mecamylamine has been researched along with Innate Inflammatory Response in 8 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease." | 1.46 | Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes. ( Akaike, A; Izumi, Y; Kume, T; Makitani, K; Nakagawa, S, 2017) |
| "Inflammation is a physiological process that characterizes many bladder diseases." | 1.35 | Role of nicotinic and estrogen signaling during experimental acute and chronic bladder inflammation. ( Bhowmick, NA; Dmochowski, RR; Iturregui, JM; Martinez-Ferrer, M; Matusik, RJ; Sharif-Afshar, AR; Starkman, J; Suzuki, K; Uwamariya, C; Visedsindh, W, 2008) |
| " This hypothesis was further established with methyllycaconitine completely inhibited the agonist effect when dosed intrathecally (1% +/- 7%)." | 1.35 | Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action. ( Billinton, A; Bingham, S; Chessell, IP; Clayton, NM; Hatcher, JP; Hille, CJ; Medhurst, SJ, 2008) |
| "Using the Shwartzman reaction, we observed that nicotine (2 mg/kg) and the novel cholinergic agent CAP55 (12 mg/kg) inhibit endothelial cell adhesion molecule expression." | 1.33 | Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. ( Al-Abed, Y; Balakhaneh, D; Huston, J; Metz, CN; Peng-Nemeroff, T; Saeed, RW; Sherry, B; Tracey, KJ; Varma, S, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Jimenez, T | 1 |
| Friedman, T | 1 |
| Vadgama, J | 1 |
| Singh, V | 1 |
| Tucker, A | 1 |
| Collazo, J | 1 |
| Sinha, S | 1 |
| Hikim, AS | 1 |
| Singh, R | 1 |
| Pervin, S | 1 |
| Makitani, K | 1 |
| Nakagawa, S | 1 |
| Izumi, Y | 1 |
| Akaike, A | 1 |
| Kume, T | 1 |
| Café-Mendes, CC | 1 |
| Garay-Malpartida, HM | 1 |
| Malta, MB | 1 |
| de Sá Lima, L | 1 |
| Scavone, C | 1 |
| Ferreira, ZS | 1 |
| Markus, RP | 1 |
| Marcourakis, T | 1 |
| Calvillo, L | 1 |
| Vanoli, E | 1 |
| Andreoli, E | 1 |
| Besana, A | 1 |
| Omodeo, E | 1 |
| Gnecchi, M | 1 |
| Zerbi, P | 1 |
| Vago, G | 1 |
| Busca, G | 1 |
| Schwartz, PJ | 1 |
| Motta, PG | 1 |
| Perez, AC | 1 |
| Alves, DP | 1 |
| Duarte, ID | 1 |
| Saeed, RW | 1 |
| Varma, S | 1 |
| Peng-Nemeroff, T | 1 |
| Sherry, B | 1 |
| Balakhaneh, D | 1 |
| Huston, J | 1 |
| Tracey, KJ | 1 |
| Al-Abed, Y | 1 |
| Metz, CN | 1 |
| Martinez-Ferrer, M | 1 |
| Iturregui, JM | 1 |
| Uwamariya, C | 1 |
| Starkman, J | 1 |
| Sharif-Afshar, AR | 1 |
| Suzuki, K | 1 |
| Visedsindh, W | 1 |
| Matusik, RJ | 1 |
| Dmochowski, RR | 1 |
| Bhowmick, NA | 1 |
| Medhurst, SJ | 1 |
| Hatcher, JP | 1 |
| Hille, CJ | 1 |
| Bingham, S | 1 |
| Clayton, NM | 1 |
| Billinton, A | 1 |
| Chessell, IP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy[NCT00752271] | 32 participants (Anticipated) | Observational | 2008-05-31 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for mecamylamine and Innate Inflammatory Response
| Article | Year |
|---|---|
Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferati | 2020 |
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes.
Topics: Acetylcholinesterase; Animals; Astrocytes; Bradykinin; Calcium; Cells, Cultured; Cerebral Cortex; Ch | 2017 |
Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus.
Topics: Aconitine; Animals; Hippocampus; Inflammation; Lipopolysaccharides; Male; Mecamylamine; NF-kappa B; | 2017 |
Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Cardiac Pacing, Artificial; Chemokine C | 2011 |
Modulation of peripheral inflammatory pain thresholds by M(1) and nicotinic receptor antagonists.
Topics: Acetylcholine; Animals; Carrageenan; Dinoprostone; Hyperalgesia; Inflammation; Male; Mecamylamine; N | 2011 |
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Carrageenan; Cel | 2005 |
Role of nicotinic and estrogen signaling during experimental acute and chronic bladder inflammation.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Nucleus; Cyclophosphamide; Cystitis; Estradiol; Fem | 2008 |
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzofurans; Dose-Res | 2008 |