mecamylamine has been researched along with Neuroblastoma in 5 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin is a potent free radical scavenger, antioxidant and neuroprotective drug." | 5.36 | Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. ( Egea, J; García, AG; López, MG; Romero, A, 2010) |
| "Nicotine has been shown to produce some beneficial effects in neurodegenerative disorders, and several studies have suggested that these effects may be mediated in part through the action of the neurotrophic factor BDNF." | 5.33 | Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. ( Carney, SL; Serres, F, 2006) |
| " It was reported recently that nicotine may have protective effects against salsolinol-induced toxicity in human neuroblastoma derived SH-SY5Y cells and that these effects of nicotine are mediated by nicotinic receptors." | 3.75 | Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. ( Das, JR; Tizabi, Y, 2009) |
| "Melatonin is a potent free radical scavenger, antioxidant and neuroprotective drug." | 1.36 | Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. ( Egea, J; García, AG; López, MG; Romero, A, 2010) |
| "Nicotine has been shown to produce some beneficial effects in neurodegenerative disorders, and several studies have suggested that these effects may be mediated in part through the action of the neurotrophic factor BDNF." | 1.33 | Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. ( Carney, SL; Serres, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, JR | 1 |
| Tizabi, Y | 1 |
| Romero, A | 1 |
| Egea, J | 1 |
| García, AG | 1 |
| López, MG | 1 |
| Serres, F | 1 |
| Carney, SL | 1 |
| Nelson, ME | 1 |
| Lindstrom, J | 1 |
| Dajas-Bailador, FA | 1 |
| Mogg, AJ | 1 |
| Wonnacott, S | 1 |
5 other studies available for mecamylamine and Neuroblastoma
| Article | Year |
|---|---|
Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells.
Topics: Analysis of Variance; Annexin A5; Apoptosis; Atropine; Cell Cycle; Cell Line, Tumor; Cell Survival; | 2009 |
Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells.
Topics: Analysis of Variance; Cell Death; Cell Line, Tumor; Drug Synergism; Galantamine; Histocytochemistry; | 2010 |
Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor.
Topics: Aconitine; Antibodies; Brain-Derived Neurotrophic Factor; Carbazoles; Carbon Isotopes; Cell Line, Tu | 2006 |
Single channel properties of human alpha3 AChRs: impact of beta2, beta4 and alpha5 subunits.
Topics: Animals; Brain Neoplasms; Electrophysiology; Hexamethonium; Humans; Kinetics; Mecamylamine; Neurobla | 1999 |
Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ stores.
Topics: Aniline Compounds; Calcium; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Fluorescent Dyes | 2002 |