Page last updated: 2024-10-30

mecamylamine and Hypoxia

mecamylamine has been researched along with Hypoxia in 15 studies

Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" In this study, we aim at deciphering the effects and possible mechanisms of prenatal severe hypoxia (PSH) on predisposition to nicotine addiction in adult rats."8.12Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. ( Stratilov, VA; Tyulkova, EI; Vetrovoy, OV, 2022)
" In this study, we aim at deciphering the effects and possible mechanisms of prenatal severe hypoxia (PSH) on predisposition to nicotine addiction in adult rats."4.12Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. ( Stratilov, VA; Tyulkova, EI; Vetrovoy, OV, 2022)
" The nicotinic blocker mecamylamine (50 microM) ablated the excitatory actions of exogenous ACh and increased, rather than decreased, AP activity during moderate hypoxia."3.75Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body. ( Donnelly, DF, 2009)
"To test the hypothesis that decreased acetylcholine (ACh) metabolism during hypoxia is behaviorally important, the effects of cholinergic drugs and 4-aminopyridine, an enhancer of ACh release, were examined in hypoxic mice."3.66Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. ( Gibson, GE; Pelmas, CJ; Peterson, C, 1983)
"Cholinergic neuronal influences on the function of male rat's hypothalamo-hypophyseal-adrenocortical (HHA) system both during basal and stressful situations (hypoxia and hypercapnia) were investigated using a cholinergic agonist (eserine) and antagonists (atropine, methyl atropine, mecamylamine and 4-(1-naphthylvinyl) pyridine)."3.65Actions of cholinergic agonist and antagonists on the adrenocortical response of basal, hypoxic, and hypercapnic rats. ( Marotta, SF; Sithichoke, N, 1977)
" Effects of mecamylamine on the spontaneous discharge rate of afferent fibres of carotid body chemoreceptors in vivo and their responses to ACh, NaCN, HCl and hypoxia were studied in sixteen cats."3.65Effects of mecamylamine on responses of carotid body chemoreceptors in vivo to physiological and pharmacological stimuli. ( Sampson, SR, 1971)
"In the absence of Ca(2+), acid, anoxia, and interruption of flow provoked receptor depression while receptor excitation induced by ACh and KCl persisted."1.25Pharmacology of pH effects on carotid body chemoreceptors in vitro. ( Eyzaguirre, C; Zapata, P, 1968)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's2 (13.33)18.2507
2000's3 (20.00)29.6817
2010's2 (13.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Stratilov, VA1
Vetrovoy, OV1
Tyulkova, EI1
Donnelly, DF1
Zakharova, EI1
Dudchenko, AM1
Germanova, EL1
Guo, L1
Li, L1
Wang, W1
Pan, Z1
Zhou, Q1
Wu, Z1
Bell, HJ1
Inoue, T1
Shum, K1
Luk, C1
Syed, NI1
Gibson, GE1
Pelmas, CJ1
Peterson, C1
Fitzgerald, RS3
Shirahata, M3
Ide, T2
Wang, HY1
Marotta, SF1
Sithichoke, N1
Penna, M1
Rodriguez, Y1
Rovere, A1
Fernandez, MA1
Novaković, L1
Eyzaguirre, C1
Zapata, P1
Liang, C1
Huckabee, WE1
Sampson, SR1
Botting, JH1
Turmer, AD1

Other Studies

15 other studies available for mecamylamine and Hypoxia

ArticleYear
Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain.
    Molecular neurobiology, 2022, Volume: 59, Issue:7

    Topics: Animals; Dopamine; Glutamic Acid; Hypoxia; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Ac

2022
Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 107, Issue:6

    Topics: Acetylcholine; Action Potentials; Analysis of Variance; Animals; Carotid Body; Chemoreceptor Cells;

2009
Effects of preconditioning on the resistance to acute hypobaric hypoxia and their correction with selective antagonists of nicotinic receptors.
    Bulletin of experimental biology and medicine, 2011, Volume: 151, Issue:2

    Topics: Aconitine; Adaptation, Physiological; Air Pressure; Animals; Asphyxia; Hypoxia; Male; Mecamylamine;

2011
Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells.
    Biochimica et biophysica acta, 2012, Volume: 1822, Issue:6

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dihydro-beta-Erythroidine; Humans; Hypoxia; Hypoxi

2012
Peripheral oxygen-sensing cells directly modulate the output of an identified respiratory central pattern generating neuron.
    The European journal of neuroscience, 2007, Volume: 25, Issue:12

    Topics: Action Potentials; Animals; Antinematodal Agents; Behavior, Animal; Brain; Dose-Response Relationshi

2007
Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:6

    Topics: 4-Aminopyridine; Aminopyridines; Animals; Arecoline; Atropine; Behavior, Animal; Cholinesterase Inhi

1983
Cholinergic aspects of carotid body chemotransduction.
    Advances in experimental medicine and biology, 1994, Volume: 360

    Topics: Animals; Atropine; Bungarotoxins; Carotid Body; Cats; Chemoreceptor Cells; Hypoxia; Mecamylamine; Pe

1994
Further cholinergic aspects of carotid body chemotransduction of hypoxia in cats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 82, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Carotid Body; Cats; Chemoreceptor Cells; Hypoxia; Mecamylamine

1997
Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation.
    Advances in experimental medicine and biology, 2000, Volume: 475

    Topics: Acetylcholine; Animals; Atropine; Carotid Body; Cats; Gallamine Triethiodide; Hypoxia; In Vitro Tech

2000
Actions of cholinergic agonist and antagonists on the adrenocortical response of basal, hypoxic, and hypercapnic rats.
    Aviation, space, and environmental medicine, 1977, Volume: 48, Issue:5

    Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Atropine; Atropine Derivatives

1977
Influence of drugs, rate changes and temperature on myocardial stimulation by hypoxia.
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:3

    Topics: Angiotensin II; Animals; Atrial Function; Bretylium Compounds; Cats; Electric Stimulation; Heart; He

1967
Pharmacology of pH effects on carotid body chemoreceptors in vitro.
    The Journal of physiology, 1968, Volume: 195, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Action Potentials; Animals; Atropine; Calcium; Carotid Body; Ca

1968
Mechanisms regulating the cardiac output response to cyanide infusion, a model of hypoxia.
    The Journal of clinical investigation, 1973, Volume: 52, Issue:12

    Topics: Animals; Aorta; Blood Pressure; Bretylium Compounds; Cardiac Output; Catheterization; Cyanides; Dise

1973
Effects of mecamylamine on responses of carotid body chemoreceptors in vivo to physiological and pharmacological stimuli.
    The Journal of physiology, 1971, Volume: 212, Issue:3

    Topics: Acetylcholine; Action Potentials; Animals; Arteries; Blood Pressure; Carotid Body; Cats; Chemorecept

1971
Mode of action of vasopressin on isolated proximal colon of the guinea-pig.
    British journal of pharmacology and chemotherapy, 1966, Volume: 28, Issue:2

    Topics: Acetylcholine; Animals; Calcium; Carbachol; Cocaine; Cold Temperature; Colon; Guinea Pigs; Hexametho

1966