mecamylamine has been researched along with Muscle Contraction in 55 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The shifts caused by atropine and pirenzepine in the dose-response curves for ACh were not parallel after in vitro treatment of the muscle with DFP." | 1.27 | Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists. ( Dwyer, TM; Farley, JM; Murali Mohan, P; Yang, CM, 1988) |
| "(-)-Nicotine was an effective antinociceptive agent in the mouse tail-flick procedure at i." | 1.27 | Pharmacological effects of 1,2,3,5,6,10b-hexahydropyrido[2,3g]indolizine, a bridged-nicotine analog. ( Aceto, MD; Awaya, H; Egle, JL; Kachur, JF; Martin, BR; May, EL, 1986) |
| " Mecamylamine shifted the dose-response curves for nicotine to the right with a gradual depression." | 1.26 | Comparative studies on anti-nicotinic action of hexamethonium, mecamylamine and adenosine in the guinea pig isolated ileum. ( Hayashi, E; Mori, M; Yamada, S, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (67.27) | 18.7374 |
| 1990's | 8 (14.55) | 18.2507 |
| 2000's | 6 (10.91) | 29.6817 |
| 2010's | 4 (7.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pauwelyn, V | 1 |
| Lefebvre, RA | 1 |
| Bozarov, A | 1 |
| Wang, YZ | 1 |
| Yu, JG | 1 |
| Wunderlich, J | 1 |
| Hassanain, HH | 1 |
| Alhaj, M | 1 |
| Cooke, HJ | 1 |
| Grants, I | 1 |
| Ren, T | 1 |
| Christofi, FL | 1 |
| Trailovic, SM | 1 |
| Ivanovic, SR | 1 |
| Varagić, VM | 1 |
| White, CW | 1 |
| Short, JL | 1 |
| Haynes, JM | 1 |
| Matsui, M | 1 |
| Ventura, S | 1 |
| Nakamori, C | 1 |
| Shiina, T | 1 |
| Shimizu, Y | 1 |
| KELKAR, VV | 1 |
| GULATI, OD | 3 |
| GOKHALE, SD | 2 |
| BURN, JH | 1 |
| NG, KK | 1 |
| Beg, AA | 1 |
| Jorgensen, EM | 1 |
| Jankovic, SM | 2 |
| Protic, BA | 2 |
| Jankovic, SV | 2 |
| Masuda, H | 1 |
| Hayashi, Y | 1 |
| Chancellor, MB | 1 |
| Kihara, K | 1 |
| de Groat, WC | 1 |
| de Miguel, F | 1 |
| Yoshimura, N | 1 |
| Hayashi, E | 2 |
| Haruno, A | 1 |
| Shimizu, T | 1 |
| Terada, M | 1 |
| Navarrete, A | 1 |
| Hong, E | 1 |
| Pang, FY | 1 |
| Mason, J | 1 |
| Holden-Dye, L | 2 |
| Franks, CJ | 1 |
| Williams, RG | 1 |
| Walker, RJ | 2 |
| Ram, JL | 1 |
| Judge, K | 1 |
| Jednak, MA | 1 |
| Hopkins, BJ | 2 |
| Hodgson, WC | 2 |
| Sutherland, SK | 2 |
| Barlocco, D | 1 |
| Cignarella, G | 1 |
| Tondi, D | 1 |
| Vianello, P | 1 |
| Villa, S | 1 |
| Bartolini, A | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Anderson, DJ | 1 |
| Kuntzweiler, TA | 1 |
| Colombo, D | 1 |
| Toma, L | 1 |
| Canney, DJ | 1 |
| Zhang, M | 1 |
| Doukas, PH | 1 |
| Massakowski, C | 1 |
| Aronstam, R | 1 |
| Gattu, M | 1 |
| Buccafusco, J | 1 |
| Trim, N | 1 |
| Ruddell, R | 1 |
| Hand, GA | 1 |
| Shealy, WD | 1 |
| Wilson, LB | 1 |
| Zhao, ZW | 1 |
| Neff, LJ | 1 |
| Durstine, JL | 1 |
| Szolcsányi, J | 1 |
| Barthó, L | 1 |
| Kaplan, PE | 1 |
| Nanninga, JB | 1 |
| Yamada, S | 1 |
| Mori, M | 1 |
| Furukawa, K | 1 |
| Fänge, R | 1 |
| Holmgren, S | 1 |
| Nilsson, S | 2 |
| Cosnier, D | 1 |
| Labrid, C | 1 |
| Rispat, G | 1 |
| Streichenberger, G | 1 |
| Robinson, CP | 1 |
| Sastry, BV | 1 |
| Varanda, WA | 1 |
| Aracava, Y | 1 |
| Sherby, SM | 1 |
| VanMeter, WG | 1 |
| Eldefrawi, ME | 1 |
| Albuquerque, EX | 1 |
| Murali Mohan, P | 1 |
| Yang, CM | 1 |
| Dwyer, TM | 1 |
| Farley, JM | 1 |
| Cocks, TM | 1 |
| Broughton, A | 1 |
| Dib, M | 1 |
| Sudhir, K | 1 |
| Angus, JA | 1 |
| Hartiala, JJ | 1 |
| Mapp, C | 1 |
| Mitchell, RA | 1 |
| Gold, WM | 1 |
| Klinge, E | 1 |
| Alaranta, S | 1 |
| Sjöstrand, NO | 1 |
| Kachur, JF | 1 |
| May, EL | 1 |
| Awaya, H | 1 |
| Egle, JL | 1 |
| Aceto, MD | 1 |
| Martin, BR | 1 |
| Alkadhi, KA | 2 |
| McIsaac, RJ | 2 |
| Sethi, OP | 1 |
| Goldenberg, MM | 1 |
| Gascon, AL | 1 |
| Walaszek, EJ | 1 |
| Nedergaard, OA | 1 |
| Bevan, JA | 1 |
| Ulrich, K | 1 |
| Akubue, PI | 1 |
| Panchal, DI | 1 |
| Burnstock, G | 1 |
| Wood, MJ | 1 |
| Funasaka, T | 1 |
| Yokota, M | 1 |
| Bowman, WC | 1 |
| Webb, SN | 1 |
| Ryan, MJ | 1 |
| Clark, KE | 1 |
| Brody, MJ | 1 |
| Grove, DJ | 1 |
| Takikita, A | 1 |
| Clarke, DE | 1 |
| Capps, PA | 1 |
| Scriabine, A | 1 |
| Stavorski, JM | 1 |
| Ludden, CT | 1 |
| Stone, CA | 1 |
| van Riezen, H | 1 |
| Barnett, A | 1 |
| Benforado, JM | 1 |
| Botting, JH | 1 |
| Turmer, AD | 1 |
55 other studies available for mecamylamine and Muscle Contraction
| Article | Year |
|---|---|
5-HT
Topics: Acetylcholine; Animals; Benzofurans; Colon; Deoxyadenine Nucleotides; Electric Stimulation; Gastric | 2017 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation | 2009 |
Ivermectin effects on motor coordination and contractions of isolated rat diaphragm.
Topics: Animals; Diaphragm; Dose-Response Relationship, Drug; Flavonolignans; Ganglionic Blockers; Ivermecti | 2011 |
Contractions of the mouse prostate elicited by acetylcholine are mediated by M(3) muscarinic receptors.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Animals; Benzofurans; Body Weight; Carbachol | 2011 |
Postnatal changes in vagal control of esophageal muscle contractions in rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Atropine; Electric Stimulation; Esophagus; Female; Ganglio | 2012 |
EFFECT OF SOME GANGLION BLOCKING DRUGS ON THE RESPONSES OF THE RABBIT TRACHEAL CHAIN TO ADRENALINE, ISOPRENALINE AND AMINOPHYLLINE.
Topics: Aminophylline; Animals; Chlorisondamine; Drug Synergism; Epinephrine; Ganglionic Blockers; Hexametho | 1964 |
THE ACTION OF PEMPIDINE AND ANTIADRENALINE SUBSTANCES AT THE SYMPATHETIC POSTGANGLIONIC TERMINATION.
Topics: Abdominal Wall; Acetylcholine; Animals; Anura; Cholinesterase Inhibitors; Dihydroergotoxine; Electro | 1965 |
EXP-1 is an excitatory GABA-gated cation channel.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Antigens, Protozoan; Barium Compounds; Bicuculli | 2003 |
Contractile effect of acetylcholine on isolated ampullar segment of Fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Diamines; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; | 2004 |
Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Atropine; Diamines; Dose-Response Relationship, Drug; Fallopian Tubes; F | 2004 |
Roles of peripheral and central nicotinic receptors in the micturition reflex in rats.
Topics: Administration, Intravesical; Animals; Capsaicin; Central Nervous System; Dose-Response Relationship | 2006 |
[The specificity of pharmacological responses in Ascaris muscle (author's transl)].
Topics: Acetylcholine; Animals; Anura; Ascaris; Dimethylphenylpiperazinium Iodide; gamma-Aminobutyric Acid; | 1980 |
A selective Ascaris acetylcholine receptor antagonist: 1,1-dimethyl-4-(2-quinolyl)-piperazinium iodide.
Topics: Animals; Ascaris; Carbachol; Cholinergic Antagonists; Dimethylphenylpiperazinium Iodide; Female; Gan | 1995 |
The effects of the nematode peptide, KHEYLRFamide (AF2), on the somatic musculature of the parasitic nematode Ascaris suum.
Topics: Acetylcholine; Animals; Ascaris suum; Female; Mecamylamine; Membrane Potentials; Muscle Contraction; | 1995 |
Antagonists of cholinergic and serotonergic responses of Aplysia buccal muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Aplysia; Atropine; Cholinergic Antag | 1994 |
Pharmacological studies of stonefish (Synanceja trachynis) venom.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Captopril; Chromones; Dose-Response Relationship, Drug; | 1994 |
Evidence for adrenergic and tachykinin activity in venom of the stonefish (Synanceja trachynis).
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Bronchoconstrict | 1996 |
Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.
Topics: Abdominal Muscles; Analgesia; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocy | 1998 |
Characterization of ethyl (3-quinuclidinyl) acetate (EQA) as a ligand for acetylcholine receptors.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Behavior, Animal; Cerebral Cortex; Evaluation Studies | 1998 |
The effects of the peptides AF3 (AVPGVLRFamide) and AF4 (GDVPGVLRFamide) on the somatic muscle of the parasitic nematodes Ascaris suum and Ascaridia galli.
Topics: Acetylcholine; Animals; Ascaridia; Ascaris suum; Dose-Response Relationship, Drug; Electrophysiology | 1997 |
Spinal cholinergic inhibition of the pressor response to muscle activation is mediated by muscarinic, but not nicotinic, receptors.
Topics: Acetylcholine; Afferent Pathways; Animals; Atropine; Bethanechol; Blood Pressure; Cats; Dose-Respons | 2000 |
Capsaicin-sensitive innervation of the guinea-pig taenia caeci.
Topics: Animals; Capsaicin; Cecum; Electric Stimulation; Fatty Acids, Unsaturated; Female; Guanethidine; Gui | 1979 |
Reduction of bladder contractility after alpha-adrenergic blockade and after ganglionic blockade.
Topics: Adult; Atropine; Ganglia, Autonomic; Humans; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; | 1979 |
Comparative studies on anti-nicotinic action of hexamethonium, mecamylamine and adenosine in the guinea pig isolated ileum.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine; Animals; Binding, Competitive; Dose-Response Relatio | 1977 |
[Mechanisms of contraction and relaxation in the response to 5'hydroxytriptamine of isolated rat ileum (author's transl)].
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Hydroxydopamines; Ileum; In Vitro Techniq | 1978 |
Autonomic nerve control of the swimbladder of the goldsinny wrasse, Ctenolabrus rupestris.
Topics: Acetylcholine; Air Sacs; Animals; Atropine; Autonomic Nervous System; Epinephrine; Fishes; Gases; Hi | 1976 |
Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis.
Topics: Animals; Antihypertensive Agents; Aorta; Autonomic Nervous System; Blood Pressure; Cerebrovascular C | 1975 |
The influence of mecamylamine on contractions induced by different agonists and on the role of calcium ions in the isolated rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium; Drug Interactions; Female; Histamine; In Vitro Tec | 1976 |
The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist.
Topics: Amphibian Venoms; Animals; Bungarotoxins; Carbachol; Electric Conductivity; In Vitro Techniques; Ion | 1985 |
Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropi | 1988 |
Endothelin is blood vessel selective: studies on a variety of human and dog vessels in vitro and on regional blood flow in the conscious rabbit.
Topics: Animals; Blood Vessels; Dogs; Endothelins; Hindlimb; Humans; In Vitro Techniques; Mecamylamine; Musc | 1989 |
Nicotine-induced respiratory effects of cigarette smoke in dogs.
Topics: Animals; Blood; Bronchial Spasm; Dogs; Female; Hexamethonium; Hexamethonium Compounds; Male; Mecamyl | 1985 |
Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.
Topics: Acetylcholine; Animals; Carbachol; Cattle; Dimethylphenylpiperazinium Iodide; Dose-Response Relation | 1988 |
Pharmacological effects of 1,2,3,5,6,10b-hexahydropyrido[2,3g]indolizine, a bridged-nicotine analog.
Topics: Analgesics; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Ileu | 1986 |
Non-nicotinic transmission during ganglionic block with chlorisondamine and nicotine.
Topics: Animals; Atropine; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Cats; Chloriso | 1973 |
Analysis of mode of action of some nicotinic blocking drugs.
Topics: Animals; Chlorisondamine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Gangl | 1973 |
Effect of preganglionic nerve stimulation on sensitivity of the superior cervical ganglion to nicotinic blocking agents.
Topics: Animals; Atropine; Cats; Chlorisondamine; Dimethylphenylpiperazinium Iodide; Electric Stimulation; G | 1974 |
Angiotensin in the analysis of the intrinsic nerve supply of isolated intestines.
Topics: Angiotensin II; Animals; Atropine; Cocaine; Epinephrine; Gerbillinae; Hexamethonium Compounds; Ileum | 1968 |
Mechanism of the musculotropic activity of angiotensin on the isolated guinea-pig seminal vsecile.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Catecholamines; Cocaine; Epinephrine; Guanethidine | 1968 |
Effects of nicotine, dimethylphenylpiperazinium and cholinergic blocking agents at adrenergic nerve endings of the rabbit pulmonary artery.
Topics: Animals; Electric Stimulation; Hexamethonium Compounds; In Vitro Techniques; Mecamylamine; Muscle Co | 1969 |
A direct and an indirect action of 5-hydroxytryptamine on the distal part of the isolated colon of the rat.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Colon; Hexamethonium Compounds; Histamin | 1965 |
The site of action of drugs on the isolated taenia caeci from the guinea-pig.
Topics: Acetylcholine; Animals; Cecum; Cocaine; Female; Guinea Pigs; Hexamethonium Compounds; Histamine; His | 1966 |
An analysis of the sympathomimetic effects of acetylcholine of the rat ileum.
Topics: Acetylcholine; Amphetamine; Animals; Bretylium Compounds; Choline; Cocaine; Dextroamphetamine; Drug | 1967 |
Innervation of the lungs of the sleepy lizard (Trachysaurus rugosus). II. Physiology and pharmacology.
Topics: Acetylcholine; Animals; Atropine; Electric Stimulation; Ganglionic Blockers; Lizards; Lung; Mecamyla | 1967 |
[Mechanism of contraction caused by nicotine on the isolated rabbit aorta, with reference to catecholamine release].
Topics: Animals; Aorta; Autonomic Agents; Bis-Trimethylammonium Compounds; Bretylium Compounds; Catecholamin | 1967 |
[Structure activity relationship of colistin derivatives].
Topics: Animals; Anura; Atropine; Blood Pressure; Blood Vessels; Cats; Colistin; Depression, Chemical; Dogs; | 1971 |
Neuromuscular blocking and ganglion blocking activities of some acetylcholine antagonists in the cat.
Topics: Animals; Cats; Electric Stimulation; Female; Gallamine Triethiodide; Ganglionic Blockers; Hexamethon | 1972 |
Neurogenic and mechanical control of canine uterine vascular resistance.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Constriction; Dilatation; Dimethylphenylpiperazinium I | 1974 |
Adrenergic and cholinergic innervation of the spleen of the cod: Gadus morhua.
Topics: Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrin | 1974 |
[Mechanism of catecholamine release in the excised guinea pig vas deferens, with special reference to the role of acetylcholine].
Topics: Acetylcholine; Animals; Atropine; Bretylium Compounds; Calcium; Catecholamines; Chlorpromazine; Elec | 1972 |
The effect of mecamylamine and pempidine on postganglionic sympathetic nerves.
Topics: Animals; Autonomic Fibers, Postganglionic; Bretylium Compounds; Cocaine; Depression, Chemical; Dextr | 1972 |
Some cardiovascular effects of germine-3-monoacetate.
Topics: Acetates; Adrenal Glands; Adrenalectomy; Amino Alcohols; Animals; Arteries; Atrial Function; Blood P | 1971 |
Effect of cholinergic and anticholingeric drugs on a new neuromuscular preparation of the chick.
Topics: Acetylcholine; Animals; Carbachol; Chickens; Decamethonium Compounds; Hexamethonium Compounds; In Vi | 1968 |
The nicotinic effects of choline esters and of nicotine in guinea pig atria.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Female; Guinea Pigs; Heart; Heart Atria; Hexamethonium | 1966 |
Mode of action of vasopressin on isolated proximal colon of the guinea-pig.
Topics: Acetylcholine; Animals; Calcium; Carbachol; Cocaine; Cold Temperature; Colon; Guinea Pigs; Hexametho | 1966 |