mecamylamine has been researched along with Tremor in 14 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To characterize the tail-tremor and locomotor hyperactivity induced by repeated nicotine administration, the effects of nicotinic, alpha-adrenergic and dopaminergic blockers were investigated in rats." | 7.69 | Characteristics of tail-tremor induced by nicotine in rats. ( Gomita, Y; Oishi, R; Suemaru, K, 1994) |
| "The effects of nicotinic and beta-adrenergic receptor antagonists on tail-tremor induced by repeated nicotine administration were investigated in rats." | 7.69 | Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. ( Gomita, Y; Kawasaki, H; Oishi, R; Suemaru, K; Tanizaki, Y, 1997) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 7.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "Studies were performed to bring out a serotoninergic involvement in physostigmine tremor, hitherto known to be working via the cholinergic system." | 7.68 | Tremorogenesis by physostigmine is unrelated to acetylcholinesterase inhibition: evidence for serotoninergic involvement. ( Ganguly, DK; Mitra, N; Mohanakumar, KP, 1990) |
| "Injection of rats with 14C-labelled nicotine (3 mg/kg sc) resulted in tremor measured by an electronic device during the first minutes after the injection." | 7.65 | Nicotine induced tremor and antidiuresis and brain nicotine levels in the rat. ( Mansner, R; Mattila, MJ, 1975) |
| " Subsequently, a single intraperitoneal injection of the nicotinic receptor antagonist mecamylamine induced behavioral symptoms of withdrawal measured as increased grooming, chewing, scratching, and shaking, plus the appearance of some unique behaviors such as jumping, leg tremors, and cage scratching." | 3.72 | Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. ( De Biasi, M; Pieri, F; Salas, R, 2004) |
| "To characterize the tail-tremor and locomotor hyperactivity induced by repeated nicotine administration, the effects of nicotinic, alpha-adrenergic and dopaminergic blockers were investigated in rats." | 3.69 | Characteristics of tail-tremor induced by nicotine in rats. ( Gomita, Y; Oishi, R; Suemaru, K, 1994) |
| "The effects of nicotinic and beta-adrenergic receptor antagonists on tail-tremor induced by repeated nicotine administration were investigated in rats." | 3.69 | Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. ( Gomita, Y; Kawasaki, H; Oishi, R; Suemaru, K; Tanizaki, Y, 1997) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 3.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "Studies were performed to bring out a serotoninergic involvement in physostigmine tremor, hitherto known to be working via the cholinergic system." | 3.68 | Tremorogenesis by physostigmine is unrelated to acetylcholinesterase inhibition: evidence for serotoninergic involvement. ( Ganguly, DK; Mitra, N; Mohanakumar, KP, 1990) |
| "Injection of rats with 14C-labelled nicotine (3 mg/kg sc) resulted in tremor measured by an electronic device during the first minutes after the injection." | 3.65 | Nicotine induced tremor and antidiuresis and brain nicotine levels in the rat. ( Mansner, R; Mattila, MJ, 1975) |
| "Pretreatment with mecamylamine lowered brain nicotine levels in adult mice, and in infant mice the nicotine levels in blood and heart were lowered as well." | 1.26 | Pharmacokinetics of nicotine in adult and infant mice. ( Mansner, R; Mattila, MJ, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iha, HA | 1 |
| Kunisawa, N | 1 |
| Shimizu, S | 1 |
| Onishi, M | 1 |
| Nomura, Y | 1 |
| Matsubara, N | 1 |
| Iwai, C | 1 |
| Ogawa, M | 1 |
| Hashimura, M | 1 |
| Sato, K | 1 |
| Kato, M | 1 |
| Ohno, Y | 1 |
| HARINGTON, M | 1 |
| KINCAID-SMITH, P | 1 |
| Salas, R | 1 |
| Pieri, F | 1 |
| De Biasi, M | 1 |
| Hassel, B | 1 |
| Itoh, M | 1 |
| Suemaru, K | 5 |
| Oishi, R | 2 |
| Gomita, Y | 5 |
| Kawasaki, H | 3 |
| Tanizaki, Y | 2 |
| Mansner, R | 2 |
| Mattila, MJ | 2 |
| Mohanakumar, KP | 1 |
| Mitra, N | 1 |
| Ganguly, DK | 1 |
| Furuno, K | 1 |
| Araki, Y | 1 |
| Retz, KC | 1 |
| Trimmer, CK | 1 |
| Forster, MJ | 1 |
| Lal, H | 1 |
14 other studies available for mecamylamine and Tremor
| Article | Year |
|---|---|
Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Gene Expression; Male; M | 2019 |
Psychosis and tremor due to mecamylamine.
Topics: Autonomic Agents; Humans; Mecamylamine; Mental Disorders; Psychoses, Substance-Induced; Psychotic Di | 1958 |
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hype | 2004 |
Nicotinic mechanisms contribute to soman-induced symptoms and lethality.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Behavior, Animal; Chemical Warfare Agents; Dise | 2006 |
The role of brain acetylcholine in phenol-induced tremor in mice.
Topics: Acetylcholine; Analysis of Variance; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dos | 1995 |
Characteristics of tail-tremor induced by nicotine in rats.
Topics: Animals; Haloperidol; Hexamethonium; Male; Mecamylamine; Motor Activity; Nicotine; Oxotremorine; Rat | 1994 |
Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats.
Topics: Adrenergic Agents; Adrenergic beta-Antagonists; Animals; Carteolol; Dimethylphenylpiperazinium Iodid | 1997 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Ani | 1997 |
Involvement of nitric oxide in development of tail-tremor induced by repeated nicotine administration in rats.
Topics: Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Nitr | 1997 |
Pharmacokinetics of nicotine in adult and infant mice.
Topics: Age Factors; Animals; Brain; Cotinine; Heart Rate; Hexamethonium Compounds; Male; Mecamylamine; Mice | 1977 |
Nicotine induced tremor and antidiuresis and brain nicotine levels in the rat.
Topics: Animals; Arecoline; Brain; Cotinine; Depression, Chemical; Diuresis; Drug Interactions; Kidney; Live | 1975 |
Tremorogenesis by physostigmine is unrelated to acetylcholinesterase inhibition: evidence for serotoninergic involvement.
Topics: Acetylcholinesterase; Animals; Atropine; Caudate Nucleus; Cyproheptadine; Mecamylamine; Mesencephalo | 1990 |
Nicotine-induced tail-tremor and drug effects.
Topics: Animals; Arecoline; Atropine; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; | 1989 |
Motor responses of autoimmune NZB/B1NJ and C57BL/6Nnia mice to arecoline and nicotine.
Topics: Animals; Arecoline; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred C57BL; | 1987 |