mecamylamine has been researched along with Memory Disorders in 18 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Global cerebral ischemia/reperfusion (GCI/R) injury encompasses complex pathophysiological sequalae, inducing loss of hippocampal neurons and behavioural deficits." | 5.40 | Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice. ( Katyal, A; Rai, S; Ray, RS, 2014) |
| "In smokers with schizophrenia and control smokers, overnight abstinence led to undetectable plasma nicotine levels and an increase in tobacco craving." | 3.73 | Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms. ( Dudas, MM; George, TP; Jatlow, PI; Krishnan-Sarin, S; Sacco, KA; Seyal, A; Termine, A; Vessicchio, JC; Wexler, BE, 2005) |
| ", by reaching the high end of a nicotinic receptor activation inverted-U dose-response function." | 1.43 | Attenuation in rats of impairments of memory by scopolamine, a muscarinic receptor antagonist, by mecamylamine, a nicotinic receptor antagonist. ( Gold, PE; Newman, LA, 2016) |
| "Global cerebral ischemia/reperfusion (GCI/R) injury encompasses complex pathophysiological sequalae, inducing loss of hippocampal neurons and behavioural deficits." | 1.40 | Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice. ( Katyal, A; Rai, S; Ray, RS, 2014) |
| "Memantine was also effective in these tests and concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorated the cognitive performance in the novel object recognition task in both mice and rats." | 1.39 | Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus. ( Hino, M; Takeda, K; Yamaguchi, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 10 (55.56) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamaguchi, Y | 1 |
| Takeda, K | 1 |
| Hino, M | 1 |
| Ray, RS | 1 |
| Rai, S | 1 |
| Katyal, A | 1 |
| Newman, LA | 1 |
| Gold, PE | 1 |
| Tajik, A | 1 |
| Rezayof, A | 1 |
| Ghasemzadeh, Z | 1 |
| Sardari, M | 1 |
| Radionova, KS | 1 |
| Belnik, AP | 1 |
| Ostrovskaya, RU | 1 |
| Rasch, B | 1 |
| Gais, S | 1 |
| Born, J | 1 |
| Wing, VC | 1 |
| Sacco, KA | 3 |
| George, TP | 3 |
| Gacar, N | 1 |
| Mutlu, O | 1 |
| Utkan, T | 1 |
| Komsuoglu Celikyurt, I | 1 |
| Gocmez, SS | 1 |
| Ulak, G | 1 |
| Sultana, R | 1 |
| Ameno, K | 1 |
| Jamal, M | 1 |
| Miki, T | 1 |
| Tanaka, N | 1 |
| Ono, J | 1 |
| Kinoshita, H | 1 |
| Nakamura, Y | 1 |
| Daniel, JM | 1 |
| Winsauer, PJ | 1 |
| Moerschbaecher, JM | 1 |
| Woodruff-Pak, DS | 1 |
| Olson, ML | 1 |
| Olson, EA | 1 |
| Qualls, JH | 1 |
| Stratton, JJ | 1 |
| Harding, JW | 1 |
| Wright, JW | 1 |
| Termine, A | 2 |
| Seyal, A | 1 |
| Dudas, MM | 2 |
| Vessicchio, JC | 2 |
| Krishnan-Sarin, S | 1 |
| Jatlow, PI | 1 |
| Wexler, BE | 2 |
| Seyal, AA | 1 |
| Allen, TM | 1 |
| Lorrio, S | 1 |
| Sobrado, M | 1 |
| Arias, E | 1 |
| Roda, JM | 1 |
| García, AG | 1 |
| López, MG | 1 |
| Mikami, A | 1 |
| Masuoka, T | 1 |
| Yasuda, M | 1 |
| Yamamoto, Y | 1 |
| Kamei, C | 1 |
| Dumas, J | 1 |
| Hancur-Bucci, C | 1 |
| Naylor, M | 1 |
| Sites, C | 1 |
| Newhouse, P | 1 |
| Hiramatsu, M | 1 |
| Murasawa, H | 1 |
| Nabeshima, T | 1 |
| Kameyama, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Acute Nicotine on Long-term Potentiation in the Dorsolateral Prefrontal Cortex of Patients With Schizophrenia and Healthy Controls[NCT01465074] | 20 participants (Actual) | Interventional | 2011-11-30 | Terminated (stopped due to Limited staff and operating resources) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for mecamylamine and Memory Disorders
| Article | Year |
|---|---|
Impaired off-line consolidation of motor memories after combined blockade of cholinergic receptors during REM sleep-rich sleep.
Topics: Adult; Affect; Association Learning; Blood Pressure; Cardiovascular Physiological Phenomena; Choline | 2009 |
Neuropsychological deficits in nonsmokers with schizophrenia: effects of a nicotinic antagonist.
Topics: Adult; Cognition Disorders; Female; Humans; Male; Mecamylamine; Memory Disorders; Nicotinic Antagoni | 2006 |
Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Cholinergic Antagonists; Cognition; Critical P | 2008 |
15 other studies available for mecamylamine and Memory Disorders
| Article | Year |
|---|---|
Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus.
Topics: Acetylcholine; Administration, Oral; Animals; Cognition; Cognition Disorders; Dihydro-beta-Erythroid | 2013 |
Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice.
Topics: Acetylcholinesterase; Animals; Brain Ischemia; Choline O-Acetyltransferase; Cholinergic Antagonists; | 2014 |
Attenuation in rats of impairments of memory by scopolamine, a muscarinic receptor antagonist, by mecamylamine, a nicotinic receptor antagonist.
Topics: Acetylcholine; Animals; Cognition; Dose-Response Relationship, Drug; Hippocampus; Male; Mecamylamine | 2016 |
Activation of the dorsal hippocampal nicotinic acetylcholine receptors improves tamoxifen-induced memory retrieval impairment in adult female rats.
Topics: Aging; Animals; Avoidance Learning; Female; Hippocampus; Mecamylamine; Memory; Memory Disorders; Nic | 2016 |
Original nootropic drug noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade.
Topics: Animals; Cholinergic Agonists; Cholinergic Antagonists; Dipeptides; Male; Mecamylamine; Memory; Memo | 2008 |
Spatial working memory impairments induced by cigarette smoking abstinence are correlated with plasma nicotine levels in schizophrenia.
Topics: Humans; Mecamylamine; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Nicotine; Nico | 2011 |
Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats.
Topics: Animals; Avoidance Learning; Male; Maze Learning; Mecamylamine; Memory Disorders; Rats; Rats, Wistar | 2011 |
Low-dose nicotine facilitates spatial memory in ApoE-knockout mice in the radial arm maze.
Topics: Analysis of Variance; Animals; Apolipoproteins E; Dose-Response Relationship, Drug; Exploratory Beha | 2013 |
Castration in rats impairs performance during acquisition of a working memory task and exacerbates deficits in working memory produced by scopolamine and mecamylamine.
Topics: Animals; Dose-Response Relationship, Drug; Ganglionic Blockers; Male; Maze Learning; Mecamylamine; M | 2003 |
Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning.
Topics: Animals; Benzylidene Compounds; Blinking; Conditioning, Eyelid; Drug Interactions; Female; Mecamylam | 2003 |
Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Male; Maze Learning; Mecamylamine; Memory | 2004 |
Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms.
Topics: Adult; Attention; Behavior, Addictive; Cognition; Cognition Disorders; Comorbidity; Female; Humans; | 2005 |
Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils.
Topics: Animals; Apoptosis; Brain Ischemia; Carotid Artery, Common; Caspase 3; Galantamine; Gerbillinae; Hip | 2007 |
Participation of cholinergic system in memory deficits induced by blockade of hippocampal mGlu(1) receptors.
Topics: Animals; Cholinergic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Dose-Res | 2007 |
Effects of U-50,488H on scopolamine-, mecamylamine- and dizocilpine-induced learning and memory impairment in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylchol | 1998 |