytometry.
Topics: Cell Cycle; Chromosome Aberrations; DNA; Fanconi Anemia; Flow Cytometry; Heterozygote; Humans; Lymph | 1990 |
Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.
Topics: Alkylating Agents; Caffeine; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosom | 1986 |
The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Female; Hodgkin Disea | 1988 |
A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.
Topics: Alkanesulfonates; Alkylating Agents; Anemia, Aplastic; Antimetabolites; Caffeine; Cell Division; Cel | 1973 |
Change in the activity of chemical mutagens during their interaction with seed metabolites.
Topics: Chromosome Aberrations; Dimethoate; Ethylenes; Hydrazines; Imines; Maleates; Mechlorethamine; Mesyla | 1971 |
Premature chromosome condensation. II. The nature of chromosome gaps produced by alkylating agents and ultraviolet light.
Topics: Animals; Cell Fusion; Cell Line; Cell Nucleus; Chromatin; Chromosome Aberrations; Chromosomes; Crice | 1974 |
Effects of nitrogen mustard on a culture of isolated tissues of Rauwolfia serpentina Benth.
Topics: Chromosome Aberrations; Culture Techniques; Mechlorethamine; Mitosis; Mutagens; Mutation; Plants, Me | 1974 |
Comparative studies of the biological effectiveness of nitrogen mustards, ethyleneimine and gamma-rays.
Topics: Azirines; Chlorophyll; Chromosome Aberrations; Edible Grain; Ethylamines; Fertility; Mechlorethamine | 1971 |
[Effect of alkylating agents on chromosomes in stages prior to DNA synthesis].
Topics: Alkylating Agents; Chromosome Aberrations; DNA; Mechlorethamine; Mutation; Phosphinic Acids; Plants | 1966 |