mecamylamine has been researched along with Retinopathy of Prematurity in 1 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Retinopathy of Prematurity: A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effect of topical or intraocular injection of mecamylamine, a nonspecific nAChR antagonist, or targeted deletion of α7- or α9-nAChRs on ischemia-induced retinal NV was determined by comparing the amount of retinal NV at P17 in these mice versus appropriate controls." | 3.85 | The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity. ( Abraham, S; Campochiaro, PA; Chadha, R; Cooke, JP; Fortmann, SD; Hackett, SF; Seidel, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hackett, SF | 1 |
| Seidel, C | 1 |
| Abraham, S | 1 |
| Chadha, R | 1 |
| Fortmann, SD | 1 |
| Campochiaro, PA | 1 |
| Cooke, JP | 1 |
1 other study available for mecamylamine and Retinopathy of Prematurity
| Article | Year |
|---|---|
The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity.
Topics: Animals; Animals, Newborn; Cholinergic Agents; Disease Models, Animal; Ischemia; Mecamylamine; Mice; | 2017 |