mecamylamine has been researched along with Drug Withdrawal Symptoms in 129 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared smokers with schizophrenia (SS; n=27) and control smokers (CS; n=26) on smoking and psychiatric outcomes at baseline, during acute smoking abstinence and reinstatement, and with pre-treatment using the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (MEC) in a human laboratory setting." | 9.12 | Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia. ( Creeden, CL; George, TP; Jatlow, PI; Sacco, KA; Vessicchio, JC; Weinberger, AH, 2007) |
| "To evaluate concurrent administration of mecamylamine (nicotine antagonist) with nicotine skin patch treatment for smoking cessation." | 9.07 | Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone. ( Behm, FM; Levin, ED; Ripka, GV; Rose, JE; Stein, RM; Westman, EC, 1994) |
| "In concurrence with clinical findings proposing alleviation of withdrawal states as a possible mechanism of bupropion and nortriptyline's smoking cessation action, both drugs were found to ameliorate somatic signs of nicotine withdrawal in rodents." | 7.74 | Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. ( Shoaib, M; Wing, VC, 2007) |
| "Individuals with schizophrenia have higher plasma nicotine levels in comparison to non-psychiatric smokers, even when differences in smoking are equated." | 6.74 | Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: a preliminary study. ( Coppola, S; George, TP; Harrison, EL; McKee, SA; Weinberger, AH, 2009) |
| "Nicotine was delivered chronically through osmotic minipumps for 28 days (40 mg/kg/day, base), and withdrawal was induced by either administering the broad-spectrum nicotinic receptor antagonist mecamylamine (i." | 5.42 | Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. ( Markou, A; Marks, MJ; Stoker, AK, 2015) |
| " We compared smokers with schizophrenia (SS; n=27) and control smokers (CS; n=26) on smoking and psychiatric outcomes at baseline, during acute smoking abstinence and reinstatement, and with pre-treatment using the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (MEC) in a human laboratory setting." | 5.12 | Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia. ( Creeden, CL; George, TP; Jatlow, PI; Sacco, KA; Vessicchio, JC; Weinberger, AH, 2007) |
| "Mecamylamine is an antihypertensive that acts via nicotinic antagonism and has been suggested as an aid in smoking cessation." | 5.08 | Mecamylamine does not precipitate withdrawal in cigarette smokers. ( Eissenberg, T; Griffiths, RR; Stitzer, ML, 1996) |
| "To evaluate concurrent administration of mecamylamine (nicotine antagonist) with nicotine skin patch treatment for smoking cessation." | 5.07 | Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone. ( Behm, FM; Levin, ED; Ripka, GV; Rose, JE; Stein, RM; Westman, EC, 1994) |
| " All mice were then, 96 hr later, challenged with mecamylamine (3 mg/kg), and tested for anxiety-like behaviors 30 min later." | 3.96 | The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal. ( Ahmad, SM; Hamid, A; Lutfy, K; Marquez, P; Nega, S, 2020) |
| "Cigarette smokers with brain damage involving the insular cortex display cessation of tobacco smoking, suggesting that this region may contribute to nicotine addiction." | 3.91 | N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. ( D'Aniello, E; Damaj, MI; Di Marzo, V; Donvito, G; Giordano, C; Guida, F; Ignatowska-Jankowska, BM; Jackson, A; Lichtman, AH; Maione, S; Mechoulam, R; Muldoon, P; Mustafa, MA; Parker, L; Petrie, GN; Piscitelli, F; Sim-Selley, L; Smoum, R; Vitale, RM, 2019) |
| " We analysed the time course of the global withdrawal score, the anxiety-like effects, monoamine concentrations, the brain-derived neurotrophic factor (BDNF) expression, the corticosterone plasmatic levels and [(3)H]epibatidine binding sites during NIC withdrawal precipitated by mecamylamine, a nicotinic receptor antagonist (MEC)." | 3.81 | Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal. ( Antonelli, MC; Balerio, GN; Bettler, B; Machado, LM; Pedrón, VT; Varani, AP, 2015) |
| "Nicotine discontinuation produces behaviors in rats that are congruent with anhedonia, and these symptoms may be related to the devaluation of non-nicotine reinforcers." | 3.81 | Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal. ( Fay, M; Green, J; Kirshenbaum, A; Parks, A; Phillips, J; Roy, T; Stone, J, 2015) |
| " Chronic intermittent non-contingent, second-hand exposure to cigarette smoke or e-cig vapour led to similar brain cotinine and nicotine levels, similar urine cotinine levels and the similar up-regulation of α4β2 nicotinic acetylcholine receptors in different brain areas, but had different effects on body weight, food intake, and the signs of mecamylamine-precipitated and spontaneous withdrawal episodic memory and emotional responses." | 3.81 | Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice. ( Braida, D; Cannazza, G; Castellana, CN; Clementi, F; Fasoli, F; Gallesi, G; Gotti, C; Lucini, V; Moretti, M; Mucchietto, V; Ponzoni, L; Sala, M; Zoli, M, 2015) |
| "Humans escalate their cigarette smoking over time, and a major obstacle in the field of pre-clinical nicotine addiction research has been the inability to produce escalated nicotine self-administration in rats." | 3.80 | Nicotine vapor inhalation escalates nicotine self-administration. ( Abdel, AY; Baynes, B; George, O; Gilpin, NW; Weil, MT; Whitaker, AM, 2014) |
| "Anhedonia was assessed with the discrete-trial current-intensity intracranial self-stimulation (ICSS) procedure after the termination of cocaine (180 mg kg(-1) day(-1), salt, 3 days, i." | 3.78 | Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. ( Markou, A; Olivier, B; Stoker, AK, 2012) |
| "Thus, it is suggested that src kinase is involved in the development of nicotine dependence-induced precipitation of its withdrawal syndrome and thus may serve as a viable pharmacological target to tackle the problem of nicotine addiction." | 3.78 | SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. ( Arora, S; Rehni, AK; Singh, TG, 2012) |
| " Although adolescents may exhibit a greater susceptibility to nicotine addiction, relatively little is known about the influence of the aversive effects of nicotine withdrawal in maintaining smoking behavior." | 3.74 | Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats. ( Lê, AD; Li, Z; Shram, MJ; Siu, EC; Tyndale, RF, 2008) |
| "In concurrence with clinical findings proposing alleviation of withdrawal states as a possible mechanism of bupropion and nortriptyline's smoking cessation action, both drugs were found to ameliorate somatic signs of nicotine withdrawal in rodents." | 3.74 | Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. ( Shoaib, M; Wing, VC, 2007) |
| " Subsequently, a single intraperitoneal injection of the nicotinic receptor antagonist mecamylamine induced behavioral symptoms of withdrawal measured as increased grooming, chewing, scratching, and shaking, plus the appearance of some unique behaviors such as jumping, leg tremors, and cage scratching." | 3.72 | Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. ( De Biasi, M; Pieri, F; Salas, R, 2004) |
| "The symptom of "diminished interest or pleasure" in rewarding stimuli is an affective symptom of nicotine and amphetamine withdrawal, and a core symptom of depression." | 3.71 | Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. ( Harrison, AA; Liem, YT; Markou, A, 2001) |
| " Because nucleus accumbens nicotinic receptors are important in nicotine addiction and because nicotinic activity can interact with opioid action, we investigated the contribution of nucleus accumbens nicotinic receptors to opioid-mediated analgesia/antinociception." | 3.71 | Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens. ( Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH, 2001) |
| "Cholinergic and anticholinergic agents were tested against the induction and expression of morphine dependence in rats." | 3.65 | Effects of cholinergic and anticholinergic drugs and a partial cholinergic agonist on the development and expression of physical dependence on morphine in rat. ( Frederickson, RC; Pinsky, C, 1975) |
| "Individuals had current alcohol dependence (n = 128), had an average age of 48." | 2.87 | Mecamylamine treatment for alcohol dependence: a randomized controlled trial. ( Arias, A; Gueorguieva, R; Jane, JS; Krystal, JH; O'Brien, E; O'Malley, SS; Petrakis, IL; Ralevski, E; Sevarino, KA, 2018) |
| "Individuals with schizophrenia have higher plasma nicotine levels in comparison to non-psychiatric smokers, even when differences in smoking are equated." | 2.74 | Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: a preliminary study. ( Coppola, S; George, TP; Harrison, EL; McKee, SA; Weinberger, AH, 2009) |
| "Nicotine withdrawal symptoms were precipitated by an acute injection of mecamylamine, a nonspecific nAChR antagonist, following chronic nicotine consumption." | 1.62 | Serotonin neurons in the median raphe nucleus bidirectionally regulate somatic signs of nicotine withdrawal in mice. ( Kobayashi, K; Murashita, T; Nishitani, N; Ohmura, Y; Yoshida, T; Yoshioka, M, 2021) |
| "Cigarette smoking and resultant nicotine dependence remain major public health problems." | 1.51 | Differential expression of nicotine withdrawal as a function of developmental age in the rat. ( Hsu, LM; Keeley, RJ; Lu, H; Mayer, TE; Stein, EA; Yang, Y, 2019) |
| "Nicotine treatment increased ACh levels to a larger extent in females than males." | 1.51 | Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal. ( Arreguin, MC; Carcoba, LM; Correa, VL; Flores, RJ; O'Dell, LE, 2019) |
| "Nicotine is a major psychoactive and addictive component of tobacco." | 1.43 | Cognitive control deficits during mecamylamine-precipitated withdrawal in mice: Possible links to frontostriatal BDNF imbalance. ( Cole, RD; Gould, TJ; Parikh, V; Patel, PJ; Poole, RL, 2016) |
| " Further development of these models, including evaluation of more clinically relevant nicotine dosing regimens and other measures of nicotine withdrawal (e." | 1.42 | A Two-Day Continuous Nicotine Infusion Is Sufficient to Demonstrate Nicotine Withdrawal in Rats as Measured Using Intracranial Self-Stimulation. ( Harris, AC; Muelken, P; Schmidt, CE; Shelley, D; Tally, L, 2015) |
| "Nicotine addiction is a chronic brain disorder that is characterized by dysphoria upon smoking cessation and relapse after brief periods of abstinence." | 1.42 | Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats. ( Bruijnzeel, AW; Guzhva, L; Ji, Y; Qi, X, 2015) |
| "Nicotine was delivered chronically through osmotic minipumps for 28 days (40 mg/kg/day, base), and withdrawal was induced by either administering the broad-spectrum nicotinic receptor antagonist mecamylamine (i." | 1.42 | Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. ( Markou, A; Marks, MJ; Stoker, AK, 2015) |
| "The nicotine plasma levels were also measured with or without methoxsalen pretreatment." | 1.40 | Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. ( Bagdas, D; Damaj, MI; Muldoon, PP; Tyndale, RF; Zhu, AZ, 2014) |
| "Mecamylamine treatment significantly attenuated expression of cocaine behavioral sensitization on both withdrawal days 7 and 14." | 1.40 | Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine. ( Fowler, JC; Froeliger, B; Lee, TH; Szabo, ST, 2014) |
| "As in humans, rodents undergo physical withdrawal symptoms after cessation from chronic nicotine characterized by increased scratching, head nods, and body shakes." | 1.39 | Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms. ( Gardner, PD; Liu, L; Pang, X; Tapper, AR; Zhao-Shea, R, 2013) |
| "Nicotine dependence was induced by implanting minipumps that delivered a nicotine solution." | 1.38 | Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats. ( Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Ji, Y; Rogers, JA; Scheick, S, 2012) |
| "Tobacco dependence is an addiction with high rates of relapse, resulting in multiple quit attempts in individuals who are trying to stop smoking." | 1.38 | Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice. ( Blendy, JA; Hilario, MR; Turner, JR, 2012) |
| " In addition, chronic administration of mecamylamine into ethanol diet-fed mice markedly attenuated the ethanol withdrawal sign scores, thus supporting the contention that nAChR is involved in ethanol dependence." | 1.36 | Inhibitory influence of mecamylamine on ethanol withdrawal-induced symptoms in C57BL/6J mice. ( Bansod, KU; Bhutada, PS; Dixit, PV; Kahale, VP; Mundhada, DR; Mundhada, YR; Umathe, SN, 2010) |
| "Mecamylamine failed to produce signs of precipitated withdrawal in either procedure." | 1.35 | Removal of continuous nicotine infusion produces somatic but not behavioral signs of withdrawal in mice. ( Harris, LS; Kwilasz, AJ; Vann, RE, 2009) |
| "When nicotine-infused rats were also treated with a MAOI, mecamylamine-induced conditioned place aversion persisted for at least 8 months of abstinence." | 1.35 | Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion. ( Cador, M; Guillem, K; Koob, GF; Stinus, L; Vouillac, C, 2008) |
| "Nicotine dependence was assessed by examining physical signs of withdrawal following an injection of the nicotinic antagonist mecamylamine (1." | 1.34 | 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. ( Koob, GF; O'Dell, LE, 2007) |
| "Finally, because anxiety and withdrawal symptoms are highly correlated in humans, we studied anxiety-like behaviors in alpha7 -/- mice using a battery of anxiety-related tests." | 1.34 | Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit. ( De Biasi, M; Gangitano, D; Main, A; Salas, R, 2007) |
| "Nicotine or morphine was administered acutely or chronically, and withdrawal syndrome was induced by spontaneous discontinuation of drug treatment or by administration of a corresponding receptor antagonist (mecamylamine and naloxone, respectively)." | 1.33 | Neurosteroids in nicotine and morphine dependence. ( Biggio, G; Brundu, A; Concas, A; Marra, C; Porcu, P; Sogliano, C, 2006) |
| "Nicotine dependence was induced via osmotic minipump in adolescent rats (releasing 22." | 1.33 | Withdrawal from chronic nicotine in adolescent and adult rats. ( Spear, LP; Wilmouth, CE, 2006) |
| "Adolescents did not display the decreases in brain reward function observed in adults experiencing withdrawal, and displayed fewer somatic signs of nicotine withdrawal relative to adults regardless of the dosing procedure used." | 1.33 | Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. ( Bruijnzeel, AW; Goldberger, BA; Koob, GF; Markou, A; Merves, ML; O'Dell, LE; Parsons, LH; Richardson, HN; Smith, RT, 2006) |
| "Nicotine was then administered s." | 1.33 | Dose, duration, and pattern of nicotine administration as determinants of behavioral dependence in rats. ( Balster, RL; Beardsley, PM; Vann, RE, 2006) |
| "Nicotine dependence was induced by continuous nicotine infusion through osmotic minipumps." | 1.32 | Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration. ( Bespalov, A; Markou, A; Semenova, S, 2003) |
| "Nicotine addiction is a major public health issue." | 1.31 | Nicotine withdrawal syndrome: behavioural distress and selective up-regulation of the cyclic AMP pathway in the amygdala. ( Hanoune, J; Monory, K; Nomikos, GG; Tzavara, ET, 2002) |
| "Nicotine-treated rats receiving mecamylamine or i." | 1.31 | Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. ( Koob, GF; Markou, A; Stinus, L; Watkins, SS, 2000) |
| "Nicotine withdrawal was significantly attenuated in knock-out mutants when compared with wild-type mice." | 1.31 | Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. ( Berrendero, F; Kieffer, BL; Maldonado, R, 2002) |
| "Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities." | 1.30 | Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. ( Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M, 1998) |
| "The nicotine abstinence was mild and protracted, lasting more than 92 h." | 1.30 | Nicotine abstinence in the mouse. ( Hadjiconstantinou, M; Isola, R; Neff, NH; Vogelsberg, V; Wemlinger, TA, 1999) |
| "The effects of chronic administration of nicotine (20 or 30 days) and its withdrawal on somatostatin-like immunorectivity and the binding of 125I-Tyr11-somatostatin in the frontoparietal cortex and hippocampus of the rat were investigated." | 1.28 | The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat. ( Arilla, E; Barrios, V; Rodríguez-Sánchez, MN, 1990) |
| "Mecamylamine (MCL) has been shown to extinguish nicotine dependence in rats and monkeys." | 1.27 | Clinical evaluation of mecamylamine for withdrawal from nicotine dependence. ( Rawson, RA; Tarver, AL; Tennant, FS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (6.98) | 18.7374 |
| 1990's | 16 (12.40) | 18.2507 |
| 2000's | 51 (39.53) | 29.6817 |
| 2010's | 45 (34.88) | 24.3611 |
| 2020's | 8 (6.20) | 2.80 |
| Authors | Studies |
|---|---|
| Rather, IIG | 1 |
| Behl, T | 1 |
| Sehgal, A | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Sharma, A | 1 |
| Bhatia, S | 1 |
| Al-Harrasi, A | 1 |
| Khan, N | 1 |
| Khan, H | 1 |
| Bungau, S | 1 |
| Alkhlaif, Y | 1 |
| El-Halawany, M | 1 |
| Toma, W | 1 |
| Park, A | 1 |
| Hamouda, AK | 1 |
| Damaj, MI | 7 |
| Tan, S | 1 |
| Xue, S | 1 |
| Behnood-Rod, A | 1 |
| Chellian, R | 1 |
| Wilson, R | 1 |
| Knight, P | 1 |
| Panunzio, S | 1 |
| Lyons, H | 1 |
| Febo, M | 2 |
| Bruijnzeel, AW | 7 |
| Keeley, RJ | 1 |
| Mayer, TE | 1 |
| Hsu, LM | 2 |
| Lu, H | 2 |
| Yang, Y | 2 |
| Stein, EA | 2 |
| Nega, S | 1 |
| Marquez, P | 1 |
| Hamid, A | 1 |
| Ahmad, SM | 1 |
| Lutfy, K | 1 |
| Sal, F | 1 |
| Prados, J | 1 |
| Urcelay, GP | 1 |
| Harris, AC | 5 |
| Nishitani, N | 1 |
| Ohmura, Y | 1 |
| Kobayashi, K | 1 |
| Murashita, T | 1 |
| Yoshida, T | 1 |
| Yoshioka, M | 1 |
| Klenowski, PM | 1 |
| Zhao-Shea, R | 2 |
| Freels, TG | 1 |
| Molas, S | 1 |
| Tapper, AR | 2 |
| Pipkin, JA | 1 |
| Cruz, B | 1 |
| Flores, RJ | 3 |
| Hinojosa, CA | 1 |
| Carcoba, LM | 3 |
| Ibarra, M | 1 |
| Francis, W | 1 |
| Nazarian, A | 1 |
| O'Dell, LE | 10 |
| Yuan, M | 1 |
| Malagon, AM | 1 |
| Yasuda, D | 1 |
| Belluzzi, JD | 1 |
| Leslie, FM | 1 |
| Zaveri, NT | 1 |
| Petrakis, IL | 1 |
| Ralevski, E | 1 |
| Gueorguieva, R | 1 |
| O'Malley, SS | 1 |
| Arias, A | 1 |
| Sevarino, KA | 1 |
| Jane, JS | 1 |
| O'Brien, E | 1 |
| Krystal, JH | 1 |
| Natividad, LA | 3 |
| Jackson, A | 3 |
| Papke, RL | 1 |
| Donvito, G | 1 |
| Piscitelli, F | 1 |
| Muldoon, P | 1 |
| Vitale, RM | 1 |
| D'Aniello, E | 1 |
| Giordano, C | 1 |
| Ignatowska-Jankowska, BM | 2 |
| Mustafa, MA | 1 |
| Guida, F | 1 |
| Petrie, GN | 1 |
| Parker, L | 1 |
| Smoum, R | 1 |
| Sim-Selley, L | 1 |
| Maione, S | 1 |
| Lichtman, AH | 2 |
| Di Marzo, V | 1 |
| Mechoulam, R | 1 |
| Correa, VL | 1 |
| Arreguin, MC | 1 |
| Muldoon, PP | 2 |
| Singh, TG | 3 |
| Rehni, AK | 3 |
| Arora, SK | 1 |
| Liu, L | 1 |
| Pang, X | 1 |
| Gardner, PD | 1 |
| Szabo, ST | 1 |
| Fowler, JC | 1 |
| Froeliger, B | 1 |
| Lee, TH | 1 |
| Bagdas, D | 1 |
| Zhu, AZ | 1 |
| Tyndale, RF | 2 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Cunningham, CS | 1 |
| Moerke, MJ | 1 |
| McMahon, LR | 1 |
| Varani, AP | 3 |
| Moutinho Machado, L | 1 |
| Balerio, GN | 4 |
| Stoker, AK | 3 |
| Marks, MJ | 1 |
| Markou, A | 12 |
| Kirshenbaum, A | 1 |
| Green, J | 1 |
| Fay, M | 1 |
| Parks, A | 1 |
| Phillips, J | 1 |
| Stone, J | 1 |
| Roy, T | 1 |
| Pedrón, VT | 1 |
| Machado, LM | 1 |
| Antonelli, MC | 1 |
| Bettler, B | 1 |
| Perez, E | 1 |
| Quijano-Cardé, N | 1 |
| De Biasi, M | 3 |
| Qi, X | 2 |
| Guzhva, L | 2 |
| Ji, Y | 2 |
| Ponzoni, L | 1 |
| Moretti, M | 1 |
| Sala, M | 1 |
| Fasoli, F | 1 |
| Mucchietto, V | 1 |
| Lucini, V | 1 |
| Cannazza, G | 1 |
| Gallesi, G | 1 |
| Castellana, CN | 1 |
| Clementi, F | 1 |
| Zoli, M | 1 |
| Gotti, C | 1 |
| Braida, D | 1 |
| Muelken, P | 1 |
| Schmidt, CE | 2 |
| Shelley, D | 2 |
| Tally, L | 1 |
| Bowers, MS | 1 |
| Maldoon, PP | 1 |
| Brynildsen, JK | 1 |
| Najar, J | 1 |
| Vaupel, DB | 1 |
| Ross, TJ | 1 |
| Parikh, V | 1 |
| Cole, RD | 1 |
| Patel, PJ | 1 |
| Poole, RL | 1 |
| Gould, TJ | 1 |
| Yang, Z | 1 |
| Shan, Z | 1 |
| Wang, KKW | 1 |
| Marcinkiewcz, CA | 1 |
| Prado, MM | 1 |
| Isaac, SK | 1 |
| Marshall, A | 1 |
| Rylkova, D | 1 |
| Trigo, JM | 1 |
| Zimmer, A | 2 |
| Maldonado, R | 6 |
| Roiko, SA | 1 |
| LeSage, MG | 1 |
| Keyler, DE | 1 |
| Pentel, PR | 1 |
| Kwilasz, AJ | 1 |
| Harris, LS | 1 |
| Vann, RE | 2 |
| McKee, SA | 1 |
| Weinberger, AH | 2 |
| Harrison, EL | 1 |
| Coppola, S | 1 |
| George, TP | 2 |
| Tejeda, HA | 1 |
| Torres, OV | 2 |
| Bhutada, PS | 1 |
| Mundhada, YR | 1 |
| Bansod, KU | 1 |
| Umathe, SN | 1 |
| Kahale, VP | 1 |
| Dixit, PV | 1 |
| Mundhada, DR | 1 |
| Scott, D | 1 |
| Hiroi, N | 1 |
| Moutinho, LM | 1 |
| Calvo, M | 1 |
| Plaza-Zabala, A | 1 |
| Flores, Á | 1 |
| Berrendero, F | 4 |
| Olivier, B | 2 |
| Arora, S | 2 |
| Ford, J | 1 |
| Rogers, JA | 1 |
| Scheick, S | 1 |
| Bishnoi, M | 1 |
| Alexander, JC | 1 |
| Weaver, MT | 1 |
| Sweitzer, M | 1 |
| Coddington, S | 1 |
| Sheppard, J | 1 |
| Verdecchia, N | 1 |
| Caggiula, AR | 1 |
| Sved, AF | 1 |
| Donny, EC | 1 |
| Liu, H | 1 |
| Lai, M | 1 |
| Zhou, X | 1 |
| Zhu, H | 1 |
| Liu, Y | 1 |
| Sun, A | 1 |
| Ma, B | 1 |
| Zhang, F | 1 |
| Zhou, W | 1 |
| Skwara, AJ | 1 |
| Karwoski, TE | 1 |
| Czambel, RK | 1 |
| Rubin, RT | 1 |
| Rhodes, ME | 1 |
| Hilario, MR | 1 |
| Turner, JR | 1 |
| Blendy, JA | 1 |
| Manbeck, KE | 1 |
| Buczynski, MW | 1 |
| Parsons, LH | 3 |
| Gilpin, NW | 1 |
| Whitaker, AM | 1 |
| Baynes, B | 1 |
| Abdel, AY | 1 |
| Weil, MT | 1 |
| George, O | 2 |
| Tzavara, ET | 1 |
| Monory, K | 1 |
| Hanoune, J | 1 |
| Nomikos, GG | 4 |
| Castañé, A | 1 |
| Valjent, E | 1 |
| Ledent, C | 1 |
| Parmentier, M | 1 |
| Valverde, O | 1 |
| Kieffer, BL | 1 |
| Cohen, C | 1 |
| Bergis, OE | 1 |
| Galli, F | 1 |
| Lochead, AW | 1 |
| Jegham, S | 1 |
| Biton, B | 1 |
| Leonardon, J | 1 |
| Avenet, P | 1 |
| Sgard, F | 1 |
| Besnard, F | 1 |
| Graham, D | 1 |
| Coste, A | 1 |
| Oblin, A | 1 |
| Curet, O | 1 |
| Voltz, C | 1 |
| Gardes, A | 1 |
| Caille, D | 1 |
| Perrault, G | 1 |
| George, P | 1 |
| Soubrie, P | 1 |
| Scatton, B | 1 |
| Besheer, J | 1 |
| Bevins, RA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Multicenter, Dose-Ranging Study of 100 or 250 μg of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation[NCT00633321] | Phase 2 | 522 participants (Anticipated) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for mecamylamine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Mecamylamine treatment for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Comorbidity; Craving; Double-Blind Method; Fem | 2018 |
Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: a preliminary study.
Topics: Adolescent; Adult; Behavior, Addictive; Double-Blind Method; Female; Humans; Male; Mecamylamine; Mid | 2009 |
Mecamylamine acutely increases human intravenous nicotine self-administration.
Topics: Adolescent; Adult; Affect; Female; Humans; Injections, Intravenous; Male; Mecamylamine; Middle Aged; | 2003 |
Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia.
Topics: Acute Disease; Adult; Cotinine; Demography; Depression; Female; Humans; Male; Mecamylamine; Nicotine | 2007 |
Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone.
Topics: Administration, Cutaneous; Adult; Affect; Blood Pressure; Breath Tests; Carbon Monoxide; Double-Blin | 1994 |
Mecamylamine does not precipitate withdrawal in cigarette smokers.
Topics: Adult; Blood Pressure; Carbon Monoxide; Female; Heart Rate; Humans; Male; Mecamylamine; Middle Aged; | 1996 |
Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking.
Topics: Administration, Cutaneous; Adolescent; Adult; Analysis of Variance; Arousal; Behavior, Addictive; Bl | 2001 |
Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms.
Topics: Administration, Cutaneous; Adult; Female; Humans; Male; Mecamylamine; Monoamine Oxidase; Neostigmine | 2001 |
121 other studies available for mecamylamine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice.
Topics: Animals; Mecamylamine; Mice; Nicotine; rho GTP-Binding Proteins; Substance Withdrawal Syndrome; Toba | 2022 |
L-theanine attenuates nicotine reward and withdrawal signs in mice.
Topics: Animals; Humans; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Antagonists; Recept | 2023 |
Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.
Topics: Animals; Anxiety; Brain; Estrous Cycle; Female; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Ni | 2019 |
Differential expression of nicotine withdrawal as a function of developmental age in the rat.
Topics: Age Factors; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Infusions, Subcutaneous; L | 2019 |
The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal.
Topics: Animals; Anxiety; Conditioning, Psychological; Depression; Female; Male; Mecamylamine; Mice; Mice, I | 2020 |
Nicotine chronic tolerance development and withdrawal in the planaria (Schmidtea mediterranea).
Topics: Animals; Behavior, Addictive; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Hu | 2021 |
Magnitude of open-field thigmotaxis during mecamylamine-precipitated nicotine withdrawal in rats is influenced by mecamylamine dose, duration of nicotine infusion, number of withdrawal episodes, and age.
Topics: Age Factors; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Locomotion; Male; Mecamy | 2021 |
Serotonin neurons in the median raphe nucleus bidirectionally regulate somatic signs of nicotine withdrawal in mice.
Topics: Animals; Female; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Optogenet | 2021 |
Further pharmacological characterization of a preclinical model of the early development of nicotine withdrawal.
Topics: Animals; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Self Stimulation; Substance Withdrawal | 2021 |
Dynamic activity of interpeduncular nucleus GABAergic neurons controls expression of nicotine withdrawal in male mice.
Topics: Animals; GABAergic Neurons; Interpeduncular Nucleus; Male; Mecamylamine; Mice; Nicotine; Substance W | 2022 |
Both nicotine reward and withdrawal are enhanced in a rodent model of diabetes.
Topics: Animals; Conditioning, Psychological; Diabetes Mellitus, Experimental; Dose-Response Relationship, D | 2017 |
The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cholinergic Agonists; Conditioning, Operant; Disea | 2017 |
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal.
Topics: Amino Acids; Animals; Disease Models, Animal; Dopamine; Female; Glutamic Acid; Male; Mecamylamine; N | 2018 |
Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Disease Mod | 2018 |
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Conditioning, Classical; Glycine; Male; Mecamyl | 2019 |
Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Female; Gene Expression | 2019 |
The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice.
Topics: Animals; Anisoles; Behavior, Animal; Cocaine; Conditioning, Psychological; Cyclohexanols; Dose-Respo | 2013 |
Pharmacological modulation of farnesyltransferase subtype I attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransfe | 2013 |
Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.
Topics: Animals; GABAergic Neurons; Glutamic Acid; Light; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice | 2013 |
Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Male; Mecamylamine; Motor Activity; Nicotine; Nicotini | 2014 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family | 2014 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys.
Topics: Animals; Discrimination Learning; Female; Macaca mulatta; Male; Mecamylamine; Neuropsychological Tes | 2014 |
Baclofen prevented the changes in c-Fos and brain-derived neutrophic factor expressions during mecamylamine-precipitated nicotine withdrawal in mice.
Topics: Animals; Baclofen; Basal Ganglia; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Mecamylamine | 2014 |
Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice.
Topics: Anhedonia; Animals; Gene Deletion; Male; Mecamylamine; Mice; Mice, Knockout; Microinjections; Nicoti | 2015 |
Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal.
Topics: Anhedonia; Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; R | 2015 |
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.
Topics: Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; | 2015 |
Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine.
Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Female; Habenula; Inte | 2015 |
Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats.
Topics: Animals; Brain; Indoles; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pyrrolidines; Rats, Wi | 2015 |
Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice.
Topics: Animals; Body Weight; Brain; Cotinine; Disease Models, Animal; Eating; Electronic Nicotine Delivery | 2015 |
A Two-Day Continuous Nicotine Infusion Is Sufficient to Demonstrate Nicotine Withdrawal in Rats as Measured Using Intracranial Self-Stimulation.
Topics: Animals; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Rats, Wistar; Self Stimulation; Subst | 2015 |
N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.
Topics: Acetylcysteine; Animals; Association Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; | 2016 |
A novel method to induce nicotine dependence by intermittent drug delivery using osmotic minipumps.
Topics: Drug Delivery Systems; Mecamylamine; Osmosis; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2016 |
Cognitive control deficits during mecamylamine-precipitated withdrawal in mice: Possible links to frontostriatal BDNF imbalance.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition; Corpus Striatum; Executive Function; Male; Me | 2016 |
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Dependovirus; Disease Models, Animal; Genetic Vec | 2016 |
Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats.
Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin.
Topics: Animals; Anxiety; beta-Endorphin; Conditioning, Classical; Crosses, Genetic; Exploratory Behavior; F | 2009 |
Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats.
Topics: Animals; Antibodies, Monoclonal; Brain; Dose-Response Relationship, Drug; Immunization, Passive; Imm | 2009 |
Removal of continuous nicotine infusion produces somatic but not behavioral signs of withdrawal in mice.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Habituation, Psy | 2009 |
Nicotine withdrawal produces a decrease in extracellular levels of dopamine in the nucleus accumbens that is lower in adolescent versus adult male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Bicuculline; Dopamine; Extracellular Space; GABA Ant | 2010 |
Inhibitory influence of mecamylamine on ethanol withdrawal-induced symptoms in C57BL/6J mice.
Topics: Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Ethanol; Male; Mecamylamine; | 2010 |
Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction.
Topics: Animals; Behavior, Addictive; Choice Behavior; Conditioning, Psychological; Cues; Male; Mecamylamine | 2010 |
Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mec | 2011 |
Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.
Topics: Animals; Antigens, Surface; Benzoxazoles; Intracellular Signaling Peptides and Proteins; Isoquinolin | 2012 |
Role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice.
Topics: Affect; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Drug Implants; Electrode | 2012 |
SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intr | 2012 |
Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.
Topics: Anhedonia; Animals; Brain; Cocaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Ni | 2012 |
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; | 2012 |
Precipitated withdrawal from nicotine reduces reinforcing effects of a visual stimulus for rats.
Topics: Animals; Conditioning, Operant; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic An | 2012 |
Galantamine attenuates the heroin seeking behaviors induced by cues after prolonged withdrawal in rats.
Topics: Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cues; Drug-Seeking Be | 2012 |
Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Female; Hypothalamus; Male; Mecamylamine; Nico | 2012 |
Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice.
Topics: Analysis of Variance; Animals; Brain; Conditioning, Operant; Electric Stimulation; Mecamylamine; Mic | 2012 |
Mecamylamine elicits withdrawal-like signs in rats following a single dose of nicotine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Subcutaneous; M | 2013 |
Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal.
Topics: Adaptation, Physiological; Age Factors; Analysis of Variance; Animals; Chromatography, High Pressure | 2012 |
Nicotine vapor inhalation escalates nicotine self-administration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose | 2014 |
Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; G-Protein-Coupl | 2013 |
Nicotine withdrawal syndrome: behavioural distress and selective up-regulation of the cyclic AMP pathway in the amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Cyclic AMP; Ganglionic Stimulants; Male; Mecamylamine; Nicotin | 2002 |
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Hot Temperature; Immersion; Male; Meca | 2002 |
Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Psychological; Locomotion; Mecamylamine; Mice; | 2002 |
SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.
Topics: Animals; Azepines; Behavior, Animal; Body Temperature; Brain; Cardiovascular System; Cells, Cultured | 2003 |
Impact of nicotine withdrawal on novelty reward and related behaviors.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Inter | 2003 |
Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration.
Topics: Animals; Behavior, Animal; Injections, Intravenous; Male; Mecamylamine; Mice; Mice, Inbred DBA; Nico | 2003 |
Characterization of spontaneous and precipitated nicotine withdrawal in the mouse.
Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Ant | 2003 |
Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response | 2004 |
Nicotine withdrawal in adolescent and adult rats.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Blinking; Disease Models, Animal; Drug Admin | 2004 |
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hype | 2004 |
Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzoxaz | 2004 |
Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene.
Topics: Analgesics; Animals; Conditioning, Classical; Dopamine; Enkephalins; Female; Hot Temperature; Male; | 2005 |
Blockade of the expression of mecamylamine-precipitated nicotine withdrawal by calcium channel antagonists.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Maze Learning; Mecamylamine; Mice; Motor | 2005 |
Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence?
Topics: Acute Disease; Animals; Bupropion; Dextromethorphan; Drug Therapy, Combination; Female; Mecamylamine | 2005 |
Dose, duration, and pattern of nicotine administration as determinants of behavioral dependence in rats.
Topics: Animals; Association Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, | 2006 |
Neurosteroids in nicotine and morphine dependence.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antag | 2006 |
Bupropion attenuates nicotine abstinence syndrome in the rat.
Topics: Animals; Association Learning; Avoidance Learning; Bupropion; Conditioning, Classical; Dopamine Upta | 2006 |
Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs.
Topics: Animals; Dopamine; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Antagonists; Nucleus Accum | 2005 |
Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2006 |
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction.
Topics: Age Factors; Animals; Behavior, Animal; Cotinine; Dose-Response Relationship, Drug; Male; Mecamylami | 2006 |
Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats.
Topics: Animals; Circadian Rhythm; Eating; Extinction, Psychological; Male; Mecamylamine; Nicotine; Rats; Ra | 2007 |
Withdrawal from chronic nicotine in adolescent and adult rats.
Topics: Age Factors; Animals; Anxiety; Body Weight; Male; Maze Learning; Mecamylamine; Rats; Rats, Sprague-D | 2006 |
'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration.
Topics: Animals; Conditioning, Operant; Food; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Nicotini | 2007 |
Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Do | 2008 |
Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal.
Topics: Animals; Antidepressive Agents; Bupropion; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Repeated administration of nicotine attenuates the development of morphine tolerance and dependence in mice.
Topics: Analgesics, Opioid; Animals; Atropine; Dose-Response Relationship, Drug; Drug Tolerance; Ganglionic | 2008 |
Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Anesthetics, Local; Animal | 2007 |
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
Topics: Amygdala; Animals; Anxiety; Behavior, Addictive; Behavior, Animal; Corticotropin-Releasing Hormone; | 2007 |
Effects of nitric oxide synthase inhibitors in attenuating nicotine withdrawal in rats.
Topics: Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male | 2008 |
Spontaneous nicotine withdrawal potentiates the effects of stress in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Di | 2008 |
Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats.
Topics: Aging; Animals; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Injecti | 2008 |
Decreased brain reward function during nicotine withdrawal in C57BL6 mice: evidence from intracranial self-stimulation (ICSS) studies.
Topics: Animals; Brain; Drug Implants; Electrodes, Implanted; Male; Mecamylamine; Mice; Mice, Inbred C57BL; | 2008 |
The effects of nicotine on locomotor activity in non-tolerant and tolerant rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hexamethonium; Hexamethonium Compounds; H | 1983 |
Nicotine does not improve discrimination of brain stimulation reward by rats.
Topics: Animals; Brain; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Hum | 1983 |
Clinical evaluation of mecamylamine for withdrawal from nicotine dependence.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Mecamylamine; Middle Aged; Nicotine; | 1984 |
The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat.
Topics: Animals; Behavior, Animal; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague- | 1994 |
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; | 1994 |
Nicotine attenuates naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: Animals; Atropine; Behavior, Animal; Benzazepines; Hexamethonium; Male; Mecamylamine; Mice; Morphine | 1996 |
Mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Drug Evaluation, Preclinical; Evaluation Studies | 1996 |
Attenuation of mecamylamine-precipitated nicotine-withdrawal aversion by the 5-HT3 receptor antagonist ondansetron.
Topics: Animals; Conditioning, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Ondansetr | 1997 |
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; D | 1998 |
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Dopamine; Homovanil | 1998 |
Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal.
Topics: Animals; Male; Mecamylamine; Naloxone; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; | 1998 |
The nitric oxide synthesis inhibitor nitro-L-arginine (L-NNA) attenuates nicotine abstinence syndrome in the rat.
Topics: Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide Synth | 1998 |
Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains.
Topics: Animals; Ganglionic Stimulants; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Inb | 1999 |
Behavioral and biochemical manifestations of mecamylamine-precipitated nicotine withdrawal in the rat: role of nicotinic receptors in the ventral tegmental area.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Hydroxyindoleacetic Acid; Male; Mecamylamine; Mot | 1999 |
Selective c-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome.
Topics: Amygdala; Animals; Behavior, Animal; Biological Transport; Brain Chemistry; Dopamine; Male; Mecamyla | 2000 |
Nicotine abstinence in the mouse.
Topics: Animals; Behavior, Animal; Body Weight; Injections, Subcutaneous; Male; Mecamylamine; Mice; Motor Ac | 1999 |
Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine; Infusion Pumps, Implantable; Male; Mecamy | 2000 |
Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.
Topics: Animals; Brain; Chlorisondamine; Injections, Intraventricular; Male; Mecamylamine; Naloxone; Nicotin | 2000 |
Modulation of opioidergic system on mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: Analgesics; Animals; Male; Mecamylamine; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Antagon | 2000 |
Intraaccumbal mecamylamine infusion does not affect dopamine output in the nucleus accumbens of chronically nicotine-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chronic Disease; Dopamine; Extracellular | 2000 |
Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro.
Topics: Animals; Animals, Newborn; Culture Techniques; Dose-Response Relationship, Drug; Ethanol; Hippocampu | 2000 |
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; | 2001 |
Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens.
Topics: Acetylcholine; Animals; Dopamine; Male; Mecamylamine; Microdialysis; Nicotine; Nucleus Accumbens; Ra | 2001 |
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; | 2001 |
Modulation of kappa-opioidergic systems on mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2002 |
Effect of pharmacological interference with various neuropathways on blockade of morphine-withdrawal hypothermia by morphine and by conditional stimulus.
Topics: Animals; Benztropine; Conditioning, Classical; Cyproheptadine; Haloperidol; Humans; Hypothermia; Mal | 1976 |
Effects of cholinergic and anticholinergic drugs and a partial cholinergic agonist on the development and expression of physical dependence on morphine in rat.
Topics: Animals; Atropine; Body Weight; Choline; Humans; Male; Mecamylamine; Morphine Dependence; Parasympat | 1975 |
The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat.
Topics: Animals; Binding, Competitive; Brain; Drug Administration Schedule; Hippocampus; Kinetics; Male; Mec | 1990 |
[Drug treatment of nicotine dependence].
Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndro | 1990 |
Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol (PTZ).
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Pentylenetetrazol | 1986 |
Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.
Topics: Animals; Atropine; Autonomic Nervous System; Diphenhydramine; Dose-Response Relationship, Drug; Drug | 1973 |
Modification of precipitated morphine and methadone abstinence in mice by acetylcholine antagonists.
Topics: Acetylcholine; Animals; Atropine; Drug Combinations; Humans; Mecamylamine; Methadone; Mice; Morphine | 1973 |
Morphine withdrawal syndrome responses to cholinergic antagonists and to a partial cholinergic agonist.
Topics: Animals; Atropine; Choline; Humans; Male; Mecamylamine; Morphine Dependence; Rats; Substance Withdra | 1973 |