mecamylamine has been researched along with Pregnancy in 14 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nefiracetam potentiated alpha4beta2-like ACh- and NMDA-induced currents at nanomolar concentrations forming bell-shaped dose-response curves with the maximum potentiation occurring at 1 and 10 nM, respectively." | 1.32 | Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors. ( Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X, 2003) |
| "Pretreatment with nicotine 1-20 micro M resulted in a dose-dependent protection against ethanol-induced toxicity." | 1.32 | Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells. ( Al-Namaeh, M; Manaye, KF; Taylor, RE; Tizabi, Y, 2003) |
| "Chlorpyrifos (CPF) is a widely used insecticides which has been shown to alter brain cell development." | 1.31 | Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. ( Addy, N; Christopher, NC; Levin, ED; Nakajima, A; Seidler, FJ; Slotkin, TA, 2001) |
| "The nicotine-induced increase of receptors in cerebral cortical cultures was not blocked by either mecamylamine or dihydro-beta-erythroidine." | 1.30 | Nicotinic receptor binding sites in rat primary neuronal cells in culture: characterization and their regulation by chronic nicotine. ( Dávila-García, MI; Houghtling, RA; Kellar, KJ; Qasba, SS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shao, XM | 1 |
| López-Valdés, HE | 1 |
| Liang, J | 1 |
| Feldman, JL | 1 |
| Singh, SP | 2 |
| Gundavarapu, S | 2 |
| Smith, KR | 1 |
| Chand, HS | 2 |
| Saeed, AI | 2 |
| Mishra, NC | 2 |
| Hutt, J | 1 |
| Barrett, EG | 1 |
| Husain, M | 1 |
| Harrod, KS | 1 |
| Langley, RJ | 2 |
| Sopori, ML | 2 |
| Tesfaigzi, Y | 1 |
| Nakamori, C | 1 |
| Shiina, T | 1 |
| Shimizu, Y | 1 |
| AGAR, H | 1 |
| BARRETT, CT | 1 |
| EXLEY, KA | 1 |
| GALARRAGA, J | 1 |
| COZZOLINO, ER | 1 |
| URANGAIMAZ, FA | 2 |
| TONNELIER, E | 1 |
| KLAUER, D | 1 |
| CHEKERDEMIAN, M | 1 |
| Narahashi, T | 1 |
| Marszalec, W | 1 |
| Moriguchi, S | 1 |
| Yeh, JZ | 1 |
| Zhao, X | 1 |
| Tizabi, Y | 1 |
| Al-Namaeh, M | 1 |
| Manaye, KF | 1 |
| Taylor, RE | 1 |
| Dávila-García, MI | 1 |
| Houghtling, RA | 1 |
| Qasba, SS | 1 |
| Kellar, KJ | 1 |
| Levin, ED | 1 |
| Addy, N | 1 |
| Nakajima, A | 1 |
| Christopher, NC | 1 |
| Seidler, FJ | 1 |
| Slotkin, TA | 1 |
| Rosecrans, JA | 1 |
| Chance, WT | 1 |
| Schechter, MD | 1 |
| Nylén, ES | 1 |
| Linnoila, RI | 1 |
| Becker, KL | 1 |
| Ryan, MJ | 1 |
| Clark, KE | 1 |
| Brody, MJ | 1 |
14 other studies available for mecamylamine and Pregnancy
| Article | Year |
|---|---|
Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats.
Topics: Administration, Inhalation; Animals; Arrhythmias, Cardiac; Cigarette Smoking; Female; Mecamylamine; | 2017 |
Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamine.
Topics: Air Pollutants; Animals; Bronchoalveolar Lavage Fluid; Bronchopulmonary Dysplasia; Female; Lung; Mec | 2013 |
HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.
Topics: Alveolar Epithelial Cells; Angiogenesis Inhibitors; Animals; Apoptosis; Apoptosis Regulatory Protein | 2015 |
Postnatal changes in vagal control of esophageal muscle contractions in rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Atropine; Electric Stimulation; Esophagus; Female; Ganglio | 2012 |
Experiences with mecamylamine in hypertensive complications of pregnancy.
Topics: Autonomic Agents; Eclampsia; Female; Humans; Hypertension; Mecamylamine; Pre-Eclampsia; Pregnancy; P | 1958 |
[Treatment of hypertension in pregnancy with mecamylamine and chlorothiazide].
Topics: Autonomic Agents; Autonomic Nervous System; Chlorothiazide; Female; Hypertension; Mecamylamine; Preg | 1961 |
[THERAPEUTICS OF ARTERIAL HYPERTENSION IN PREGNANCY].
Topics: Female; Guanethidine; Hibernation; Humans; Hydralazine; Hypertension; Hypothermia, Induced; Maternal | 1964 |
Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.
Topics: Acetylcholine; Aconitine; Alzheimer Disease; Animals; Brain Chemistry; Bungarotoxins; Dihydro-beta-E | 2003 |
Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells.
Topics: Aconitine; Animals; Cells, Cultured; Central Nervous System Depressants; Cerebellum; Culture Media; | 2003 |
Nicotinic receptor binding sites in rat primary neuronal cells in culture: characterization and their regulation by chronic nicotine.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding, Competitive; Brain Chemistry; Brain Stem; Cell | 1999 |
Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Chlorpyrifos; Female; Insecticides; Male; Maze Learning | 2001 |
The discriminative stimulus properties of nicotine, d-amphetamine and morphine in dopamine depleted rats.
Topics: Animals; Brain Chemistry; Dextroamphetamine; Dopamine; Female; Hydroxydopamines; Mecamylamine; Morph | 1976 |
Prenatal cholinergic stimulation of pulmonary neuroendocrine cells by nicotine.
Topics: Animals; Calcitonin; Cricetinae; Female; Lung; Mecamylamine; Mesocricetus; Nicotine; Pregnancy; Rece | 1988 |
Neurogenic and mechanical control of canine uterine vascular resistance.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Constriction; Dilatation; Dimethylphenylpiperazinium I | 1974 |