mecamylamine has been researched along with Hypoxia in 15 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we aim at deciphering the effects and possible mechanisms of prenatal severe hypoxia (PSH) on predisposition to nicotine addiction in adult rats." | 8.12 | Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. ( Stratilov, VA; Tyulkova, EI; Vetrovoy, OV, 2022) |
| " In this study, we aim at deciphering the effects and possible mechanisms of prenatal severe hypoxia (PSH) on predisposition to nicotine addiction in adult rats." | 4.12 | Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. ( Stratilov, VA; Tyulkova, EI; Vetrovoy, OV, 2022) |
| " The nicotinic blocker mecamylamine (50 microM) ablated the excitatory actions of exogenous ACh and increased, rather than decreased, AP activity during moderate hypoxia." | 3.75 | Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body. ( Donnelly, DF, 2009) |
| "To test the hypothesis that decreased acetylcholine (ACh) metabolism during hypoxia is behaviorally important, the effects of cholinergic drugs and 4-aminopyridine, an enhancer of ACh release, were examined in hypoxic mice." | 3.66 | Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits. ( Gibson, GE; Pelmas, CJ; Peterson, C, 1983) |
| "Cholinergic neuronal influences on the function of male rat's hypothalamo-hypophyseal-adrenocortical (HHA) system both during basal and stressful situations (hypoxia and hypercapnia) were investigated using a cholinergic agonist (eserine) and antagonists (atropine, methyl atropine, mecamylamine and 4-(1-naphthylvinyl) pyridine)." | 3.65 | Actions of cholinergic agonist and antagonists on the adrenocortical response of basal, hypoxic, and hypercapnic rats. ( Marotta, SF; Sithichoke, N, 1977) |
| " Effects of mecamylamine on the spontaneous discharge rate of afferent fibres of carotid body chemoreceptors in vivo and their responses to ACh, NaCN, HCl and hypoxia were studied in sixteen cats." | 3.65 | Effects of mecamylamine on responses of carotid body chemoreceptors in vivo to physiological and pharmacological stimuli. ( Sampson, SR, 1971) |
| "In the absence of Ca(2+), acid, anoxia, and interruption of flow provoked receptor depression while receptor excitation induced by ACh and KCl persisted." | 1.25 | Pharmacology of pH effects on carotid body chemoreceptors in vitro. ( Eyzaguirre, C; Zapata, P, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Stratilov, VA | 1 |
| Vetrovoy, OV | 1 |
| Tyulkova, EI | 1 |
| Donnelly, DF | 1 |
| Zakharova, EI | 1 |
| Dudchenko, AM | 1 |
| Germanova, EL | 1 |
| Guo, L | 1 |
| Li, L | 1 |
| Wang, W | 1 |
| Pan, Z | 1 |
| Zhou, Q | 1 |
| Wu, Z | 1 |
| Bell, HJ | 1 |
| Inoue, T | 1 |
| Shum, K | 1 |
| Luk, C | 1 |
| Syed, NI | 1 |
| Gibson, GE | 1 |
| Pelmas, CJ | 1 |
| Peterson, C | 1 |
| Fitzgerald, RS | 3 |
| Shirahata, M | 3 |
| Ide, T | 2 |
| Wang, HY | 1 |
| Marotta, SF | 1 |
| Sithichoke, N | 1 |
| Penna, M | 1 |
| Rodriguez, Y | 1 |
| Rovere, A | 1 |
| Fernandez, MA | 1 |
| Novaković, L | 1 |
| Eyzaguirre, C | 1 |
| Zapata, P | 1 |
| Liang, C | 1 |
| Huckabee, WE | 1 |
| Sampson, SR | 1 |
| Botting, JH | 1 |
| Turmer, AD | 1 |
15 other studies available for mecamylamine and Hypoxia
| Article | Year |
|---|---|
Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain.
Topics: Animals; Dopamine; Glutamic Acid; Hypoxia; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Ac | 2022 |
Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body.
Topics: Acetylcholine; Action Potentials; Analysis of Variance; Animals; Carotid Body; Chemoreceptor Cells; | 2009 |
Effects of preconditioning on the resistance to acute hypobaric hypoxia and their correction with selective antagonists of nicotinic receptors.
Topics: Aconitine; Adaptation, Physiological; Air Pressure; Animals; Asphyxia; Hypoxia; Male; Mecamylamine; | 2011 |
Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dihydro-beta-Erythroidine; Humans; Hypoxia; Hypoxi | 2012 |
Peripheral oxygen-sensing cells directly modulate the output of an identified respiratory central pattern generating neuron.
Topics: Action Potentials; Animals; Antinematodal Agents; Behavior, Animal; Brain; Dose-Response Relationshi | 2007 |
Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Arecoline; Atropine; Behavior, Animal; Cholinesterase Inhi | 1983 |
Cholinergic aspects of carotid body chemotransduction.
Topics: Animals; Atropine; Bungarotoxins; Carotid Body; Cats; Chemoreceptor Cells; Hypoxia; Mecamylamine; Pe | 1994 |
Further cholinergic aspects of carotid body chemotransduction of hypoxia in cats.
Topics: Acetylcholine; Animals; Atropine; Carotid Body; Cats; Chemoreceptor Cells; Hypoxia; Mecamylamine | 1997 |
Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation.
Topics: Acetylcholine; Animals; Atropine; Carotid Body; Cats; Gallamine Triethiodide; Hypoxia; In Vitro Tech | 2000 |
Actions of cholinergic agonist and antagonists on the adrenocortical response of basal, hypoxic, and hypercapnic rats.
Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Atropine; Atropine Derivatives | 1977 |
Influence of drugs, rate changes and temperature on myocardial stimulation by hypoxia.
Topics: Angiotensin II; Animals; Atrial Function; Bretylium Compounds; Cats; Electric Stimulation; Heart; He | 1967 |
Pharmacology of pH effects on carotid body chemoreceptors in vitro.
Topics: Acetylcholine; Acetylcholinesterase; Action Potentials; Animals; Atropine; Calcium; Carotid Body; Ca | 1968 |
Mechanisms regulating the cardiac output response to cyanide infusion, a model of hypoxia.
Topics: Animals; Aorta; Blood Pressure; Bretylium Compounds; Cardiac Output; Catheterization; Cyanides; Dise | 1973 |
Effects of mecamylamine on responses of carotid body chemoreceptors in vivo to physiological and pharmacological stimuli.
Topics: Acetylcholine; Action Potentials; Animals; Arteries; Blood Pressure; Carotid Body; Cats; Chemorecept | 1971 |
Mode of action of vasopressin on isolated proximal colon of the guinea-pig.
Topics: Acetylcholine; Animals; Calcium; Carbachol; Cocaine; Cold Temperature; Colon; Guinea Pigs; Hexametho | 1966 |